Acquired multidrug antifungal resistance in Candida lusitaniae during therapy

Asner, Sandra A.; Giulieri, Stefano; Diezi, Manuel; Marchetti, Oscar; Sanglard, Dominique

doi:10.1128/aac.02204-15

Cited by 82Antifungal resistance and susceptibilityFungal Plant Pathogen ControlFungal and yeast genetics research

Acquired multidrug antifungal resistance in Candida lusitaniae during therapy

Open access

Asner, Sandra A., Giulieri, Stefano, Diezi, Manuel, Marchetti, Oscar, Sanglard, Dominique·2015·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.02204-15PMC PMC4649199

Open this paper in CoChat — free account Open PDF

Abstract

Candida lusitaniae is usually susceptible to echinocandins. Beta-1,3-glucan synthase encoded by FKS genes is the target of echinocandins. A few missense mutations in the C. lusitaniae FKS1 hot spot 1 (HS1) have been reported. We report here the rapid emergence of antifungal resistance in C. lusitaniae isolated during therapy with amphotericin B (AMB), caspofungin (CAS), and azoles for treatment of persistent candidemia in an immunocompromised child with severe enterocolitis and visceral adenoviral disease. As documented from restriction fragment length polymorphism (RFLP) and random amplified polymorphic DNA (RAPD) analysis, the five C. lusitaniae isolates examined were related to each other. From antifungal susceptibility and molecular analyses, 5 different profiles (P) were obtained. These profiles included the following: profile 1 (P1) (CAS MIC [μg/ml], 0.5; fluconazole [FLC] MIC, 0.25), determined while the patient was being treated with liposomal AMB for 3 months; P2 (FLC MIC [μg/ml], 0.25; CAS MIC, 4), while the patient was being treated with CAS for 2 weeks; P3 (CAS MIC [μg/ml], 0.5; FLC MIC, 32), while the patient was being treated with azoles and CAS initially followed by azoles alone for a week; P4 (CAS MIC [μg/ml], 8; FLC MIC, 8), while the patient was being treated with both drugs for 3 weeks; and P5 (AMB MIC [μg/ml], 0.125; CAS MIC, 8), while the patient was being treated with AMB and FLC for 2 weeks. CAS resistance was associated with resistance not only to micafungin and anidulafungin but also to AMB. Analysis of CAS resistance revealed 3 novel FKS1 mutations in CAS-resistant isolates (S638Y in P2; S631Y in P4; S638P in P5). While S638Y and -P are within HS1, S631Y is in close proximity to this domain but was confirmed to confer candin resistance using a site-directed mutagenesis approach. FLC resistance could be linked with overexpression of major facilitator gene 7 (MFS7) in C. lusitaniae P2 and P4 and was associated with resistance to 5-flurocytosine. This clinical report describes resistance of C. lusitaniae to all common antifungals. While candins or azole resistance followed monotherapy, multidrug antifungal resistance emerged during combined therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/aac.02204-15

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Multidrug resistance is not restricted to C. glabrata or C. auris; other examples include C. kefyr, C. lusitaniae, and C. albicans.
“However, MDR is not restricted to C. glabrata or C. auris. Other examples include C. kefyr [57], C. lusitaniae [58], and C. albicans [59,60,61].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [58]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917 · see citing works
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
Ghannoum, M. A., & Rice, L. B. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.4.501 · Cited by 1,788 · see citing works
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
Montague, T. G., Cruz, J. M. B. S., Gagnon, J. A., Church, G. M., & Valen, E. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku410 · Cited by 1,203 · see citing works
Adenovirus Infections in Immunocompetent and Immunocompromised Patients
Lion, T. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00116-13 · Cited by 864 · see citing works
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Sanglard, D., & Odds, F. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00181-0 · Cited by 784 · see citing works
Self-citation
Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism
Snelders, E., van der Lee, H. A. L., Kuijpers, J., Rijs, A. J. M. M., Varga, J., Samson, R. A., Mellado, E., Donders, A. R. T., Melchers, W. J. G., & Verweij, P. E. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050219 · Cited by 726 · see citing works
Resistance to echinocandin-class antifungal drugs.
Perlin, D. S. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.04.002 · Cited by 512 · see citing works
CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae
Mans, R., van Rossum, H. M., Wijsman, M., Backx, A. H., Kuijpers, N. G. A., van den Broek, M. A., Daran-Lapujade, P. A. S., Pronk, J. T., van Maris, A. J. A., & Daran, J.-M. G. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov004 · Cited by 487 · see citing works
Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates
Park, S., Kelly, R., Kahn, J. N., Robles, J., Hsu, M.-J., Register, E., Li, W., Vyas, V., Fan, H., Abruzzo, G., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.8.3264-3273.2005 · Cited by 434 · see citing works
Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
Sanglard, D., Ischer, F., Monod, M., & Billé, J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.10.2300 · Cited by 402 · see citing works
Self-citation
Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
Pfaller, M. A., Diekema, D. J., Andes, D. R., Arendrup, M. C., Brown, S. D., Lockhart, S. R., Motyl, M. R., & Perlin, D. S. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.01.004 · Cited by 335 · see citing works
Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal Resistance
Sanguinetti, M., Posteraro, B., Fiori, B., Ranno, S., Torelli, R., & Fadda, G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.668-679.2005 · Cited by 319 · see citing works
The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: Recommendations from the Third European Conference on Infections in Leukemia
Mikulska, M., Calandra, T., Sanguinetti, M., Poulain, D., Viscoli, C., & the Third European Conference on Infections in Leukemia Group (2010) · Critical Care · doi:10.1186/cc9365 · Cited by 319 · see citing works
Wild-type MIC distributions, epidemiological cutoff values and species-specific clinical breakpoints for fluconazole and Candida: Time for harmonization of CLSI and EUCAST broth microdilution methods
Pfaller, M. A., Andes, D., Diekema, D. J., Espinel-Ingroff, A., & Sheehan, D. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.09.002 · Cited by 314 · see citing works
Echinocandin resistance: an emerging clinical problem?
Arendrup, M. C., & Perlin, D. S. (2014) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000111 · Cited by 299 · see citing works
Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011.
Lockhart, S. R., Iqbal, N., Cleveland, A. A., Farley, M. M., Harrison, L. H., Bolden, C. B., Baughman, W., Stein, B., Hollick, R., Park, B. J., et al. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01283-12 · Cited by 299 · see citing works
Mutations in the multi‐drug resistance regulator MRR1 , followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole‐resistant Candida albicans strains
Dunkel, N., Blaß, J., Rogers, P. D., & Morschhäuser, J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06309.x · Cited by 278 · see citing works
ECIL recommendations for the use of biological markers for the diagnosis of invasive fungal diseases in leukemic patients and hematopoietic SCT recipients
Marchetti, O., Lamoth, F., Mikulska, M., Viscoli, C., Verweij, P., Bretagne, S., & Groups, A. T. E. C. O. I. I. L. (. L. W. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.178 · Cited by 275 · see citing works
Self-citation
Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis
Abruzzo, G. K., Flattery, A. M., Gill, C. J., Kong, L., Smith, J. G., Pikounis, V. B., Balkovec, J. M., Bouffard, A., Dropinski, J. F., Rosen, H., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.11.2333 · Cited by 241 · see citing works
Candida Bloodstream Infections: Comparison of Species Distributions and Antifungal Resistance Patterns in Community-Onset and Nosocomial Isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009
Pfaller, M. A., Moet, G. J., Messer, S. A., Jones, R. N., & Castanheira, M. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01079-10 · Cited by 238 · see citing works
Role of FKS mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance
Pham, C. D., Iqbal, N., Bolden, C. B., Kuykendall, R. J., Harrison, L. H., Farley, M. M., Schaffner, W., Beldavs, Z. G., Chiller, T. M., Park, B. J., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03255-14 · Cited by 231 · see citing works
Assessing Resistance to the Echinocandin Antifungal Drug Caspofungin in Candida albicans by Profiling Mutations in FKS1
Balashov, S. V., Park, S., & Perlin, D. S. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01653-05 · Cited by 225 · see citing works
Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis
Laverdière, M., LALONDE, R. G., Baril, J.-G., Sheppard, D. C., Park, S., & Perlin, D. S. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl022 · Cited by 192 · see citing works
Echinocandin Susceptibility Testing ofCandidaSpecies: Comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, Disk Diffusion, and Agar Dilution Methods with RPMI and IsoSensitest Media
Arendrup, M. C., Garcia-Effron, G., Lass-Flörl, C., Lopez, A. G., Rodriguez-Tudela, J.-L., Cuenca-Estrella, M., & Perlin, D. S. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01256-09 · Cited by 158 · see citing works
Drug-ResistantCandida glabrataInfection in Cancer Patients
Farmakiotis, D., Tarrand, J. J., & Kontoyiannis, D. P. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2011.140685 · Cited by 152 · see citing works
Acquired resistance to echinocandins in Candida albicans: case report and review
Baixench, M.-T., Aoun, N. B. T., Desnos‐Ollivier, M., Garcia‐Hermoso, D., Bretagne, S., Ramires, S., Piketty, C., & Dannaoui, É. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm095 · Cited by 149 · see citing works
Mutations in the fks1 Gene in Candida albicans , C. tropicalis , and C. krusei Correlate with Elevated Caspofungin MICs Uncovered in AM3 Medium Using the Method of the European Committee on Antibiotic Susceptibility Testing
Desnos-Ollivier, M., Bretagne, S., Raoux, D., Hoinard, D., Dromer, F., & Dannaoui, E. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00088-08 · Cited by 132 · see citing works
Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals
Eddouzi, J., Parker, J. E., Vale-Silva, L. A., Coste, A., Ischer, F., Kelly, S., Manai, M., & Sanglard, D. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00555-13 · Cited by 128 · see citing works
Self-citation
Multiplex Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Quantification in Human Plasma of Fluconazole, Itraconazole, Hydroxyitraconazole, Posaconazole, Voriconazole, Voriconazole- N -Oxide, Anidulafungin, and Caspofungin
Decosterd, L. A., Rochat, B., Pesse, B., Mercier, T., Tissot, F., Widmer, N., Billé, J., Calandra, T., Zanolari, B., & Marchetti, O. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00404-10 · Cited by 122 · see citing works
Self-citation
Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase
Kahn, J. N., Garcia-Effron, G., Hsu, M.-J., Park, S., Marr, K. A., & Perlin, D. S. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00067-07 · Cited by 118 · see citing works
Contribution of CgPDR1-Regulated Genes in Enhanced Virulence of Azole-Resistant Candida glabrata
Ferrari, S., Sanguinetti, M., Torelli, R., Posteraro, B., & Sanglard, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017589 · Cited by 110 · see citing works
Self-citation
Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient
Chapeland‐Leclerc, F., Hennequin, C., Papon, N., Noël, T., Girard, A., Socié, G., Ribaud, P., & Lacroix, C. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01138-09 · Cited by 104 · see citing works
Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species
García‐Effrón, G., Chua, D. J., Tomada, J. R. T., DiPersio, J. R., Perlin, D. S., Ghannoum, M. A., & Bonilla, H. F. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00998-09 · Cited by 104 · see citing works
Candida lusitaniaefungemia in cancer patients: risk factors for amphotericin B failure and outcome
Atkinson, B. J., Lewis, R. E., & Kontoyiannis, D. P. (2008) · Medical Mycology · doi:10.1080/13693780801968571 · Cited by 99 · see citing works
Epidemiology of nosocomial acquisition of Candida lusitaniae
Sánchez, V., Vázquez, J. A., Barth-Jones, D. C., Dembry, L., Sobel, J. D., & Zervos, M. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.11.3005-3008.1992 · Cited by 97 · see citing works
Impact of New Antifungal Breakpoints on Antifungal Resistance in Candida Species
Fothergill, A. W., Sutton, D. A., McCarthy, D. I., & Wiederhold, N. P. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.03044-13 · Cited by 96 · see citing works
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance
Papon, N., Noël, T., Florent, M., Gibot‐Leclerc, S., Jean, D., Chastin, C., Villard, J.-F., & Chapeland‐Leclerc, F. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00824-06 · Cited by 86 · see citing works
Colony morphology switching of Candida lusitaniae and acquisition of multidrug resistance during treatment of a renal infection in a newborn: case report and review of the literature
Favel, A., Michel-Nguyen, A., Peyron, F., Martin, C., Thomachot, L., Datry, A., Bouchara, J., Challier, S., Noël, T., Chastin, C., et al. (2003) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(03)00094-4 · Cited by 67 · see citing works
Nonsense and Missense Mutations in FCY2 and FCY1 Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae
Florent, M., Noël, T., Ruprich‐Robert, G., Silva, B. D., Fitton‐Ouhabi, V., Chastin, C., Papon, N., & Chapeland‐Leclerc, F. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00880-08 · Cited by 50 · see citing works
Phenotypic Switching in Candida lusitaniae on Copper Sulfate Indicator Agar: Association with Amphotericin B Resistance and Filamentation
Miller, N. S., Dick, J. D., & Merz, W. G. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.4.1536-1539.2006 · Cited by 44 · see citing works
Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment.
Desnos-Ollivier, M., Moquet, O., Chouaki, T., Guérin, A.-M., & Dromer, F. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00325-11 · Cited by 37 · see citing works
Emergence of multiple resistance profiles involving azoles, echinocandins and amphotericin B in Candida glabrata isolates from a neutropenia patient with prolonged fungaemia
Cho, E., Shin, J. H., Kim, S. H., Kim, H., Park, J. S., Sung, H., Kim, M., & Im, H. J. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku518 · Cited by 36 · see citing works
Detection of Caspofungin Resistance in Candida spp. by Etest
Desnos‐Ollivier, M., Dromer, F., & Dannaoui, É. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00053-08 · Cited by 35 · see citing works
Epidemiology of Echinocandin Resistance in Candida
Grossman, N. T., Chiller, T. M., & Lockhart, S. R. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-014-0209-7 · Cited by 28 · see citing works
Echinocandin-Resistant Candida: Molecular Methods and Phenotypes
Perlin, D. S. (2011) · Current Fungal Infection Reports · doi:10.1007/s12281-011-0054-x · Cited by 20 · see citing works
Combination of different molecular mechanisms leading to fluconazole resistance in a Candida lusitaniae clinical isolate
Reboutier, D., Piednoël, M., Boisnard, S., Conti, A., Chevalier, V., Florent, M., Gibot‐Leclerc, S., Silva, B. D., Chastin, C., Fallague, K., et al. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.10.019 · Cited by 20 · see citing works
Characterization of a New Clinical Yeast Species, Candida tunisiensis sp. nov., Isolated from a Strain Collection from Tunisian Hospitals
Eddouzi, J., Hofstetter, V., Groenewald, M., Manaï, M., & Sanglard, D. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01627-12 · Cited by 18 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707 · see citing works
Emerging Threats in Antifungal-Resistant Fungal Pathogens
Sanglard, D. (2016) · Frontiers in Medicine · doi:10.3389/fmed.2016.00011 · Cited by 420 · see citing works
Self-citation
The rapid emergence of antifungal-resistant human-pathogenic fungi
Lockhart, S. R., Chowdhary, A., & Gold, J. A. W. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00960-9 · Cited by 315 · see citing works
Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
Ksiezopolska, E., & Gabaldón, T. (2018) · Genes · doi:10.3390/genes9090461 · Cited by 230 · see citing works
Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides
Chang, Z., & Heitman, J. (2019) · mBio · doi:10.1128/mbio.02579-19 · Cited by 202 · see citing works
On the Origins of a Species: What Might Explain the Rise of Candida auris?
Jackson, B. R., Chow, N. A., Forsberg, K., Litvintseva, A. P., Lockhart, S. R., Welsh, R. M., Vallabhaneni, S., & Chiller, T. M. (2019) · Journal of Fungi · doi:10.3390/jof5030058 · Cited by 165 · see citing works
New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
Geddes‐McAlister, J., & Shapiro, R. S. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13739 · Cited by 159 · see citing works
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Hoenigl, M., Arastehfar, A. A., Arendrup, M. C., Brüggemann, R. J. M., Carvalho, A., Chiller, T. M., Chen, W., Egger, M., Feys, S., Gangneux, J., et al. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00074-23 · Cited by 160 · see citing works
A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise
Howard, K. C., Dennis, E. K., Watt, D. S., & Garneau‐Tsodikova, S. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00556k · Cited by 147 · see citing works
Use of RNA-Protein Complexes for Genome Editing in Non- albicans Candida Species
Grahl, N., Demers, E. G., Crocker, A. W., & Hogan, D. A. (2017) · mSphere · doi:10.1128/msphere.00218-17 · Cited by 133 · see citing works
Epidemiology of antifungal resistance in human pathogenic yeasts: current viewpoint and practical recommendations for management
Farmakiotis, D., & Kontoyiannis, D. P. (2017) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2017.05.019 · Cited by 76 · see citing works
Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection
Demers, E. G., Biermann, A. R., Masonjones, S., Crocker, A. W., Ashare, A., Stajich, J., & Hogan, D. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807698115 · Cited by 63 · see citing works
Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae
Kannan, A., Asner, S. A., Trachsel, E., Kelly, S., Parker, J., & Sanglard, D. (2019) · mBio · doi:10.1128/mbio.02512-19 · Cited by 63 · see citing works
Self-citation
Contamination of cockroaches (Insecta: Blattaria) to medically fungi: A systematic review and meta-analysis
Nasirian, H. (2017) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2017.04.012 · Cited by 55 · see citing works
Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
Mendoza-Reyes, D. F., Gómez-Gaviria, M., & Mora-Montes, H. M. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s383785 · Cited by 57 · see citing works
Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
Dudiuk, C., Berrío, I., Leonardelli, F., Morales-López, S. E., Theill, L., Macedo, D., Rodríguez, J. Y., Salcedo, S., Marín, A., Gamarra, S. P., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz178 · Cited by 47 · see citing works
Role of Antifungal Combinations in Difficult to Treat Candida Infections
Vitale, R. G. (2021) · Journal of Fungi · doi:10.3390/jof7090731 · Cited by 49 · see citing works
Development of a CRISPR-Cas9 System for Efficient Genome Editing of Candida lusitaniae
Norton, E. L., Sherwood, R. K., & Bennett, R. J. (2017) · mSphere · doi:10.1128/msphere.00217-17 · Cited by 41 · see citing works
Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae
Hashemi, S. E., Shokohi, T., Abastabar, M., Aslani, N., Ghadamzadeh, M., & Haghani, I. (2019) · Current Medical Mycology · doi:10.18502/cmm.5.4.2062 · Cited by 45 · see citing works
Invasive Candida infection: epidemiology, clinical and therapeutic aspects of an evolving disease and the role of rezafungin
Oliva, A., Rosa, F. G. D., Mikulska, M., Pea, F., Sanguinetti, M., Tascini, C., & Venditti, M. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2240956 · Cited by 40 · see citing works
Lactoferrin, chitosan and Melaleuca alternifolia —natural products that show promise in candidiasis treatment
Felipe, L. D. O., Júnior, W. F. D. S., de Araújo, K. C., & Fabrino, D. L. (2017) · Brazilian Journal of Microbiology · doi:10.1016/j.bjm.2017.05.008 · Cited by 35 · see citing works
Candida lusitaniae in Kuwait: Prevalence, antifungal susceptibility and role in neonatal fungemia
Khan, Z., Ahmad, S., Al‐Sweih, N., Khan, S. I., & Joseph, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213532 · Cited by 35 · see citing works
A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical Breakpoints
Astvad, K. M. T., Arıkan-Akdağlı, S., & Arendrup, M. C. (2022) · Journal of Fungi · doi:10.3390/jof8020141 · Cited by 31 · see citing works
Role of FKS Gene in the Susceptibility of Pathogenic Fungi to Echinocandins
Hori, Y., & Shibuya, K. (2018) · Medical Mycology Journal · doi:10.3314/mmj.18.004 · Cited by 28 · see citing works
Epidemiology of yeast species causing bloodstream infection in Tehran, Iran (2015–2017); superiority of 21-plex PCR over the Vitek 2 system for yeast identification
Kord, M., Salehi, M., Khodavaisy, S., Hashemi, S. J., Ghazvini, R. D., Rezaei, S., Maleki, A., Elmimoghaddam, A., Alijani, N., Abdollahi, A., et al. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001189 · Cited by 28 · see citing works
Yeast Species in the Oral Cavities of Older People: A Comparison between People Living in Their Own Homes and Those in Rest Homes
Thiyahuddin, N. M., Lamping, E., Rich, A. M., & Cannon, R. D. (2019) · Journal of Fungi · doi:10.3390/jof5020030 · Cited by 28 · see citing works
Identification of Virulence Factors in Isolates of Candida haemulonii, Candida albicans and Clavispora lusitaniae with Low Susceptibility and Resistance to Fluconazole and Amphotericin B
Angiolella, L., Rojas, F. D., Giammarino, A., Bellucci, N., & Giusiano, G. (2024) · Microorganisms · doi:10.3390/microorganisms12010212 · Cited by 27 · see citing works
Emerging Complexity and the Need for Advanced Drug Delivery in Targeting Candida Species
Wadhwa, R., Pandey, P., Gupta, G., Aggarwal, T., Kumar, N., Mehta, M., Satija, S., Gulati, M., Madan, J., Dureja, H., et al. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191026105308 · Cited by 27 · see citing works
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
Scott, N. E., Erayil, S. E., Kline, S. E., & Selmecki, A. M. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00543-23 · Cited by 25 · see citing works
A Practical Guide to Antifungal Susceptibility Testing
Otto, W. R., Arendrup, M. C., & Fisher, B. T. (2023) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piad014 · Cited by 25 · see citing works
Molecular Identification and Antifungal Susceptibility Pattern of Non-albicans Candida Species Isolated from Vulvovaginal Candidiasis
Nejat, Z. A., Farahyar, S., Falahati, M., Ashrafi‐Khozani, M., Hosseini, A. F., Faiazy, A., Ekhtiari, M., & Hashemi-Hafshejani, S. (2017) · PubMed Central · doi:10.22034/ibj.22.1.33 · Cited by 25 · see citing works
Candida lusitaniae Breakthrough Fungemia in an Immuno-Compromised Adolescent: Case Report and Review of the Literature
Apsemidou, A., Füller, M. A., Idelevich, E. A., Kurzai, O., Tragiannidis, A., & Groll, A. H. (2020) · Journal of Fungi · doi:10.3390/jof6040380 · Cited by 25 · see citing works
Structural analysis and antimicrobial activity of 2[1H]-pyrimidinethione/selenone derivatives
Żesławska, E., Korona‐Głowniak, I., Szczesio, M., Ołczak, A., Żylewska, A., Tejchman, W., & Malm, A. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.04.067 · Cited by 23 · see citing works
Species distribution and antifungal susceptibility profile of Candida isolates from blood and other normally sterile foci from pediatric ICU patients in Tehran, Iran
Mirhendi, H., Charsizadeh, A., Eshaghi, H., Nikmanesh, B., & Arendrup, M. C. (2019) · Medical Mycology · doi:10.1093/mmy/myz047 · Cited by 21 · see citing works
Participation of the ABC Transporter CDR1 in Azole Resistance of Candida lusitaniae
Borgeat, V., Brandalise, D., Grenouillet, F., & Sanglard, D. (2021) · Journal of Fungi · doi:10.3390/jof7090760 · Cited by 21 · see citing works
Self-citation
Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1
Demers, E. G., Stajich, J., Ashare, A., Occhipinti, P., & Hogan, D. A. (2021) · mBio · doi:10.1128/mbio.03328-20 · Cited by 18 · see citing works
Antifungal susceptibility testing following the CLSI M27 document, along with the measurement of MFC/MIC ratio, could be the optimal approach to detect amphotericin B resistance in Clavispora ( Candida ) lusitaniae . Susceptibility patterns of contemporary isolates of this species
Sasoni, N., Caracciolo, B., Cabeza, M. S., Gamarra, S. P., Carnovale, S., & García‐Effrón, G. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00968-23 · Cited by 18 · see citing works
Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent Candida spp. to Triazoles and Amphotericin B and Aspergillus spp. to Caspofungin: Further Assessment of Modal Variability
Espinel‐Ingroff, A., Sasso, M., Turnidge, J. D., Arendrup, M. C., Botterel, F., Bourgeois, N., Bouteille, B., Cantón, R., Cassaing, S., Dannaoui, É., et al. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01093-21 · Cited by 17 · see citing works
Long-term stability of acquired drug resistance and resistance associated mutations in the fungal pathogen Nakaseomyces glabratus (Candida glabrata)
Ksiezopolska, E., Schikora-Tamarit, M. À., Carlos Nunez-Rodriguez, J., & Gabaldón, T. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1416509 · Cited by 15 · see citing works
Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr
Asadzadeh, M., Alfouzan, W. A., Parker, J. E., Meis, J. F. G. M., Kelly, S. L., Joseph, L., & Ahmad, S. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01474-23 · Cited by 15 · see citing works
Echinocandins Susceptibility Patterns of 2,787 Yeast Isolates: Importance of the Thresholds for the Detection of FKS Mutations
Desnos-Ollivier, M., Bretagne, S., Lortholary, O., Dromer, F., & the French Mycoses Study Group N. Brieu CH Aix, T. C. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01725-21 · Cited by 13 · see citing works
Clavispora lusitaniae: From a saprophytic yeast to an emergent pathogen
Rojas, O. C., Montoya, A. M., & Treviño‐Rangel, R. D. J. (2024) · Fungal Biology · doi:10.1016/j.funbio.2024.05.013 · Cited by 12 · see citing works
Les levures du clade CTG (clade Candida) : biologie, incidence en santé humaine et applications en biotechnologie
Defosse, T. A., Govic, Y. L., Courdavault, V., Clastre, M., Vandeputte, P., Chabasse, D., Bouchara, J.-P., Giglioli‐Guivarc’h, N., & Papon, N. (2018) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2018.02.009 · Cited by 12 · see citing works
Challenging SNP impact on caspofungin resistance by full-lengthFKS1allele replacement inCandida lusitaniae
Accoceberry, I., Couzigou, C., Fitton‐Ouhabi, V., Biteau, N., & Noël, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky475 · Cited by 12 · see citing works
A Case for Antifungal Stewardship
Miller, R. A. (2018) · Current Fungal Infection Reports · doi:10.1007/s12281-018-0307-z · Cited by 11 · see citing works
Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung
Murante, D., Demers, E. G., Kurbessoian, T., Ruzic, M., Ashare, A., Stajich, J., & Hogan, D. A. (2023) · mBio · doi:10.1128/mbio.01171-23 · Cited by 8 · see citing works
In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against Candida auris
Caballero, U., Eraso, E., Pemán, J., Quindós, G., Vozmediano, V., Schmidt, S., & Jauregizar, N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111767 · Cited by 8 · see citing works
Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran
Kord, M., Salehi, M., Hashemi, S. J., Abdollahi, A., Alijani, N., Maleki, A., Mahmoudi, S., Ahmadikia, K., Parsameher, N., Moradi, M., et al. (2022) · Current Medical Mycology · doi:10.18502/cmm.8.3.11207 · Cited by 8 · see citing works
Nanosecond duration pulsed electric field together with formic acid triggers caspase-dependent apoptosis in pathogenic yeasts
Novickij, V., Staigvila, G., Gudiukaitė, R., Zinkevičienė, A., Girkontaitė, I., Paškevičius, A., Švedienė, J., Markovskaja, S., Novickij, J., & Lastauskienė, E. (2019) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2019.04.007 · Cited by 8 · see citing works
Epidemiology of Candidemia in Mashhad, Northeast Iran: A Prospective Multicenter Study (2019–2021)
Dolatabadi, S., Najafzadeh, M. J., Raeisabadi, A., Zarrinfar, H., Jalali, M., Spruijtenburg, B., Meijer, E. F. J., Meis, J. F. G. M., Lass‐Flörl, C., & de Groot, T. (2024) · Journal of Fungi · doi:10.3390/jof10070481 · Cited by 7 · see citing works
Mechanisms of Drug Resistance in Candida albicans
Sanglard, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-50409-4_15 · Cited by 7 · see citing works
Self-citation
Application of pulsed electric fields for the elimination of highly drug-resistant Candida grown under modelled microgravity conditions
Lastauskienė, E., Novickij, V., Zinkevičienė, A., Girkontaitė, I., Paškevičius, A., Švedienė, J., Markovskaja, S., & Novickij, J. (2018) · International Journal of Astrobiology · doi:10.1017/s1473550418000332 · Cited by 7 · see citing works
False-positive HIV serology, Candida lusitaniae pneumonia, and a novel mutation in the CYBB gene
Banday, A. Z., Nataraj, L., Jindal, A. K., Kaur, H., Anjani, G., Sharma, M., Vignesh, P., & Rawat, A. K. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152110 · Cited by 7 · see citing works
Should Etest MICs for Yeasts Be Categorized by Reference (BPs/ECVs) or by Etest (ECVs) Cutoffs as Determinants of Emerging Resistance?
Espinel‐Ingroff, A., & Dannaoui, É. (2020) · Current Fungal Infection Reports · doi:10.1007/s12281-020-00378-3 · Cited by 7 · see citing works
Uncommon cause of fungemia in a patient with renal cell cancer
Mishra, R., Kelly, P., Toolsie, O., Ayyadurai, P., & Adrish, M. (2017) · Medicine · doi:10.1097/md.0000000000008510 · Cited by 7 · see citing works
In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence
Ross, Z. K., Alsayegh, S., Zhao, Y., McPherson, S., Munro, C. A., & Lorenz, A. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128322 · Cited by 6 · see citing works
Drivers of diversification in fungal pathogen populations
Murante, D., & Hogan, D. A. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012430 · Cited by 6 · see citing works
Total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethyl-octahydro-naphthalene-1,4a(2 H )-diol
Liu, Q., Han, L., Qin, B., Mu, Y., Guan, P., Wang, S., & Huang, X. (2018) · Organic Chemistry Frontiers · doi:10.1039/c8qo00225h · Cited by 6 · see citing works
Bilateral Candida endophthalmitis accompanying Candida lusitaniae bloodstream infection: A case report
Yamamoto, S., Ikeda, M., Fujimoto, F., Okamoto, K., Wakabayashi, Y., Sato, T., Tatsuno, K., Kaburaki, T., Yoshida, S., Okugawa, S., et al. (2017) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2017.10.002 · Cited by 5 · see citing works
Comparison of PCR-RFLP with 21-plex PCR and rDNA Sequencing for Identification of Clinical Yeast Isolates
Kord, M., Elmimoghaddam, A., Hashemi, S. J., Reziae, S., Ghazvini, R. D., Salehi, M., Abdollahi, A., Ahmadi, A., Getso, M. I., Boekhout, T., et al. (2021) · Mycopathologia · doi:10.1007/s11046-020-00522-0 · Cited by 4 · see citing works
Candida lusitaniae Fungemia in Children: A multicenter case series of emerging pathogen
Snapiri, O., Danziger, C. R., Sachs, N., Krause, I., Zvi, H. B., Danino, D., Kriger, O., Shachor‐Meyouhas, Y., Averbuch, D., & Bilavsky, E. (2024) · Medical Mycology · doi:10.1093/mmy/myae057 · Cited by 3 · see citing works
Phenotypical Differences at the Physiological and Clinical Level between Two Genetically Closely Related Clavispora lusitaniae Strains Isolated from Patients
Pierantoni, D. C., Giuliano, S., Conti, A., Corte, L., Angelini, J., Cardinali, G., & Tascini, C. (2024) · Journal of Fungi · doi:10.3390/jof10070460 · Cited by 3 · see citing works
Coordinated regulation of Mdr1- and Cdr1-mediated protection from antifungals by the Mrr1 transcription factor in emerging Candida spp.
Rajesh-Khanna, D.-S., Páez, C. G. P., He, S., Dolan, E. G., Mirpuri, K. S., Stajich, J., & Hogan, D. A. (2025) · mBio · doi:10.1128/mbio.01323-25 · Cited by 3 · see citing works
Utilizing the subtractive proteomics approach to design ensemble vaccine against Candida lusitaniae for immune response stimulation; a bioinformatics study
Naz, H., Timotheous, R., Sarwar, M. F., Nadeem, T., Awan, M. F., Ali, S., Awais, S., & Ahmed, I. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316264 · Cited by 2 · see citing works
Candida lusitaniae from Commensal to Opportunistic: A Growing Clinical Concern
Rojas, O. C., & González, G. M. (2025) · Infectious diseases · doi:10.5772/intechopen.1012969 · Cited by 1 · see citing works
Candida auris: Steckbrief eines neuen Pilzes
Wagener, J., & Kurzai, O. (2019) · Deutsches Ärzteblatt · doi:10.3238/persinfek.2019.07.22.01 · Cited by 1 · see citing works
Perfil de sensibilidade a antifúngicos de Candida lusitaniae isolada de caso de peritonite felina
Amorim, C. F., Antón, A. R. S., & Portela, R. W. (2023) · Revista de Ciências Médicas e Biológicas · doi:10.9771/cmbio.v22i3.57627 · Cited by 1 · see citing works
Synergistic antifungal action of algal-nanochitosan composite against drug resistant Clavispora lusitaniae
Salem, S. H., Hifney, A. F., Mazrou, Y. S. A., Nehela, Y., Makhlouf, A. H., & Hassan, E. A. (2025) · Algal Research · doi:10.1016/j.algal.2025.104263 · Cited by 1 · see citing works
Current and potential treatment options for invasiveCandidainfections
Pyrpasopoulou, A., Iosifidis, Ε., & Roilides, E. (2017) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2017.1379392
Comparison of Primers for Oral Mycobiome Study in Intubated Patients
Choi, Y. H., Kim, S. H., Kim, M. S., & Na, H. S. (2021) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2021.51.3.112
Transcriptional response of Candida auris to the Mrr1 inducers methylglyoxal and benomylPreprint
Biermann, A. R., & Hogan, D. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.02.482751
Antifungals
(2016) · Reactions Weekly · doi:10.1007/s40278-016-12527-7
Candida Lusitaniae Endophthalmitis: A Brief Literature Review with a Focus on Treatment Options
Shaikh, H., Weber, D. M., Hamburger, J. L., & Vareechon, C. (2022) · Private Practice Infectious Disease · doi:10.55636/ppid2040013
References
Larone, D. H., Westblade, D. L. F., Burd, D. E. M., Lockhart, D. S. R., Procop, G. W., & Walsh, T. J. (2023) · Wiley eBooks · doi:10.1002/9781683674436.ref
Candidiasis
Bendel, C. M., & Swanson, E. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-79525-8.00044-5
Encephalopathy and Endophthalmitis Following Device‐Related Invasive Clavispora Lusitaniae Infection in an Immunocompetent Patient: A Case Report
Cui, Y., Huang, Z., Han, H., Ma, Y., Li, S., Hu, Y., Zhang, H., Zhang, X., Zhao, X., Yu, D., et al. (2025) · Clinical Case Reports · doi:10.1002/ccr3.70550
Study of Multiple Drug Resistance Pattern and Biofilm Formation of Candida Species Isolated from Iraqi Patients
Al-Ameri, Z. A., & Al-Musawi, M. T. (2025) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_334_23
Développement d'outils moléculaires standardisés pour les espèces levuriformes du clade CTG
Defosse, T. A. (2017) · doi:10.70675/0b0be3fczcf6fz4a4dza200zd3ff62d249ab
Functional characterization of Candida auris DHA1 transporters conferring flucytosine resistance
Malik, S., Saini, A., Khatoon, R., & Banerjee, A. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1806653
Candida lusitaniae Peritonitis Associated With Nonsurgical Pneumoperitoneum: A Case Report Exploring a Causal Relationship or Coincidence
Shokry, M. M., Ciulla, L., Przeslawski, C., Caceres, L., Fan, W., & Rebock, M. (2026) · Cureus · doi:10.7759/cureus.112257
Captive lizards (Squamata: Sauria) as reservoirs of medically important and antifungal-resistant yeasts
Samarelli, R., Pugliese, N., Mendoza‐Roldan, J. A., Miglianti, M., Fagundes‐Moreira, R., Laricchiuta, P., Legrottaglie, M., Danesi, P., Otranto, D., & Giusiano, G. (2026) · Medical Mycology · doi:10.1093/mmy/myag083
Candida lusitaniae as an Unusual Cause of Otomycosis: A Case Report and Literature Review
Abderrahmani, J., Nejjari, M. A., & Hami, A. (2026) · Cureus · doi:10.7759/cureus.115614

Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment.
Desnos-Ollivier, M., Moquet, O., Chouaki, T., Guérin, A.-M., & Dromer, F. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00325-11 · Cited by 37 · see citing works
Construction d'une souche de Candida lusitaniae génétiquement modifiée pour l'étude des mutations de résistance aux échinocandines caractérisées chez des isolats cliniques
Couzigou, C. (2016) · HAL
Candida spp. with Acquired Echinocandin Resistance, France, 2004–20101
Dannaoui, E., Desnos-Ollivier, M., Garcia-Hermoso, D., Grenouillet, F., Cassaing, S., Baixench, M.-T., Bretagne, S., Dromer, F., Lortholary, O., & the French Mycoses Study Group (2012) · Emerging infectious diseases · doi:10.3201/eid1801.110556 · Cited by 130 · see citing works
DISPATCHES Candida spp. with Acquired
Garcia‐Hermoso, D., Grenouillet, F., Cassaing, S., Baixench, M.-T., Bretagne, S., & Lortholary, O. (2013)
Stepwise development of a homozygous S80P substitution in Fks1p, conferring echinocandin resistance in Candida tropicalis.
Jensen, R. H., Johansen, H. K., & Arendrup, M. C. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01193-12 · Cited by 47 · see citing works

Authors: Asner, S. A., Giulieri, S., Diezi, M., Marchetti, O., & Sanglard, D.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
ORCID: Asner, Sandra A.
Giulieri, Stefano
Diezi, Manuel
Sanglard, Dominique
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2015-12
Volume: 59
Issue: 12
Pages: 7715-7722
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.02204-15
PMC: PMC4649199
OpenAlex: W2234679454
Cited by: 82
References: 48
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 2
FWCI: 6.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
SERVAL (Université de Lausanne) (publishedVersion, other-oa)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Pfizer
Astellas Pharma
Universität Zürich
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida lusitaniae, echinocandin resistance, caspofungin resistance, fluconazole resistance, FKS1 mutations, beta-1,3-glucan synthase, candidemia, persistent candidemia, liposomal amphotericin B, azoles, immunocompromised children
MeSH terms: Amino Acid Sequence, Antifungal Agents, Candida, Candidiasis, DNA, Fungal, Female, Galactose, Humans, Infant, Mannans, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Polymorphism, Restriction Fragment Length, Leukemia, Myeloid, Acute, Immunocompromised Host, Drug Monitoring, Drug Resistance, Multiple, Fungal, beta-Glucans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Acquired multidrug antifungal resistance in Candida lusitaniae during therapy

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks