The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection
Open accessAbstract
SUMMARY: Respiratory syncytial virus (RSV) is one of the commonest and most troublesome viruses of infancy. It causes most cases of bronchiolitis, which is associated with wheezing in later childhood. In primary infection, the peak of disease typically coincides with the development of specific T- and B-cell responses, which seem, in large part, to be responsible for disease. Animal models clearly show that a range of immune responses can enhance disease severity, particularly after vaccination with formalin-inactivated RSV. Prior immune sensitization leads to exuberant chemokine production, an excessive cellular influx, and an overabundance of cytokines during RSV challenge. Under different circumstances, specific mediators and T-cell subsets and antibody-antigen immune complex deposition are incriminated as major factors in disease. Animal models of immune enhancement permit a deep understanding of the role of specific immune responses in RSV disease, assist in vaccine design, and indicate which immunomodulatory therapy might be beneficial to children with bronchiolitis.
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Citations
Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Asthma and Wheezing in the First Six Years of Life
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Intraepithelial lymphocytes: exploring the Third Way in immunology
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Respiratory Syncytial Virus Up-regulates TLR4 and Sensitizes Airway Epithelial Cells to Endotoxin
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Double-Stranded RNA Induces the Synthesis of Specific Chemokines by Bronchial Epithelial Cells
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Cited by
Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123158 · Cited by 830
Eosinophils: Biological Properties and Role in Health and Disease
HOGAN, S. P., ROSENBERG, H. F., MOQBEL, R., PHIPPS, S., FOSTER, P. S., LACY, P., KAY, A. B., & ROTHENBERG, M. E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02958.x · Cited by 834
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 747
Self-citationWelliver, T. P., Garofalo, R. P., Hosakote, Y., Hintz, K. H., Avendano, L., Sanchez, K., Velozo, L., Jafri, H., Chavez‐Bueno, S., Ogra, P. L., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/512615 · Cited by 425
Sex Differences in Pediatric Infectious Diseases
Muenchhoff, M., & Goulder, P. J. R. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu232 · Cited by 406
Metadata
- Authors
- Openshaw, P. J. M., & Tregoning, J. S.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2005-07
- Volume
- 18
- Issue
- 3
- Pages
- 541-555
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2146660032
- Cited by
- 292
- References
- 9
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Openshaw, P. J. M., & Tregoning, J. S. (2005). Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.18.3.541-555.2005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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