Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children
Open accessAbstract
Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of cereal gluten proteins. This disorder is associated with imbalances in the gut microbiota composition that could be involved in the pathogenesis of CD. The aim of this study was to characterize the composition and diversity of the cultivable duodenal mucosa-associated bacteria of CD patients and control children. Duodenal biopsy specimens from patients with active disease on a gluten-containing diet (n= 32), patients with nonactive disease after adherence to a gluten-free diet (n= 17), and controls (n= 8) were homogenized and plated on plate count agar, Wilkins-Chalgren agar, brain heart agar, or yeast, Casitone, and fatty acid agar. The isolates were identified by partial 16S rRNA gene sequencing. Renyi diversity profiles showed the highest diversity values for active CD patients, followed by nonactive CD patients and control individuals. Members of the phylum Proteobacteria were more abundant in patients with active CD than in the other child groups, while those of the phylum Firmicutes were less abundant. Members of the families Enterobacteriaceae and Staphylococcaceae, particularly the species Klebsiella oxytoca,Staphylococcus epidermidis, and Staphylococcus pasteuri, were more abundant in patients with active disease than in controls. In contrast, members of the family Streptococcaceae were less abundant in patients with active CD than in controls. Furthermore, isolates of the Streptococcus anginosus and Streptococcus mutans groups were more abundant in controls than in both CD patient groups, regardless of inflammatory status. The findings indicated that the disease is associated with the overgrowth of possible pathobionts that exclude symbionts or commensals that are characteristic of the healthy small intestinal microbiota.
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Most studies have found significant differences between healthy children and children with celiac disease in duodenal and oral microbial populations.
“Most studies, but not all,48 have found significant differences between healthy children and children with CD in the duodenal49,50 and oral51 microbial populations.”
From The Gut Microbiome and the Brain (2014) · cites this paper as [49]
Cites
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Preparation of Genomic DNA from Bacteria
Wilson, K. J. (2001) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0204s56 · Cited by 2,082 · see citing works
Walker‐Smith, J. A., Guandalini, S., Schmitz, J., Shmerling, D. H., & Visakorpi, J. K. (1990) · Archives of Disease in Childhood · doi:10.1136/adc.65.8.909 · Cited by 1,492 · see citing works
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311 · see citing works
Multiple common variants for celiac disease influencing immune gene expression
Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,026 · see citing works
Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works
The role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786 · see citing works
Revised criteria for diagnosis of coeliac disease
Walker‐Smith, J. A., Guandalini, S., Schmitz, J., Shmerling, D. H., & Visakorpi, J. K. (1990) · Cited by 599 · see citing works
Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works
Diversity of the human gastrointestinal tract microbiota revisited
Rajilić‐Stojanović, M., Smidt, H., & De Vos, W. M. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01369.x · Cited by 559 · see citing works
Stene, L. C., Honeyman, M. C., Hoffenberg, E. J., Haas, J. E., Sokol, R. J., Emery, L. M., Taki, I., Norris, J. M., Erlich, H. A., Eisenbarth, G. S., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00741.x · Cited by 556 · see citing works
Comparison of different methods for diversity ordering
Tóthmérész, B. (1995) · Journal of Vegetation Science · doi:10.2307/3236223 · Cited by 545 · see citing works
Gophna, U., Sommerfeld, K., Gophna, S., Doolittle, W., & van Zanten, S. V. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01004-06 · Cited by 541 · see citing works
Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy
van Nimwegen, F. A., Penders, J., Stobberingh, E. E., Postma, D. S., Koppelman, G. H., Kerkhof, M., Reijmerink, N. E., Dompeling, E., van den Brandt, P. A., Ferreira, I., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.07.027 · Cited by 493 · see citing works
Nilsen, E. M., Jahnsen, F. L., Lundin, K. E. A., Johansen, F., FAUSA, O., Sollid, L. M., Jahnsen, J., Scott, H., & Brandtzaeg, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70134-9 · Cited by 471 · see citing works
Hayashi, H., Sakamoto, M., & Benno, Y. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02731.x · Cited by 458 · see citing works
Satokari, R. M., Vaughan, E. E., Akkermans, A. D. L., Saarela, M., & de Vos, W. M. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.2.504-513.2001 · Cited by 444 · see citing works
Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Self-citationSpecific duodenal and faecal bacterial groups associated with paediatric coeliac disease
Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.061366 · Cited by 354 · see citing works
Self-citationMucosal and Invading Bacteria in Patients with Inflammatory Bowel Disease Compared with Controls
Kleessen, B., Kroesen, A. J., Buhr, H. J., & Blaut, M. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202320378220 · Cited by 351 · see citing works
De Palma, G., Nadal, I., Medina, M., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-63 · Cited by 330 · see citing works
Self-citationDi Cagno, R., De Angelis, M., De Pasquale, I., Ndagijimana, M., Vernocchi, P., Ricciuti, P., Gagliardi, F., Laghi, L., Crecchio, C., Guerzoni, M. E., et al. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-219 · Cited by 317 · see citing works
The intestinal microbiota and chronic disorders of the gut
Dupont, A. W., & DuPont, H. L. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.133 · Cited by 306 · see citing works
Coeliac disease: an update for pathologists
Dickson, B. C., Streutker, C., & Chetty, R. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.035345 · Cited by 300 · see citing works
Advances in Celiac Disease and Gluten-Free Diet
Niewinski, M. M. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.01.011 · Cited by 280 · see citing works
A distinctive 'microbial signature' in celiac pediatric patients
Schippa, S., Iebba, V., Barbato, M., Nardo, G. D., Totino, V., Checchi, M. P., Longhi, C., Maiella, G., Cucchiara, S., & Conte, M. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-175 · Cited by 259 · see citing works
McLoughlin, R. M., & Mills, K. H. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.012 · Cited by 200 · see citing works
Sanz, Y., Sánchez, E., Marzotto, M., Calabuig, M., Torriani, S., & Dellaglio, F. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00337.x · Cited by 173 · see citing works
Self-citationNistal, E., Caminero, A., Vivas, S., Morales, J., de Miera, L. E. S., Rodrı́guez-Aparicio, L. B., & Casqueiro, J. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.025 · Cited by 170 · see citing works
Ou, G., Hedberg, M., Hörstedt, P., Baranov, V., Forsberg, G., Drobni, M., Sandström, O., Nyunt Wai, S., Johansson, I., Hammarström, M.-L., et al. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.524 · Cited by 169 · see citing works
The Biochemical Basis of Celiac Disease
Wieser, H., & Koehler, P. (2008) · Cereal Chemistry · doi:10.1094/cchem-85-1-0001 · Cited by 160 · see citing works
Laparra, J. M., Olivares, M., Gallina, O., & Sanz, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030744 · Cited by 153 · see citing works
Self-citationPathomechanisms in celiac disease
Koning, F., Schuppan, D., Cerf–Bensussan, N., & Sollid, L. M. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.02.003 · Cited by 151 · see citing works
Intestinal dysbiosis in inflammatory bowel disease
Kaur, N. J., Chen, C.-C., Luther, J., & Kao, J. Y. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.17863 · Cited by 138 · see citing works
Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free Rats
Cinová, J., Palma, G. D., Štëpánková, R., Kofroňová, O., Kverka, M., Sanz, Y., & Tučková, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016169 · Cited by 133 · see citing works
Self-citationLaparra, J. M., & Sanz, Y. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22459 · Cited by 131 · see citing works
Self-citationAdaptive and innate immune responses in celiac disease
Gianfrani, C., Auricchio, S., & Troncone, R. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.02.017 · Cited by 125 · see citing works
Characterization of IL-17A–Producing Cells in Celiac Disease Mucosa
Monteleone, I., Sarra, M., Blanco, G. D. V., Paoluzi, O. A., Franzè, E., Fina, D., Fabrizi, A., MacDonald, T. T., Pallone, F., & Monteleone, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901919 · Cited by 122 · see citing works
Intestinal Bacteroides species associated with coeliac disease
Sánchez, E., Donat, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.076950 · Cited by 95 · see citing works
Self-citationThe Role of Bacteria in the Pathogenesis of Inflammatory Bowel Disease
Friswell, M. K., Campbell, B. J., & Rhodes, J. M. (2010) · Gut and Liver · doi:10.5009/gnl.2010.4.3.295 · Cited by 91 · see citing works
De Palma, G., Cinova, J., Stepankova, R., Tuckova, L., & Sanz, Y. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0709471 · Cited by 90 · see citing works
Self-citationSánchez, E., Nadal, I., Donat, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-50 · Cited by 83 · see citing works
Self-citationGut matters: Microbe-host interactions in allergic diseases
Hörmannsperger, G., Clavel, T., & Haller, D. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.993 · Cited by 74 · see citing works
Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study
Acar, S., Yetkıner, A. A., Ersin, N. K., Önçağ, Ö., Aydoğdu, S., & Arıkan, Ç. (2011) · Medical Principles and Practice · doi:10.1159/000331794 · Cited by 72 · see citing works
Characterization of Gliadin-Specific Th17 Cells from the Mucosa of Celiac Disease Patients
Fernández, S., Molina, I. J., Romero, P., González, R., Peña, J., Sánchez, F., Reynoso, F. R., Pérez-Navero, J. L., Estévez, O. A., Ortega, C., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.465 · Cited by 67 · see citing works
Intestinal Staphylococcus spp. and virulent features associated with coeliac disease
Sánchez, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2012) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2012-200759 · Cited by 62 · see citing works
Self-citationReview: Tools for the tract: understanding the functionality of the gastrointestinal tract
Kovatcheva‐Datchary, P., Zoetendal, E. G., Venema, K., de Vos, W. M., & Smidt, H. (2009) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x09337646 · Cited by 39 · see citing works
Coeliac disease and the risk of infections: Table 1
Walters, J. R. F., Bamford, K. B., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2008.151571 · Cited by 20 · see citing works
Novel Perspectives in Celiac Disease Therapy
Sanz, Y. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557510909030359 · Cited by 17 · see citing works
Self-citationAnaerobic facultative bacteria isolated from the gut of rabbits fed different diets
Canganella, F., Zirletta, G., Gualterio, L., MASSA, S., & Trovatelli, L. D. (1992) · Zentralblatt für Mikrobiologie · doi:10.1016/s0232-4393(11)80384-7 · Cited by 10 · see citing works
Dubreuil, L., Houcke, I., & Leroy, I. (1996) · PubMed · Cited by 5 · see citing works
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Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Regional Diversity of the Gastrointestinal Microbiome
Martinez, K., Leone, V., & Chang, E. B. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.011 · Cited by 468 · see citing works
Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E. A., Makharia, G. K., Mearin, M. L., Murray, J. A., Verdu, E. F., & Kaukinen, K. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0054-z · Cited by 441 · see citing works
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity
Kinashi, Y., & Hase, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673708 · Cited by 362 · see citing works
Novel players in coeliac disease pathogenesis: role of the gut microbiota
Verdu, E. F., Galipeau, H. J., & Jabrì, B. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.90 · Cited by 247 · see citing works
Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies
Tye–Din, J. A., Galipeau, H. J., & Agardh, D. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00350 · Cited by 198 · see citing works
Pathogenic role of the gut microbiota in gastrointestinal diseases
Nagao‐Kitamoto, H., Kitamoto, S., Kuffa, P., & Kamada, N. (2016) · Intestinal Research · doi:10.5217/ir.2016.14.2.127 · Cited by 174 · see citing works
Gut Microbiota and Celiac Disease
Marasco, G., Biase, A. R. D., Schiumerini, R., Eusebi, L. H., Iughetti, L., Ravaioli, F., Scaioli, E., Colecchia, A., & Festi, D. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-4020-2 · Cited by 169 · see citing works
Ponziani, F. R., Zocco, M. A., D’Aversa, F., Pompili, M., & Gasbarrini, A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4491 · Cited by 173 · see citing works
Celiac Disease and the Microbiome
Valitutti, F., Cucchiara, S., & Fasano, A. (2019) · Nutrients · doi:10.3390/nu11102403 · Cited by 157 · see citing works
D’Argenio, V., Casaburi, G., Precone, V., Pagliuca, C., Colicchio, R., Sarnataro, D., Discepolo, V., Kim, S. M., Russo, I., Blanco, G. D. V., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.95 · Cited by 150 · see citing works
Klemenak, M., Dolinšek, J., Langerholc, T., Gioia, D. D., & Mičetić‐Turk, D. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3769-7 · Cited by 150 · see citing works
Li, G., Yang, M. J., Zhou, K., Zhang, L., Tian, L., Lv, S., Jin, Y. T., Qian, W., Xiong, H., Lin, R., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1412.12047 · Cited by 141 · see citing works
Environmental Enteropathy: Elusive but Significant Subclinical Abnormalities in Developing Countries
Watanabe, K., & Petri, W. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.07.030 · Cited by 139 · see citing works
World Perspective and Celiac Disease Epidemiology
Catassi, C., Gatti, S., & Lionetti, E. (2015) · Digestive Diseases · doi:10.1159/000369518 · Cited by 127 · see citing works
Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice
Galipeau, H. J., McCarville, J. L., Hübener, S., Litwin, O., Meisel, M., Jabrì, B., Sanz, Y., Murray, J. A., Jordana, M., Alaedini, A., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.07.018 · Cited by 128 · see citing works
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Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases
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Primec, M., Klemenak, M., Gioia, D. D., Aloisio, I., Cionci, N. B., Quagliariello, A., Gorenjak, M., Mičetić‐Turk, D., & Langerholc, T. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.931 · Cited by 116 · see citing works
Pötgens, S. A., Brossel, H., Sboarina, M., Catry, E., Cani, P. D., Neyrinck, A. M., Delzenne, N. M., & Bindels, L. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-30569-5 · Cited by 114 · see citing works
A microbiota-centric view of diseases of the upper gastrointestinal tract
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Francavilla, R., Ercolini, D., Piccolo, M., Vannini, L., Siragusa, S., De Filippis, F., De Pasquale, I., Di Cagno, R., Di Toma, M., Gozzi, G., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00362-14 · Cited by 111 · see citing works
Cukrowská, B., Sowińska, A., Bierła, J. B., Czarnowska, E., Rybak, A., & Grzybowska‐Chlebowczyk, U. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i42.7505 · Cited by 111 · see citing works
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Herrán, A. R., Pérez-Andrés, J., Caminero, A., Nistal, E., Vivas, S., de Morales, J. M. R., & Casqueiro, J. (2017) · Research in Microbiology · doi:10.1016/j.resmic.2017.04.008 · Cited by 89 · see citing works
Penny, H. A., Baggus, E. M., Rej, A., Snowden, J. A., & Sanders, D. S. (2020) · Nutrients · doi:10.3390/nu12010216 · Cited by 95 · see citing works
Shanahan, E. R., Zhong, L., Talley, N. J., Morrison, M., & Holtmann, G. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13622 · Cited by 92 · see citing works
Akobeng, A. K., Singh, P., Kumar, M., & Khodor, S. A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02324-y · Cited by 92 · see citing works
Gastrointestinal microbiome and gluten in celiac disease
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Cristofori, F., Indrio, F., Miniello, V. L., Angelis, M. D., & Francavilla, R. (2018) · Nutrients · doi:10.3390/nu10121824 · Cited by 78 · see citing works
Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease
Bascuñán, K. A., Araya, M., Roncoroni, L., Doneda, L., & Elli, L. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz080 · Cited by 76 · see citing works
Serena, G., Yan, S., Camhi, S. S., Patel, S., Lima, R. S., Sapone, A., Leonard, M. M., Mukherjee, R., Nath, B. J., Lammers, K. M., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12911 · Cited by 74 · see citing works
Chander, A. M., Yadav, H., Jain, S., Bhadada, S. K., & Dhawan, D. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02597 · Cited by 74 · see citing works
Lionetti, E., & Catassi, C. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.08.002 · Cited by 72 · see citing works
Sroka-Oleksiak, A., Młodzińska, A., Bulanda, M., Salamon, D., Major, P., Stanek, M., & Gosiewski, T. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020369 · Cited by 70 · see citing works
Dysbiosis a risk factor for celiac disease
Girbovan, A. H., Sur, G., Samaşcă, G., & Lupan, I. (2017) · Medical Microbiology and Immunology · doi:10.1007/s00430-017-0496-z · Cited by 71 · see citing works
Biase, A. R. D., Marasco, G., Ravaioli, F., Dajti, E., Colecchia, L., Righi, B., D’Amico, V., Festi, D., Iughetti, L., & Colecchia, A. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15183 · Cited by 72 · see citing works
Verdu, E. F., & Schuppan, D. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.016 · Cited by 72 · see citing works
Review article: Epidemiology of coeliac disease
Makharia, G. K., Chauhan, A. K., Singh, P., & Ahuja, V. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16787 · Cited by 90 · see citing works
Lundin, K. E. A., & Sollid, L. M. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000041 · Cited by 66 · see citing works
Mohan, M., Chow, C. T., Ryan, C., Chan, L. S., Dufour, J., Aye, P. P., Blanchard, J., Moehs, C. P., & Sestak, K. (2016) · Nutrients · doi:10.3390/nu8110684 · Cited by 63 · see citing works
Sanz, Y. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000440991 · Cited by 62 · see citing works
Self-citationBiogeographic Variation and Functional Pathways of the Gut Microbiota in Celiac Disease
Constante, M., Libertucci, J., Galipeau, H. J., Szamosi, J. C., Rueda, G. H., Miranda, P. M., Pinto-Sánchez, M. I., Southward, C. M., Rossi, L., Fontes, M. E., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.088 · Cited by 63 · see citing works
García-Mazcorro, J. F., Rivera-Gutiérrez, X., Cobos-Quevedo, O., Grube-Pagola, P., Meixueiro-Daza, A., Hernández-Flores, K. G., Cabrera-Jorge, F. J., Vivanco-Cid, H., Dowd, S. E., & Remes-Troche, J. M. (2018) · Nutrients · doi:10.3390/nu10111641 · Cited by 60 · see citing works
Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
Darby, A., Lertpiriyapong, K., Sarkar, U., Seneviratne, U. I., Park, D. S., Gamazon, E. R., Batchelder, C., Cheung, C., Buckley, E. M., Taylor, N. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100542 · Cited by 59 · see citing works
Intestinal microbiota during early life – impact on health and disease
Nylund, L., Satokari, R. M., Salminen, S., & de Vos, W. M. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000627 · Cited by 58 · see citing works
Scherf, K. A., Catassi, C., Chirdo, F. G., Ciclitira, P. J., Feighery, C., Gianfrani, C., Koning, F., Lundin, K. E. A., Schuppan, D., SMULDERS, M. J. M., et al. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00029 · Cited by 58 · see citing works
Celiac disease: should we care about microbes?
Caminero, A., & Verdu, E. F. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00099.2019 · Cited by 57 · see citing works
Sarshar, M., Scribano, D., Ambrosi, C., Palamara, A. T., & Masotti, A. (2020) · Cancers · doi:10.3390/cancers12082174 · Cited by 53 · see citing works
Rueda‐Ruzafa, L., Cedillo, J. L., & Hone, A. J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031189 · Cited by 50 · see citing works
The Role of Environmental Factors in the Development of Celiac Disease: What Is New?
Lionetti, E., & Catassi, C. (2015) · Diseases · doi:10.3390/diseases3040282 · Cited by 53 · see citing works
The role of infectious mediators and gut microbiome in the pathogenesis of celiac disease.
Rostami‐Nejad, M., Ishaq, S., Dulaimi, D. A., Zali, M. R., & Rostami, K. (2015) · PubMed · Cited by 46 · see citing works
Gut microbiome investigation in celiac disease: from methods to its pathogenetic role
Sacchetti, L., & Nardelli, C. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0657 · Cited by 46 · see citing works
Salivary and fecal microbiota and metabolome of celiac children under gluten-free diet
Angelis, M. D., Vannini, L., Cagno, R. D., Cavallo, N., Minervini, F., Francavilla, R., Ercolini, D., & Gobbetti, M. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.07.025 · Cited by 42 · see citing works
Small Bowel Bacterial Overgrowth in Children
Sieczkowska, A., Landowski, P., Kamińska, B., & Lifschitz, C. H. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000920 · Cited by 41 · see citing works
Giorgi, A., Cerrone, R., Capobianco, D., Filardo, S., Mancini, P., Zanni, F., Fanelli, S., Mastromarino, P., & Mosca, L. (2020) · Nutrients · doi:10.3390/nu12020495 · Cited by 43 · see citing works
Rodríguez‐García, C., Sánchez‐Quesada, C., Algarra, I., & Gaforio, J. J. (2020) · Nutrients · doi:10.3390/nu12061705 · Cited by 44 · see citing works
Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics
Olshan, K. L., Leonard, M. M., Serena, G., Zomorrodi, A. R., & Fasano, A. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1840354 · Cited by 43 · see citing works
Fecal and Duodenal Microbiota in Pediatric Celiac Disease
Abdukhakimova, D., Dossybayeva, K., & Poddighe, D. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.652208 · Cited by 42 · see citing works
The microbiota as a component of the celiac disease and non-celiac gluten sensitivity
Nylund, L., Kaukinen, K., & Lindfors, K. (2016) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2016.01.002 · Cited by 40 · see citing works
Gut microbes and adverse food reactions: Focus on gluten related disorders
Galipeau, H. J., & Verdu, E. F. (2014) · Gut Microbes · doi:10.4161/19490976.2014.969635 · Cited by 39 · see citing works
Ercolini, D., Francavilla, R., Vannini, L., Filippis, F. D., Capriati, T., Cagno, R. D., Iacono, G., Angelis, M. D., & Gobbetti, M. (2015) · Scientific Reports · doi:10.1038/srep18571 · Cited by 38 · see citing works
The Role of Gluten in Gastrointestinal Disorders: A Review
Cenni, S., Sesenna, V., Boiardi, G., Casertano, M., Russo, G., Reginelli, A., Esposito, S., & Strisciuglio, C. (2023) · Nutrients · doi:10.3390/nu15071615 · Cited by 38 · see citing works
Chander, A. M., Nair, G. R., Kaur, G., Kochhar, R. K., Dhawan, D. K., Bhadada, S. K., & Mayilraj, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00129 · Cited by 37 · see citing works
Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases
Marietta, E. V., Mangalam, A. K., Taneja, V., & Murray, J. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573079 · Cited by 36 · see citing works
García‐Santisteban, I., Cilleros‐Portet, A., Moyua-Ormazabal, E., Kurilshikov, A., Zhernakova, A., García‐Etxebarria, K., Fernández‐Jiménez, N., & Bilbao, J. R. (2020) · Nutrients · doi:10.3390/nu12051420 · Cited by 35 · see citing works
Ren, Z., Pan, L., Huang, Y., Chen, H., Liu, Y., Liu, H., Tu, X., Liu, Y., Li, B., Dong, X., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114059 · Cited by 33 · see citing works
Kaliciak, I., Drogowski, K., Garczyk, A., Kopeć, S., Horwat, P., Bogdański, P., Stelmach-Mardas, M., & Mardas, M. (2022) · Nutrients · doi:10.3390/nu14102083 · Cited by 34 · see citing works
Lupu, V. V., Trandafir, L. M., Răileanu, A. A., Mihai, C. M., Morariu, I. D., Stârcea, I. M., Mocanu, A., Butnariu, L. I., Stoleriu, G., Șalaru, D. L., et al. (2023) · Nutrients · doi:10.3390/nu15112499 · Cited by 35 · see citing works
Review article: exposure to microbes and risk of coeliac disease
Størdal, K., Kahrs, C. R., Tapia, G., Agardh, D., Kurppa, K., & Stene, L. C. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16161 · Cited by 33 · see citing works
Lionetti, E., Castellaneta, S. P., Francavilla, R., Pulvirenti, A., & Catassi, C. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.023 · Cited by 32 · see citing works
A Metabolomic Perspective on Coeliac Disease
Calabrò, A., Gralka, E., Luchinat, C., Saccenti, E., & Tenori, L. (2014) · Autoimmune Diseases · doi:10.1155/2014/756138 · Cited by 32 · see citing works
Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review
Wyst, K. B. V., Ortega‐Santos, C. P., Toffoli, S., Lahti, C. E., & Whisner, C. M. (2021) · Obesity Reviews · doi:10.1111/obr.13175 · Cited by 34 · see citing works
Bevilacqua, A., Costabile, A., Bergillos-Meca, T., Gonzalez, I., Landriscina, L., Ciuffreda, E., D’Agnello, P., Corbo, M. R., Sinigaglia, M., & Lamacchia, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162770 · Cited by 29 · see citing works
The role of gut microbiota in intestinal and liver diseases
Hrncir, T., Hrncirova, L., Kverka, M., & Tlaskalová‐Hogenová, H. (2018) · Laboratory Animals · doi:10.1177/0023677218818605 · Cited by 29 · see citing works
Zanini, B., Marullo, M., Villanacci, V., Salemme, M., Lanzarotto, F., Ricci, C., & Lanzini, A. (2016) · Nutrients · doi:10.3390/nu8090525 · Cited by 28 · see citing works
Fawley, J. A., Koehler, S. M., Cabrera, S., Lam, V., Fredrich, K. M., Hessner, M. J., Salzman, N. H., & Gourlay, D. M. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.03.049 · Cited by 27 · see citing works
Non-Host Factors Influencing Onset and Severity of Celiac Disease
Galipeau, H. J., Hinterleitner, R., Leonard, M. M., & Caminero, A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.030 · Cited by 28 · see citing works
Wei, B., Wang, P., Yan, Z., & Yan, R. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9285-x · Cited by 25 · see citing works
Carreras, J. (2022) · Healthcare · doi:10.3390/healthcare10081550 · Cited by 24 · see citing works
How the Microbiota May Affect Celiac Disease and What We Can Do
Matera, M., & Guandalini, S. (2024) · Nutrients · doi:10.3390/nu16121882 · Cited by 23 · see citing works
Fungal Dysbiosis in Children with Celiac Disease
Mouzan, M. I. E., Al‐Hussaini, A. A., Fanelli, B. C., Assiri, A. A., Alsaleem, B., Mofarreh, M. A. A., Sarkhy, A. A. A., & Alasmi, M. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06823-8 · Cited by 24 · see citing works
Staphylococcus pasteuri infective endocarditis: A case report
Ramnarain, J., Yoon, J. W., & Runnegar, N. J. (2019) · IDCases · doi:10.1016/j.idcr.2019.e00656 · Cited by 20 · see citing works
Gut dysbiosis mediates the association between antibiotic exposure and chronic disease
Guarner, F., Fernández, L. B., Cruchet, S., Damião, A. O. M. C., Saito, A. M., Lopez, J. P. R., Silva, L. R., & Díaz, M. Á. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1477882 · Cited by 21 · see citing works
Gluten-free diet and gut microbiome
Polo, A., Arora, K., Ameur, H., Cagno, R. D., Angelis, M. D., & Gobbetti, M. (2020) · Journal of Cereal Science · doi:10.1016/j.jcs.2020.103058 · Cited by 19 · see citing works
Gut microbiota in gastrointestinal diseases
Bhattacharjee, G., Khambhati, K., Gohil, N., Singh, P., Gohil, J., Gautam, H., Maurya, R., Chu, D., Ramakrishna, S., & Singh, V. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.06.028 · Cited by 19 · see citing works
Metabolism of wheat proteins by intestinal microbes: Implications for wheat related disorders
Caminero, A., & Verdu, E. F. (2019) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2019.04.001 · Cited by 18 · see citing works
Gastrointestinal Tract Microbiome Effect and Role in Disease Development
Crnčević, N., Hukić, M., Deumić, S., Selimagić, A., Đozić, A., Gavrankapetanović, I., Klepo, D., & Avdić, M. (2022) · Diseases · doi:10.3390/diseases10030045 · Cited by 17 · see citing works
Tran, T. M. T., Senger, S., Baldassarre, M., Brosnan, R. A., Cristofori, F., Crocco, M., Santis, S. D., Elli, L., Faherty, C. S., Francavilla, R., et al. (2024) · Pediatric Research · doi:10.1038/s41390-023-02960-0 · Cited by 18 · see citing works
An Unusual Case of Staphylococcus pasteuri Osteomyelitis
Santoiemma, P. P., Kalainov, D. M., Mehta, M. P., & Bolon, M. K. (2020) · Infectious Disease Reports · doi:10.4081/idr.2020.8523 · Cited by 16 · see citing works
Zevit, N., & Shamir, R. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000450396.76521.b0 · Cited by 16 · see citing works
Metabolomics and lipidomics signature in celiac disease: a narrative review
Rostami‐Nejad, M., Asri, N., Bakhtiari, S., Khalkhal, E., Maleki, S., Rezaei–Tavirani, M., Jahani‐Sherafat, S., & Rostami, K. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01295-2 · Cited by 17 · see citing works
Structural bases of T cell antigen receptor recognition in celiac disease
Ciacchi, L., Reid, H. H., & Rossjohn, J. (2022) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2022.102349 · Cited by 14 · see citing works
Martín‐Masot, R., Díaz‐Castro, J., Moreno‐Fernández, J., Navas‐López, V. M., & Nestares, T. (2020) · Nutrients · doi:10.3390/nu12113427 · Cited by 13 · see citing works
Liu, Z., Sun, F., Braun, J. G., McGovern, D. P. B., & Piantadosi, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu778 · Cited by 12 · see citing works
Rewiring of Microbiota Networks in Erosive Inflammation of the Stomach and Small Bowel
Chen, X., Fan, H., Zhang, H.-K., Qin, H.-W., Shen, L., Yu, X., Zhang, J., & Zhu, J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00299 · Cited by 11 · see citing works
San-Martín, M. I., Chamizo‐Ampudia, A., Sanchiz, Á., Ferrero, M. Á. M., Martı́nez-Blanco, H., Rodrı́guez-Aparicio, L. B., & Navasa, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104818 · Cited by 15 · see citing works
- Authors
- Sánchez, E., Donat, E., Ribes-Koninckx, C., Fernández-Murga, M. L., & Sanz, Y.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital Universitario La Fe, Valencia, Spain
- Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2013-09-15
- Volume
- 79
- Issue
- 18
- Pages
- 5472-5479
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC3754165
- OpenAlex
- W2127055805
- Cited by
- 171
- References
- 55
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 10 · 2022: 10 · 2021: 18 · 2020: 18 · 2019: 18 · 2018: 11 · 2017: 12 · 2016: 17 · 2015: 12 · 2014: 15 · 2013: 1
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danone
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- celiac disease, duodenal mucosa, gut microbiota, cultivable bacteria, pathobionts, Klebsiella oxytoca, Staphylococcus epidermidis, Streptococcus mutans, Streptococcus anginosus, Proteobacteria, Firmicutes, 16S rRNA gene sequencing, gluten-free diet, children, microbial diversity
- MeSH terms
- Bacteria, Bacteriological Techniques, Biopsy, Celiac Disease, Child, Child, Preschool, DNA, Bacterial, DNA, Ribosomal, Duodenum, Humans, Intestinal Mucosa, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Biodiversity
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