Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase
Open accessAbstract
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1 . The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
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Secondary resistance to echinocandins is attributed to point mutations in FKS1 and/or FKS2 genes, which encode the (1,3)-β-D-glucan synthase complex.
“Resistance is attributed to point mutations in the FKS1 and/or FKS2 genes (Table 2, [119–121]) which encode the (1,3)-β-D-glucan synthase complex [121].”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [119]
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- Authors
- Kahn, J. N., Garcia-Effron, G., Hsu, M.-J., Park, S., Marr, K. A., & Perlin, D. S.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Public Health Research Institute, New Jersey Medical School—UMDNJ, Newark, New Jersey
- Rutgers New Jersey Medical School (US)
- Fred Hutch Cancer Center (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2007-05
- Volume
- 51
- Issue
- 5
- Pages
- 1876-1878
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC1855530
- OpenAlex
- W2114785045
- Cited by
- 118
- References
- 18
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- echinocandin resistance, Candida krusei, glucan synthase, FKS1, heterozygous mutation, acute myeloid leukemia, antifungal resistance, Candida
- MeSH terms
- Caspofungin, Micafungin, Anidulafungin, Amino Acid Sequence, Antifungal Agents, Candida, Glucosyltransferases, Lipoproteins, Microbial Sensitivity Tests, Molecular Sequence Data, Peptides, Cyclic, Protein Subunits, Drug Resistance, Fungal, Echinocandins, Lipopeptides
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