The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

Rybak, Jeffrey M; Cuomo, Christina A; David Rogers, P

doi:10.1016/j.mib.2022.102208

Cited by 113Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

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Rybak, Jeffrey M, Cuomo, Christina A, David Rogers, P·2022·Current Opinion in Microbiology

DOI 10.1016/j.mib.2022.102208PMC PMC10364995

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Abstract

Fungal infections are responsible for significant morbidity and mortality. Resistance to the limited number of agents in the antifungal armamentarium among pathogenic fungi represents a growing public health threat. Particularly concerning is the emerging fungal pathogen Candida auris that frequently exhibits resistance to the triazole class of antifungals and amphotericin B, and for which isolates resistant to all of the major antifungal classes have been reported. In this brief review, we provide an overview of what is currently known about the molecular and genetic basis for antifungal resistance in this fungal pathogen.

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Mutations in MRR1A appear to play a more restrictive role with resistance through an N647T substitution, reported specifically in clade III isolates.
“In contrast, mutations in MRR1A appear to play a more restrictive role with resistance through an N647T substitution, which is reported specifically in clade III isolates56.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [56]

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Authors: Rybak, J. M., Cuomo, C. A., & David Rogers, P.
Affiliations: St. Jude Children's Research Hospital (US)
Broad Institute (US)
ORCID: Rybak, Jeffrey M
Cuomo, Christina A
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2022-12
Volume: 70
Pages: 102208
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2022.102208
PMC: PMC10364995
OpenAlex: W4304777637
Cited by: 113
References: 39
Citations by year: 2026: 30 · 2025: 34 · 2024: 25 · 2023: 22 · 2022: 2
FWCI: 3.19
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Current Opinion in Microbiology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion, cc-by-nc-nd)
Funders: Canadian Institute for Advanced Research
St. Jude Children's Research Hospital
Broad Institute (U19AI110818)
National Institutes of Health (NIAID-R01, AI058145)
National Institute of Allergy and Infectious Diseases (U19AI110818, NIAID R01, R01AI058145, AI058145, R01AI143197, R01AI131620)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: Candida auris, antifungal resistance, triazole resistance, amphotericin B resistance, molecular mechanisms of resistance, genetic basis of resistance, emerging fungal pathogens, fungal infection
MeSH terms: Candida auris, Amphotericin B, Antifungal Agents, Candida, Microbial Sensitivity Tests, Drug Resistance, Fungal

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The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

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