Cited by 210Antifungal resistance and susceptibilityFungal and yeast genetics researchMitochondrial Function and Pathology

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

Open access

Shingu-Vazquez, Miguel, Traven, Ana·2011·Eukaryotic Cell

DOI 10.1128/ec.05184-11PMC PMC3209048

Open this paper in CoChat — free account

Abstract

Recently, mitochondria have been identified as important contributors to the virulence and drug tolerance of human fungal pathogens. In different scenarios, either hypo- or hypervirulence can result from changes in mitochondrial function. Similarly, specific mitochondrial mutations lead to either sensitivity or resistance to antifungal drugs. Here, we provide a synthesis of this emerging field, proposing that mitochondrial function in membrane lipid homeostasis is the common denominator underlying the observed effects of mitochondria in drug tolerance (both sensitivity and resistance). We discuss how the contrasting effects of mitochondrial dysfunction on fungal drug tolerance and virulence could be explained and the potential for targeting mitochondrial factors for future antifungal drug development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/ec.05184-11

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Importing Mitochondrial Proteins: Machineries and Mechanisms
Chacińska, A., Koehler, C. M., Milenkovic, D., Lithgow, T. J., & Pfanner, N. (2009) · Cell · doi:10.1016/j.cell.2009.08.005 · Cited by 1,528
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science · doi:10.1126/science.1175088 · Cited by 1,275
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes
Hillenmeyer, M. E., Fung, E., Wildenhain, J., Pierce, S. E., Hoon, S. S., Lee, W., Proctor, M. J., St.Onge, R. P., Tyers, M., Koller, D., et al. (2008) · Science · doi:10.1126/science.1150021 · Cited by 978
Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes
Okamoto, K., & Shaw, J. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.093019 · Cited by 737
Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Noble, S. M., French, S., Kohn, L. A., Chen, V., & Johnson, A. D. (2010) · Nature Genetics · doi:10.1038/ng.605 · Cited by 678
Cytochrome P450 enzymes in the fungal kingdom
Cresnar, B., & Petrič, Š. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.06.020 · Cited by 406
Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors
Douglas, C. M., D'Ippolito, J. A., Shei, G.-J., Meinz, M., Onishi, J. C., Marrinan, J. A., Li, W., Abruzzo, G. K., Flattery, A. M., Bartizal, K. F., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.11.2471 · Cited by 344
Niche-specific regulation of central metabolic pathways in a fungal pathogen
Barelle, C. J., Priest, C. L., MacCallum, D. M., Gow, N. A. R., Odds, F. C., & Brown, A. J. P. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00676.x · Cited by 336
Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States
Byrnes, E. J., Li, W., Lewit, Y., Ma, H., Voelz, K., Ren, P., Carter, D. A., Chaturvedi, V., Bildfell, R. J., May, R. C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000850 · Cited by 330

Flagged first, then by citations

Show all 91 references

Sorted by citations

Emerging rules for effective antimicrobial coatings
Salwiczek, M., Qu, Y., Gardiner, J., Strugnell, R. A., Lithgow, T. J., McLean, K. M., & Thissen, H. W. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.09.008 · Cited by 312
System-level impact of mitochondria on fungal virulence: to metabolism and beyond
Calderone, R., Li, D., & Traven, A. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov027 · Cited by 101
Self-citation
Mitochondria Influence CDR1 Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans
Thomas, E., Roman, E., Claypool, S., Manzoor, N., Pla, J., & Panwar, S. L. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00889-13 · Cited by 105
Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis
Grahl, N., Dinamarco, T. M., Willger, S. D., Goldman, G. H., & Cramer, R. A. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08034.x · Cited by 99
Elucidating Drug Resistance in Human Fungal Pathogens
Xie, J. L., Polvi, E. J., Shekhar‐Guturja, T., & Cowen, L. E. (2014) · Future Microbiology · doi:10.2217/fmb.14.18 · Cited by 103
Rosmarinic acid–Modes of antimicrobial and antibiofilm activities of a common plant polyphenol
Ivanov, M., Kostić, M., Stojković, D., & Soković, M. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2021.11.050 · Cited by 98
Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants
Sun, N., Fonzi, W., Chen, H., She, X., Zhang, L., Zhang, L., & Calderone, R. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01520-12 · Cited by 94
Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
Li, Y., Zhang, Y., Zhang, C., Wang, H., Wei, X., Chen, P., & Lü, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911560116 · Cited by 87
MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae
Zhong, K., Xiao, L., Xinyi, L., Kong, X., Zhang, H., Zheng, X., Wang, P., & Zhang, Z. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005823 · Cited by 84
Mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus : therapeutic and evolutionary implications
Neubauer, M., Zhu, Z., Penka, M., Helmschrott, C., Wagener, N., & Wagener, J. (2015) · Molecular Microbiology · doi:10.1111/mmi.13167 · Cited by 76
Terpenoids with antifungal activity trigger mitochondrial dysfunction in Saccharomyces cerevisiae
Haque, E., Irfan, S., Kamil, M., Sheikh, S., Hasan, A., Ahmad, A., Lakshmi, V., Nazir, A., & Mir, S. S. (2016) · Microbiology · doi:10.1134/s0026261716040093 · Cited by 77
Exploiting mitochondria as targets for the development of new antifungals
Li, D., & Calderone, R. (2017) · Virulence · doi:10.1080/21505594.2016.1188235 · Cited by 67
Comparative Lipidomics in Clinical Isolates of Candida albicans Reveal Crosstalk between Mitochondria, Cell Wall Integrity and Azole Resistance
Singh, A., Yadav, V., & Prasad, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039812 · Cited by 72
Aspergillus terreus: Novel lessons learned on amphotericin B resistance
Posch, W., Blatzer, M., Wilflingseder, D., & Lass‐Flörl, C. (2018) · Medical Mycology · doi:10.1093/mmy/myx119 · Cited by 74
Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells
Benhamou, R. I., Bibi, M., Steinbuch, K. B., Engel, H., Levin, M., Roichman, Y., Berman, J., & Fridman, M. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00339 · Cited by 71
Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi
Verma, S., Shakya, V. P. S., & Idnurm, A. (2018) · Virulence · doi:10.1080/21505594.2017.1414133 · Cited by 67
Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses
Pathirana, R. U., Friedman, J., Norris, H. L., Salvatori, O., McCall, A. D., Kay, J. G., & Edgerton, M. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01872-17 · Cited by 72
Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p
Tong, Y., Zhang, J., Sun, N., Wang, X.-M., Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., et al. (2021) · Science Bulletin · doi:10.1016/j.scib.2020.12.035 · Cited by 70
Global Transcriptome Profile of Cryptococcus neoformans during Exposure to Hydrogen Peroxide Induced Oxidative Stress
Upadhya, R., Campbell, L. T., Donlin, M. J., Aurora, R., & Lodge, J. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055110 · Cited by 69
The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals
Tucey, T. M., Verma-Gaur, J., Nguyen, J., Hewitt, V. L., Lo, T. L., Shingu-Vazquez, M., Robertson, A. A. B., Hill, J. R., Pettolino, F. A., Beddoe, T., et al. (2016) · mSphere · doi:10.1128/msphere.00074-16 · Cited by 66
Self-citation
Are mitochondria the Achilles’ heel of the Kingdom Fungi?
Chatre, L., & Ricchetti, M. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.05.001 · Cited by 66
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)- d -Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus
Satish, S., Jiménez-Ortigosa, C., Zhao, Y., Lee, M. H., Dolgov, E., Krüger, T., Park, S., Denning, D. W., Kniemeyer, O., Brakhage, A. A., et al. (2019) · mBio · doi:10.1128/mbio.00779-19 · Cited by 64
Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition
Duvenage, L., Walker, L. A., Bojarczuk, A., Johnston, S. A., MacCallum, D. M., Munro, C. A., & Gourlay, C. W. (2019) · mBio · doi:10.1128/mbio.02535-18 · Cited by 61
“Mitochondria have essential roles in pathogenicity (46) and antifungal drug resistance (3).”
Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence
Chang, A. L., & Doering, T. L. (2018) · mBio · doi:10.1128/mbio.01375-18 · Cited by 58
A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance
Vincent, B. M., Langlois, J.-B., Srinivas, R., Lancaster, A. K., Scherz-Shouval, R., Whitesell, L., Tidor, B., Buchwald, S. L., & Lindquist, S. (2016) · Cell Chemical Biology · doi:10.1016/j.chembiol.2016.06.016 · Cited by 58
“We anticipate that mitochondria will prove essential to many other fungal virulence processes, as others have begun to reveal (Grahl et al., 2015; Shingu-Vazquez and Traven, 2011; Sun et al., 2013).”
Potential targets for the development of new antifungal drugs
Su, H., Han, L., & Huang, X. (2018) · The Journal of Antibiotics · doi:10.1038/s41429-018-0100-9 · Cited by 63
Mitochondrial Sorting and Assembly Machinery Subunit Sam37 in Candida albicans: Insight into the Roles of Mitochondria in Fitness, Cell Wall Integrity, and Virulence
Qu, Y., Jelicic, B., Pettolino, F., Perry, A., Lo, T. L., Hewitt, V. L., Bantun, F., Beilharz, T. H., Peleg, A. Y., Lithgow, T., et al. (2012) · Eukaryotic Cell · doi:10.1128/ec.05292-11 · Cited by 57
Self-citation
The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways
Tscherner, M., Zwolanek, F., Jenull, S., Sedlazeck, F. J., Petryshyn, A., Frohner, I. E., Mavrianos, J., Chauhan, N., von Haeseler, A., & Kuchler, K. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005218 · Cited by 57
Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis: Defective colonization in host tissues by mitochondrial mutants
She, X., Khamooshi, K., Gao, Y., Shen, Y., Lv, Y., Calderone, R., Fonzi, W., Liu, W., & Li, D. (2015) · Cellular Microbiology · doi:10.1111/cmi.12438 · Cited by 51
“Our current study supports the idea of others that a loss of mitochondrial function causes reduced virulence or biofilm formation in C. albicans (Table 2) (Marchais et al., 2005; Bambach et al., 2009; Becker et al., 2010; Noble et al., 2010; Shingú-Vázquez and Traven, 2011; Qu et al., 2012).”
BackgroundResultInfluential
A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion
García, C., Burgain, A., Chaillot, J., Pic, É., Khemiri, I., & Sellam, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29973-8 · Cited by 51
Mitochondria-Mediated Azole Drug Resistance and Fungal Pathogenicity: Opportunities for Therapeutic Development
Song, J., Zhou, J., Zhang, L., & Li, R. (2020) · Microorganisms · doi:10.3390/microorganisms8101574 · Cited by 51
Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy
McLellan, C. A., Vincent, B. M., Solis, N. V., Lancaster, A. K., Sullivan, L. B., Hartland, C. L., Youngsaye, W., Filler, S. G., Whitesell, L., & Lindquist, S. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2534 · Cited by 49
Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures
Badrane, H., Cheng, S., Dupont, C., Hao, B., Driscoll, E., Morder, K., Liu, G., Newbrough, A., Fleres, G., Kaul, D., et al. (2023) · doi:10.21203/rs.3.rs-2706400/v1 · Cited by 48
Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2
Xie, J. L., Bohovych, I., Wong, E. O. Y., Lambert, J., Gingras, A., Khalimonchuk, O., Cowen, L. E., & Leach, M. D. (2017) · Microbial Cell · doi:10.15698/mic2017.10.594 · Cited by 45
The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans
Caza, M., Hu, G., Price, M., Perfect, J. R., & Kronstad, J. W. (2016) · mSphere · doi:10.1128/msphere.00080-15 · Cited by 48
Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2
Pais, P., Costa, C., Pires, C. M. B. F., Shimizu, K., Chibana, H., & Teixeira, M. C. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045344 · Cited by 47
Cellular iron homeostasis mediated by the Mrs4–Ccc1–Smf3 pathway is essential for mitochondrial function, morphogenesis and virulence in Candida albicans
Xu, N., Dong, Y., Cheng, X., Yu, Q., Qian, K., Mao, J., Jia, C., Ding, X., Zhang, B., Chen, Y., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.12.009 · Cited by 50
Antifungal Activity of Spent Coffee Ground Extracts
Calheiros, D., Días, M. I., Calhelha, R. C., Barros, L., Ferreira, I. C. F. R., Fernandes, C., & Gonçalves, T. (2023) · Microorganisms · doi:10.3390/microorganisms11020242 · Cited by 48
Promising Perspectives for Detection, Identification, and Quantification of Plant Pathogenic Fungi and Oomycetes through Targeting Mitochondrial DNA
Kulik, T., Bilska, K., & Żelechowski, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072645 · Cited by 45
Lipids of Candida albicans and their role in multidrug resistance
Prasad, R., & Singh, A. (2013) · Current Genetics · doi:10.1007/s00294-013-0402-1 · Cited by 45
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi
Bromley, M., Johns, A., Davies, E. A., Fraczek, M. G., Gilsenan, J. M., Kurbatova, N., Keays, M., Kapushesky, M., Gut, M., Gut, I. G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158724 · Cited by 44
Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis
Ma, L., Huang, D., Cuomo, C. A., Sykes, S. M., Fantoni, G., Das, B., Sherman, B. T., Yang, J., Huber, C., Xia, Y., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-224444 · Cited by 44
Transient mitochondria dysfunction confers fungal cross-resistance against phagocytic killing and fluconazole
Siscar-Lewin, S., Gabaldón, T., Aldejohann, A. M., Kurzai, O., Hube, B., & Brunke, S. (2021) · mBio · doi:10.1128/mbio.01128-21 · Cited by 36
Can Saccharomyces cerevisiae keep up as a model system in fungal azole susceptibility research?
Demuyser, L., & Dijck, P. V. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.02.002 · Cited by 44
Candida glabrata : a deadly companion?
Bolotin‐Fukuhara, M., & Fairhead, C. (2014) · Yeast · doi:10.1002/yea.3019 · Cited by 42
MSS2 maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in Candida albicans
Ke, C.-L., Liao, Y.-T., & Lin, C.-H. (2021) · Virulence · doi:10.1080/21505594.2020.1870082 · Cited by 41
Derivatives of the Antimalarial Drug Mefloquine Are Broad-Spectrum Antifungal Molecules with Activity against Drug-Resistant Clinical Isolates
Montoya, M. C., Beattie, S., Alden, K. M., & Krysan, D. J. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02331-19 · Cited by 42
Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity
Song, J., Xiao, L., & Li, R. (2020) · Molecular Microbiology · doi:10.1111/mmi.14586 · Cited by 38
Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?
Kuchler, K., Jenull, S., Shivarathri, R., & Chauhan, N. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005938 · Cited by 40
Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility
Liston, S. D., Whitesell, L. J., Kapoor, M., Shaw, K. J., & Cowen, L. E. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00261-20 · Cited by 40
Mechanistic insights into Candida biofilm eradication potential of eucalyptol
Gupta, P., Pruthi, V., & Poluri, K. M. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14940 · Cited by 40
The Rbf1, Hfl1 and Dbp4 of Candida albicans regulate common as well as transcription factor-specific mitochondrial and other cell activities
Khamooshi, K., Sikorski, P., Sun, N., Calderone, R., & Li, D. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-56 · Cited by 37
Identification and Analysis of Cation Channel Homologues in Human Pathogenic Fungi
Prole, D. L., & Taylor, C. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042404 · Cited by 37
Transcriptional Profiling of a Yeast Colony Provides New Insight into the Heterogeneity of Multicellular Fungal Communities
Traven, A., Jänicke, A., Harrison, P. F., Swaminathan, A., Seemann, T., & Beilharz, T. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046243 · Cited by 36
Self-citation
Comparative Genomics of Sibling Fungal Pathogenic Taxa Identifies Adaptive Evolution without Divergence in Pathogenicity Genes or Genomic Structure
Sillo, F., Garbelotto, M. M., Friedman, M., & Gonthier, P. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv209 · Cited by 37
A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence
Long, N., Xu, X., Qian, H., Zhang, S., & Lü, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00716 · Cited by 36
An Assessment of Growth Media Enrichment on Lipid Metabolome and the Concurrent Phenotypic Properties of Candida albicans
Mahto, K. K., Singh, A., Khandelwal, N., Bhardwaj, N., Jaykar, J., & Prasad, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113664 · Cited by 34
Mitochondrial Respiratory Pathways Inhibition in Rhizopus oryzae Potentiates Activity of Posaconazole and Itraconazole via Apoptosis
Shirazi, F., & Kontoyiannis, D. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063393 · Cited by 35
Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Do, E., Hu, G., Caza, M., Oliveira, D. L., Kronstad, J. W., & Jung, W. H. (2014) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2014.12.006 · Cited by 34
Connecting iron regulation and mitochondrial function in Cryptococcus neoformans
Horianopoulos, L. C., & Kronstad, J. W. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.04.002 · Cited by 32
Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans
Verma‐Gaur, J., Qu, Y., Harrison, P. F., Lo, T. L., Quenault, T., Dagley, M. J., Belousoff, M. J., Powell, D., Beilharz, T. H., & Traven, A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005590 · Cited by 33
Self-citation
Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans
Li, L., Liao, Z., Yang, Y., Lv, L., Cao, Y., & Zhu, Z. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192328 · Cited by 31
Amphotericin B Resistance in Aspergillus terreus Is Overpowered by Coapplication of Pro-oxidants
Blatzer, M., Jukic, E., Posch, W., Schöpf, B., Binder, U., Steger, M., Blum, G., Hackl, H., Gnaiger, E., Lass‐Flörl, C., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6220 · Cited by 33
Lipidomics and in Vitro Azole Resistance in Candida albicans
Singh, A., Mahto, K. K., & Prasad, R. (2013) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2012.0075 · Cited by 31
Multidrug-Resistant Transporter Mdr1p-Mediated Uptake of a Novel Antifungal Compound
Sun, N., Li, D., Fonzi, W. A., Li, X. V., Zhang, L., & Calderone, R. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01504-13 · Cited by 30
The ERMES (Endoplasmic Reticulum and Mitochondria Encounter Structures) mediated functions in fungi
Kundu, D., & Pasrija, R. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.02.010 · Cited by 29
The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans
Horianopoulos, L. C., Hu, G., Caza, M., Schmitt, K., Overby, P., Johnson, J. D., Valerius, O., Braus, G. H., & Kronstad, J. W. (2020) · mBio · doi:10.1128/mbio.01127-20 · Cited by 30
Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells
Garcia-Rubio, R., Jimenez-Ortigosa, C., DeGregorio, L., Quinteros, C., Shor, E., & Perlin, D. S. (2021) · mBio · doi:10.1128/mbio.01959-21 · Cited by 29
Development of high methanol-tolerance Pichia pastoris based on iterative adaptive laboratory evolution
Wang, S., Wang, Y., Yuan, Q., Yang, L. S., Zhao, F., Lin, Y. C., & Han, S. (2023) · Green Chemistry · doi:10.1039/d3gc02874g · Cited by 29
Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development
Navarro-Espíndola, R., Suaste-Olmos, F., & Peraza‐Reyes, L. (2020) · Journal of Fungi · doi:10.3390/jof6040302 · Cited by 30
Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata
Gale, A. N., Pavesic, M. W., Nickels, T. J., Xu, Z., Cormack, B. P., & Cunningham, K. W. (2023) · mSphere · doi:10.1128/msphere.00254-23 · Cited by 27
Antifungal Mechanism of Natural Products Derived from Plants: A Review
Long, N., & Li, F. (2024) · Natural Product Communications · doi:10.1177/1934578x241271747 · Cited by 32
Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity
Xue, Y.-P., Kao, M.-C., & Lan, C.-Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-50114-2 · Cited by 25
Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus
Sturm, L., Geißel, B., Martin, R., & Wagener, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01017 · Cited by 23
Target- and prodrug-based design for fungal diseases and cancer-associated fungal infections
Liu, N., Tu, J., Huang, Y., Yang, W., Wang, Q., Li, Z., & Sheng, C. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114819 · Cited by 24
Mitochondrial Two-Component Signaling Systems in Candida albicans
Mavrianos, J., Berkow, E. L., Desai, C., Pandey, A., Batish, M., Rabadi, M. J., Barker, K. S., Pain, D., Rogers, P. D., Eugenín, E. A., et al. (2013) · Eukaryotic Cell · doi:10.1128/ec.00048-13 · Cited by 24
Mitochondrial fission protein MoFis1 mediates conidiation and is required for full virulence of the rice blast fungus Magnaporthe oryzae
Khan, I. A., Ning, G., Liu, X., Feng, X., Lin, F., & Lu, J. (2015) · Microbiological Research · doi:10.1016/j.micres.2015.06.002 · Cited by 24
Cutaneous, Subcutaneous and Systemic Mycology
Samanta, I. (2015) · Springer eBooks · doi:10.1007/978-81-322-2280-4_4 · Cited by 23
Global analyses of Ceratocystis cacaofunesta mitochondria: from genome to proteome
Ambrósio, A. B., do Nascimento, L. C., de Oliveira, B. V., Teixeira, P. J. P. L., Tibúrcio, R., Thomazella, D. P. D. T., Leme, A. F. P., Carazzolle, M. F., Vidal, R. O., Mieczkowski, P. A., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-91 · Cited by 23
The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance in Cryptococcus
Sun, S., Fu, C., Ianiri, G., & Heitman, J. (2019) · Genetics · doi:10.1534/genetics.119.302824 · Cited by 23
The hypoxia‐induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus
Kroll, K., Shekhova, E., Mattern, D. J., Thywissen, A., Jacobsen, I. D., Strassburger, M., Heinekamp, T., Shelest, E., Brakhage, A. A., & Kniemeyer, O. (2016) · Molecular Microbiology · doi:10.1111/mmi.13377 · Cited by 22
Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates
Quirino, A., Giorgi, V., Palma, E., Marascio, N., Morelli, P., Maletta, A., Divenuto, F., Angelis, G. D., Tancrè, V., Nucera, S., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11030361 · Cited by 25
Mitochondrial Membrane-Associated Protein Mba1 Confers Antifungal Resistance by Affecting the Production of Reactive Oxygen Species in Aspergillus fumigatus
Zhu, G., Chen, S., Zhang, Y., & Lü, L. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00225-23 · Cited by 23
Transcriptomic and biochemical analyses revealed antifungal mechanism of trans-anethole on Aspergillus flavus growth
Lei, J.-D., Li, Q., Zhang, S., Lv, Y., Zhai, H.-C., Wei, S., Ma, P.-A., & Hu, Y. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12791-y · Cited by 22
Role of Catalase Overproduction in Drug Resistance and Virulence in Candida Albicans
Román, E., Prieto, D., Martín, R. J., Correia, I., Arango, A. C. M., Alonso‐Monge, R., Zaragoza, Ó., & Plá, J. (2016) · Future Microbiology · doi:10.2217/fmb-2016-0067 · Cited by 23
Editorial: The Significance of Mitogenomics in Mycology
Kulik, T., van Diepeningen, A. D., & Hausner, G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.628579 · Cited by 22
The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of Candida albicans
Koch, B., Tucey, T. M., Lo, T. L., Novakovic, S., Boag, P., & Traven, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02555 · Cited by 21
Self-citation
The phosphoinositide 3-kinase regulates retrograde trafficking of the iron permease CgFtr1 and iron homeostasis in Candida glabrata
Sharma, V., Purushotham, R., & Kaur, R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.751529 · Cited by 22
Targeting the Mitochondrial Respiratory Chain of Cryptococcus through Antifungal Chemosensitization: A Model for Control of Non-Fermentative Pathogens
Jong Heon, K. I. M., Haff, R. P., Faria, N., Martins, M. D. L., Chan, K. L., & Campbell, B. (2013) · Molecules · doi:10.3390/molecules18088873 · Cited by 22
Membrane-Anchored Cyclic Peptides as Effectors of Mitochondrial Oxidative Phosphorylation
Shirey, K., Stover, K. R., Cleary, J. D., Hoang, N., & Hosler, J. P. (2016) · Biochemistry · doi:10.1021/acs.biochem.5b01368 · Cited by 21
The F1Fo-ATP Synthase β Subunit Is Required for Candida albicans Pathogenicity Due to Its Role in Carbon Flexibility
Li, S., Wu, H.-T., Liu, Y., Jiang, Y.-Y., Zhang, Y., Liu, W., Zhu, K., Li, D., & Zhang, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01025 · Cited by 22
Synthesis and testing of novel alternative oxidase (AOX) inhibitors with antifungal activity against Moniliophthora perniciosa (Stahel), the causal agent of witches' broom disease of cocoa, and other phytopathogens
Barsottini, M. R., Pires, B. A., Vieira, M. L., Pereira, J. G., Costa, P. C., Sanitá, J., Coradini, A., Mello, F., Marschalk, C., Silva, E. M., et al. (2019) · Pest Management Science · doi:10.1002/ps.5243 · Cited by 19
Genome-Wide Transcription Study of Cryptococcus neoformans H99 Clinical Strain versus Environmental Strains
Movahed, E., Munusamy, K., Tan, G. M. Y., Looi, C. Y., Tay, S. T., & Wong, W. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137457 · Cited by 18
Mitochondrial Control of Fungal Cell Walls: Models and Relevance in Fungal Pathogens
Koch, B., & Traven, A. (2019) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2019_183 · Cited by 19
Self-citation
Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents
Obando, D., Koda, Y., Pantarat, N., Lev, S., Zuo, X., Oei, J. B., Widmer, F., Djordjevic, J. T., Sorrell, T. C., & Jolliffe, K. A. (2018) · ChemMedChem · doi:10.1002/cmdc.201800331 · Cited by 18
The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans
Do, E., Park, M., Hu, G., Caza, M., Kronstad, J. W., & Jung, W. H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.123 · Cited by 18
A Proteomic Landscape of Candida albicans in the Stepwise Evolution to Fluconazole Resistance
Song, N., Zhou, X., Li, D., Li, X., & Liu, W. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02105-21 · Cited by 17
Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans
Hossain, S., Veri, A. O., Liu, Z., Iyer, K. R., O’Meara, T. R., Robbins, N., & Cowen, L. E. (2021) · Genetics · doi:10.1093/genetics/iyab095 · Cited by 19
Use of Haploid Model of Candida albicans to Uncover Mechanism of Action of a Novel Antifungal Agent
Truong, T., Suriyanarayanan, T., Zeng, G., Le, T. D., Liu, L., Li, J., Tong, C., Wang, Y., & Seneviratne, C. J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00164 · Cited by 16
The C3HC type zinc-finger protein (ZFC3) interacting with Lon/MAP1 is important for mitochondrial gene regulation, infection hypha development and longevity of Magnaporthe oryzae
Liu, S., Wei, Y., & Zhang, S. (2020) · BMC Microbiology · doi:10.1186/s12866-020-1711-4 · Cited by 16

Authors: Shingu-Vazquez, M., & Traven, A.
Affiliations: Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
Monash University (AU)
Corresponding author: Traven, Ana
ORCID: Traven, Ana
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2011-11
Volume: 10
Issue: 11
Pages: 1376-1383
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.05184-11
PMC: PMC3209048
OpenAlex: W2155416658
Cited by: 209
References: 91
Citations by year: 2026: 15 · 2025: 21 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 9 · 2013: 16 · 2012: 6
FWCI: 1.23
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Monash University Research Portal (Monash University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondria, fungal pathogenesis, drug tolerance, antifungal resistance, fungal virulence, mitochondrial dysfunction, membrane lipid homeostasis, mitochondrial mutations, antifungal drug development, hypervirulence
MeSH terms: Antifungal Agents, Azoles, Candida albicans, Cryptococcus neoformans, Fungi, Humans, Membrane Lipids, Microbial Sensitivity Tests, Mitochondria, Mycoses, Polyenes, Saccharomyces cerevisiae, Drug Resistance, Fungal, Candida glabrata, Mitochondrial Membranes, Drug Discovery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks