A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations
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Abstract
Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe and mild COVID-19 are compared.
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The S-Flow assay measures antibody binding to cells expressing the Wuhan S protein.
“we adapted the flow cytometry-based S-Flow assay, which we previously established to measure the levels of antibodies binding to cells expressing the Wuhan S protein 35 .”
From Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies (2021) · cites this paper as [35]
The positivity threshold of the S-Flow assay was defined as specific binding above 40%, determined after testing 253 pre-pandemic samples.
“After testing 253 pre-pandemic samples, the positivity of a sample was defined as a specific binding above 40%.”
From Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies (2021) · cites this paper as [35]
The S-Flow serological assay, assessed with the Wuhan S protein on 253 pre-pandemic samples and 377 RT-qPCR-confirmed SARS-CoV-2 samples, has a sensitivity of 99.2% (95% CI 97.69-99.78%) and a specificity of 100% (98.5-100%).
“The specificity and sensitivity of the S-Flow serological assay were originally assessed with the Wuhan S protein using 253 pre-pandemic samples and 377 RT-qPCR-confirmed SARS-CoV-2 samples.The sensitivity is 99.2% with a 95% confidence interval of 97.69-99.78%and the specificity is 100% (98.5-100%) 33,35 .”
From Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies (2021) · cites this paper as [35]
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- Authors
- Grzelak, L., Temmam, S., Planchais, C., Demeret, C., Tondeur, L., Huon, C., Guivel-Benhassine, F., Staropoli, I., Chazal, M., Dufloo, J., Planas, D., Buchrieser, J., Rajah, M. M., Robinot, R., Porrot, F., Albert, M., Chen, K.-Y., Crescenzo-Chaigne, B., Donati, F., Anna, F., Souque, P., Gransagne, M., Bellalou, J., Nowakowski, M., Backovic, M., Bouadma, L., Le Fevre, L., Le Hingrat, Q., Descamps, D., Pourbaix, A., Laouénan, C., Ghosn, J., Yazdanpanah, Y., Besombes, C., Jolly, N., Pellerin-Fernandes, S., Cheny, O., Ungeheuer, M.-N., Mellon, G., Morel, P., Rolland, S., Rey, F. A., Behillil, S., Enouf, V., Lemaitre, A., Créach, M.-A., Petres, S., Escriou, N., Charneau, P., Fontanet, A., Hoen, B., Bruel, T., Eloit, M., Mouquet, H., Schwartz, O., & van der Werf, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- Inserm (FR)
- Virus and Immunity Unit, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France.
- Structural Virology Unit, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France.
- Medical and Infectious Diseases Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Bichat–Claude-Bernard University Hospital, Paris, France.
- Université of Paris, INSERM UMR 1137 IAME, Paris, France.
- Assistance Publique – Hôpitaux de Paris (FR)
- Investigation Clinique et Accès aux Ressources Biologiques (ICAReB), Center for Translational Research, Institut Pasteur, Paris, France.
- Hôpital Necker-Enfants Malades (FR)
- Établissement Français du Sang (FR)
- Hôpital Cochin (FR)
- Direction alerte et crises, réserve sanitaire, Santé publique France, Saint-Maurice, France.
- Centre d’épidémiologie et de santé publique des armées, Marseille, France.
- Plate-Forme Technologique Production et Purification de Protéines Recombinantes, Institut Pasteur, Paris, France.
- Conservatoire National des Arts et Métiers (FR)
- Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.
- Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Paris, France.
- Corresponding author
- Grzelak, Ludivine
- Temmam, Sarah
- Planchais, Cyril
- Demeret, Caroline
- Mouquet, Hugo
- Schwartz, Olivier
- ORCID
- Grzelak, Ludivine
- Temmam, Sarah
- Planchais, Cyril
- Demeret, Caroline
- Tondeur, Laura
- Huon, Christèle
- Staropoli, Isabelle
- Chazal, Maxime
- Dufloo, Jeremy
- Planas, Delphine
- Buchrieser, Julian
- Rajah, Maaran Michael
- Robinot, Remy
- Porrot, Françoise
- Albert, Mélanie
- Chen, Kuang-Yu
- Crescenzo-Chaigne, Bernadette
- Donati, Flora
- Anna, François
- Souque, Philippe
- Bellalou, Jacques
- Backovic, Marija
- Bouadma, Lila
- Le Hingrat, Quentin
- Descamps, Diane
- Laouénan, Cédric
- Ghosn, Jade
- Yazdanpanah, Yazdan
- Besombes, Camille
- Jolly, Nathalie
- Ungeheuer, Marie-Noëlle
- Mellon, Guillaume
- Morel, Pascal
- Rolland, Simon
- Rey, Felix A.
- Behillil, Sylvie
- Enouf, Vincent
- Lemaitre, Audrey
- Créach, Marie-Aude
- Petres, Stephane
- Escriou, Nicolas
- Charneau, Pierre
- Fontanet, Arnaud
- Hoen, Bruno
- Bruel, Timothée
- Eloit, Marc
- Mouquet, Hugo
- Schwartz, Olivier
- van der Werf, Sylvie
- Venue
- Science Translational Medicine
- Published
- 2020-09-02
- Volume
- 12
- Issue
- 559
- Pages
- eabc3103
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7665313
- OpenAlex
- W3057728496
- Cited by
- 310
- References
- 46
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 14 · 2023: 38 · 2022: 64 · 2021: 110 · 2020: 72
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Translational Medicine (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- Funders
- Gilead Sciences (HIV cure program)
- Sidaction
- Ministère de l’Enseignement supérieur, de la Recherche et de l’Innovation
- European Research Council (RECOVER)
- Agence Nationale de la Recherche (ANR-14-CE14-0029, Oh’ticks, ANR-14-CE14-0015-01)
- Labex IBEID (ANR-10-LABX-62-IBEID)
- Institut Pasteur
- CNRS
- INSERM
- Agence Nationale de Recherches sur le Sida et les Hepatites Virales
- REACTing
- Université PSL
- Santé Publique France
- Labex Milieu Intérieur (ANR-10-LABX-69-01)
- Labex VRI (ANR- 10-LABX-77)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, serological assays, SARS-CoV-2 antibodies, antibody titers, neutralizing antibodies, seroconversion, seroprevalence, nucleocapsid protein, spike protein, luciferase immunoprecipitation system, ELISA, asymptomatic infection, hospitalized patients, blood donors, assay sensitivity
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, France, Humans, Luciferases, Male, Middle Aged, Neutralization Tests, Pneumonia, Viral, Serologic Tests, Cohort Studies, Seroepidemiologic Studies, Coronavirus Infections, Clinical Laboratory Techniques, Immunoprecipitation, Young Adult, Translational Research, Biomedical, Pandemics, Healthy Volunteers, Spike Glycoprotein, Coronavirus
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