Intestinal microflora and metabolic diseases

Serino, M.; Luche, E.; Chabo, C.; Amar, J.; Burcelin, R.

doi:10.1016/j.diabet.2009.03.003

Cited by 77Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

Intestinal microflora and metabolic diseases

Serino, M., Luche, E., Chabo, C., Amar, J., Burcelin, R.·2009·Diabetes & Metabolism

DOI 10.1016/j.diabet.2009.03.003

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Abstract

Recent advances in molecular sequencing technology have allowed researchers to answer major questions regarding the relationship between a vast genomic diversity-such as found in the intestinal microflora-and host physiology. Over the past few years, it has been established that, in obesity, type 1 diabetes and Crohn's disease-to cite but a few-the intestinal microflora play a pathophysiological role and can induce, transfer or prevent the outcome of such conditions. A few of the molecular vectors responsible for this regulatory role have been determined. Some are related to control of the immune, vascular, endocrine and nervous systems located in the intestines. However, more important is the fact that the intestinal microflora-to-host relationship is bidirectional, with evidence of an impact of the host genome on the intestinal microbiome. This means that the ecology shared by the host and gut microflora should now be considered a new player that can be manipulated, using pharmacological and nutritional approaches, to control physiological functions and pathological outcomes. What now remains is to demonstrate the molecular connection between the intestinal microflora and metabolic diseases. We propose here that the proinflammatory lipopolysaccharides play a causal role in the onset of metabolic disorders.

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Numerous facets of GI microbial community composition and metabolism have been associated with various disease states, including CVD, obesity, diabetes, and features of metabolic syndrome.
“Numerous facets of GI microbial community composition and metabolism have been associated with various disease states, including CVD, obesity, diabetes, and features of metabolic syndrome[274,310–313].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [310]

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Authors: Serino, M., Luche, E., Chabo, C., Amar, J., & Burcelin, R.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Hôpital Rangueil (FR)
Corresponding author: Burcelin, R.
ORCID: Chabo, C.
Amar, J.
Burcelin, R.
Venue: Diabetes & Metabolism
Publisher: Elsevier BV
Published: 2009-09
Volume: 35
Issue: 4
Pages: 262-272
ISSN: 1262-3636 (ISSN-L)
DOI: 10.1016/j.diabet.2009.03.003
OpenAlex: W2111508743
Cited by: 77
References: 98
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 2 · 2012: 8
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes & Metabolism (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, metabolic disorders, obesity, type 1 diabetes, Crohn's disease, host-microbe interactions, lipopolysaccharide, inflammation, gut immune system, microbiota-targeted therapy, pharmacological manipulation
MeSH terms: Animals, Humans, Intestines, Metabolic Diseases, Colony Count, Microbial, Bacterial Physiological Phenomena, Probiotics, Prebiotics

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