A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

“Mini-mental state”

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282

Fitting Linear Mixed-Effects Models Using lme4

Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015) · Journal of Statistical Software · doi:10.18637/jss.v067.i01 · Cited by 86,835

[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].

Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012

Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review

Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589

Conducting Meta-Analyses in R with the metafor Package

Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464

Older Adults' Reasons for Using Technology while Aging in Place

Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852

Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly

Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

A scaling normalization method for differential expression analysis of RNA-seq data

Robinson, M. D., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r25 · Cited by 7,876

dbSNP: the NCBI database of genetic variation

Sherry, S. T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.308 · Cited by 7,502

Linear Mixed-Effects Models using 'Eigen' and S4

Bates, D. M., Maechler, M., Bolker, B. M., & Walker, S. C. (2015) · Cited by 5,924

Feature Selection with the Boruta Package

Kursa, M. B., & Rudnicki, W. R. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i11 · Cited by 5,659

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062

Genetic effects on gene expression across human tissues

GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036

Fixed-and random-effects models in meta-analysis.

Hedges, L. V., & Vevea, J. L. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.4.486 · Cited by 2,977

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Petersen, R. C., Aisen, P. S., Beckett, L. A., Donohue, M. C., Gamst, A. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Shaw, L. M., Toga, A. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cb3e25 · Cited by 2,572

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Feldman, H. H., Frisoni, G. B., Hampel, H., Jagust, W. J., Johnson, K. A., Knopman, D. S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002923 · Cited by 1,864

High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis

Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610

Landscape of X chromosome inactivation across human tissues

GTEx Consortium, Tukiainen, T., Villani, A.-C., Yen, A., Rivas, M. A., Marshall, J. L., Satija, R., Aguirre, M., Gauthier, L., Fleharty, M., et al. (2017) · Nature · doi:10.1038/nature24265 · Cited by 1,138

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Weiner, M. W., Veitch, D. P., Aisen, P. S. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Liu, E., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1769 · Cited by 1,033

Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences

Mielke, M., Vemuri, P., & Rocca, W. (2014) · Clinical Epidemiology · doi:10.2147/clep.s37929 · Cited by 1,021

The incidence of dementia: A meta-analysis

Jorm, A. F., & Jolley, D. (1998) · Neurology · doi:10.1212/wnl.51.3.728 · Cited by 903

A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

Carithers, L. J., Ardlie, K., Barcus, M., Branton, P. A., Britton, A., Buia, S. A., Compton, C. C., DeLuca, D. S., Peter-Demchok, J., Gelfand, E. T., et al. (2015) · Biopreservation and Biobanking · doi:10.1089/bio.2015.0032 · Cited by 833

A refined method for the meta-analysis of controlled clinical trials with binary outcome

Hartung, J., & Knapp, G. (2001) · Statistics in Medicine · doi:10.1002/sim.1009 · Cited by 775

Prevalence of mild cognitive impairment is higher in men

Petersen, R. C., Roberts, R. O., Knopman, D. S., Geda, Y. E., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., & Rocca, W. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f11d85 · Cited by 771

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Horvath, S., Gurven, M., Levine, M. E., Trumble, B. C., Kaplan, H. S., Allayee, H., Ritz, B. R., Chen, B. H., Lu, A. T.-H., Rickabaugh, T. M., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1030-0 · Cited by 749

Reframing sexual differentiation of the brain

McCarthy, M. M., & Arnold, A. P. (2011) · Nature Neuroscience · doi:10.1038/nn.2834 · Cited by 728

Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

Kivipelto, M., Helkala, E.-L., Hänninen, T., Laakso, M. P., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · Neurology · doi:10.1212/wnl.56.12.1683 · Cited by 717

Mild cognitive impairment, amnestic type

Ganguli, M., Dodge, H. H., Shen, C., & DeKosky, S. T. (2004) · Neurology · doi:10.1212/01.wnl.0000132523.27540.81 · Cited by 674

Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654

What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?

Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587

Fast and efficient QTL mapper for thousands of molecular phenotypes

Ongen, H., Buil, A., Brown, A. A., Dermitzakis, E. T., & Delaneau, O. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv722 · Cited by 580

A Reevaluation of the Duration of Survival after the Onset of Dementia

Wolfson, C. M., Wolfson, D. B., Asgharian, M., M’lan, C. E., Østbye, T., Rockwood, K. J., & Hogan, D. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441501 · Cited by 553

Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets

Klein, W. L. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00050-5 · Cited by 551

On tests of the overall treatment effect in meta-analysis with normally distributed responses

Hartung, J., & Knapp, G. (2001) · Statistics in Medicine · doi:10.1002/sim.791 · Cited by 543

Vascular risk factors, incidence of MCI, and rates of progression to dementia

Solfrizzi, V., Panza, F., Colacicco, A. M., D’Introno, A., Capurso, C., Torres, F., Grigoletto, F., Maggi, S., Del Parigi, A., Reiman, E. M., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000144281.38555.e3 · Cited by 530

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer’s disease

Wang, M., Beckmann, N. D., Roussos, P., Wang, E., Zhou, X., Wang, Q., Ming, C., Neff, R., Ma, W., Fullard, J. F., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.185 · Cited by 502

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Weiner, M. W., Veitch, D. P., Aisen, P. S. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Liu, E., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.09.172 · Cited by 497

A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies

Stegle, O., Parts, L., Durbin, R., & Winn, J. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000770 · Cited by 497

Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men

Ferrini, R. L., & Barrett-Connor, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009519 · Cited by 473

Dementia and survival in Parkinson disease: A 12-year population study

Buter, T. C., van den Hout, A., Matthews, F. E., Larsen, J. P., Brayne, C., & Aarsland, D. (2008) · Neurology · doi:10.1212/01.wnl.0000306632.43729.24 · Cited by 451

Alzheimer’s Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

Saykin, A. J., Shen, L., Foroud, T. M., Potkin, S. G., Swaminathan, S., Kim, S., Risacher, S. L., Nho, K., Huentelman, M. J., Craig, D. W., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.013 · Cited by 442

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

Allen, M., Carrasquillo, M. M., Funk, C., Heavner, B. D., Zou, F., Younkin, C. S., Burgess, J. D., Chai, H.-S., Crook, J., Eddy, J. A., et al. (2016) · Scientific Data · doi:10.1038/sdata.2016.89 · Cited by 439

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

Cissé, M., Halabisky, B., Harris, J., Devidze, N., Dubal, D. B., Sun, B., Orr, A., Lotz, G., Kim, D. H., Hamto, P., et al. (2011) · Nature · doi:10.1038/nature09635 · Cited by 433

A simple confidence interval for meta-analysis

Sidik, K., & Jonkman, J. N. (2002) · Statistics in Medicine · doi:10.1002/sim.1262 · Cited by 431

Sex and the development of Alzheimer's disease

Pike, C. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23827 · Cited by 416

Age, Sex, andAPOEε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

Jack, C. R., Wiste, H. J., Weigand, S. D., Knopman, D. S., Vemuri, P., Mielke, M. M., Lowe, V. J., Senjem, M. L., Gunter, J. L., Machulda, M. M., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4821 · Cited by 412

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402

Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome

Lederer, D., Grisart, B., Digilio, M. C., Benoît, V., Crespin, M., Ghariani, S., Maystadt, I., Dallapiccola, B., & Verellen‐Dumoulin, C. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.021 · Cited by 374

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults

Buckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., Jacobs, H. I. L., Papp, K. V., Amariglio, R. E., Properzi, M. J., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.4693 · Cited by 373

Heritability and genomics of gene expression in peripheral blood

Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y.-H., et al. (2014) · Nature Genetics · doi:10.1038/ng.2951 · Cited by 362

Predicting Time to Nursing Home Care and Death in Individuals With Alzheimer Disease

Stern, Y. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340040030 · Cited by 359

Global survey of escape from X inactivation by RNA-sequencing in mouse

Yang, F., Babak, T., Shendure, J., & Disteche, C. M. (2010) · Genome Research · doi:10.1101/gr.103200.109 · Cited by 350

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

Hohman, T. J., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Gifford, K. A., Bush, W. S., Chibnik, L. B., Mukherjee, S., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0821 · Cited by 340

Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study

Jack, C. R., Wiste, H. J., Weigand, S. D., Therneau, T. M., Knopman, D. S., Lowe, V., Vemuri, P., Mielke, M. M., Roberts, R. O., Machulda, M. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30077-7 · Cited by 333

Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?

Hebert, L. E., Scherr, P. A., McCann, J. J., Beckett, L. A., & Evans, D. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.2.132 · Cited by 331 · cited 2×

Life Extension Factor Klotho Enhances Cognition

Dubal, D. B., Yokoyama, J. S., Zhu, L., Broestl, L., Worden, K., Wang, D., Sturm, V. E., Kim, D., Klein, E., Yu, G.-Q., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.076 · Cited by 329

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

Shpargel, K. B., Sengoku, T., Yokoyama, S., & Magnuson, T. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002964 · Cited by 320

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

Wang, J., Tanila, H., Puoliväli, J., Kadish, I., & Groen, T. V. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.009 · Cited by 316

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

Chin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

Saykin, A. J., Shen, L., Yao, X., Kim, S., Nho, K. T., Risacher, S. L., Ramanan, V. K., Foroud, T., Faber, K. M., Sarwar, N., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.05.009 · Cited by 307

Escape from X Inactivation Varies in Mouse Tissues

Berletch, J. B., Ma, W., Yang, F., Shendure, J., Noble, W. S., Distèche, C. M., & Deng, X. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005079 · Cited by 307

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

Webster, J. A., Gibbs, J. R., Clarke, J., Ray, M., Zhang, W., Holmans, P., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.011 · Cited by 304

What predicts mortality in Parkinson disease?

Forsaa, E. B., Larsen, J. O., Wentzel‐Larsen, T., & Alves, G. W. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f61311 · Cited by 304

Prevalence of biologically vs clinically defined alzheimer spectrum entities using the National Institute on Aging–Alzheimer's Association Research Framework

Jack, C. R., Therneau, T. M., Weigand, S. D., Wiste, H. J., Knopman, D. S., Vemuri, P., Lowe, V. J., Mielke, M. M., Roberts, R. O., Machulda, M. M., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1971 · Cited by 300

The incidence of MCI differs by subtype and is higher in men

Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., Rocca, W. A., & Petersen, R. C. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452862 · Cited by 290

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

Morley, J. E., Kaiser, F. E., Raum, W. J., Perry, H. M., Flood, J. F., Jensen, J., Silver, A. J., & Roberts, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7537 · Cited by 289

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

Hirata-Fukae, C., Li, H.-F., Hoe, H.-S., Gray, A. J., Minami, S. S., Hamada, K., Niikura, T., Hua, F., Tsukagoshi-Nagai, H., Horikoshi-Sakuraba, Y., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.079 · Cited by 284

The UTX gene escapes X inactivation in mice and humans

Greenfield, A. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.4.737 · Cited by 276

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., Lim, Y. Y., Papp, K. V., Jacobs, H. I. L., Burnham, S., Hanseeuw, B. J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.010 · Cited by 276

Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

Callahan, M. J., Lipinski, W. J., Bian, F., Durham, R. A., Pack, A., & Walker, L. C. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64064-3 · Cited by 274

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

Carroll, J. C., Rosario, E. R., Kreimer, S., Villamagna, A., Gentzschein, E., Stanczyk, F. Z., & Pike, C. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.009 · Cited by 273

Correlates of Cognitive Function in Middle-Aged Adults

Cerhan, J. R., Folsom, A. R., Mortimer, J. A., Shahar, E., Knopman, D. S., McGovern, P. G., Hays, M. A., Crum, L. D., & HEISS, G. M. (1998) · Gerontology · doi:10.1159/000021991 · Cited by 272

Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease

Rockenstein, E. M., McConlogue, L., Tan, H. T., Power, M., Masliah, E., & Mucke, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28257 · Cited by 255

Increased risk of mortality in Alzheimer's disease patients with more advanced educational and occupational attainment

Stern, Y., Tang, M. X., Denaro, J., & Mayeux, R. (1995) · Annals of Neurology · doi:10.1002/ana.410370508 · Cited by 252

Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease

Williams, M. M., Xiong, C., Morris, J. C., & Galvin, J. E. (2006) · Neurology · doi:10.1212/01.wnl.0000247041.63081.98 · Cited by 239

X-linked genes and mental functioning

Skuse, D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi112 · Cited by 236

Early‐onset Alzheimer's disease

Heyman, A., Wilkinson, W. E., Hurwitz, B. J., Helms, M. J., Haynes, C. S., Utley, C. M., & Gwyther, L. P. (1987) · Neurology · doi:10.1212/wnl.37.6.980 · Cited by 233

Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland

Koivisto, K. J., Reinikainen, K. J., Hänninen, T., Vanhanen, M., Helkala, E.-L., Mykkänen, L. M., Laakso, M., Pyörälà, K., & Riekkinen, P. J. (1995) · Neurology · doi:10.1212/wnl.45.4.741 · Cited by 233

Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase

Walport, L. J., Hopkinson, R. J., Vollmar, M., Madden, S. K., Gileadi, C., Oppermann, U. C. T., Schofield, C. J., & Johansson, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555052 · Cited by 229

Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities

Mahadevaiah, S. K. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.4.715 · Cited by 228

KDM6A Point Mutations Cause Kabuki Syndrome

Miyake, N., Mizuno, S., Okamoto, N., Ohashi, H., Shiina, M., Ogata, K., Tsurusaki, Y., Nakashima, M., Saitsu, H., Niikawa, N., et al. (2012) · Human Mutation · doi:10.1002/humu.22229 · Cited by 216

Escape from X inactivation in mice and humans

Berletch, J. B., Yang, F., & Distèche, C. M. (2010) · Genome biology · doi:10.1186/gb-2010-11-6-213 · Cited by 211

Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes

Vawter, M. P., Evans, S. J., Choudary, P. V., Tomita, H., Meador-Woodruff, J., Molnar, M., Li, J. Z., López, J. F., Myers, R. M., Cox, D. R., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300337 · Cited by 204

Mutation Update for Kabuki Syndrome GenesKMT2DandKDM6Aand Further Delineation of X-Linked Kabuki Syndrome Subtype 2

Bögershausen, N., Gâtinois, V., Riehmer, V., Kayserili, H., Becker, J., Thoenes, M., Şimşek‐Kiper, P. Ö., Barat‐Houari, M., Elcioglu, N. H., Wieczorek, D., et al. (2016) · Human Mutation · doi:10.1002/humu.23026 · Cited by 200

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Dubal, D. B., Zhu, L., Sanchez, P. E., Worden, K., Broestl, L., Johnson, E. C. B., Ho, K., Yu, G.-Q., Kim, D., Bétourné, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5791-12.2015 · Cited by 196

MLL2 and KDM6A mutations in patients with Kabuki syndrome

Miyake, N., Koshimizu, E., Okamoto, N., Mizuno, S., Ogata, T., Nagai, T., Kosho, T., Ohashi, H., Kato, M., Sasaki, G., et al. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36072 · Cited by 190

Kabuki syndrome genes KMT2D and KDM6A : functional analyses demonstrate critical roles in craniofacial, heart and brain development

Laarhoven, P. M. V., Neitzel, L. R., Quintana, A. M., Geiger, E. A., Zackai, E. H., Clouthier, D. E., Artinger, K., Ming, J. E., & Shaikh, T. H. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv180 · Cited by 187

The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity

Itoh, Y., Golden, L. C., Itoh, N., Matsukawa, M. A., Ren, E., Tse, V., Arnold, A. P., & Voskuhl, R. R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126250 · Cited by 185

An H–YDb epitope is encoded by a novel mouse Y chromosome gene

Greenfield, A., Scott, D. M., Pennisi, D. J., Ehrmann, I. E., Ellis, P., Cooper, L. T., Simpson, E., & Koopman, P. A. (1996) · Nature Genetics · doi:10.1038/ng1296-474 · Cited by 181

Persistent metabolic youth in the aging female brain

Goyal, M. S., Blazey, T., Su, Y., Couture, L. E., Durbin, T. J., Bateman, R. J., Benzinger, T. L. S., Morris, J. C., Raichle, M. E., & Vlassenko, A. G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815917116 · Cited by 181

Estimation of lifetime risks of Alzheimer's disease dementia using biomarkers for preclinical disease

Brookmeyer, R., & Abdalla, N. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.03.005 · Cited by 176

Sex-Specific Differences in Expression of Histone DemethylasesUtxandUtyin Mouse Brain and Neurons

Xu, J., Deng, X., Watkins, R., & Distèche, C. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5382-07.2008 · Cited by 173

Assessment of demographic, genetic, and imaging variables associated with brain resilience and cognitive resilience to pathological tau in patients with Alzheimer disease

Ossenkoppele, R., Lyoo, C. H., Jester-Broms, J., Sudre, C. H., Cho, H., Ryu, Y. H., Choi, J. Y., Smith, R., Strandberg, O., Palmqvist, S., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.5154 · Cited by 161

Mouse Models for Evaluating Sex Chromosome Effects that Cause Sex Differences in Non‐Gonadal Tissues

Arnold, A. P. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01831.x · Cited by 161

CIND and MCI in the Italian elderly

Carlo, A. D., Lamassa, M., Baldereschi, M., Inzitari, M., Scafato, E., Farchi, G., & Inzitari, D. (2007) · Neurology · doi:10.1212/01.wnl.0000263132.99055.0d · Cited by 150

Factors affecting survival in Alzheimer's disease

Burns, A. S., Lewis, G., Jacoby, R. J., & Levy, R. (1991) · Psychological Medicine · doi:10.1017/s0033291700020468 · Cited by 149

Prognostic Factors in Very Old Demented Adults: A Seven‐Year Follow‐Up From a Population‐Based Survey in Stockholm

Agüero‐Torres, H., Fratiglioni, L., Guo, Z., Viitanen, M., & Winblad, B. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb02464.x · Cited by 147

Collagen VI protects neurons against Aβ toxicity

Cheng, J. S., Dubal, D. B., Kim, D. H., Legleiter, J. A., Cheng, I. H.-J., Yu, G.-Q., Tesseur, I. C., Wyss‐Coray, T., Bonaldo, P., & Mucke, L. (2009) · Nature Neuroscience · doi:10.1038/nn.2240 · Cited by 145

CIND AND MCI IN THE ITALIAN ELDERLY: FREQUENCY, VASCULAR RISK FACTORS, PROGRESSION TO DEMENTIA

Solfrizzi, V., Reiman, E. M., Caselli, R. J., Parigi, A., Capurso, A., & Panza, F. (2007) · Neurology · doi:10.1212/01.wnl.0000295706.28423.65 · Cited by 141

The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region

Eicher, E. M., Hale, D. W., Hunt, P. A., Lee, B. K., Tucker, P. K., King, T. R., Eppig, J. T., & Washburn, L. L. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133152 · Cited by 137

Widespread sex dimorphism in aging and age-related diseases

Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 130

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

Elmaleh, D. R., Farlow, M. R., Conti, P. S., Tompkins, R. G., Kundakovic, L., & Tanzi, R. E. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190507 · Cited by 129

Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study

Jack, C. R., Therneau, T. M., Wiste, H. J., Weigand, S. D., Knopman, D. S., Lowe, V. J., Mielke, M. M., Vemuri, P., Roberts, R. O., Machulda, M. M., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00323-3 · Cited by 129

The Transition From Home to Nursing Home Mortality Among People With Dementia

Aneshensel, C. S., Pearlin, L. I., Levy-Storms, L., & Schuler, R. H. (2000) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/55.3.s152 · Cited by 117

Factors Affecting Course and Survival in Alzheimer's Disease

Bracco, L. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540240057016 · Cited by 116

Amyotrophic Lateral Sclerosis Mortality in the United States, 1979–2001

Sejvar, J. J., Holman, R. C., Bresee, J., Kochanek, K. D., & Schonberger, L. B. (2005) · Neuroepidemiology · doi:10.1159/000086679 · Cited by 115

Microglial microRNAs mediate sex-specific responses to tau pathology

Kodama, L., Guzman, E., Etchegaray, J. I., Li, Y., Sayed, F. A., Zhou, L., Zhou, Y., Zhan, L., Le, D., Udeochu, J. C., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0560-7 · Cited by 115

Occurrence of cognitive impairment and dementia in the community

Caracciolo, B., Palmer, K., Monastero, R., Winblad, B. G., Bäckman, L., & Fratiglioni, L. (2008) · Neurology · doi:10.1212/01.wnl.0000288180.21984.cb · Cited by 109

Differential contributions of ovarian and extraovarian factors to age- related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL/6J mice

Nelson, J. F., Felicio, L. S., Osterburg, H. H., & Finch, C. E. (1992) · Endocrinology · doi:10.1210/endo.130.2.1733727 · Cited by 102

Aging and hormones of the hypothalamo-pituitary axis: Gonadotropic axis in men and somatotropic axes in men and women

Veldhuis, J. D. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.12.005 · Cited by 98

Assessment of Cell Viability in Primary Neuronal Cultures

Aras, M. A., Hartnett, K. A., & Aizenman, E. (2008) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0718s44 · Cited by 92

Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities

Dubal, D. B. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00018-7 · Cited by 92

Gender differences in predictors of mortality in nursing home residents with AD

Lapane, K. L., Gambassi, G., Landi, F., Sgadari, A., Mor, V., & Bernabei, R. (2001) · Neurology · doi:10.1212/wnl.56.5.650 · Cited by 91

PLASMA TESTOSTERONE LEVELS IN C57BL/6J MALE MICE: EFFECTS OF AGE AND DISEASE

Nelson, J. F., Latham, K. R., & Finch, C. E. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0800744 · Cited by 82

Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau

Digma, L. A., Madsen, J. R., Rissman, R. A., Jacobs, D. M., Brewer, J. B., Banks, S. J., Initiative, A. D. N., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa025 · Cited by 80

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

Halford, R. W., & Russell, D. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813349106 · Cited by 75

The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

Initiative, A. D. N., Bonham, L. W., Desikan, R. S., & Yokoyama, J. S. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0339-y · Cited by 75

Female XX sex chromosomes increase survival and extend lifespan in aging mice

Davis, E. J., Lobach, I. V., & Dubal, D. B. (2018) · Aging Cell · doi:10.1111/acel.12871 · Cited by 74

Psychosis of Alzheimer Disease: Prevalence, Incidence, Persistence, Risk Factors, and Mortality

Franch, J. V., Pousa, S. L., Calvó‐Perxas, L., & Garre‐Olmo, J. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.051 · Cited by 73

Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation

Gažová, I., Lengeling, A., & SUMMERS, K. M. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.04.012 · Cited by 69

Incorporating sex as a biological variable in neuroscience: what do we gain?

McCarthy, M. M., Woolley, C. S., & Arnold, A. P. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.137 · Cited by 67

The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice

Tang, G.-B., Zeng, Y., Liu, P., Mi, T., Zhang, S.-F., Dai, S., Tang, Q.-Y., Yang, L. S., Xu, Y.-J., Yan, H.-L., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00267 · Cited by 65

Predicting Survival in Patients with Early Alzheimer’s Disease

Claus, J. J., van Gool, W. A., Teunisse, S., Walstra, G. J. M., Kwa, V. I. H., Hijdra, A., Verbeeten, B., Jr., Koelman, J. H. T. M., Bour, L. J., & de Visser, B. W. O. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017073 · Cited by 64

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Dubal, D. B., Broestl, L., & Worden, K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-24 · Cited by 62

Cognitive aging is not created equally: differentiating unique cognitive phenotypes in “normal” adults

Casaletto, K. B., Elahi, F. M., Staffaroni, A. M., Walters, S. M., Contreras, W. R., Wolf, A. A., Dubal, D. B., Miller, B. L., Yaffe, K. S., & Kramer, J. H. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.007 · Cited by 58

Female Bias in Rhox6 and 9 Regulation by the Histone Demethylase KDM6A

Berletch, J. B., Deng, X., Nguyen, D. K., & Distèche, C. M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003489 · Cited by 57

UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling

Lei, X., & Jiao, J. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.008 · Cited by 57

Factors associated with mortality in patients with early‐onset Alzheimer's disease: a five‐year longitudinal study

Ueki, A., Shinjo, H., Shimode, H., Nakajima, T., & Morita, Y. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.419 · Cited by 56

Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice

Broestl, L., Worden, K., Moreno, A. J., Davis, E. J., Wang, D., Garay, B. I., Singh, T., Verret, L., Palop, J. J., & Dubal, D. B. (2018) · eNeuro · doi:10.1523/eneuro.0132-17.2018 · Cited by 35

Mortality in incident dementia – results from the German Study on Aging, Cognition, and Dementia in Primary Care Patients

Röhr, S., Luck, T., Bickel, H., Brettschneider, C., Ernst, A., Fuchs, A., Heser, K., König, H. ‐., Jessen, F., Lange, C., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12454 · Cited by 33

Survival of Alzheimer's Disease Patients in Korea

Go, S. M., Lee, K. S., Seo, S. W., Chin, J., Kang, S. J., Moon, S. Y., Na, D. L., & Cheong, H. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000347133 · Cited by 33

Are patients with Alzheimer's disease surviving longer in recent years?

Beard, C. M., Kokmen, E., O’Brien, P. C., & Kurland, L. T. (1994) · Neurology · doi:10.1212/wnl.44.10.1869 · Cited by 33

Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005

Kihira, T., Yoshida, S., Okamoto, K., Kazimoto, Y., Ookawa, M., Hama, K., Miwa, H., & Kondo, T. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.11.011 · Cited by 27

A simple test of copying ability and sex define survival in patients with early Alzheimer's disease

Claus, J. J., Walstra, G. J. M., Bossuyt, P. M., Teunisse, S., & van Gool, W. A. (1999) · Psychological Medicine · doi:10.1017/s0033291798007375 · Cited by 22

Survival in Early Onset Dementia: Effects of Urbanization and Socio-Economic Deprivation

Thomas, B. M., McGonigal, G., McQuade, C. A., Starr, J. M., & Whalley, L. J. (1997) · Neuroepidemiology · doi:10.1159/000109682 · Cited by 21

De novo exonic deletion of KDM6A in a Chinese girl with Kabuki syndrome: A case report and brief literature review

Yang, P., Tan, H., Xia, Y., Yu, Q., Wei, X., Guo, R., Peng, Y., Chen, C., Li, H., Mei, L., et al. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37634 · Cited by 19

X Inactivation in Mouse ES Cells: Histone Modifications and FISH

Panning, B. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)76028-5 · Cited by 13

UTX – moonlighting in the cytoplasm?

Wiedemuth, R., Thieme, S., Navratiel, K., Dorschner, B. W., & Brenner, S. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.004 · Cited by 8

Sex differences in biological aging with a focus on human studies

Hägg, S., & Jylhävä, J. (2021) · eLife · doi:10.7554/elife.63425 · Cited by 442

Mechanisms of sex differences in Alzheimer’s disease

Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease

Arenaza‐Urquijo, E. M., Boyle, R., Casaletto, K., Anstey, K. J., Vila‐Castelar, C., Colverson, A., Palpatzis, E., Eissman, J. M., Kheng Siang Ng, T., Raghavan, S., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13844 · Cited by 223

Sex Differences in Alzheimer’s Disease: Insights From the Multiomics Landscape

Guo, L., Zhong, M. B., Zhang, L., Zhang, B., & Cai, D. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.968 · Cited by 164

Small molecule cognitive enhancer reverses age-related memory decline in mice

Krukowski, K., Nolan, A., Frias, E. S., Boone, M., Ureta, G., Grue, K. A., Paladini, M. S., Elizarraras, E., Delgado, L. M., Bernales, S., et al. (2020) · eLife · doi:10.7554/elife.62048 · Cited by 167

The missing X factor in Alzheimer disease

Ferretti, M. T., & Chadha, A. S. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00573-x · Cited by 16

IL-17A levels in Alzheimer’s disease brains are mediated by X chromosome dosage

Misrani, A., Wang, J., Xu, Y., & Liu, F. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112065

The Role of the Inactive X-Chromosome in Longevity and Neurodegeneration

Davis, E. J. (2020) · eScholarship (California Digital Library)

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

Davis, E. J., Solsberg, C. W., White, C. C., Miñones-Moyano, E., Sirota, M., Chibnik, L. B., Bennett, D. A., Jager, P. L. D., Yokoyama, J. S., & Dubal, D. B. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.2806 · Cited by 76

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Dubal, D. B., Broestl, L., & Worden, K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-24 · Cited by 62