Cited by 176Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

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Davis, Emily J., Broestl, Lauren, Abdulai-Saiku, Samira, Worden, Kurtresha, Bonham, Luke W., Miñones-Moyano, Elena, Moreno, Arturo J., Wang, Dan, Chang, Kevin, Williams, Gina, Garay, Bayardo I., Lobach, Iryna, Devidze, Nino, Kim, Daniel, Anderson-Bergman, Cliff, Yu, Gui-Qiu, White, Charles C., Harris, Julie A., Miller, Bruce L., Bennett, David A., Arnold, Arthur P., De Jager, Phil L., Palop, Jorge J., Panning, Barbara, Yokoyama, Jennifer S., Mucke, Lennart, Dubal, Dena B.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aaz5677PMC PMC8409261

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Abstract

The second X chromosome confers resilience in a mouse model of Alzheimer’s disease potentially through the X-linked gene Kdm6a .

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Authors: Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., Garay, B. I., Lobach, I., Devidze, N., Kim, D., Anderson-Bergman, C., Yu, G.-Q., White, C. C., Harris, J. A., Miller, B. L., Bennett, D. A., Arnold, A. P., De Jager, P. L., Palop, J. J., Panning, B., Yokoyama, J. S., Mucke, L., & Dubal, D. B.
Affiliations: University of California, San Francisco (US)
Gladstone Institutes (US)
Broad Institute (US)
Allen Institute for Brain Science (US)
Rush University Medical Center (US)
University of California, Los Angeles (US)
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Corresponding author: Davis, Emily J.
Broestl, Lauren
Dubal, Dena B.
ORCID: Davis, Emily J.
Broestl, Lauren
Abdulai-Saiku, Samira
Worden, Kurtresha
Bonham, Luke W.
Miñones-Moyano, Elena
Moreno, Arturo J.
Wang, Dan
Chang, Kevin
Williams, Gina
Garay, Bayardo I.
Lobach, Iryna
Kim, Daniel
Anderson-Bergman, Cliff
White, Charles C.
Harris, Julie A.
Miller, Bruce L.
Bennett, David A.
Arnold, Arthur P.
De Jager, Phil L.
Palop, Jorge J.
Panning, Barbara
Yokoyama, Jennifer S.
Mucke, Lennart
Dubal, Dena B.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-08-26
Volume: 12
Issue: 558
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaz5677
PMC: PMC8409261
OpenAlex: W3080470877
Cited by: 176
References: 141
Citations by year: 2026: 19 · 2025: 32 · 2024: 28 · 2023: 26 · 2022: 44 · 2021: 21 · 2020: 6
FWCI: 14.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Science Foundation (1650113)
National Institutes of Health (AG023501, NS043196, AG011385 and NS065780, P30AG10161, R01AG15819, and R01AG17917, U01AG46152 and U01AG61356, CTSI UL1 TR000004, AG049152, NS092918 and AG034531, R01AG36836)
Larry L. Hillblom Foundation
American Federation for Aging Research
Glenn Foundation for Medical Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, X chromosome, sex chromosomes, resilience, cognitive decline, aging, preclinical Alzheimer's disease, mouse model, brain gene expression, disease susceptibility
MeSH terms: Alzheimer Disease, Animals, Female, Male, Sex Characteristics, Testis, X Chromosome, Y Chromosome, Mice

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A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

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