Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents

Baillie, G. S.

doi:10.1093/jac/46.3.397

Cited by 389Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents

Baillie, G. S.·2000·Journal of Antimicrobial Chemotherapy

DOI 10.1093/jac/46.3.397

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Abstract

Extracellular polymeric material (EP), comprising the matrix of Candida albicans biofilms, was isolated and its composition was compared with that of EP obtained from culture supernatants of planktonically grown (suspended) organisms. Both preparations consisted of carbohydrate, protein, phosphorus and hexosamine, but biofilm EP contained significantly less total carbohydrate (41%) and protein (5%) than planktonic EP. It also had a higher proportion of glucose (16%) and contained galactose, suggesting that it might possess components unique to biofilms. To investigate whether the EP matrix plays a role in the resistance of biofilms to antifungal agents, susceptibility profiles of biofilms incubated statically (which have relatively little matrix) were compared with those for biofilms incubated with gentle shaking (which produce much more matrix material). Biofilms grown with or without shaking did not exhibit significant differences in susceptibility to any of the drugs tested, indicating that drug resistance is unrelated to the extent of matrix formation. However, biofilms formed on two different types of polyvinyl chloride catheter, obtained from different manufacturers, showed differences in susceptibility to amphotericin B, suggesting that drug resistance may arise as a result of highly specific, surface-induced gene expression.

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Secreted extracellular matrix contributes to biofilm drug resistance, both acting as a physical barrier to drug penetration and directly contributing to the overall structural integrity of the biofilm.
“Secreted extracellular matrix also contributes to biofilm drug resistance, both acting as a physical barrier to drug penetration and directly contributing to the overall structural integrity of the biofilm (2, 11, 130, 135).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [11]

A modified uronic acid carbazole reaction
Bitter, T., & Muir, H. M. (1962) · Analytical Biochemistry · doi:10.1016/0003-2697(62)90095-7 · Cited by 6,239 · see citing works
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396 · see citing works
Bacterial Biofilms in Nature and Disease
Costerton, J. W., Cheng, K. J., Geesey, G. G., Ladd, T. I., Nickel, J. C., Dasgupta, M., & Marrie, T. J. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.002251 · Cited by 3,145 · see citing works
Biomaterial-Centered Infection: Microbial Adhesion Versus Tissue Integration
Gristina, A. G. (1987) · Science · doi:10.1126/science.3629258 · Cited by 2,161 · see citing works
THE REACTION OF ACETYLCHOLINE AND OTHER CARBOXYLIC ACID DERIVATIVES WITH HYDROXYLAMINE, AND ITS ANALYTICAL APPLICATION
Hestrin, S. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56740-5 · Cited by 1,929 · see citing works
Epidemiology of nosocomial fungal infections
Fridkin, S. K., & Jarvis, W. R. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.499 · Cited by 782 · see citing works
Biofilm formation by Candida species on the surface of catheter materials in vitro
Hawser, S. P., & Douglas, L. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.3.915-921.1994 · Cited by 599 · see citing works
Exopolysaccharide production in biofilms: substratum activation of alginate gene expression by Pseudomonas aeruginosa
Davies, D. G., Chakrabarty, A. M., & Geesey, G. G. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.4.1181-1186.1993 · Cited by 427 · see citing works
Resistance of Candida albicans biofilms to antifungal agents in vitro
Hawser, S., & Douglas, L. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.2128 · Cited by 407 · see citing works
Sensitivity of biofilms to antimicrobial agents
Brown, M. R., & Gilbert, P. (1993) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1993.tb04345.x · Cited by 327 · see citing works
Role of dimorphism in the development of Candida albicans biofilms
BAILLIE, G. S., & DOUGLAS, L. J. (1999) · Journal of Medical Microbiology · doi:10.1099/00222615-48-7-671 · Cited by 304 · see citing works
Self-citation
Inhibition of tobramycin diffusion by binding to alginate
Nichols, W. W., Dorrington, S. M., Slack, M., & Walmsley, H. L. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.4.518 · Cited by 294 · see citing works
Evidence of autoinducer activity in naturally occurring biofilms
McLean, R. J. C., Whiteley, M., Stickler, D. J., & Fuqua, W. C. (1997) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb12653.x · Cited by 290 · see citing works
Extracellular products as mediators of the formation and detachment of Pseudomonas fluorescens biofilms
Allison, D., Ruiz, B., SanJosé, C., et al. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13225.x · Cited by 259 · see citing works
Bacterial Biofilms In Nature And Disease
Costerton, J. W. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.micro.41.1.435 · Cited by 250 · see citing works
The Penetration of Antibiotics into Aggregates of Mucoid and Non-mucoid Pseudomonas aeruginosa
Nichols, W. W., Evans, M. J., Slack, M., & Walmsley, H. L. (1989) · Microbiology · doi:10.1099/00221287-135-5-1291 · Cited by 249 · see citing works
Effect of Growth Rate on Resistance of Candida albicans Biofilms to Antifungal Agents
Baillie, G. S., & Douglas, L. J. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.1900 · Cited by 234 · see citing works
Self-citation
Susceptibility of Pseudomonas aeruginosa and Escherichia coli biofilms towards ciprofloxacin: effect of specific growth rate
Evans, D. J., Allison, D., Brown, M. R., & Gilbert, P. (1991) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/27.2.177 · Cited by 230 · see citing works
Biofilms on Indwelling Urethral Catheters Produce Quorum-Sensing Signal Molecules In Situ and In Vitro
Stickler, D. J., Morris, N., McLean, R. J. C., & Fuqua, C. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.9.3486-3490.1998 · Cited by 220 · see citing works
Pathobiology of Infection in Prosthetic Devices
Dougherty, S. H. (1988) · Clinical Infectious Diseases · doi:10.1093/clinids/10.6.1102 · Cited by 193 · see citing works
Pyruvic Acid, a Unique Component of an Exocellular Bacterial Polysaccharide
Sloneker, J. H., & Orentas, D. G. (1962) · Nature · doi:10.1038/194478a0 · Cited by 188 · see citing works
Production of extracellular matrix by Candida albicans biofilms
Hawser, S., Baillie, G. S., & Douglas, L. (1998) · Journal of Medical Microbiology · doi:10.1099/00222615-47-3-253 · Cited by 184 · see citing works
Self-citation
[48] Candida biofilms and their susceptibility to antifungal agents
Baillie, G. S., & Douglas, L. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)10050-8 · Cited by 160 · see citing works
Self-citation
Extracellular Polymer of Candida albicans: Isolation, Analysis and Role in Adhesion
McCourtie, J., & Douglas, L. (1985) · Microbiology · doi:10.1099/00221287-131-3-495 · Cited by 145 · see citing works
Physiological responses induced in bacteria adhering to surfaces
Dagostino, L., Goodman, A. E., & Marshall, K. C. (1991) · Biofouling · doi:10.1080/08927019109378201 · Cited by 99 · see citing works
Iron-Limited Biofilms of Candida albicans and Their Susceptibility to Amphotericin B
Baillie, G. S., & Douglas, L. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.2146 · Cited by 94 · see citing works
Self-citation
Infection associated with medical devices
Tunney, M. M., Gorman, S. P., & Patrick, S. (1996) · Reviews in Medical Microbiology · doi:10.1097/00013542-199610000-00002 · Cited by 78 · see citing works
Epidemiology of nosocomial fungal infections.
Fridkin, S. K., & Jarvis, W. R. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.499-511.1996 · Cited by 64 · see citing works
Antibiotic resistance of biofilms
Foley, I., & Gilbert, P. (1996) · Biofouling · doi:10.1080/08927019609386290 · Cited by 51 · see citing works
Adherence of Candida albicans to human buccal epithelial cells: host-induced protein synthesis and signaling events
Bailey, A., Wadsworth, E., & Calderone, R. (1995) · Infection and Immunity · doi:10.1128/iai.63.2.569-572.1995 · Cited by 51 · see citing works
Blood group glycolipids as epithelial cell receptors for Candida albicans
Cameron, B., & Douglas, L. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.891-896.1996 · Cited by 49 · see citing works
Extracellular products as mediators of the formation and detachment of Pseudomonas fluorescens biofilms
Allison, D. (1998) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(98)00386-3 · Cited by 33 · see citing works

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Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137 · see citing works
Candida biofilms and their role in infection
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Candida albicans Biofilms and Human Disease
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Candida glabrata, Candida parapsilosis and Candida tropicalis : biology, epidemiology, pathogenicity and antifungal resistance
Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W., & Azeredo, J. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00278.x · Cited by 969 · see citing works
CandidaBiofilms: an Update
Ramage, G., Saville, S. P., Thomas, D. P., & López-Ribot, J. L. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.4.633-638.2005 · Cited by 678 · see citing works
Fungal Biofilm Resistance
Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583 · see citing works
Candida biofilms on implanted biomaterials: a clinically significant problem
Ramage, G., MartÃnez, J. P., & LÃ³pez-Ribot, J. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00117.x · Cited by 575 · see citing works
Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance
Al-Fattani, M. A., & Douglas, L. J. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46569-0 · Cited by 548 · see citing works
How to build a biofilm: a fungal perspective
Blankenship, J. R., & Mitchell, A. P. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.003 · Cited by 530 · see citing works
Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells
LaFleur, M. D., Kumamoto, C. A., & Lewis, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-06 · Cited by 521 · see citing works
Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
Nobile, C. J., Andes, D. R., Nett, J. E., Smith, F. J., Yue, F., Phan, Q.-T., Edwards, J. E., Filler, S. G., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020063 · Cited by 507 · see citing works
Our Current Understanding of Fungal Biofilms
Ramage, G., Mowat, E., Jones, B., Williams, C., & Lopez-Ribot, J. (2009) · Critical Reviews in Microbiology · doi:10.3109/10408410903241436 · Cited by 483 · see citing works
Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
Ramage, G. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf049 · Cited by 468 · see citing works
Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis
Scorzoni, L., de Paula e Silva, A. C. A., Marcos, C. M., Assato, P. A., de Melo, W. C. M. A., de Oliveira, H. C., Costa-Orlandi, C. B., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00036 · Cited by 418 · see citing works
Mechanisms of Candida Biofilm Drug Resistance
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Putative Role of β-1,3 Glucans in Candida albicans Biofilm Resistance
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Biofilms of non-Candida albicans Candidaspecies: quantification, structure and matrix composition
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Development and Characterization of an In Vivo Central Venous Catheter Candida albicans Biofilm Model
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Biofilm Matrix Regulation by Candida albicans Zap1
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Biofilm lifestyle of Candida: a mini review
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Adherence and biofilm formation of non-Candida albicans Candida species
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Candida albicans forms biofilms on the vaginal mucosa
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Recent insights into Candida albicans biofilm resistance mechanisms
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Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms
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Candida albicans biofilm development, modeling a host–pathogen interaction
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Interaction of Candida albicans Biofilms with Antifungals: Transcriptional Response and Binding of Antifungals to Beta-Glucans
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Martel, C. M., Parker, J. E., Bader, O., Weig, M., Gross, U., Warrilow, A. G. S., Kelly, D. E., & Kelly, S. L. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00303-10 · Cited by 165 · see citing works
Interface of Candida albicans Biofilm Matrix-Associated Drug Resistance and Cell Wall Integrity Regulation
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Role for Cell Density in Antifungal Drug Resistance in Candida albicans Biofilms
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Candida albicans biofilms: building a heterogeneous, drug-tolerant environment
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Proteomics for the analysis of the Candida albicans biofilm lifestyle
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Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole
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Role of matrix β-1,3 glucan in antifungal resistance of non-albicans Candida biofilms
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Exopolysaccharide analysis of biofilm‐forming Candida albicans
Lal, P., Sharma, D., Pruthi, P., & Pruthi, V. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04634.x · Cited by 76 · see citing works
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Pitangui, N. S., Sardi, J. C. O., Silva, J. F., Benaducci, T., Moraes da Silva, R. A., Rodríguez-Arellanes, G., Taylor, M. L., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2012) · Biofouling · doi:10.1080/08927014.2012.703659 · Cited by 69 · see citing works
Time Course Analysis of Candida albicans Metabolites during Biofilm Development
Zhu, Z., Wang, H., Shang, Q., Jiang, Y., Cao, Y., & Chai, Y. (2013) · Journal of Proteome Research · doi:10.1021/pr300447k · Cited by 66 · see citing works
Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms
LaFleur, M. D., Lucumi, E., Napper, A. D., Diamond, S. L., & Lewis, K. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq530 · Cited by 59 · see citing works
Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection
Nett, J. E., Brooks, E. G., Cabezas-Olcoz, J., Sanchez, H., Zarnowski, R., Marchillo, K., & Andes, D. R. (2014) · Infection and Immunity · doi:10.1128/iai.02284-14 · Cited by 58 · see citing works
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Truong, T., Zeng, G., Qingsong, L., Kwang, L. T., Tong, C., Chan, F. Y., Wang, Y., & Seneviratne, C. J. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.061523 · Cited by 45 · see citing works
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Sun, J., Li, Z., Chu, H., Guo, J., Jiang, G., & Qi, Q. (2016) · Mycopathologia · doi:10.1007/s11046-015-9894-1 · Cited by 32 · see citing works
The eagle-like effect of echinocandins: what’s in a name?
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Effect of Cu~(2+) on biofilm and extracellular polymeric substance
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Zhao, L. (2009) · Journal of Modern Stomatology

Authors: Baillie, G. S.
Affiliations: University of Glasgow (GB)
Corresponding author: Baillie, G. S.
ORCID: Baillie, G. S.
Venue: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press (OUP)
Published: 2000-09-01
Volume: 46
Issue: 3
Pages: 397-403
ISSN: 0305-7453 (ISSN-L)
1460-2091
DOI: 10.1093/jac/46.3.397
OpenAlex: W2112458089
Cited by: 389
References: 32
Citations by year: 2026: 3 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 18 · 2016: 23 · 2015: 19 · 2014: 34 · 2013: 18 · 2012: 29
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Locations: Journal of Antimicrobial Chemotherapy (publishedVersion)
PubMed (publishedVersion)
Funders: Heriot-Watt University
Sir Jules Thorn Charitable Trust
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida albicans, biofilm, biofilm matrix, antifungal resistance, amphotericin B, planktonic versus biofilm growth, glucose, galactose, polyvinyl chloride catheters, antifungal susceptibility
MeSH terms: Antifungal Agents, Candida albicans, Candidiasis, Dentures, Drug Resistance, Microbial, Humans, Microbial Sensitivity Tests, Polymers, Stomatitis, Biofilms

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Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents

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