Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata

Whaley, Sarah G.; Zhang, Qing; Caudle, Kelly E.; Rogers, P. David

doi:10.1128/aac.01070-18

Cited by 59Antifungal resistance and susceptibilityDrug Transport and Resistance MechanismsFungal and yeast genetics research

Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata

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Whaley, Sarah G., Zhang, Qing, Caudle, Kelly E., Rogers, P. David·2018·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.01070-18PMC PMC6153852

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Abstract

The utility of the azole antifungals for the treatment of invasive candidiasis is severely hampered by azole resistance in Candida glabrata . This resistance is mediated almost exclusively by activating mutations in the zinc cluster transcription factor Pdr1, which controls the genes encoding the multidrug resistance transporters Cdr1, Pdh1, and Snq2.

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In Candida glabrata, nearly all clinical triazole resistance is attributable to overexpression of CgCDR1, CgPDH1, and CgSNQ2.
“in which nearly all of the clinical triazole resistance is attributable to overexpression of the ATP-binding cassette (ABC)-type efflux pump-encoding genes C. glabrata CDR1 (CgCDR1), CgPDH1, and CgSNQ2 (16).”
From Mutations in TAC1B : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris (2020) · cites this paper as [16]

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BackgroundResult
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Influential
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Candida glabrata maintains two Hap1 homologs, Zcf27 and Zcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditionsPreprint
Saha, D., Gregor, J. B., Hoda, S., Eastman, K. E., Navarrete, M., Wisecaver, J. H., & Briggs, S. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.20.599910
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Background
Promising Role of Fruitless Wolfberry Bud Tea in Combating Nakaseomyces glabratus Resistance
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“According to Whaley et al. [49], CDR1 is the main transporter linked to PDR1 that causes multidrug resistance to azoles in the clinical isolate of N. glabratus being studied.”
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Self-citation
Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata
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Additional file 1 of Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1
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The azole-resistance phenotype of a Nakaseomyces glabratus clinical strain encoding a wild-type PDR1 allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis
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Authors: Whaley, S. G., Zhang, Q., Caudle, K. E., & Rogers, P. D.
Affiliations: University of Tennessee Health Science Center (US)
ORCID: Whaley, Sarah G.
Zhang, Qing
Caudle, Kelly E.
Rogers, P. David
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2018-10
Volume: 62
Issue: 10
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.01070-18
PMC: PMC6153852
OpenAlex: W2884775618
Cited by: 59
References: 31
Citations by year: 2026: 7 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 1
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI058145, R01AI131620)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida glabrata, azole resistance, ABC transporters, CDR1, PDR1, multidrug resistance, antifungal resistance, clinical isolates
MeSH terms: Antifungal Agents, Azoles, Fungal Proteins, Membrane Proteins, Microbial Sensitivity Tests, ATP-Binding Cassette Transporters, Drug Resistance, Fungal, Membrane Transport Proteins, Candida glabrata

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Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata

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