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Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment

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Cleary, John D., Garcia-Effron, Guillermo, Chapman, Stanley W., Perlin, David S.·2008·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.01568-07PMC PMC2415792

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Abstract

We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.

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Authors: Cleary, J. D., Garcia-Effron, G., Chapman, S. W., & Perlin, D. S.
Affiliations: University of Mississippi (US)
Public Health Research Institute, UMDNJ-New Jersey Medical School, Newark, New Jersey
Rutgers New Jersey Medical School (US)
Corresponding author: Cleary, John D.
ORCID: Cleary, John D.
Perlin, David S.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2008-06
Volume: 52
Issue: 6
Pages: 2263-2265
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.01568-07
PMC: PMC2415792
OpenAlex: W2167509781
Cited by: 118
References: 15
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 16
FWCI: 11.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida glabrata, candidemia, caspofungin, FKS1 mutations, fluconazole resistance, clonal isolates, recurrent fungal infection, antifungal susceptibility, echinocandin resistance
MeSH terms: Caspofungin, Aged, Antifungal Agents, Candidiasis, Female, Fungal Proteins, Glucosyltransferases, Humans, Membrane Proteins, Microbial Sensitivity Tests, Mutation, Fungemia, Fatal Outcome, Drug Resistance, Fungal, Candida glabrata, Echinocandins, Lipopeptides

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Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment

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