The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Role of Matrix β-1,3 Glucan in Antifungal Resistance of Non-albicans Candida Biofilms
Open accessAbstract
Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this is important for other Candida spp. We identified β-1,3 glucan in the matrix, found that the matrix sequesters antifungal drug, and enhanced antifungal susceptibility with matrix β-1,3 glucan hydrolysis.
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“C. glabrata biofilms display antifungal resistance, and are characterized by a compact dense structure of yeast cells nested in an extracellular matrix which is composed of high levels of proteins and carbohydrates including β-1,3 glucan [50,51,52].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [52]
In the citing paper
“It is thought that biofilms prevent, to a greater or lesser extent, the penetration of antifungal drugs through their structure, by the establishment of a diffusion barrier, which acts as an ion-exchange resin, binding charged antibiotic molecules, contributing to biofilm drug resistance, including in the case of C. glabrata [44,150,155].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [155]
In the citing paper
“When induced, the disruption of β-1,3-glucans or a β-1,3-glucanase treatment have been shown to increase susceptibility of biofilms to fluconazole and the addition of exogenous β-1,3 glucans has been demonstrated to result in the rise of resistance to fluconazole in planktonic cells [155].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [155]
In the citing paper
“Thus, treatment of biofilms with β-1,3-glucanase increases the susceptibility of biofilms to fluconazole (130), and addition of exogenous β-1,3-glucans increases the tolerance of planktonic cells to fluconazole (122).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [122]
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Citations
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Cited by
Sorted by citations
The global problem of antifungal resistance: prevalence, mechanisms, and management
Perlin, D. S., Rautemaa-Richardson, R., & Alastruey-Izquierdo, A. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30316-x · Cited by 1,055
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Mechanisms of Candida Biofilm Drug Resistance
Taff, H. T., Mitchell, K. F., Edward, J. A., & Andes, D. R. (2013) · Future Microbiology · doi:10.2217/fmb.13.101 · Cited by 422
Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis
Scorzoni, L., de Paula e Silva, A. C. A., Marcos, C. M., Assato, P. A., de Melo, W. C. M. A., de Oliveira, H. C., Costa-Orlandi, C. B., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00036 · Cited by 418
Metadata
- Authors
- Mitchell, K. F., Taff, H. T., Cuevas, M. A., Reinicke, E. L., Sanchez, H., & Andes, D. R.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Puerto Rico at Cayey (PR)
- University of Wisconsin, Madison, Wisconsin, USA
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2013-04
- Volume
- 57
- Issue
- 4
- Pages
- 1918-1920
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3623361
- OpenAlex
- W2122010658
- Cited by
- 104
- References
- 24
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 15 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 4
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008692)
- National Institute of Allergy and Infectious Diseases (NIH R01 AI073289-01, R01AI073289)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- β-1,3-glucan, Candida biofilms, non-albicans Candida, antifungal resistance, biofilm matrix, antifungal susceptibility, glucan hydrolysis
- MeSH terms
- Antifungal Agents, Candida albicans, Proteoglycans, Biofilms, Drug Resistance, Fungal, beta-Glucans
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