Effect of whole-grain barley on the human fecal microbiota and metabolome

De Angelis, Maria; Montemurno, Eustacchio; Vannini, Lucia; Cosola, Carmela; Cavallo, Noemi; Gozzi, Giorgia; Maranzano, Valentina; Di Cagno, Raffaella; Gobbetti, Marco; Gesualdo, Loreto

doi:10.1128/aem.02507-15

Cited by 145Gut microbiota and healthFood composition and propertiesProbiotics and Fermented Foods

Effect of whole-grain barley on the human fecal microbiota and metabolome

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De Angelis, Maria, Montemurno, Eustacchio, Vannini, Lucia, Cosola, Carmela, Cavallo, Noemi, Gozzi, Giorgia, Maranzano, Valentina, Di Cagno, Raffaella +2 more·2015·Applied and Environmental Microbiology

DOI 10.1128/aem.02507-15PMC PMC4616929

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Abstract

In this study, we compared the fecal microbiota and metabolomes of 26 healthy subjects before (HS) and after (HSB) 2 months of diet intervention based on the administration of durum wheat flour and whole-grain barley pasta containing the minimum recommended daily intake (3 g) of barley β-glucans. Metabolically active bacteria were analyzed through pyrosequencing of the 16S rRNA gene and community-level catabolic profiles. Pyrosequencing data showed that levels of Clostridiaceae (Clostridium orbiscindens and Clostridium sp.), Roseburia hominis, and Ruminococcus sp. increased, while levels of other Firmicutes and Fusobacteria decreased, from the HSB samples to the HS fecal samples. Community-level catabolic profiles were lower in HSB samples. Compared to the results for HS samples, cultivable lactobacilli increased in HSB fecal samples, while the numbers of Enterobacteriaceae, total coliforms, and Bacteroides, Porphyromonas, Prevotella, Pseudomonas, Alcaligenes, and Aeromonas bacteria decreased. Metabolome analyses were performed using an amino acid analyzer and gas chromatography-mass spectrometry solid-phase microextraction. A marked increase in short-chain fatty acids (SCFA), such as 2-methyl-propanoic, acetic, butyric, and propionic acids, was found in HSB samples with respect to the HS fecal samples. Durum wheat flour and whole-grain barley pasta containing 3% barley β-glucans appeared to be effective in modulating the composition and metabolic pathways of the intestinal microbiota, leading to an increased level of SCFA in the HSB samples.

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Supplementation with wholegrain products containing β-glucans supports the growth of lactobacilli and bifidobacteria in humans and rats.
“For example, supplementation studies demonstrated that wholegrain products containing β-glucans (soluble nonstarch polysaccharides) support the growth of lactobacilli and bifidobacteria in humans (71) and rats (72)”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [71]

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Authors: De Angelis, M., Montemurno, E., Vannini, L., Cosola, C., Cavallo, N., Gozzi, G., Maranzano, V., Di Cagno, R., Gobbetti, M., & Gesualdo, L.
Affiliations: Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy
University of Bari Aldo Moro (IT)
University of Bologna (IT)
ORCID: Vannini, Lucia
Cosola, Carmela
Gozzi, Giorgia
Gobbetti, Marco
Gesualdo, Loreto
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2015-11-15
Volume: 81
Issue: 22
Pages: 7945-7956
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.02507-15
PMC: PMC4616929
OpenAlex: W2119675235
Cited by: 145
References: 65
Citations by year: 2026: 6 · 2025: 5 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 23 · 2020: 17 · 2019: 6 · 2018: 16 · 2017: 20 · 2016: 7 · 2015: 1
FWCI: 6.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
Open Research (University of Surrey) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: whole grain barley, barley β-glucan, durum wheat flour, fecal microbiota, gut metabolome, short-chain fatty acids, Clostridiaceae, Roseburia hominis, Ruminococcus, lactobacilli, dietary intervention, gut microbiota modulation
MeSH terms: Adult, Bacteria, Hordeum, Diet, Feces, Female, Humans, Italy, Male, Gas Chromatography-Mass Spectrometry, Middle Aged, Phylogeny, RNA, Ribosomal, 16S, Triticum, Sequence Analysis, DNA, Solid Phase Microextraction, Metabolome, Microbiota

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Effect of whole-grain barley on the human fecal microbiota and metabolome

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