Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary‐care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins
Abstract
Summary: Background: Candida auris is an emerging, potentially multidrug‐resistant pathogen that exhibits clade‐specific resistance to fluconazole and also develops resistance to echinocandins and amphotericin B easily. This study analysed 49 C auris isolates for alterations in hotspot‐1 and hotspot‐2 of FKS1 for the detection of mutations conferring reduced susceptibility to echinocandins. Methods: C auris isolates (n = 49) obtained from 18 immunocompromised patients during June 2016‐December 2018 were analysed. Antifungal susceptibility testing was performed by Etest and broth microdilution‐based MICRONAUT‐AM assay. Mutations in hotspot‐1 and hotspot‐2 regions of FKS1 were detected by PCR sequencing and fingerprinting of the isolates was done by short tandem repeat typing. Results: The patients had multiple comorbidities/risk factors for Candida spp. infection including cancer/leukaemia/lymphoma/myeloma (n = 16), arterial/central line (n = 17), urinary catheter (n = 17), mechanical ventilation (n = 14) and major surgery (n = 9) and received antifungal drugs as prophylaxis and/or empiric treatment. Seven patients developed C auris candidemia/breakthrough candidemia, nine patients had candiduria with/without candidemia and four patients developed surgical site/respiratory infection. Resistance to fluconazole and amphotericin B was detected in 44 and four isolates, respectively. Twelve C auris isolates from eight patients showed reduced susceptibility to echinocandins. Seven isolates contained hostspot‐1 mutations and three isolates from a candidemia patient contained R1354H mutation in hotspot‐2 of FKS1. Ten patients died, five were cured, two were lost to follow‐up and treatment details for one patient were not available. Conclusions: Our findings describe development of a novel mutation in FKS1 conferring reduced susceptibility to echinocandins in one patient during treatment and unfavourable clinical outcome for many C auris‐infected patients.
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Several amino acid substitutions in FKS1 have been associated with decreased echinocandin susceptibility in C. auris.
“Several amino acid substitutions in FKS1 have also been associated with decreased echinocandin susceptibility in C. auris12,37–42.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [40]
Cites
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662 · see citing works
Self-citationPfaller, M. A., Diekema, D. J., Turnidge, J. D., Castanheira, M., & Jones, R. N. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy358 · Cited by 825 · see citing works
Alexander, B. D., Johnson, M. D., Pfeiffer, C. D., Jiménez-Ortigosa, C., Catania, J., Booker, R., Castanheira, M., Messer, S. A., Perlin, D. S., & Pfaller, M. A. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit136 · Cited by 778 · see citing works
First hospital outbreak of the globally emerging Candida auris in a European hospital
Schelenz, S., Hagen, F., Rhodes, J. L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Trimlett, R., Meis, J. F., et al. (2016) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-016-0132-5 · Cited by 768 · see citing works
Self-citationChowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Self-citationMultidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707 · see citing works
Global trends in the distribution of Candida species causing candidemia
Guinea, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12539 · Cited by 680 · see citing works
Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx480 · Cited by 577 · see citing works
Self-citationChanges in the epidemiological landscape of invasive candidiasis
Lamoth, F., Lockhart, S. R., Berkow, E. L., & Calandra, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx444 · Cited by 547 · see citing works
Kathuria, S., Singh, P. K., Sharma, C., Prakash, A., Masih, A., Kumar, A., Meis, J. F. G. M., & Chowdhary, A. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00367-15 · Cited by 536 · see citing works
Self-citationChanging epidemiology of systemic fungal infections
Richardson, M., & Lass-Flörl, C. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.01978.x · Cited by 524 · see citing works
Resistance to echinocandin-class antifungal drugs.
Perlin, D. S. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.04.002 · Cited by 512 · see citing works
Antifungal drug resistance among <i>Candida</i> species: mechanisms and clinical impact
Sanguinetti, M., Posteraro, B., & Lass‐Flörl, C. (2015) · Mycoses · doi:10.1111/myc.12330 · Cited by 394 · see citing works
Echinocandin resistance in Candida.
Perlin, D. S. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ791 · Cited by 374 · see citing works
Potential Fifth Clade of <i>Candida auris,</i> Iran, 2018
Chow, N. A., de Groot, T., Badali, H., Abastabar, M., Chiller, T. M., & Meis, J. F. (2019) · Emerging Infectious Diseases · doi:10.3201/eid2509.190686 · Cited by 356 · see citing works
Self-citationRuiz‐Gaitán, A., Moret, A. M., Tasias‐Pitarch, M., Aleixandre‐López, A. I., Martínez‐Morel, H., Calabuig, E., Salavert‐Lletí, M., Ramírez, P., López‐Hontangas, J. L., Hagen, F., et al. (2018) · Mycoses · doi:10.1111/myc.12781 · Cited by 343 · see citing works
Self-citationEpidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
Cortegiani, A., Misseri, G., Fasciana, T., Giammanco, A., Giarratano, A., & Chowdhary, A. (2018) · Journal of Intensive Care · doi:10.1186/s40560-018-0342-4 · Cited by 332 · see citing works
The changing epidemiology of healthcare-associated candidemia over three decades
Diekema, D., Arbefeville, S., Boyken, L., Kroeger, J., & Pfaller, M. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.02.001 · Cited by 309 · see citing works
Diagnosing invasive candidiasis
Clancy, C. J., & Nguyen, M. H. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01909-17 · Cited by 293 · see citing works
McCarty, T. P., & Pappas, P. G. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.013 · Cited by 285 · see citing works
Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Self-citationUnderstanding Echinocandin Resistance in the Emerging Pathogen Candida auris
Kordalewska, M., Lee, A., Park, S., Berrio, I., Chowdhary, A., Zhao, Y., & Perlin, D. S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00238-18 · Cited by 247 · see citing works
Cornely, O. A., Hoenigl, M., Lass‐Flörl, C., Chen, S. C. ‐., Kontoyiannis, D. P., Morrissey, C. O., & Thompson, G. R. (2019) · Mycoses · doi:10.1111/myc.12960 · Cited by 224 · see citing works
Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris
Chaabane, F., Graf, A., Jequier, L., & Coste, A. T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02788 · Cited by 223 · see citing works
Rybak, J. M., Muñoz, J. F., Barker, K. S., Parker, J. E., Esquivel, B. D., Berkow, E. L., Lockhart, S. R., Gade, L., Palmer, G. E., White, T. C., et al. (2020) · mBio · doi:10.1128/mbio.00365-20 · Cited by 202 · see citing works
Breakthrough invasive fungal infections: Who is at risk?
Jenks, J. D., Cornely, O. A., Chen, S. C. ‐., Thompson, G. R., & Hoenigl, M. (2020) · Mycoses · doi:10.1111/myc.13148 · Cited by 191 · see citing works
Healey, K. R., Kordalewska, M., Jiménez Ortigosa, C., Singh, A., Berrío, I., Chowdhary, A., & Perlin, D. S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01427-18 · Cited by 165 · see citing works
Ben-Ami, R., Garcia-Effron, G., Lewis, R. E., Gamarra, S., Leventakos, K., Perlin, D. S., & Kontoyiannis, D. P. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir351 · Cited by 162 · see citing works
Chen, J., Tian, S., Han, X., Chu, Y., Wang, Q., Zhou, B., & Shang, H. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05543-0 · Cited by 159 · see citing works
Epidemiologic Shift in Candidemia Driven by <i>Candida auris</i>, South Africa, 2016–20171
van Schalkwyk, E., Mpembe, R. S., Thomas, J., Shuping, L., Ismail, H., Lowman, W., Karstaedt, A. S., Chibabhai, V., Wadula, J., Avenant, T., et al. (2019) · Emerging Infectious Diseases · doi:10.3201/eid2509.190040 · Cited by 137 · see citing works
Kurtz, M., Abruzzo, G. K., Flattery, A. M., Bartizal, K. F., Marrinan, J. A., Li, W., Milligan, J. A., Nollstadt, K. H., & Douglas, C. M. (1996) · Infection and Immunity · doi:10.1128/iai.64.8.3244-3251.1996 · Cited by 136 · see citing works
Rybak, J. M., Barker, K. S., Muñoz, J. F., Parker, J. E., Ahmad, S., Mokaddas, E., Abdullah, A., Elhagracy, R. S., Kelly, S. L., Cuomo, C. A., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2021.11.024 · Cited by 120 · see citing works
Self-citationKhan, Z., Ahmad, S., Al-Sweih, N., Joseph, L., Alfouzan, W., & Asadzadeh, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195743 · Cited by 109 · see citing works
Self-citationKhan, Z. U., Al‐Sweih, N., Ahmad, S., Al-Kazemi, N., Khan, S. I., Joseph, L., & Chandy, R. G. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00222-07 · Cited by 105 · see citing works
Self-citationShastri, P. S., Shankarnarayan, S. A., Oberoi, J., Rudramurthy, S. M., Wattal, C., & Chakrabarti, A. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.01.004 · Cited by 103 · see citing works
Nobrega de Almeida, J., Brandão, I. B., Francisco, E. C., de Almeida, S. L. R., de Oliveira Dias, P., Pereira, F. M., Santos Ferreira, F., de Andrade, T. S., de Miranda Costa, M. M., de Souza Jordão, R. T., et al. (2021) · Mycoses · doi:10.1111/myc.13320 · Cited by 100 · see citing works
Self-citationSchroeder, M. L., Weber, T., Denker, T., Winterland, S., Wichmann, D., Rohde, H., Ozga, A., Fischer, M., & Kluge, S. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00755-8 · Cited by 90 · see citing works
de Groot, T., Puts, Y., Berrío, I., Chowdhary, A., & Meis, J. F. G. M. (2020) · mBio · doi:10.1128/mbio.02971-19 · Cited by 88 · see citing works
Self-citationMathur, P., Hasan, M. F., Singh, P. K., Malhotra, R., Walia, K., & Chowdhary, A. (2018) · Mycoses · doi:10.1111/myc.12790 · Cited by 86 · see citing works
Ahmad, S., Joseph, L., Parker, J. E., Asadzadeh, M., Kelly, S. L., Meis, J. F. G. M., & Khan, Z. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01900-18 · Cited by 83 · see citing works
Self-citationCandidemia in the elderly: What does it change?
Barchiesi, F., Orsetti, E., Mazzanti, S., Trave, F., Salvi, A., Nitti, C., & Manso, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176576 · Cited by 81 · see citing works
Ahmad, S., Khan, Z., Al‐Sweih, N., Alfouzan, W. A., & Joseph, L. (2019) · Mycoses · doi:10.1111/myc.13022 · Cited by 78 · see citing works
Self-citationMolecular Epidemiology of Candida Auris Outbreak in a Major Secondary-Care Hospital in Kuwait
Alfouzan, W. A., Ahmad, S., Dhar, R., Asadzadeh, M., Merdasi, N. A., Abdo, N. M., Joseph, L., de Groot, T., Alali, W. Q., Khan, Z., et al. (2020) · Journal of Fungi · doi:10.3390/jof6040307 · Cited by 76 · see citing works
Self-citationJamal, W. Y., Ahmad, S., Khan, Z., & Rotimi, V. O. (2014) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2014.05.031 · Cited by 74 · see citing works
Self-citationPfaller, M. A., Messer, S. A., Diekema, D. J., Jones, R. N., & Castanheira, M. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02481-13 · Cited by 74 · see citing works
Boroujeni, Z. B., Shamsaei, S., Yarahmadi, M., Getso, M. I., Khorashad, A. S., Haghighi, L., Raissi, V., Zareei, M., Mohammadzade, A. S., Moqarabzadeh, V., et al. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104616 · Cited by 71 · see citing works
Invasive candidiasis: A review of nonculture-based laboratory diagnostic methods
Ahmad, S., & Khan, Z. U. (2012) · Indian Journal of Medical Microbiology · doi:10.4103/0255-0857.99482 · Cited by 67 · see citing works
Self-citationArendrup, M. C., Pfaller, M. A., & the Danish Fungaemia Study Group (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00355-12 · Cited by 67 · see citing works
Khan, Z., Ahmad, S., Al‐Sweih, N., Mokaddas, E. M., Al-Banwan, K., Alfouzan, W. A., Al‐Obaid, I., Alobaid, K., Asadzadeh, M., Jeragh, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216250 · Cited by 65 · see citing works
Self-citationKhan, Z., Ahmad, S., Benwan, K., Purohit, P., Al-Obaid, I., Bafna, R., Emara, M., Mokaddas, E., Abdullah, A. A., Al-Obaid, K., et al. (2018) · Infection · doi:10.1007/s15010-018-1164-y · Cited by 63 · see citing works
Self-citationGarcía-Bustos, V., Salavert, M., Gaitán, A. C. R., Cabañero-Navalón, M. D., Sigona-Giangreco, I. A., & Pemán, J. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.02.001 · Cited by 62 · see citing works
Characteristics and Management of Candidaemia Episodes in an Established Candida auris Outbreak
Bayona, J. V. M., Tormo, N., García, C. S., Rodríguez, P. H., de Medrano, V. A. L., Gómez, C. F., & Cardona, C. G. (2020) · Antibiotics · doi:10.3390/antibiotics9090558 · Cited by 62 · see citing works
Shin, J. H., Kim, M., Jang, S. J., Ju, M. Y., Kim, S. H., Shin, M., Suh, S., & Ryang, D. W. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06440-11 · Cited by 61 · see citing works
Sharma, D., Paul, R. A., Rudramurthy, S. M., Kashyap, N., Bhattacharya, S., Soman, R., Shankarnarayan, S. A., Chavan, D., Singh, S., Das, P., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01652-21 · Cited by 60 · see citing works
Khan, Z. U., Ahmad, S., Hagen, F., Fell, J. W., Kowshik, T., Chandy, R. G., & Boekhout, T. (2009) · Antonie van Leeuwenhoek · doi:10.1007/s10482-009-9406-8 · Cited by 59 · see citing works
Self-citationOngoing Challenges with Healthcare-Associated Candida auris Outbreaks in Oman
Al-Maani, A. S., Paul, H. E., Al-Rashdi, A., Wahaibi, A. S. A., Al‐Jardani, A., AlAbri, A., Al-Balushi, M. K., Al-Abri, S., Reesi, M. A., Maqbali, A. A., et al. (2019) · Journal of Fungi · doi:10.3390/jof5040101 · Cited by 57 · see citing works
Self-citationAsadzadeh, M., Ahmad, S., Hagen, F., Meis, J. F. G. M., Al‐Sweih, N., & Khan, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142880 · Cited by 54 · see citing works
Self-citationHannan, K. N. A., Miller, J. L., Chiang, A., Mai, N., Levato, J., LaChance, E., Anderson, M., Beganovic, M., & Dela‐Pena, J. (2020) · Emerging infectious diseases · doi:10.3201/eid2605.191588 · Cited by 52 · see citing works
Al-Baqsami, Z. F., Ahmad, S., & Khan, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-63240-z · Cited by 50 · see citing works
Self-citationGaitán, A. C. R., Cantón, E., Fernández-Rivero, M. E., Ramírez, P., & Pemán, J. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.02.005 · Cited by 48 · see citing works
Song, Y., Chen, X., Yan, Y., Wan, Z., Liu, W. Y., & Li, R. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01401 · Cited by 46 · see citing works
Kim, E. J., Lee, E., Kwak, Y. G., Yoo, H. M., Choi, J. Y., Kim, S. R., Shin, M. J., Yoo, S.-Y., Cho, N.-H., & Choi, Y. H. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.606976 · Cited by 45 · see citing works
Khan, Z., Ahmad, S., Mokaddas, E. M., Meis, J. F. G. M., Joseph, L., Abdullah, A. A., & Vayalil, S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01926-17 · Cited by 42 · see citing works
Self-citationEmergence of resistantCandida glabratain Germany
Aldejohann, A. M., Herz, M., Martin, R., Walther, G., & Kurzai, O. (2021) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlab122 · Cited by 41 · see citing works
Ben-Ami, R., & Kontoyiannis, D. P. (2012) · Virulence · doi:10.4161/viru.3.1.18886 · Cited by 39 · see citing works
Recognition and diagnosis of invasive fungal infections in neonates
Calley, J. L., & Warris, A. (2017) · Journal of Infection · doi:10.1016/s0163-4453(17)30200-1 · Cited by 39 · see citing works
Candida lusitaniae in Kuwait: Prevalence, antifungal susceptibility and role in neonatal fungemia
Khan, Z., Ahmad, S., Al‐Sweih, N., Khan, S. I., & Joseph, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213532 · Cited by 35 · see citing works
Self-citationAsadzadeh, M., Ahmad, S., Al‐Sweih, N., Hagen, F., Meis, J. F. G. M., & Khan, Z. (2019) · Scientific Reports · doi:10.1038/s41598-018-37855-2 · Cited by 34 · see citing works
Self-citationZeng, Z., Ding, Y., Tian, G., Yang, K., Deng, J. M., Li, G., & Liu, J. (2020) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-020-00798-3 · Cited by 34 · see citing works
Candida kefyr in Kuwait: Prevalence, antifungal drug susceptibility and genotypic heterogeneity
Ahmad, S., Khan, Z., Al‐Sweih, N., Alfouzan, W. A., Joseph, L., & Asadzadeh, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240426 · Cited by 33 · see citing works
Self-citationLuzzati, R., Cavinato, S., Deiana, M. L., Rosin, C., Maurel, C., & Borelli, M. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0251-x · Cited by 32 · see citing works
Chen, X.-C., Xu, J., & Wu, D.-P. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1523 · Cited by 32 · see citing works
Posteraro, B., Carolis, E. D., Criscuolo, M., Ballanti, S., Angelis, G. D., Principe, M. I. D., Delia, M., Fracchiolla, N., Marchesi, F., Nadali, G., et al. (2020) · Mycoses · doi:10.1111/myc.13130 · Cited by 30 · see citing works
Epidemiology of Candidemia in Kuwait: A Nationwide, Population-Based Study
Alobaid, K., Ahmad, S., Asadzadeh, M., Mokaddas, E. M., Al‐Sweih, N., Benwan, K. A., Alfouzan, W. A., Al‐Obaid, I., Jeragh, A., Al-Roomi, E., et al. (2021) · Journal of Fungi · doi:10.3390/jof7080673 · Cited by 30 · see citing works
Self-citationThe eagle-like effect of echinocandins: what’s in a name?
Vanstraelen, K., Lagrou, K., Maertens, J., Wauters, J., Willems, L., & Spriet, I. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2013.841543 · Cited by 28 · see citing works
Breda, G. L., Tuon, F. F., Meis, J. F. G. M., Herkert, P. F., Hagen, F., de Oliveira, L. Z., Dias, V. D. C., da Cunha, C. A., & Queiroz‐Telles, F. (2017) · Medical Mycology · doi:10.1093/mmy/myx077 · Cited by 27 · see citing works
Self-citationSfeir, M. M., Jiménez-Ortigosa, C., Gamaletsou, M. N., Schuetz, A. N., Soave, R., Van Besien, K., Small, C. B., Perlin, D. S., & Walsh, T. J. (2020) · Journal of Fungi · doi:10.3390/jof6010020 · Cited by 19 · see citing works
All You Need To Know and More about the Diagnosis and Management of Rare Yeast Infections
Sprute, R., Cornely, O. A., Chen, S. C. ‐., Seidel, D., Schuetz, A. N., & Zhang, S. X. (2021) · mBio · doi:10.1128/mbio.01594-21 · Cited by 19 · see citing works
Bretagne, S., Desnos‐Ollivier, M., Sitbon, K., Lortholary, O., Che, D., Dromer, F., & YEASTS, P. O. T. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.641965 · Cited by 18 · see citing works
Kato, H., Hagihara, M., Shibata, Y., Asai, N., Yamagishi, Y., Iwamoto, T., & Mikamo, H. (2021) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2021.06.017 · Cited by 17 · see citing works
Healey, K. R., Kordalewska, M., Ortigosa, C. J., et al. (2018) · Greater South Information System · doi:10.60692/4cj01-enq89 · Cited by 14 · see citing works
Zatta, M., Bella, S. D., Giacobbe, D. R., Puente, F. D., Merelli, M., Azzini, A. M., Brugnaro, P., Vedovelli, C., Cattelan, A. M., Busetti, M., et al. (2020) · Gerontology · doi:10.1159/000510638 · Cited by 13 · see citing works
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Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00007-2 · Cited by 304 · see citing works
Rybak, J. M., Cuomo, C. A., & David Rogers, P. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102208 · Cited by 113 · see citing works
Spruijtenburg, B., Ahmad, S., Asadzadeh, M., Alfouzan, W., Al‐Obaid, I., Mokaddas, E., Meijer, E. F. J., Meis, J. F., & de Groot, T. (2023) · Mycoses · doi:10.1111/myc.13655 · Cited by 61 · see citing works
Self-citationAl-Obaid, I., Asadzadeh, M., Ahmad, S., Alobaid, K., Alfouzan, W., Bafna, R., Emara, M., & Joseph, L. (2022) · Journal of Fungi · doi:10.3390/jof8030267 · Cited by 39 · see citing works
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- Authors
- Asadzadeh, M., Mokaddas, E., Ahmad, S., Abdullah, A. A., de Groot, T., Meis, J. F., & Shetty, S. A.
- Affiliations
- Kuwait University (KW)
- Ibn Sina Hospital (KW)
- Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital Nijmegen The Netherlands
- Radboud University Medical Center (NL)
- Corresponding author
- Ahmad, Suhail
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2022-01-03
- Volume
- 65
- Issue
- 3
- Pages
- 331-343
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W4200483743
- Cited by
- 55
- References
- 83
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 17 · 2022: 6
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, echinocandin resistance, FKS1 mutations, immunocompromised patients, candidemia, candiduria, antifungal resistance, fluconazole resistance, amphotericin B resistance, short tandem repeat typing, molecular characterization
- MeSH terms
- Candida auris, Antifungal Agents, Humans, Kuwait, Microbial Sensitivity Tests, Mutation, Immunocompromised Host, Drug Resistance, Fungal, Echinocandins, Candidemia, Tertiary Care Centers
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