Proton transport and pH control in fungi

Kane, Patricia M.

doi:10.1007/978-3-319-25304-6_3

Cited by 131Fungal and yeast genetics researchATP Synthase and ATPases ResearchBacterial Genetics and Biotechnology

Proton transport and pH control in fungi

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Kane, Patricia M.·2016·Advances in Experimental Medicine and Biology

DOI 10.1007/978-3-319-25304-6_3PMC PMC5957285

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Abstract

Despite diverse and changing extracellular environments, fungi maintain a relatively constant cytosolic pH and numerous organelles of distinct lumenal pH. Key players in fungal pH control are V-ATPases and the P-type proton pump Pma1. These two proton pumps act in concert with a large array of other transporters and are highly regulated. The activities of Pma1 and the V-ATPaseare coordinated under some conditions, suggesting that pH in the cytosol and organelles is not controlled independently. Genomic studies, particularly in the highly tractable S. cerevisiae, are beginning to provide a systems-level view of pH control, including transcriptional responses to acid or alkaline ambient pH and definition of the full set of regulators required to maintain pH homeostasis. Genetically encoded pH sensors have provided new insights into localized mechanisms of pH control, as well as highlighting the dynamic nature of pH responses to the extracellular environment. Recent studies indicate that cellular pH plays a genuine signaling role that connects nutrient availability and growth rate through a number of mechanisms. Many of the pH control mechanisms found in S. cerevisiae are shared with other fungi, with adaptations for their individual physiological contexts. Fungi deploy certain proton transport and pH control mechanisms not shared with other eukaryotes; these regulators of cellular pH are potential antifungal targets. This re view describes current and emerging knowledge proton transport and pH control mechanisms in S. cerevisiae and briefly discusses how these mechanisms vary among fungi.

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Pma1 is a fungal plasma-membrane single-subunit P-type H+-ATPase that extrudes protons across the plasma membrane at the expense of ATP hydrolysis, contributing to cytosolic pH regulation and generation of the transmembrane electrochemical proton gradient that drives secondary nutrient transport.
“Pma1, encoded by PMA1, is a fungal plasma-membrane single-subunit P-type H+-ATPase that extrudes protons across the plasma membrane at the expense of ATP hydrolysis, thereby contributing to cytosolic pH regulation and to the generation of the transmembrane electrochemical proton gradient that drives secondary nutrient transport [32,33,34].”
From Ovotransferrin and Its γ-Core-Containing Peptides Impair Pma1-Dependent Proton Homeostasis in Candida albicans (2026) · cites this paper as [34]
Section 3.1 identifies Pma1 as a single-subunit plasma-membrane P-type H+-ATPase and describes its ATP consumption, electrogenic H+ transport, and role in cytosolic pH and membrane potential. The passages found do not establish the further claim that its proton gradient drives secondary nutrient transport; no page numbers were available in our copy. (LLM, conf=0.83)
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Loss of Vacuolar H+-ATPase Activity in Organelles Signals Ubiquitination and Endocytosis of the Yeast Plasma Membrane Proton pump Pma1p
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Self-citation
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Research works printed but not linked: 2

[97]Diakov TT Kane PM 2010 Regulation of V-ATPase activity and assembly by extracellular pH J Biol Chem M110.110122 [pii] 10.1074/jbc.M110.110122 PMC2911326 20511227 · DOI
[114]Hirata R Takatsuki A 2001 Role of organelle acidification in intracellular protein transport RIKEN Review 41 90 91

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Lactoferrin perturbs lipid rafts and requires integrity of Pma1p–lipid rafts association to exert its antifungal activity against Saccharomyces cerevisiae
Santos-Pereira, C., Andrés, M. T., Chaves, S. R., Fierro, J. F., Gerós, H., Manon, S., Rodrigues, L. R., & Côrte-Real, M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.224 · Cited by 21 · see citing works
Ovotransferrin and Its γ-Core-Containing Peptides Impair Pma1-Dependent Proton Homeostasis in Candida albicans
Antuña, V., Fierro, P., Fierro, J. F., Álvarez, Á. L., & Andrés, M. T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167415
“It uses ATP to extrude protons and thereby helps maintain cytosolic pH, membrane potential, and the proton gradient required for secondary transport [32–34].”

The proton pump ATPase of lysosomes and related organelles of the vacuolar apparatus
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Vacuolar ATPase (V-ATPase) Proton Pump and Its Significance in Human Health
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Vacuolar acidification relies on the combined activity of endomembrane proton pumps
Kriegel, A. (2015) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00019166
Rotating with the brakes on and other unresolved features of the vacuolar ATPase
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Authors: Kane, P. M.
Affiliations: SUNY Upstate Medical University (US)
Corresponding author: Kane, Patricia M.
ORCID: Kane, Patricia M.
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer International Publishing
Published: 2016
Volume: 892
Pages: 33-68
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-3-319-25304-6_3
PMC: PMC5957285
OpenAlex: W2345147274
Semantic Scholar: a981d86a6d129011e242938382935e1dcb2cbbfb
Cited by: 131
References: 192
Citations by year: 2026: 13 · 2025: 11 · 2024: 17 · 2023: 18 · 2022: 15 · 2021: 12 · 2020: 19 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 2
FWCI: 9.03
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (unspecified)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01-GM50322, R01GM050322)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: proton transport, pH homeostasis, fungi, V-ATPase, Pma1, intracellular pH, Saccharomyces cerevisiae, pH sensor, pH signaling, antifungal drug targets, proton transporters
MeSH terms: Cell Membrane, Proton-Translocating ATPases, Hydrogen-Ion Concentration, Models, Molecular, Protons, Saccharomyces cerevisiae, Species Specificity, Vacuoles, Signal Transduction, Gene Expression, Ion Transport, Vacuolar Proton-Translocating ATPases, Saccharomyces cerevisiae Proteins

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Proton transport and pH control in fungi

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