Salivary Microbiota and Metabolome Associated with Celiac Disease
Open accessAbstract
This study aimed to investigate the salivary microbiota and metabolome of 13 children with celiac disease (CD) under a gluten-free diet (treated celiac disease [T-CD]). The same number of healthy children (HC) was used as controls. The salivary microbiota was analyzed by an integrated approach using culture-dependent and -independent methods. Metabolome analysis was carried out by gas chromatography-mass spectrometry–solid-phase microextraction. Compared to HC, the number of some cultivable bacterial groups (e.g., total anaerobes) significantly ( P < 0.05) differed in the saliva samples of the T-CD children. As shown by community-level catabolic profiles, the highest Shannon's diversity and substrate richness were found in HC. Pyrosequencing data showed the highest richness estimator and diversity index values for HC. Levels of Lachnospiraceae , Gemellaceae , and Streptococcus sanguinis were highest for the T-CD children. Streptococcus thermophilus levels were markedly decreased in T-CD children. The saliva of T-CD children showed the largest amount of Bacteroidetes (e.g., Porphyromonas sp., Porphyromonas endodontalis , and Prevotella nanceiensis ), together with the smallest amount of Actinobacteria . T-CD children were also characterized by decreased levels of some Actinomyces species, Atopobium species, and Corynebacterium durum . Rothia mucilaginosa was the only Actinobacteria species found at the highest level in T-CD children. As shown by multivariate statistical analyses, the levels of organic volatile compounds markedly differentiated T-CD children. Some compounds (e.g., ethyl-acetate, nonanal, and 2-hexanone) were found to be associated with T-CD children. Correlations (false discovery rate [FDR], <0.05) were found between the relative abundances of bacteria and some volatile organic compounds (VOCs). The findings of this study indicated that CD is associated with oral dysbiosis that could affect the oral metabolome.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most studies have found significant differences between healthy children and children with celiac disease in duodenal and oral microbial populations.
“Most studies, but not all,48 have found significant differences between healthy children and children with CD in the duodenal49,50 and oral51 microbial populations.”
From The Gut Microbiome and the Brain (2014) · cites this paper as [51]
Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb00917.x · Cited by 49,574 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Petersen, P. E. (2003) · Community Dentistry And Oral Epidemiology · doi:10.1046/j..2003.com122.x · Cited by 3,179 · see citing works
Husby, S., Koletzko, S., Korponay‐Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31821a23d0 · Cited by 2,683 · see citing works
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works
The oral microbiome in health and disease
Wade, W. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.006 · Cited by 1,347 · see citing works
Functional diversity of microbial communities: A quantitative approach
Zak, J. C., Willig, M. R., Moorhead, D., & Wildman, H. (1994) · Soil Biology and Biochemistry · doi:10.1016/0038-0717(94)90131-7 · Cited by 1,305 · see citing works
Human oral, gut, and plaque microbiota in patients with atherosclerosis
Koren, O., Spor, A., Felin, J., Fåk, F., Stombaugh, J., Tremaroli, V., Behre, C. J., Knight, R., Fagerberg, B., Ley, R. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011383107 · Cited by 1,196 · see citing works
De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D. I., Cristofori, F., Guerzoni, M. E., Gobbetti, M., & Francavilla, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076993 · Cited by 887 · see citing works
Self-citationRapidly denoising pyrosequencing amplicon reads by exploiting rank-abundance distributions
Reeder, J., & Knight, R. D. (2010) · Nature Methods · doi:10.1038/nmeth0910-668b · Cited by 679 · see citing works
Bacterial diversity in the oral cavity of 10 healthy individuals
Bik, E. M., Long, C. D., Armitage, G. C., Loomer, P., Emerson, J., Mongodin, E. F., Nelson, K. E., Gill, S. R., Fraser-Liggett, C. M., & Relman, D. A. (2010) · The ISME Journal · doi:10.1038/ismej.2010.30 · Cited by 651 · see citing works
Stene, L. C., Honeyman, M. C., Hoffenberg, E. J., Haas, J. E., Sokol, R. J., Emery, L. M., Taki, I., Norris, J. M., Erlich, H. A., Eisenbarth, G. S., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00741.x · Cited by 556 · see citing works
Kumar, P., Griffen, A. L., Moeschberger, M. L., & Leys, E. J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.8.3944-3955.2005 · Cited by 488 · see citing works
(2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000413582.61110.4a · Cited by 454 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Said, H. S., Suda, W., Nakagome, S., Chinen, H., Oshima, K., Kim, S., Kimura, R., Iraha, A., Ishida, H., Fujita, J., et al. (2013) · DNA Research · doi:10.1093/dnares/dst037 · Cited by 394 · see citing works
Oral biofilms, periodontitis, and pulmonary infections
Paju, S., & Scannapieco, F. A. (2007) · Oral Diseases · doi:10.1111/j.1601-0825.2007.01410a.x · Cited by 368 · see citing works
Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease
Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.061366 · Cited by 354 · see citing works
Periodontal Disease and Coronary Heart Disease
Beck, J. D., Eke, P. I., HEISS, G. M., Madianos, P., Couper, D. J., Lin, D., MOSS, K. L., Elter, J. R., & Offenbacher, S. (2005) · Circulation · doi:10.1161/circulationaha.104.511998 · Cited by 348 · see citing works
Di Cagno, R., De Angelis, M., De Pasquale, I., Ndagijimana, M., Vernocchi, P., Ricciuti, P., Gagliardi, F., Laghi, L., Crecchio, C., Guerzoni, M. E., et al. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-219 · Cited by 317 · see citing works
Self-citationThe widening spectrum of celiac disease
Murray, J. A. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.3.354 · Cited by 316 · see citing works
Advances in Celiac Disease and Gluten-Free Diet
Niewinski, M. M. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.01.011 · Cited by 280 · see citing works
Analysis of Oral Microbiota in Children with Dental Caries by PCR-DGGE and Barcoded Pyrosequencing
Ling, Z., Kong, J., Jia, P., Wei, C., Wang, Y., Pan, Z., Huang, W., Li, L., Chen, H., & Xiang, C. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9712-8 · Cited by 268 · see citing works
From Exogenous to Endogenous: The Inevitable Imprint of Mass Spectrometry in Metabolomics
Want, E. J., Nordström, A., Morita, H., & Siuzdak, G. E. (2006) · Journal of Proteome Research · doi:10.1021/pr060505+ · Cited by 260 · see citing works
A distinctive 'microbial signature' in celiac pediatric patients
Schippa, S., Iebba, V., Barbato, M., Nardo, G. D., Totino, V., Checchi, M. P., Longhi, C., Maiella, G., Cucchiara, S., & Conte, M. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-175 · Cited by 259 · see citing works
Saliva Metabolomics Opens Door to Biomarker Discovery, Disease Diagnosis, and Treatment
Zhang, A., Sun, H. J., & Wang, X. (2012) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9891-5 · Cited by 213 · see citing works
Filippis, F. D., Storia, A. L., Villani, F., & Ercolini, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070222 · Cited by 203 · see citing works
Self-citationErcolini, D., De Filippis, F., La Storia, A., & Iacono, M. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02218-12 · Cited by 175 · see citing works
Self-citationSanz, Y., Sánchez, E., Marzotto, M., Calabuig, M., Torriani, S., & Dellaglio, F. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00337.x · Cited by 173 · see citing works
Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children
Sánchez, E., Donat, E., Ribes-Koninckx, C., Fernández-Murga, M. L., & Sanz, Y. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00869-13 · Cited by 171 · see citing works
Ou, G., Hedberg, M., Hörstedt, P., Baranov, V., Forsberg, G., Drobni, M., Sandström, O., Nyunt Wai, S., Johansson, I., Hammarström, M.-L., et al. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.524 · Cited by 169 · see citing works
Cagno, R. D., Rizzello, C. G., Gagliardi, F., Ricciuti, P., Ndagijimana, M., Francavilla, R., Guerzoni, M. E., Crecchio, C., Gobbetti, M., & Angelis, M. D. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02793-08 · Cited by 157 · see citing works
Self-citationCrecchio, C., Gelsomino, A., Ambrosoli, R., Minati, J. L., & Ruggiero, P. (2004) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2004.05.008 · Cited by 156 · see citing works
Effect of lactose on gut microbiota and metabolome of infants with cow’s milk allergy
Francavilla, R., Calasso, M. P., Calace, L., Siragusa, S., Ndagijimana, M., Vernocchi, P., Brunetti, L. M., Mancino, G., Tedeschi, G., Guerzoni, E., et al. (2012) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2012.01286.x · Cited by 151 · see citing works
Self-citationEpidemiology of Celiac Disease
Ludvigsson, J. F., & Murray, J. A. (2018) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2018.09.004 · Cited by 148 · see citing works
Siragusa, S., Cagno, R. D., Ercolini, D., Minervini, F., Gobbetti, M., & Angelis, M. D. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01524-08 · Cited by 134 · see citing works
Self-citationMinervini, F., Angelis, M. D., Cagno, R. D., Pinto, D., Siragusa, S., Rizzello, C. G., & Gobbetti, M. (2010) · Food Microbiology · doi:10.1016/j.fm.2010.05.021 · Cited by 128 · see citing works
Self-citationPyrosequencing analysis of the human microbiota of healthy Chinese undergraduates
Ling, Z., Liu, X., Luo, Y., Yuan, L., Nelson, K. E., Wang, Y., Xiang, C., & Li, L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-390 · Cited by 127 · see citing works
Microbial ecosystems therapeutics: a new paradigm in medicine?
Petrof, E., Claud, E. C., Gloor, G. B., & Allen‐Vercoe, E. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0039 · Cited by 124 · see citing works
Saliva from Obese Individuals Suppresses the Release of Aroma Compounds from Wine
Piombino, P., Genovese, A., Esposito, S., Luigi Moio, B., Cutolo, P. P., Chambery, A., Severino, V., Moneta, E., Smith, D. P., Owens, S. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085611 · Cited by 124 · see citing works
Self-citationMaternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infant
Boggess, K., Beck, J. D., Murtha, A. P., MOSS, K. L., & Offenbacher, S. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.11.059 · Cited by 122 · see citing works
Zamakhchari, M., Wei, G., Dewhirst, F. E., Lee, J., Schuppan, D., Oppenheim, F. G., & Helmerhorst, E. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024455 · Cited by 121 · see citing works
Fernandez-Feo, M., Wei, G., Blumenkranz, G., Dewhirst, F. E., Schuppan, D., Oppenheim, F. G., & Helmerhorst, E. J. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12249 · Cited by 110 · see citing works
Toscano, V., Conti, F., Anastasi, E., Mariani, P., Tiberti, C., Poggi, M., Montuori, M., Monti, S., Laureti, S., Cipolletta, E., et al. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02187.x · Cited by 110 · see citing works
Intra-individual diversity and similarity of salivary and faecal microbiota
Maukonen, J., Mättö, J., Suihko, M., & Saarela, M. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47352-0 · Cited by 110 · see citing works
ORAL MICROFLORA AS A CAUSE OF ENDOCARDITIS AND OTHER DISTANT SITE INFECTIONS
Lockhart, P. B., & Durack, D. T. (1999) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70111-2 · Cited by 104 · see citing works
Genome–genome interactions: bacterial communities in initial dental plaque
Kolenbrander, P. E., Egland, P. G., Diaz, P. I., & Palmer, R. J., Jr. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.11.005 · Cited by 99 · see citing works
Intestinal Bacteroides species associated with coeliac disease
Sánchez, E., Donat, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.076950 · Cited by 95 · see citing works
Kusano, M., Mendez, E. A., & Furton, K. G. (2012) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2012.02215.x · Cited by 92 · see citing works
Takeshita, T., Nakano, Y., Kumagai, T., Yasui, M., Kamio, N., Shibata, Y., Shiota, S., & Yamashita, Y. (2008) · The ISME Journal · doi:10.1038/ismej.2008.91 · Cited by 86 · see citing works
Sánchez, E., Nadal, I., Donat, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-50 · Cited by 83 · see citing works
Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study
Acar, S., Yetkıner, A. A., Ersin, N. K., Önçağ, Ö., Aydoğdu, S., & Arıkan, Ç. (2011) · Medical Principles and Practice · doi:10.1159/000331794 · Cited by 72 · see citing works
Harnessing the power of the human microbiome
Blaser, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002112107 · Cited by 67 · see citing works
Pyrosequencing Analysis of the Salivary Microbiota of Healthy Chinese Children and Adults
Ling, Z., Liu, X., Wang, Y., Li, L., & Xiang, C. (2012) · Microbial Ecology · doi:10.1007/s00248-012-0123-x · Cited by 67 · see citing works
Ndagijimana, M., Laghi, L., Vitali, B., Placucci, G., Brigidi, P., & Guerzoni, M. E. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.04.016 · Cited by 64 · see citing works
Intestinal Staphylococcus spp. and virulent features associated with coeliac disease
Sánchez, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2012) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2012-200759 · Cited by 62 · see citing works
Shteyer, E., Berson, T., Lachmanovitz, O., et al. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31828b3705 · Cited by 62 · see citing works
The presence and distribution of dental enamel defects and caries in children with celiac disease
Avşar, A., & Kalaycı, A. G. (2008) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2008.2379 · Cited by 61 · see citing works
Immunopathogenesis of celiac disease
Tye–Din, J. A., & Anderson, R. P. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0085-9 · Cited by 53 · see citing works
Changes in whole saliva in patients with coeliac disease
Lenander‐Lumikari, M., Ihalin, R., & Lähteenoja, H. (2000) · Archives of Oral Biology · doi:10.1016/s0003-9969(00)00008-x · Cited by 49 · see citing works
Fish, H., Costello, B. D. L., & Ratcliffe, N. A. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/3/036004 · Cited by 49 · see citing works
Bacterial diversity in the human saliva from different ages.
Kang, J.-G., Kim, S. H., & Ahn, T. (2006) · PubMed · Cited by 42 · see citing works
Oral ecosystem alterations in celiac children: A follow-up study
Mina, S., Riga, C., Azcurra, A. I., et al. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.08.017 · Cited by 24 · see citing works
Metabolic fingerprinting as a tool to monitor whole-cell biotransformations
Winder, C. L., Cornmell, R. J., Schuler, S., Jarvis, R. M., Stephens, G., & Goodacre, R. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4342-z · Cited by 24 · see citing works
Yamane, K., Nambu, T., Yamanaka, T., Mashimo, C., Sugimori, C., Leung, K., & Fukushima, H. (2010) · Sequencing · doi:10.1155/2010/457236 · Cited by 24 · see citing works
Alterations of the oral ecosystem in children with celiac disease.
Mina, S., Azcurra, A. I., Dorronsoro, S., & Brunotto, M. N. (2008) · PubMed · Cited by 21 · see citing works
Coeliac disease and the risk of infections: Table 1
Walters, J. R. F., Bamford, K. B., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2008.151571 · Cited by 20 · see citing works
Novel Perspectives in Celiac Disease Therapy
Sanz, Y. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557510909030359 · Cited by 17 · see citing works
IgA anti-tissue transglutaminase antibodies, first line in the diagnosis of celiac disease.
Samaşcă, G., Iancu, M. A., Farcău, D., et al. (2011) · PubMed · Cited by 16 · see citing works
Épidemiologie de la maladie cœliaque
Lamireau, T., & Clouzeau, H. (2011) · Pathologie Biologie · doi:10.1016/j.patbio.2011.03.005 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Vernocchi, P., Del Chierico, F., & Putignani, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01144 · Cited by 426 · see citing works
Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy
Bajaj, J. S., Betrapally, N. S., Hylemon, P. B., Heuman, D. M., Daita, K., White, M. B., Unser, A., Thacker, L. R., Sanyal, A. J., Kang, D. J., et al. (2015) · Hepatology · doi:10.1002/hep.27819 · Cited by 325 · see citing works
Oral microbiome: possible harbinger for children’s health
Xiao, J., Fiscella, K. A., & Gill, S. R. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0082-x · Cited by 223 · see citing works
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health
Gomez, A., & Nelson, K. E. (2017) · Microbial Ecology · doi:10.1007/s00248-016-0854-1 · Cited by 175 · see citing works
- Authors
- Francavilla, R., Ercolini, D., Piccolo, M., Vannini, L., Siragusa, S., De Filippis, F., De Pasquale, I., Di Cagno, R., Di Toma, M., Gozzi, G., Serrazanetti, D. I., De Angelis, M., & Gobbetti, M.
- Affiliations
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy
- University of Bologna (IT)
- Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Portici, Italy
- Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy
- ORCID
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2014-06
- Volume
- 80
- Issue
- 11
- Pages
- 3416-3425
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC4018861
- OpenAlex
- W1998119456
- Cited by
- 111
- References
- 77
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 5 · 2022: 15 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Keywords
- celiac disease, salivary microbiota, salivary metabolome, oral dysbiosis, gluten-free diet, children, volatile organic compounds, Streptococcus thermophilus, Rothia mucilaginosa, Bacteroidetes, actinobacteria
- MeSH terms
- Celiac Disease, Child, Humans, Gas Chromatography-Mass Spectrometry, Saliva, Metabolome, Volatile Organic Compounds, Biota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
