Multilocus sequence type analysis reveals both clonality and recombination in populations of Candida glabrata bloodstream isolates from U.S. surveillance studies
Open accessAbstract
The human commensal yeast Candida glabrata is becoming increasingly important as an agent of nosocomial bloodstream infection. However, relatively little is known concerning the genetics and population structure of this species. We have analyzed 230 incident bloodstream isolates from previous and current population-based surveillance studies by using multilocus sequence typing (MLST). Our results show that in the U.S. cities of Atlanta, GA; Baltimore, MD; and San Francisco, CA during three time periods spanning 1992 to 2009, five populations of C. glabrata bloodstream isolates are defined by a relatively small number of sequence types. There is little genetic differentiation in the different C. glabrata populations. We also show that there has been a significant temporal shift in the prevalence of one major subtype in Atlanta. Our results support the concept that both recombination and clonality play a role in the population structure of this species.
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C. glabrata ST distribution in Atlanta area hospitals changed significantly between 1992 and 2008.
“Figure 2A shows that C. glabrata ST distribution in Atlanta area hospitals changed significantly between 1992 and 2008”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Lott et al., 2010
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- Authors
- Lott, T. J., Frade, J. P., & Lockhart, S. R.
- Affiliations
- Centers for Disease Control and Prevention (US)
- ORCID
- Lockhart, Shawn R.
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2010-04
- Volume
- 9
- Issue
- 4
- Pages
- 619-625
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC2863408
- OpenAlex
- W2154807668
- Cited by
- 58
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida glabrata, bloodstream infection, nosocomial infections, clonality, recombination, population structure, multilocus sequence typing, sequence types, fungal genomics
- MeSH terms
- Candidiasis, Cross Infection, Genetics, Population, Genotype, Georgia, Humans, Phylogeny, Population Surveillance, Recombination, Genetic, San Francisco, Baltimore, Bacterial Typing Techniques, Sequence Analysis, DNA, Candida glabrata
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