Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy
Open accessAbstract
The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart.
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The second isolate of the pair NRZ-2016-057/NRZ-2016-058 presented a non-synonymous mutation S663P in FKS2, which correlated with the acquisition of echinocandin resistance.
“the second isolate of the pair NRZ-2016-057/NRZ-2016-058 presented a non-synonymous mutation in FKS2 (S663P), which correlated with the acquisition of echinocandin resistance.”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Barber et al., 2018
CMRL2, CMRL4, and NRZ-2016-058 were shown to be echinocandin resistant.
“DSY565, CMRL6, NRZ-2016-057, and NRZ-2016-058 were shown to be azole resistant; and CMRL2, CMRL4, and NRZ-2016-058 were shown to be echinocandin resistant (Biswas et al., 2017; Vale-Silva et al., 2017; Barber et al., 2018).”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Barber et al., 2018
DSY565, CMRL6, NRZ-2016-057, and NRZ-2016-058 were shown to be azole resistant.
“DSY565, CMRL6, NRZ-2016-057, and NRZ-2016-058 were shown to be azole resistant; and CMRL2, CMRL4, and NRZ-2016-058 were shown to be echinocandin resistant (Biswas et al., 2017; Vale-Silva et al., 2017; Barber et al., 2018).”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Barber et al., 2018
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- Authors
- Barber, A. E., Weber, M., Kaerger, K., Linde, J., Gölz, H., Duerschmied, D., Markert, A., Guthke, R., Walther, G., & Kurzai, O.
- Affiliations
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- University of Freiburg (DE)
- University of Würzburg (DE)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2019-02
- Volume
- 63
- Issue
- 2
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC6355595
- OpenAlex
- W2902287163
- Semantic Scholar
- e93f1ad90d1bdbc027a17c4c4b03def158e532c6
- Cited by
- 32
- References
- 22
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Robert Koch Institute (1369-240)
- Free State of Thuringia
- Deutsche Forschungsgemeinschaft (TR124)
- Bundesministerium für Bildung und Forschung (03ZZ0809A)
- EC | European Regional Development Fund
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida glabrata, echinocandin resistance, antifungal resistance, comparative genomics, candidiasis, opportunistic fungal pathogens
- MeSH terms
- Antifungal Agents, Candidiasis, Fungal Proteins, Humans, Microbial Sensitivity Tests, Genomics, Candida glabrata, Echinocandins
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