Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease
Abstract
Aims: To identify specific gut bacteria associated with coeliac disease (CD) at diagnosis and after treatment with a gluten-free diet (GFD) in a paediatric population. Methods: 30 and 18 faecal samples from untreated and treated CD patients and 25 and 8 biopsy samples from untreated and treated CD patients, respectively, were analysed. In addition, 30 faecal and 8 biopsy samples from control children were evaluated for comparative purposes. Gut bacterial groups were quantified by real-time PCR. Results: Bacteroides and Clostridium leptum groups were more abundant in faeces and biopsies of CD patients than in controls regardless of the stage of the disease. E coli and Staphylococcus counts were also higher in faeces and biopsies of non-treated CD patients than in those of controls, but their levels were normalised after treatment with a GFD. Bifidobacterium levels were lower in faeces of both groups of CD patients and in biopsies of untreated CD patients compared to controls. Similar bacterial groups were related to CD in biopsies and faeces, indicating that faecal microbiota partly reflects that of the small intestine in CD patients, and could constitute a convenient biological index of this disorder. Conclusions: Duodenal and faecal microbiota is unbalanced in children with untreated CD and only partially restored after long-term treatment with a GFD, constituting a novel factor linked to this disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduced levels of Bifidobacterium species in celiac disease do not become normal with a gluten-free diet.
“but reduced levels of Bifidobacterium species, a replicable finding, do not become normal with a gluten-free diet.52,53”
From The Gut Microbiome and the Brain (2014) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works
Mucosal flora in inflammatory bowel disease
Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344 · see citing works
Allergy development and the intestinal microflora during the first year of life
Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203 · see citing works
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053 · see citing works
Collado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706 · see citing works
Self-citationMalinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
Matsuki, T., Watanabe, K., Fujimoto, J., Takada, T., & Tanaka, R. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.12.7220-7228.2004 · Cited by 656 · see citing works
Intestinal microflora of Estonian and Swedish infants
Sepp, E., Julge, K., Vasar, M., Naaber, P., Björkstén, B., & Mikelsaar, M. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb15178.x · Cited by 416 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Self-citationGut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
Conte, M. P., Schippa, S., Zamboni, I., Penta, M., Chiarini, F., Seganti, L., Osborn, J., Falconieri, P., Borrelli, O., & Cucchiara, S. (2006) · Gut · doi:10.1136/gut.2005.078824 · Cited by 383 · see citing works
Wang, M., Ahrné, S., Jeppsson, B. W., & Molin, G. (2005) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2005.03.012 · Cited by 373 · see citing works
Coeliac disease: an update for pathologists
Dickson, B. C., Streutker, C., & Chetty, R. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.035345 · Cited by 300 · see citing works
Molecular Characterization of Rectal Mucosa-Associated Bacterial Flora in Inflammatory Bowel Disease
Mylonaki, M., Rayment, N. B., Rampton, D. S., Hudspith, B. N., & Brostoff, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000159663.62651.4f · Cited by 250 · see citing works
Fang, H., & Hedin, G. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.7.2894-2899.2003 · Cited by 190 · see citing works
Presence of Bacteria and Innate Immunity of Intestinal Epithelium in Childhood Celiac Disease
Forsberg, G., Fahlgren, A., Hörstedt, P., Hammarström, S., Hernell, O., & Hammarström, M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04157.x · Cited by 187 · see citing works
Sanz, Y., Sánchez, E., Marzotto, M., Calabuig, M., Torriani, S., & Dellaglio, F. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00337.x · Cited by 173 · see citing works
Self-citationDifferences between the fecal microbiota of coeliac infants and healthy controls.
Collado, M. C., Calabuig, M., & Sanz, Y. (2007) · PubMed · Cited by 144 · see citing works
Self-citationGut Microflora Associated Characteristics in Children with Celiac Disease
Tjellström, B., Stenhammar, L., Högberg, L., Fälth‐Magnusson, K., Magnusson, K., Midtvedt, T., Sundqvist, T., & Norin, E. L. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00313.x · Cited by 137 · see citing works
The role of Escherichia coli in inflammatory bowel disease
Rhodes, J. M. (2007) · Gut · doi:10.1136/gut.2006.111872 · Cited by 137 · see citing works
Intestinal colonization, microbiota, and probiotics
Salminen, S., & Isolauri, E. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.06.062 · Cited by 134 · see citing works
Fasano, A., & Catassi, C. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.01.008 · Cited by 120 · see citing works
Ward, L. J. H., Brown, J. C. S., & Davey, G. P. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13177.x · Cited by 63 · see citing works
Mucosal bacteria in ulcerative colitis
Macfarlane, S., Furrie, E., Kennedy, A., Cummings, J. H., & Macfarlane, G. T. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041347 · Cited by 63 · see citing works
Microbiota Composition of the Intestinal Mucosa: Association with Fecal Microbiota?
Ouwehand, A. C., Salminen, S., Arvola, T., Ruuska, T. H., & Isolauri, E. (2004) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2004.tb03544.x · Cited by 61 · see citing works
Overton, L. T., & Ewente, M. R. (2008) · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [10]10. Conte MP , Schippa S, Zamboni I, et al . Gut-associated bacterial microbiota in paediatric patients with IBD. Gut 2006; 55 (12):1760-7.
- [12]12. Sartor RB . Therapeutic manipulation of the enteric microflora in IBDs: antibiotics, probiotics, and prebiotics. Gastroenterology 2004; 126 : 1620-33.
- [13]13. Swidsinski A , Ladhoff A, Pernthaler A, et al . Mucosal flora in IBD. Gastroenterology 2002; 122 : 44-54.
- [15]15. Rhodes JM . The role of Escherichia coli in IBD. Gut 2007; 56 (5):610-2.
Cited by
Sorted by citations
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462 · see citing works
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
Tlaskalová-Hogenová, H., Štěpánková, R., Kozáková, H., Hudcovic, T., Vannucci, L., Tučková, L., Rossmann, P., Hrnčíř, T., Kverka, M., Zákostelská, Z., et al. (2011) · Cellular & Molecular Immunology · doi:10.1038/cmi.2010.67 · Cited by 693 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29877 · Cited by 381 · see citing works
Self-citationEffects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects
De Palma, G., Nadal, I., Collado, M. C., & Sanz, Y. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509371767 · Cited by 344 · see citing works
De Palma, G., Nadal, I., Medina, M., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-63 · Cited by 330 · see citing works
Self-citationNistal, E., Caminero, A., Herrán, A. R., Arias, L., Vivas, S., de Morales, J. M. R., Calleja, S., de Miera, L. E. S., Arroyo, P., & Casqueiro, J. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21830 · Cited by 187 · see citing works
Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children
Sánchez, E., Donat, E., Ribes-Koninckx, C., Fernández-Murga, M. L., & Sanz, Y. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00869-13 · Cited by 171 · see citing works
Self-citationOu, G., Hedberg, M., Hörstedt, P., Baranov, V., Forsberg, G., Drobni, M., Sandström, O., Nyunt Wai, S., Johansson, I., Hammarström, M.-L., et al. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.524 · Cited by 169 · see citing works
Leonard, M. M., Valitutti, F., Karathia, H., Pujolassos, M., Kenyon, V., Fanelli, B., Troisi, J., Subramanian, P., Camhi, S., Colucci, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020322118 · Cited by 162 · see citing works
Celiac Disease and the Microbiome
Valitutti, F., Cucchiara, S., & Fasano, A. (2019) · Nutrients · doi:10.3390/nu11102403 · Cited by 157 · see citing works
Laparra, J. M., Olivares, M., Gallina, O., & Sanz, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030744 · Cited by 153 · see citing works
Self-citationDuodenal microbiota composition and mucosal homeostasis in pediatric celiac disease
Cheng, J., Kalliomäki, M., Heilig, H. G., Palva, A., Lähteenoja, H., de Vos, W. M., Salojärvi, J., & Satokari, R. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-113 · Cited by 152 · see citing works
Salivary Microbiota and Metabolome Associated with Celiac Disease
Francavilla, R., Ercolini, D., Piccolo, M., Vannini, L., Siragusa, S., De Filippis, F., De Pasquale, I., Di Cagno, R., Di Toma, M., Gozzi, G., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00362-14 · Cited by 111 · see citing works
Reddel, S., Putignani, L., & Del Chierico, F. (2019) · Nutrients · doi:10.3390/nu11020373 · Cited by 104 · see citing works
De Palma, G., Cinova, J., Stepankova, R., Tuckova, L., & Sanz, Y. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0709471 · Cited by 90 · see citing works
Self-citationImmune Development and Intestinal Microbiota in Celiac Disease
Pozo-Rubio, T., Olivares, M., Nova, E., De Palma, G., Mujico, J. R., Ferrer, M. D., Marcos, A., & Sanz, Y. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/654143 · Cited by 82 · see citing works
Self-citationCaminero, A., Nistal, E., Herrán, A. R., Pérez-Andrés, J., Ferrero, M. A., Vaquero Ayala, L., Vivas, S., Ruiz de Morales, J. M. G., Albillos, S. M., & Casqueiro, F. J. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515002767 · Cited by 70 · see citing works
Sanz, Y. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000440991 · Cited by 62 · see citing works
Self-citation
- Authors
- Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital General Universitario De Valencia (ES)
- Corresponding author
- Sanz, Y
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2008-11-07
- Volume
- 62
- Issue
- 3
- Pages
- 264-269
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2120243636
- Cited by
- 354
- References
- 25
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 19 · 2021: 27 · 2020: 34 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 22 · 2015: 33 · 2014: 31 · 2013: 30 · 2012: 17
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- celiac disease, pediatric celiac disease, gut microbiota, duodenal microbiota, fecal microbiota, gluten-free diet, Bacteroides, Clostridium leptum, Bifidobacterium, Escherichia coli, Staphylococcus, small bowel biopsy
- MeSH terms
- Bacteria, Biopsy, Celiac Disease, Child, Child, Preschool, Duodenum, Feces, Female, Humans, Male, Bacterial Typing Techniques, Case-Control Studies, Polymerase Chain Reaction, Diet, Gluten-Free
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
