CoChat
Sign Up
Cited by 582

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Human RAS Superfamily Proteins and Related GTPases

Colicelli, John·2004·Science's STKE
DOI 10.1126/stke.2502004re13
Open this paper in CoChat — free account

Abstract

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at least 35 related human proteins. Using a somewhat broader definition of sequence similarity reveals a more extended superfamily of more than 170 RAS-related proteins. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis–coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Gα family. The members of each family can, in turn, be arranged into evolutionarily conserved branches. These groupings reflect structural, biochemical, and functional conservation. Recent findings have provided insights into the signaling characteristics of representative members of most RAS superfamily branches. The analysis presented here may serve as a guide for predicting the function of numerous uncharacterized superfamily members. Also described are guanosine triphosphatases (GTPases) distinct from members of the RAS superfamily. These related proteins employ GTP binding and GTPase domains in diverse structural contexts, expanding the scope of their function in humans.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/stke.2502004re13

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 263

  1. 10.1073/pnas.84.7.1814 · DOI
  2. 10.1002/j.1460-2075.1982.tb01276.x · DOI · Paper page
  3. 10.1016/0092-8674(95)90507-3 · DOI
  4. 10.1126/science.271.5250.810 · DOI
  5. 10.1016/S0092-8674(00)80226-3 · DOI
  6. 10.1126/science.1062023 · DOI · Paper page
  7. 10.1074/jbc.271.12.6794 · DOI
  8. 10.1126/science.2406906 · DOI
  9. 10.1016/S0021-9258(19)77694-7 · DOI
  10. 10.1159/000136714 · DOI
  11. 10.1126/science.8493579 · DOI
  12. 10.1016/S0079-6603(02)71047-7 · DOI
  13. L. A. Feig, G. M. Cooper, Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8, 3235–3243 (1988).
  14. S. Y. Chen, S. Y. Huff, C. C. Lai, C. J. Der, S. Powers, Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene 9, 2691–2698 (1994).
  15. 10.1126/science.1087761 · DOI
  16. 10.1016/S0898-6568(98)00063-1 · DOI
  17. 10.1016/S0968-0004(96)10062-1 · DOI
  18. 10.1016/S0960-9822(98)70257-X · DOI
  19. 10.1038/366643a0 · DOI
  20. F. Tamanoi D. S. Sigman Eds. Protein Lipidation vol. 21 (Academic Press San Diego CA 2001).
  21. 10.1074/jbc.271.9.4671 · DOI
  22. 10.1016/S0021-9258(17)31698-8 · DOI
  23. 10.1074/jbc.270.44.26347 · DOI
  24. 10.1046/j.1432-1327.1999.00815.x · DOI
  25. 10.1074/jbc.M000397200 · DOI
  26. 10.1074/jbc.M104658200 · DOI
  27. 10.1021/bi00083a001 · DOI
  28. 10.1073/pnas.90.8.3675 · DOI
  29. 10.1016/0014-5793(94)80406-0 · DOI
  30. W. H. Kirsten, L. A. Mayer, Malignant lymphomas of extrathymic origin induced in rats by murine erythroblastosis virus. J. Natl. Cancer Inst. 43, 735–746 (1969).
  31. J. J. Harvey, An unidentified virus which causes the rapid production of tumours in mice. Nature 204, 1104–1105 (1964).
  32. 10.1016/0092-8674(81)90388-3 · DOI
  33. 10.1073/pnas.78.2.1181 · DOI
  34. 10.1038/290261a0 · DOI
  35. 10.1038/346754a0 · DOI
  36. L. A. Feig, G. M. Cooper, Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Mol. Cell. Biol. 8, 2472–2478 (1988).
  37. G. Patel, M. J. MacDonald, R. Khosravi-Far, M. M. Hisaka, C. J. Der, Alternate mechanisms of ras activation are complementary and favor and formation of ras-GTP. Oncogene 7, 283–288 (1992).
  38. 10.1002/ajmg.10692 · DOI
  39. 10.1146/annurev.genom.3.022502.103043 · DOI
  40. 10.1016/S1535-6108(02)00093-4 · DOI
  41. 10.1200/JCO.2003.10.130 · DOI
  42. 10.1016/0304-3835(96)04372-8 · DOI
  43. 10.1023/A:1006491619920 · DOI
  44. 10.1016/0092-8674(90)90149-9 · DOI
  45. 10.1016/0092-8674(90)90150-D · DOI
  46. 10.1016/0092-8674(90)90151-4 · DOI · Paper page
  47. 10.1016/S0022-5347(01)64362-3 · DOI
  48. 10.1007/s00232-002-1026-4 · DOI
  49. 10.1016/S0092-8674(00)80607-8 · DOI · Paper page
  50. 10.1128/MCB.20.7.2475-2487.2000 · DOI
  51. 10.1128/MCB.22.14.5128-5140.2002 · DOI
  52. 10.1091/mbc.01-11-0552 · DOI
  53. 10.1038/35070050 · DOI
  54. 10.1038/nrm1105 · DOI · Paper page
  55. 10.1074/jbc.M105888200 · DOI
  56. 10.1016/S0021-9258(18)61562-5 · DOI
  57. 10.1042/bj3550145 · DOI
  58. 10.1074/jbc.M001813200 · DOI
  59. 10.1073/pnas.1037299100 · DOI
  60. 10.1073/pnas.96.24.13813 · DOI
  61. 10.1074/jbc.M103133200 · DOI
  62. 10.1038/304497a0 · DOI
  63. 10.1038/304501a0 · DOI
  64. S. Guil, N. de La Iglesia, J. Fernandez-Larrea, D. Cifuentes, J. C. Ferrer, J. J. Guinovart, M. Bach-Elias, Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus. Cancer Res. 63, 5178–5187 (2003).
  65. 10.1016/0092-8674(85)90280-6 · DOI
  66. 10.1016/0092-8674(91)90065-7 · DOI
  67. 10.1016/0092-8674(90)90495-Z · DOI
  68. 10.1038/36849 · DOI
  69. 10.1016/S0896-6273(00)80471-7 · DOI · Paper page
  70. 10.1016/S0896-6273(00)81008-9 · DOI · Paper page
  71. 10.1523/JNEUROSCI.23-03-00748.2003 · DOI
  72. 10.1073/pnas.90.13.6213 · DOI
  73. 10.1016/0092-8674(93)90307-C · DOI
  74. 10.1038/364352a0 · DOI
  75. 10.1038/364308a0 · DOI
  76. 10.1073/pnas.90.18.8683 · DOI
  77. 10.1042/bj3510289 · DOI
  78. 10.1016/S0955-0674(97)80060-9 · DOI
  79. 10.1073/pnas.93.14.6924 · DOI
  80. 10.1073/pnas.212516099 · DOI
  81. 10.1038/ncb833 · DOI
  82. 10.1038/nature00848 · DOI
  83. 10.1002/j.1460-2075.1996.tb00602.x · DOI
  84. 10.1073/pnas.91.26.12609 · DOI
  85. A. Kikuchi, S. D. Demo, Z. H. Ye, Y. W. Chen, L. T. Williams, ralGDS family members interact with the effector loop of ras p21. Mol. Cell. Biol. 14, 7483–7491 (1994).
  86. 10.1074/jbc.271.47.29903 · DOI
  87. 10.1038/sj.onc.1204053 · DOI
  88. 10.1002/j.1460-2075.1996.tb00416.x · DOI
  89. 10.1128/MCB.21.17.5958-5969.2001 · DOI
  90. 10.1101/gad.993902 · DOI
  91. 10.1128/MCB.22.3.916-926.2001 · DOI
  92. 10.1073/pnas.94.10.4954 · DOI
  93. 10.1016/S1534-5807(01)00008-9 · DOI · Paper page
  94. 10.1016/S1074-7613(00)80452-5 · DOI
  95. 10.1016/S0960-9822(02)00683-8 · DOI
  96. 10.1093/emboj/20.4.743 · DOI
  97. 10.1073/pnas.97.16.9064 · DOI
  98. 10.1074/jbc.M312867200 · DOI
  99. 10.1038/nature02237 · DOI
  100. 10.1128/MCB.23.3.933-949.2003 · DOI
  101. 10.1242/jcs.00689 · DOI
  102. 10.1073/pnas.91.16.7558 · DOI
  103. S. M. Graham, A. D. Cox, G. Drivas, M. G. Rush, P. D’Eustachio, C. J. Der, Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation. Mol. Cell. Biol. 14, 4108–4115 (1994).
  104. 10.1182/blood.V94.7.2433.419k31_2433_2444 · DOI · Paper page
  105. A. D. Cox, T. R. Brtva, D. G. Lowe, C. J. Der, R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells. Oncogene 9, 3281–3288 (1994).
  106. Y. Huang, R. Saez, L. Chao, E. Santos, S. A. Aaronson, A. M. Chan, A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. Oncogene 11, 1255–1260 (1995).
  107. G. J. Clark, M. S. Kinch, T. M. Gilmer, K. Burridge, C. J. Der, Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers. Oncogene 12, 169–176 (1996).
  108. 10.1038/bjc.1998.490 · DOI
  109. 10.1016/S0960-9822(06)00028-5 · DOI · Paper page
  110. 10.1128/MCB.21.11.3750-3762.2001 · DOI
  111. 10.1042/bj3000303 · DOI
  112. 10.1093/emboj/18.5.1270 · DOI
  113. 10.1083/jcb.148.6.1151 · DOI
  114. S. J. McLeod A. J. Shum R. L. Lee F. Takei M. R. Gold The Rap GTPases regulate integrin-mediated adhesion cell spreading actin polymerization and Pyk2 tyrosine phosphorylation in B lymphocytes. J. Biol. Chem. (2003). · DOI
  115. 10.1016/0092-8674(89)90985-9 · DOI
  116. 10.1016/S0092-8674(00)80184-1 · DOI
  117. 10.1038/ncb874 · DOI · Paper page
  118. 10.1074/jbc.M008970200 · DOI
  119. 10.1016/S1535-6108(03)00163-6 · DOI
  120. 10.1016/S0092-8674(03)00155-7 · DOI · Paper page
  121. 10.1128/MCB.23.3.1112-1124.2003 · DOI · Paper page
  122. 10.1038/sj.onc.1206003 · DOI
  123. 10.1038/ni950 · DOI
  124. 10.1016/S0962-8924(03)00152-1 · DOI · Paper page
  125. 10.1128/MCB.20.2.462-467.2000 · DOI
  126. 10.1038/sj.embor.embor899 · DOI
  127. 10.1128/MCB.24.13.5746-5756.2004 · DOI
  128. S. H. Park, R. A. Weinberg, A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene 11, 2349–2355 (1995).
  129. 10.1074/jbc.270.38.22473 · DOI · Paper page
  130. 10.1128/MCB.15.8.4578 · DOI · Paper page
  131. 10.1242/jcs.113.16.2837 · DOI · Paper page
  132. 10.1093/emboj/18.13.3629 · DOI · Paper page
  133. 10.1074/jbc.M302191200 · DOI
  134. 10.1038/ncb728 · DOI · Paper page
  135. 10.1074/jbc.M308702200 · DOI · Paper page
  136. 10.1038/ncb720 · DOI · Paper page
  137. 10.1083/jcb.200308070 · DOI
  138. 10.1242/jcs.00401 · DOI
  139. 10.1074/jbc.M201092200 · DOI
  140. 10.1523/JNEUROSCI.16-21-06784.1996 · DOI
  141. 10.1038/sj.onc.1203836 · DOI
  142. 10.1016/S0014-5793(01)03264-1 · DOI
  143. 10.1006/abbi.1999.1448 · DOI
  144. 10.1038/nature01646 · DOI
  145. 10.1074/jbc.M202150200 · DOI
  146. 10.1073/pnas.142193799 · DOI
  147. 10.1073/pnas.96.1.214 · DOI
  148. L. Wang, A. Hoque, R. Z. Luo, J. Yuan, Z. Lu, A. Nishimoto, J. Liu, A. A. Sahin, S. M. Lippman, R. C. Bast, Jr., Y. Yu, Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin. Cancer Res. 9, 3660–3666 (2003).
  149. 10.1074/jbc.273.6.3129 · DOI
  150. 10.1038/sj.bjp.0704680 · DOI
  151. 10.1210/endo.142.6.8209 · DOI
  152. G. Vaidyanathan M. J. Cismowski G. Wang T. S. Vincent K. D. Brown S. M. Lanier The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene 23 5858–5863 (2004). · DOI
  153. 10.1038/sj.onc.1207161 · DOI
  154. 10.1126/science.287.5454.869 · DOI
  155. 10.1074/jbc.M301021200 · DOI
  156. 10.1074/jbc.272.35.21982 · DOI
  157. 10.1042/bj3470223 · DOI
  158. 10.1126/science.8248782 · DOI · Paper page
  159. 10.1126/science.7912851 · DOI · Paper page
  160. 10.1073/pnas.2437756100 · DOI
  161. 10.1038/35079621 · DOI
  162. 10.1093/emboj/20.15.4076 · DOI
  163. 10.1016/j.cub.2003.08.042 · DOI
  164. 10.1042/bj20020829 · DOI
  165. 10.1016/j.bbrc.2004.02.091 · DOI
  166. 10.1242/jcs.00661 · DOI
  167. 10.1038/sj.onc.1205792 · DOI
  168. 10.1016/S1097-2765(03)00220-X · DOI · Paper page
  169. 10.1016/S0960-9822(03)00506-2 · DOI · Paper page
  170. 10.1038/ncb999 · DOI
  171. 10.1016/S0092-8674(04)00003-0 · DOI · Paper page
  172. 10.1242/jcs.01118 · DOI
  173. 10.1038/nrc725 · DOI · Paper page
  174. 10.1038/sj.onc.1203233 · DOI
  175. 10.1126/science.273.5272.245 · DOI
  176. 10.1038/11056 · DOI
  177. 10.1126/science.271.5249.648 · DOI
  178. 10.1126/science.271.5249.645 · DOI
  179. 10.1074/jbc.M306904200 · DOI
  180. 10.1074/jbc.M203569200 · DOI
  181. 10.1074/jbc.271.23.13556 · DOI
  182. 10.1016/S0021-9258(19)84716-6 · DOI · Paper page
  183. 10.1074/jbc.270.39.22731 · DOI
  184. 10.1074/jbc.M301418200 · DOI
  185. 10.1016/S0960-9822(02)00423-2 · DOI
  186. 10.1016/S0092-8674(00)81050-8 · DOI
  187. 10.1073/pnas.93.11.5615 · DOI
  188. 10.1016/j.cell.2004.06.027 · DOI
  189. 10.1093/emboj/cdg110 · DOI
  190. 10.1016/S0960-9822(03)00418-4 · DOI
  191. 10.1128/MCB.23.12.4219-4229.2003 · DOI
  192. 10.1016/S0092-8674(03)00315-5 · DOI
  193. 10.1074/jbc.M208609200 · DOI
  194. 10.1042/bj20031041 · DOI
  195. 10.1073/pnas.84.23.8210 · DOI
  196. E. R. Nimmo, P. G. Sanders, R. A. Padua, D. Hughes, R. Williamson, K. J. Johnson, The MEL gene: A new member of the RAB/YPT class of RAS-related genes. Oncogene 6, 1347–1351 (1991).
  197. N. Segev, Ypt/rab gtpases: Regulators of protein trafficking. Sci. STKE 2001, re11 (2001).
  198. H. Stenmark V. M. Olkkonen The Rab GTPase family. Genome Biol. 2 REVIEWS3007 (2001). · DOI
  199. 10.1006/jmbi.2001.5072 · DOI
  200. 10.1002/j.1460-2075.1996.tb00529.x · DOI

200 of 263 shown

Cited by

See all 582

Metadata

Authors
Colicelli, J.
Affiliations
Department of Biological Chemistry and Molecular Biology Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Venue
Science's STKE
Publisher
American Association for the Advancement of Science (AAAS)
Published
2004-09-14
Volume
2004
Issue
250
ISSN
1525-8882
DOI
10.1126/stke.2502004re13
Cited by
582
References
15
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review