Cited by 139Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate

Open access
Rodero, Laura, Mellado, Emilia, Rodriguez, A. Carolina, Salve, Angela, Guelfand, Liliana, Cahn, Pedro, Cuenca-Estrella, Manuel, Davel, Graciela +1 more·2003·Antimicrobial Agents and Chemotherapy

Abstract

Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-α lanosterol demethylase gene ( ERG11 ) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.

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Registry

Crossref · 10.1128/aac.47.11.3653-3656.2003

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15 of 15 references verified0 citation errors · 0 not checkable

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  • For C. neoformans, a limited number of ERG11 mutations have been described in azole-resistant clinical isolates.

    “For C. neoformans, a limited number of ERG11 mutations have been described in azole-resistant clinical isolates16.”

    From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [16]

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Authors
Rodero, L., Mellado, E., Rodriguez, A. C., Salve, A., Guelfand, L., Cahn, P., Cuenca-Estrella, M., Davel, G., & Rodriguez-Tudela, J. L.
Affiliations
  • Administración Nacional de Laboratorios e Institutos de Salud (AR)
  • Instituto de Salud Carlos III (ES)
  • Hospital Fernández (AR)
  • Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
Venue
Antimicrobial Agents and Chemotherapy
Published
2003-11
Volume
47
Issue
11
Pages
3653-3656
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2142427146
Cited by
139
References
15
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 3 · 2017: 10 · 2016: 10 · 2015: 5 · 2014: 14 · 2013: 6 · 2012: 5
FWCI
1.17
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
Cryptococcus neoformans, fluconazole resistance, ERG11, lanosterol 14α-demethylase, point mutations, recurrent meningitis, AIDS, antifungal resistance, clinical isolates
MeSH terms
Acquired Immunodeficiency Syndrome, Adult, Amino Acid Sequence, Antifungal Agents, Cloning, Molecular, Cryptococcus neoformans, Cytochrome P-450 Enzyme System, Genotype, Humans, Male, Microbial Sensitivity Tests, Molecular Sequence Data, Oxidoreductases, Plasmids, Recurrence, Fluconazole, Meningitis, Cryptococcal, Point Mutation, Amino Acid Substitution, Drug Resistance, Fungal, Sterol 14-Demethylase

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