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MgrA Represses Biofilm Formation in Staphylococcus aureus

Trotonda, María Pilar, Tamber, Sandeep, Memmi, Guido, Cheung, Ambrose L.·2008·Infection and Immunity
DOI 10.1128/iai.00735-08
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Abstract

MgrA is a pleiotropic regulator that controls autolysis, virulence, and efflux pump activity in Staphylococcus aureus . We recently found that mgrA mutants of strains RN6390, SH1000, and MW2 also displayed enhanced biofilm formation compared with their respective parents. The biofilms formed by mgrA mutants of RN6390 and MW2 are independent of sigB and ica loci, two genetic elements that have been previously associated with biofilm formation in S. aureus . Biofilms formed by mgrA mutants are dependent on the expression of surface proteins mediated by the sortase gene srtA . Extracellular DNA was also a crucial component of the early biofilm of mgrA mutants. Genetic analysis indicated that biofilm formation in mgrA mutants is mediated in part by agr RNAIII, a genetic locus regulated by mgrA . Additionally, SarA is important to biofilm formation in mgrA mutants since the double sarA mgrA mutants failed to form biofilms compared to single mgrA mutants of RN6390 and MW2. However, the SarA-mediated effect is independent of agr and proteases such as V8 protease and aureolysin. Collectively, our data showed MgrA to be a repressor of biofilm formation, and biofilms formed by mgrA mutants have features that are distinct from other reported biofilm types in S. aureus .

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Metadata

Authors
Trotonda, M. P., Tamber, S., Memmi, G., & Cheung, A. L.
Affiliations
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
2008-12
Volume
76
Issue
12
Pages
5645-5654
ISSN
  • 0019-9567
  • 1098-5522
DOI
10.1128/iai.00735-08
Cited by
103
References
2
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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CoChat. (2026). Citation check: MgrA Represses Biofilm Formation in Staphylococcus aureus. https://app.cochat.ai/papers/10.1128/iai.00735-08
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Trotonda, M. P., Tamber, S., Memmi, G., & Cheung, A. L. (2008). MgrA Represses Biofilm Formation in Staphylococcus aureus. Infection and Immunity. https://doi.org/10.1128/iai.00735-08

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.