Cited by 210Antifungal resistance and susceptibilityFungal and yeast genetics researchMitochondrial Function and Pathology

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Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

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Shingu-Vazquez, Miguel, Traven, Ana·2011·Eukaryotic Cell

DOI 10.1128/ec.05184-11PMC PMC3209048

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Abstract

Recently, mitochondria have been identified as important contributors to the virulence and drug tolerance of human fungal pathogens. In different scenarios, either hypo- or hypervirulence can result from changes in mitochondrial function. Similarly, specific mitochondrial mutations lead to either sensitivity or resistance to antifungal drugs. Here, we provide a synthesis of this emerging field, proposing that mitochondrial function in membrane lipid homeostasis is the common denominator underlying the observed effects of mitochondria in drug tolerance (both sensitivity and resistance). We discuss how the contrasting effects of mitochondrial dysfunction on fungal drug tolerance and virulence could be explained and the potential for targeting mitochondrial factors for future antifungal drug development.

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Authors: Shingu-Vazquez, M., & Traven, A.
Affiliations: Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
Monash University (AU)
Corresponding author: Traven, Ana
ORCID: Traven, Ana
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2011-11
Volume: 10
Issue: 11
Pages: 1376-1383
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.05184-11
PMC: PMC3209048
OpenAlex: W2155416658
Cited by: 209
References: 91
Citations by year: 2026: 15 · 2025: 21 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 9 · 2013: 16 · 2012: 6
FWCI: 1.23
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Monash University Research Portal (Monash University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondria, fungal pathogenesis, drug tolerance, antifungal resistance, fungal virulence, mitochondrial dysfunction, membrane lipid homeostasis, mitochondrial mutations, antifungal drug development, hypervirulence
MeSH terms: Antifungal Agents, Azoles, Candida albicans, Cryptococcus neoformans, Fungi, Humans, Membrane Lipids, Microbial Sensitivity Tests, Mitochondria, Mycoses, Polyenes, Saccharomyces cerevisiae, Drug Resistance, Fungal, Candida glabrata, Mitochondrial Membranes, Drug Discovery

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Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

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