A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate
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population toward multiazole resistance, highlighting the multifactorial nature of the acquisition of azole resistance and pointing out a new player in azole resistance.
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Previous studies on in vitro-acquired drug resistance in C. glabrata have evaluated fitness costs of echinocandin resistance or used transcriptomics to unveil mechanisms contributing to azole resistance, but the genome-wide genetic alterations involved during this process remain elusive.
“Previous studies on in vitro-acquired drug resistance in C. glabrata have evaluated the fitness costs of echinocandin resistance23 or used transcriptomics to unveil the mechanisms contributing to azole resistance,24 but the genome-wide genetic alterations involved during this process remain elusive.”
From Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata (2021) · cites this paper as [24]
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- Authors
- Cavalheiro, M., Costa, C., Silva-Dias, A., Miranda, I. M., Wang, C., Pais, P., Pinto, S. N., Mil-Homens, D., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Silva, R. M., Mira, N. P., Fialho, A. M., Chibana, H., Rodrigues, A. G., Butler, G., & Teixeira, M. C.
- Affiliations
- University of Lisbon (PT)
- Universidade do Porto (PT)
- University College Dublin (IE)
- Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
- Medical Mycology Research Center, Chiba University, Chiba, Japan
- University of Aveiro (PT)
- Chiba University (JP)
- Corresponding author
- Teixeira, Miguel C.
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2019-01
- Volume
- 63
- Issue
- 1
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC6325195
- OpenAlex
- W2905924707
- Cited by
- 42
- References
- 54
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 5
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (12/IA/1343)
- MEC | Fundação para a Ciência e a Tecnologia (PTDC/BBB-BIO/4004/2014, UID/BIO/04565/2013, PTDC/BII-BIO/28216/2017)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida glabrata, fluconazole resistance, in vitro evolution, transcriptomics, azole resistance, clinical isolates
- MeSH terms
- Antifungal Agents, Azoles, Clotrimazole, Ergosterol, Humans, Microbial Sensitivity Tests, Transcription Factors, Triazoles, Fluconazole, Gene Expression Regulation, Fungal, Drug Resistance, Fungal, Membrane Transport Proteins, Candida glabrata, Transcriptome, Voriconazole
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