The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins
Abstract
Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.
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Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
The multiple faces of caveolae
Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Fibroblast biology in three-dimensional collagen matrices
Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819
Cell Mechanics: Integrating Cell Responses to Mechanical Stimuli
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Metadata
- Authors
- Alenghat, F. J., & Ingber, D. E.
- Venue
- Science's STKE
- Published
- 2002-02-12
- Volume
- 2002
- Issue
- 119
- Pages
- pe6-pe6
- ISSN
- 1525-8882 (ISSN-L)
- OpenAlex
- W2153287457
- Cited by
- 494
- References
- 28
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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