The Glycosylphosphatidylinositol-Anchored Protease Sap9 Modulates the Interaction of Candida albicans with Human Neutrophils

Hornbach, Anke; Heyken, Antje; Schild, Lydia; Hube, Bernhard; Löffler, Jürgen; Kurzai, Oliver

doi:10.1128/iai.00723-09

Cited by 47Antifungal resistance and susceptibilityFungal and yeast genetics researchNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The Glycosylphosphatidylinositol-Anchored Protease Sap9 Modulates the Interaction of Candida albicans with Human Neutrophils

Open access

Hornbach, Anke, Heyken, Antje, Schild, Lydia, Hube, Bernhard, Löffler, Jürgen, Kurzai, Oliver·2009·Infection and Immunity

DOI 10.1128/iai.00723-09PMC PMC2786460

Open this paper in CoChat — free account

Abstract

Human polymorphonuclear neutrophils (PMNs) play a major role in the immune defense against invasive Candida albicans infection. This fungal pathogen produces a set of aspartic proteases that directly contributes to virulence properties such as adhesion, tissue invasion, and immune evasion. We show here that, in contrast to other secreted proteases, the cell surface-associated isoform Sap9 has a major impact on the recognition of C. albicans by PMNs. SAP9 is required for the induction of PMN chemotaxis toward C. albicans filaments, an essential prerequisite of effective PMN activation. Furthermore, deletion of SAP9 leads to a mitigated release of reactive oxygen intermediates (ROI) in human PMNs and decreases C. albicans -induced apoptosis triggered by ROI formation. In confrontation assays, killing of a SAP9 deletion mutant is reduced in comparison to wild-type C. albicans . These data clearly implicate Sap9 protease activity in the initiation of protective innate immunity and suggest novel molecular mechanisms in C. albicans -host interaction leading to neutrophil activation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/iai.00723-09

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increased Sap9 expression has been associated with adhesion to epithelial cells and epithelial damage during oral infection, making it an important mediator of host-pathogen interactions.
“Increased Sap9 expression has been associated with adhesion to epithelial cells and epithelial damage during oral infection [62], making it an important mediator of host-pathogen interactions [65].”
From Carbon source‐induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen <scp> C </scp> andida albicans (2012) · cites this paper as [65]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
HOW NEUTROPHILS KILL MICROBES
Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783 · see citing works
Chronic Granulomatous Disease: Report on a National Registry of 368 Patients
Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728 · see citing works
Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
Gillum, A. M., Tsay, E. Y. H., & Kirsch, D. R. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00328721 · Cited by 1,253 · see citing works
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Naglik, J. R., Challacombe, S. J., & Hube, B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.400-428.2003 · Cited by 1,179 · see citing works
Self-citation
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00659.x · Cited by 1,014 · see citing works
Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia
Pizzo, P. A., Robichaud, K. J., Gill, F. A., & Witebsky, F. G. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90594-0 · Cited by 859 · see citing works
How human neutrophils kill and degrade microbes: an integrated view
Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756 · see citing works
A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation
Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627 · see citing works
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
Quinn, M. T., & Gauss, K. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404216 · Cited by 480 · see citing works
Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood
Fradin, C., De Groot, P., MacCallum, D., Schaller, M., Klis, F., Odds, F. C., & Hube, B. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04557.x · Cited by 455 · see citing works
Self-citation
Candida albicans proteinases and host/pathogen interactions
Naglik, J., Albrecht, A., Bader, O., & Hube, B. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00439.x · Cited by 399 · see citing works
Self-citation
Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
Hube, B., Monod, M., Schofield, D. A., Brown, A. J. P., & Gow, N. A. R. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01269.x · Cited by 373 · see citing works
Self-citation
Candida albicans Biofilms: a Developmental State Associated With Specific and Stable Gene Expression Patterns
García-Sánchez, S., Aubert, S., Iraqui, I., Janbon, G., Ghigo, J.-M., & d'Enfert, C. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.536-545.2004 · Cited by 353 · see citing works
Neutrophils undergo apoptosis following ingestion of Escherichia coli
Watson, R. W. G., Redmond, H. P., Wang, J. H., Condron, C. M., & Bouchier‐Hayes, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3986 · Cited by 303 · see citing works
CIp10, an efficient and convenient integrating vector for Candida albicans
Murad, A. M. A., Lee, P. R., Broadbent, I. D., Barelle, C. J., & Brown, A. J. P. (2000) · Yeast · doi:10.1002/1097-0061(20000315)16:4 · Cited by 303 · see citing works
CAUSES OF DEATH IN ADULTS WITH ACUTE LEUKEMIA
CHANG, H.-Y., Rodriguez, V., Narboni, G., Bodey, G. P., Luna, M. A., & Freireich, E. J. (1976) · Medicine · doi:10.1097/00005792-197605000-00005 · Cited by 302 · see citing works
In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination: C. albicans genes associated with oral candidiasis
Zakikhany, K., Naglik, J. R., Schmidt-Westhausen, A., Holland, G., Schaller, M., & Hube, B. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01009.x · Cited by 288 · see citing works
Self-citation
A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence
Sanglard, D., Hube, B., Monod, M., Odds, F. C., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3539-3546.1997 · Cited by 282 · see citing works
Self-citation
Inhibition of the Spontaneous Apoptosis of Neutrophil Granulocytes by the Intracellular Parasite Leishmania major
Aga, E., Katschinski, D. M., van Zandbergen, G., Laufs, H., Hansen, B., Müller, K., Solbach, W., & Laskay, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.898 · Cited by 281 · see citing works
Glycosylphosphatidylinositol-anchored Proteases of Candida albicans Target Proteins Necessary for Both Cellular Processes and Host-Pathogen Interactions
Albrecht, A., Felk, A., Pichova, I., Naglik, J. R., Schaller, M., de Groot, P., MacCallum, D., Odds, F. C., Schäfer, W., Klis, F., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509297200 · Cited by 270 · see citing works
Self-citation
Modulation of phagocyte apoptosis by bacterial pathogens
DeLeo, F. R. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000031448.64969.fa · Cited by 264 · see citing works
Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs
Felk, A., Kretschmar, M., Albrecht, A., Schaller, M., Beinhauer, S., Nichterlein, T., Sanglard, D., Körting, H. C., Schäfer, W., & Hube, B. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3689-3700.2002 · Cited by 258 · see citing works
Self-citation
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
Naglik, J. R., Moyes, D., Makwana, J., Kanzaria, P., Tsichlaki, E., Weindl, G., Tappuni, A. R., Rodgers, C. A., Woodman, A. J., Challacombe, S. J., et al. (2008) · Microbiology · doi:10.1099/mic.0.2008/022293-0 · Cited by 253 · cited 1× · see citing works
“Although both of these genes are expressed in different infection models, the expression of SAP7 does not correlate with virulence (34, 50).”
BackgroundSelf-citation
Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans
Rubin-Bejerano, I., Fraser, I., Grisafi, P., & Fink, G. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834481100 · Cited by 223 · see citing works
The Aspergillus fumigatus Transcriptional Regulator AfYap1 Represents the Major Regulator for Defense against Reactive Oxygen Intermediates but Is Dispensable for Pathogenicity in an Intranasal Mouse Infection Model
Lessing, F., Kniemeyer, O., Wozniok, I., Loeffler, J., Kurzai, O., Haertl, A., & Brakhage, A. A. (2007) · Eukaryotic Cell · doi:10.1128/ec.00267-07 · Cited by 221 · see citing works
Self-citation
Misexpression of the Opaque-Phase-Specific Gene PEP1 ( SAP1 ) in the White Phase of Candida albicans Confers Increased Virulence in a Mouse Model of Cutaneous Infection
Kvaal, C. A., Lachke, S. A., Srikantha, T., Daniels, K. J., McCoy, J. W., & Soll, D. R. (1999) · Infection and Immunity · doi:10.1128/iai.67.12.6652-6662.1999 · Cited by 221 · see citing works
Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity
Schaller, M., Schäfer, W., Körting, H. C., & Hube, B. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00957.x · Cited by 211 · see citing works
Self-citation
Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors
White, T. C., & Agabian, N. M. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.18.5215-5221.1995 · Cited by 211 · see citing works
Polymorphonuclear neutrophils as accessory cells for T‐cell activation: major histocompatibility complex class II restricted antigen‐dependent induction of T‐cell proliferation
Radsak, M. P., Iking‐Konert, C., Stegmaier, S., et al. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00140.x · Cited by 201 · see citing works
A Simplified New Assay for Assessment of Fungal Cell Damage with the Tetrazolium Dye, (2,3)-bis-(2-Methoxy-4-Nitro-5-Sulphenyl)-(2H)-Tetrazolium-5-Carboxanilide (XTT)
Meshulam, T., Levitz, S. M., Christin, L., & Diamond, R. D. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.4.1153 · Cited by 191 · see citing works
The Secreted Aspartyl Proteinases Sap1 and Sap2 Cause Tissue Damage in an In Vitro Model of Vaginal Candidiasis Based on Reconstituted Human Vaginal Epithelium
Schaller, M., Bein, M., Körting, H. C., Baur, S., Hamm, G., Monod, M., Beinhauer, S., & Hube, B. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3227-3234.2003 · Cited by 190 · see citing works
Self-citation
Evidence that Members of the Secretory Aspartyl Proteinase Gene Family, in ParticularSAP2,Are Virulence Factors forCandidaVaginitis
Bernardis, F. D., Arancia, S., Morelli, L., Hube, B., Sanglard, D., Schäfer, W., & Cassone, A. (1999) · The Journal of Infectious Diseases · doi:10.1086/314546 · Cited by 169 · see citing works
Self-citation
The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages
Zepelin, M. B., Beggah, S., Boggian, K., Sanglard, D., & Monod, M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00815.x · Cited by 169 · see citing works
Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase
Colina, A. R., Aumont, F., Deslauriers, N., Belhumeur, P., & de Repentigny, L. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4514-4519.1996 · Cited by 161 · see citing works
Candida albicans secreted aspartyl proteinases.
Hube, B. (1996) · PubMed · Cited by 159 · see citing works
Self-citation
Differential activation of a Candida albicans virulence gene family during infection
Staib, P., Kretschmar, M., Nichterlein, T., Hof, H., & Morschhäuser, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110031497 · Cited by 153 · see citing works
A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide
Meiller, T. F., Hube, B., Schild, L., Shirtliff, M. E., Scheper, M. A., Winkler, R., Ton, A., & Jabra‐Rizk, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005039 · Cited by 140 · see citing works
Self-citation
Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component
Rubin-Bejerano, I., Abeijón, C., Magnelli, P. E., Grisafi, P. L., & Fink, G. R. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.002 · Cited by 119 · see citing works
Degradation of humoral host defense by Candida albicans proteinase
Kaminishi, H., 宮口, 英., Tamaki, T., Suenaga, N., Hisamatsu, M., Mihashi, I., Matsumoto, H., Maeda, H., & Hagihara, Y. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.984-988.1995 · Cited by 116 · see citing works
Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes
Copping, V. M. S., Barelle, C. J., Hube, B., Gow, N. A. R., Brown, A. J. P., & Odds, F. C. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki088 · Cited by 113 · see citing works
Self-citation
Germ Tubes and Proteinase Activity Contribute to Virulence of Candida albicans in Murine Peritonitis
Kretschmar, M., Hube, B., Bertsch, T., Sanglard, D., Merker, R., Schröder, M., Hof, H., & Nichterlein, T. (1999) · Infection and Immunity · doi:10.1128/iai.67.12.6637-6642.1999 · Cited by 108 · see citing works
Self-citation
Identification of pH-Regulated Antigen 1 Released from Candida albicans as the Major Ligand for Leukocyte Integrin αMβ2
Soloviev, D. A., Fonzi, W. A., Sentandreu, R., Pluskota, E., Forsyth, C. B., Yadav, S. P., & Plow, E. F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2038 · Cited by 82 · see citing works
Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida.
Rüchel, R. (1986) · PubMed · Cited by 80 · see citing works
Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils
Wozniok, I., Hornbach, A., Schmitt, C., Frosch, M., Einsele, H., Hube, B., Löffler, J., & Kurzai, O. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01086.x · Cited by 76 · see citing works
Self-citation
PHAGOCYTOSIS OF CANDIDA ALBICANS INDUCES APOPTOSIS OF HUMAN NEUTROPHILS
Rotstein, D., Parodo, J. C., Taneja, R., & Marshall, J. C. (2000) · Shock · doi:10.1097/00024382-200014030-00006 · Cited by 72 · see citing works
Role of reactive oxygen species in neutrophil apoptosis following ingestion of heat-killedStaphylococcus aureus
YAMAMOTO, A., Taniuchi, S., Tsuji, S., Hasui, M., Kobayashi, Y., & Kobayashi, Y. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01930.x · Cited by 66 · see citing works
Migration of the fungal pathogen Candida albicans across endothelial monolayers
Zink, S., Nass, T., Rosen, P., & Ernst, J. F. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5085-5091.1996 · Cited by 63 · see citing works
Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
Kretschmar, M., Felk, A., Staib, P., Schaller, M., Hess, D., Callapina, M., Morschhäuser, J., Schäfer, W., Körting, H. C., Hof, H., et al. (2002) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0478 · Cited by 54 · see citing works
Self-citation
Neutrophil chemotaxis by pathogen-associated molecular patterns - formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus
Dürr, M. C., Kristian, S. A., Otto, M. J., et al. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00610.x · Cited by 52 · see citing works
Scanning electron microscope study ofCandida albicansinvasion of cultured human cervical epithelial cells
Farrell, S. M., Hawkins, D. F., & Ryder, T. A. (1983) · Medical Mycology · doi:10.1080/00362178385380391 · Cited by 47 · see citing works
Induction of SAP7 Correlates with Virulence in an Intravenous Infection Model of Candidiasis but Not in a Vaginal Infection Model in Mice
Taylor, B., Hannemann, H., Sehnal, M., Biesemeier, A., Schweizer, A., Röllinghoff, M., & Schröppel, K. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.7061-7063.2005 · Cited by 44 · see citing works
Tetracycline-Inducible Expression of Individual Secreted Aspartic Proteases in Candida albicans Allows Isoenzyme-Specific Inhibitor Screening
Staib, P., Lermann, U., Blaß-Warmuth, J., Degel, B., Würzner, R., Monod, M., Schirmeister, T., & Morschhäuser, J. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01072-07 · Cited by 41 · see citing works
Modulation of Neutrophil‐Mediated Activity Against the Pseudohyphal Form ofCandida albicansby Granulocyte Colony‐Stimulating Factor (G‐CSF) Administered In Vivo
Gaviria, J. M., van Burik, J. H., Dale, D. C., Root, R. K., & Liles, W. C. (1999) · The Journal of Infectious Diseases · doi:10.1086/314728 · Cited by 40 · see citing works
Effect of pH and human saliva on protease production by Candida albicans
Germaine, G. R., & Tellefson, L. M. (1981) · Infection and Immunity · doi:10.1128/iai.31.1.323-326.1981 · Cited by 40 · see citing works
Identification of a Mannoprotein Fraction from Candida albicans that Enhances Human Polymorphonuclear Leukocyte (PMNL) Functions and Stimulates Lactoferrin in PMNL Inhibition of Candidal Growth
Palma, C., Serbousek, D., Torosantucci, A., et al. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.5.1103 · Cited by 40 · see citing works
Interactions of Candida albicans Yeast Cells, Germ Tubes and Hyphae with Human Polymorphonuclear Leucocytes in vitro
Cockayne, A., & Odds, F. C. (1984) · Microbiology · doi:10.1099/00221287-130-3-465 · Cited by 38 · see citing works
Involvement of p38-mitogen-activated protein kinase in staphylococcus aureus-induced neutrophil apoptosis
Lundqvist‐Gustafsson, H., Norrman, S., Nilsson, J., et al. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.4.642 · Cited by 32 · see citing works
Inhibition of Human Neutrophil Apoptosis by Paracoccidioides brasiliensis: Role of Interleukin‐8
Acorci-Valério, M. J., Dias‐Melicio, L. A., Golim, M. D. A., Bordon‐Graciani, A. P., Peraçoli, M. T. S., & Soares, Â. M. V. C. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02199.x · Cited by 28 · see citing works
Polymorphism of is a major factor in the interaction with human dendritic cells
Kurzai, O. (2005) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2005.02.003 · Cited by 22 · see citing works
Self-citation
Haemoperfused liver as an ex vivo model for organ invasion of Candida albicans
Thewes, S., Reed, H.-K., Große‐Siestrup, C., et al. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46760-0 · Cited by 14 · see citing works

Flagged first, then by citations

Sorted by citations

Carbon source‐induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen <scp> C </scp> andida albicans
Ene, I. V., Heilmann, C. J., Sorgo, A. G., Walker, L. A., de Koster, C. G., Munro, C. A., Klis, F. M., & Brown, A. J. P. (2012) · Proteomics · doi:10.1002/pmic.201200228 · Cited by 159 · see citing works
“Increased Sap9 expression has been associated with adhesion to epithelial cells and epithelial damage during oral infection [62], making it an important mediator of host-pathogen interactions [65].”
Background
Proteolytic Cleavage of Covalently Linked Cell Wall Proteins by Candida albicans Sap9 and Sap10
Schild, L., Heyken, A., de Groot, P. W. J., Hiller, E., Mock, M., de Koster, C., Horn, U., Rupp, S., & Hube, B. (2011) · Eukaryotic Cell · doi:10.1128/ec.00210-10 · Cited by 104 · see citing works
Self-citation
Extracellular proteinases of Candida species pathogenic yeasts
Rapala‐Kozik, M., Bochenska, O., Zajac, D., Karkowska‐Kuleta, J., Gogol, M., Zawrotniak, M., & Kozik, A. (2018) · Molecular Oral Microbiology · doi:10.1111/omi.12206 · Cited by 94 · see citing works
Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans
Buu, L.-M., & Chen, Y.-C. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-101 · Cited by 27 · see citing works

STUDY OF PROTEASES AND PROTEASE INHIBITORS FROM STREPTOMYCES STRAINS
Kalchev, K., Rabadjiev, Y., Ganchev, D., et al. (2013) · Bulgarian Portal for Open Science · Cited by 1 · see citing works
Use of modified superabsorbent polymer dressings for protease modulation in improved chronic wound care.
Tarlton, J. F., & Munro, H. S. (2013) · PubMed · Cited by 7 · see citing works
KARAKTERISASI PROTEASE DARI ISOLAT BAKTERI ASAL TUMBUHAN RAWA DARI INDRALAYA
Baehaki, A., & Rinto (2012) · Jurnal Pengolahan Hasil Perikanan Indonesia · doi:10.17844/jphpi.v15i1.5335
The effect of legume protease inhibitors on native milk and bacterial proteases
Richards, M., de Kock, H. L., Duodu, K. G., et al. (2014) · LWT · doi:10.1016/j.lwt.2014.01.003 · Cited by 9 · see citing works
The protease web
Esser‐Skala, W., & Fortelny, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85696-6.00001-9 · Cited by 1 · see citing works

Authors: Hornbach, A., Heyken, A., Schild, L., Hube, B., Löffler, J., & Kurzai, O.
Affiliations: University of Würzburg (DE)
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
University of Würzburg, Department of Internal Medicine II, Würzburg, Germany
Corresponding author: Kurzai, Oliver
ORCID: Hube, Bernhard
Kurzai, Oliver
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2009-12
Volume: 77
Issue: 12
Pages: 5216-5224
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00723-09
PMC: PMC2786460
OpenAlex: W2114844963
Cited by: 47
References: 61
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 7
FWCI: 3.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: Candida albicans, neutrophils, aspartic protease, GPI-anchored proteins, neutrophil chemotaxis, reactive oxygen species, neutrophil apoptosis, innate immunity, fungal virulence, host-pathogen interaction, neutrophil killing
MeSH terms: Candida albicans, Fungal Proteins, Humans, Immunologic Factors, Neutrophils, Aspartic Acid Endopeptidases, Gene Deletion, Reactive Oxygen Species, Cell Migration Assays, Leukocyte

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Glycosylphosphatidylinositol-Anchored Protease Sap9 Modulates the Interaction of Candida albicans with Human Neutrophils

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks