Cross-Sectional and Longitudinal Comparisons of the Predominant Fecal Microbiota Compositions of a Group of Pediatric Patients with Cystic Fibrosis and Their Healthy Siblings
Open accessAbstract
Although only poorly documented, it can be assumed that intensive antibiotic treatments of chronic lung infections in patients with cystic fibrosis (CF) also affect the diversity and metabolic functioning of the gastrointestinal microbiota and potentially lead to a state of dysbiosis. A better knowledge of the differences in gut microbiota composition and stability between patients with CF and healthy subjects could lead to optimization of current antibiotic therapies and/or development of add-on therapies. Using conventional culturing and population fingerprinting by denaturing gradient gel electrophoresis (DGGE) of 16S rRNA amplicons, we compared the predominant fecal microbiota of 21 patients with CF and 24 healthy siblings in a cross-sectional study. General medium counts, as well as counts on media specific for lactic acid bacteria, clostridia, Bifidobacterium spp., Veillonella spp., and Bacteroides-Prevotella spp., were consistently higher in sibling samples than in CF samples, whereas the reverse was found for enterobacterial counts. DGGE fingerprinting uncovered large intersubject variations in both study groups. On the other hand, the cross-sectional data indicated that the predominant fecal microbiota of patients and siblings had comparable species richness. In addition, a longitudinal study was performed on 7 or 8 consecutive samples collected over a 2-year period from two patients and their respective siblings. For these samples, DGGE profiling indicated an overall trend toward lower temporal stability and lower species richness in the predominant fecal CF microbiota. The observed compositional and dynamic perturbations provide the first evidence of a general dysbiosis in children with CF compared to their siblings.
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In general, cystic fibrosis patients, regardless of their genetic background, display a permanent dysbiosis, motivated in part by the characteristics of the disease (thick mucus secretion and pancreatic insufficiency) and the effect related to the aggressive antibiotic therapy.
“In general, these patients, regardless of their genetic background, display a permanent dysbiosis, motivated in part by the characteristics of the disease (thick mucus secretion and pancreatic insufficiency) and the effect related to the aggressive antibiotic therapy [87] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [87]
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- Authors
- Duytschaever, G., Huys, G., Bekaert, M., Boulanger, L., De Boeck, K., & Vandamme, P.
- Affiliations
- Ghent University (BE)
- Universitair Ziekenhuis Leuven (BE)
- Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
- Corresponding author
- Duytschaever, Gwen
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2011-11-15
- Volume
- 77
- Issue
- 22
- Pages
- 8015-8024
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC3208981
- OpenAlex
- W2066754577
- Cited by
- 114
- References
- 83
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 4
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Funders
- Universiteit Gent
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- cystic fibrosis, gut microbiota, fecal microbiota composition, dysbiosis, antibiotic therapy, lactic acid bacteria, Clostridia, Bifidobacterium, Veillonella, Bacteroides-Prevotella, Enterobacteriaceae, temporal stability, species richness, children, healthy siblings
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Cross-Sectional Studies, Cystic Fibrosis, DNA, Bacterial, DNA, Ribosomal, Feces, Humans, Longitudinal Studies, RNA, Ribosomal, 16S, DNA Fingerprinting, Siblings, Gastrointestinal Tract, Biodiversity, Denaturing Gradient Gel Electrophoresis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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