Improving turnaround times with artificial intelligence in microbiology
Open accessAbstract
This dual-center study evaluated the impact of artificial intelligence (AI) on urine culture turnaround times in Canadian diagnostic laboratories using microbiology laboratory automation. Data were collected before and after the implementation of PhenoMATRIX (PM), an AI-based software that provides continuous culture sorting and result interpretation support. In both a low-volume tertiary care hospital and a high-volume community laboratory, PM enabled earlier availability of interpretable results; however, reductions in time to result reporting (TTRR) were contingent on workflows for result release. At the tertiary care site, implementation of PM alone was associated with increased TTRR, reflecting delays between result availability and reporting. Integration of PM+ enabled automated release of negative results as they became available, resulting in a TTRR reduction of approximately 1.3 h. At the community laboratory, where PM+ was not implemented, a TTRR improvement of approximately 5.3 h was achieved by advancing manual screening workflows (08:00 vs 16:00), facilitating earlier review and release of PM-generated results. These findings indicate that AI-driven culture assessment reduces TTRR when coupled with processes that enable timely result release, either through automated reporting or optimized laboratory review workflows. IMPORTANCE: Advances in artificial intelligence (AI), coupled with the power of laboratory automation, is the next step in the evolution of the clinical microbiology laboratory. We demonstrated that bacterial culture assessment (urine cultures) by AI decreases the time required to release results to clinicians and reduces the hands-on time required by technologists to analyze and finalize laboratory analysis. This study was performed in two different laboratories that differed not only in geography but also in scope and scale. The same ultimate benefits were seen in both institutions demonstrating that this technology is widely applicable for most laboratories.
AI snapshot
Written from the paper’s full text.
TL;DR
This dual-center Canadian study evaluated whether AI-based PhenoMATRIX (PM) and automated release (PM+) reduce urine culture time to result reporting (TTRR) in automated microbiology laboratories. PM enabled earlier result availability, but TTRR reductions depended on result-release workflows: PM+ at QEII reduced TTRR by ~1.3 h, while workflow changes at Dynacare without PM+ reduced TTRR by ~5.3 h.
Key findings
- At QEII, PM alone did not reduce TTRR; with PM+, mean TTRR decreased by approximately 1 h 19 min (≈1.3 h) from June 2023 to May 2025. By 17 h, final reports released increased to 24.9% with PM+ vs 8.3% PrePM and 7.3% PostPM; by 18 h, 49.6% vs 33.0% and 22.2%; pending reports beyond 24 h fell from 29.7% PrePM and 29.8% PostPM to 24.1% PM+.
- At Dynacare, after PM plus workflow changes (urine screening expanded from 16:00–24:00 to 08:00–24:00), mean final report TTRR improved by approximately 5 h 18 min (≈5.3 h) from May 2022 to May 2023. Reports released by 17 h increased from 10.8% to 27.4%; by 18 h from 21.6% to 50.8%; by 24 h from 58.7% to 76.8%; pending beyond 24 h decreased from 41.3% to 23.2%.
- Productivity changes included reallocation of one full-time equivalent (FTE) from the urine bench at Dynacare; at QEII, total laboratory automation and PostPM+ allowed reallocation of two FTE positions, one through reduced labor with automation and one from urine screening to another laboratory area.
- Daily average urine culture volumes increased from 167 in 2023 to approximately 180 in 2024–2025 at QEII (~7%) and from 1,593 in 2022 to 1,778 in 2023 at Dynacare (~11.6%).
Methods
- Dual-center before-after study at QEII, a tertiary care hospital in Halifax processing over 65,000 urine specimens annually, and Dynacare Laboratories in Brampton, Ontario, a high-volume community laboratory processing approximately 650,000 urine specimens annually. Study period was May 2022 to May 2025, with discrete timepoints: QEII June 2023 (PrePM), September 2024 (PostPM), May 2025 (PostPM+); Dynacare May 2022 (PrePM) and May 2023 (PostPM).
- Midstream urine specimens were plated and incubated using WASPLab automation and imaged at approximately 16 h. Organism identification used Vitek MS, and antimicrobial susceptibility testing used MALDI-TOF Vitek 2 MS per CLSI guidelines; E. coli with characteristic colonies was reported without MS confirmation at both sites.
- Main analysis was descriptive comparison of TTRR and proportions of final reports released by time thresholds before and after PM/PM+ implementation. TTRR definitions differed by site: Dynacare measured from specimen placement on WASPLab to final approval/release in the LIS; QEII measured from specimen receipt in the laboratory to result release in the LIS, including ID and/or AST when performed. No formal statistical testing is described.
Limitations
- The paper does not include an explicit limitations section.
- Evident: At Dynacare, PM+ was not implemented, and the TTRR improvement coincided with workflow changes (expanded screening hours and one FTE reallocation), so the independent effect of AI cannot be isolated from workflow changes.
- Evident: TTRR definitions differed between sites, and the design uses discrete before/after timepoints without a concurrent control; at QEII PM alone did not reduce TTRR (the abstract describes increased TTRR), underscoring dependence on result-release workflows.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
7 of 12 cited sources checked · 5 supported · 0 flagged · accuracy not yet measured
- Premisecitation
Prior studies have shown the accuracy of these algorithms across multiple specimen types and media.
“Prior studies have shown the accuracy of these algorithms across multiple specimen types and media (2–6).”
Quote in the paperNot a substantial claim3 of 5 sources checked- cites [2] Faron ML, Buchan BW, Coon C, Liebregts T, van Bree A, Jansz AR, Soucy G, Korver J, Ledeboer NA. 2016. Automatic digital analysis of chromogenic media for vancomycin-resistant-Enterococcus screens using copan WASPLab. J Clin Microbiol 54: 2464– 2469. doi: 10.1128/JCM.01040-16 27413193 PMC5035414 source
- cites [3] Faron ML, Buchan BW, Vismara C, Lacchini C, Bielli A, Gesu G, Liebregts T, van Bree A, Jansz A, Soucy G, Korver J, Ledeboer NA. 2016. Automated scoring of chromogenic media for detection of methicillin-resistant Staphylococcus aureus by use of WASPLab image analysis software. J Clin Microbiol 54: 620– 624. doi: 10.1128/JCM.02778-15 26719443 PMC4767952 source
- cites [4] Faron M.L, Buchan BW, Relich RF, Clark J, Ledeboer NA. 2020. Evaluation of the WASPLab segregation software to automatically analyze urine cultures using routine blood and macconkey agars. J Clin Microbiol 58: e01683-19. doi: 10.1128/JCM.01683-19 31941690 PMC7098764 source
- cites [5] Van TT, Mata K, Dien Bard J. 2019. Automated detection of Streptococcus pyogenes pharyngitis by use of colorex strep A CHROMagar and WASPLab artificial intelligence chromogenic detection module software. J Clin Microbiol 57: e00811-19. doi: 10.1128/JCM.00811-19 31434725 PMC6812993 source
- cites [6] Baker J, Timm K, Faron M, Ledeboer N, Culbreath K. 2020. Digital image analysis for the detection of group B Streptococcus from ChromID StreptoB media using a phenomatrix artificial intelligence software algorithm. J Clin Microbiol 59: e01902-19. doi: 10.1128/JCM.01902-19 33087433 PMC7771474 source
The Results report the imaging algorithm’s performance for GBS screening on ChromID GBS medium, and the Discussion describes earlier algorithm studies on other chromogenic media. The paper therefore supports accuracy findings across media, but its own evaluation uses vaginal-rectal swabs and does not establish accuracy across multiple specimen types. (LLM, conf=0.82)
Experimental — accuracy not yet measured
- Findingown data
At Dynacare, the overall mean final report TTRR improved by approximately 5 h and 18 min from May 2022 to May 2023.
“Overall, the mean final report TTRR improved by approximately 5 h and 18 min from May 2022 to May 2023.”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
At Dynacare, where PM+ was not implemented, a larger reduction in TTRR (~5.3 h) was observed following PM implementation.
“At the high-volume community laboratory (Dynacare), where PM+ was not implemented, a larger reduction in TTRR (~5.3 h) was observed following PM implementation.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Findingreasoning
At Halifax, one FTE savings was achieved through a reduction in labor requirements with the introduction of the TLA.
“One FTE savings (reallocation) was achieved through a reduction in labor requirements with the introduction of the TLA”
Quote in the paperNot a substantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Findingreasoning
At the community laboratory, a TTRR improvement of approximately 5.3 h was achieved.
“At the community laboratory, where PM+ was not implemented, a TTRR improvement of approximately 5.3 h was achieved by advancing manual screening workflows (08:00 vs 16:00), facilitating earlier review and release of PM-generated results.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Findingown data
At QEII, with PM+, the percentage of final urine culture reports released by 17 h was 24.9%, compared with 8.3% in PrePM and 7.3% in PostPM.
“Specifically, the percentage of final reports released by 17 h increased to 24.9%, compared with 8.3% in the PrePM phase and 7.3% in PostPM.”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
The same ultimate benefits were seen in both institutions.
“The same ultimate benefits were seen in both institutions demonstrating that this technology is widely applicable for most laboratories.”
Quote in the paperSubstantial claim - Findingreasoning
In Halifax, the implementation of TLA and PostPM+ allowed the reallocation of two FTE positions.
“In Halifax, the implementation of TLA and PostPM+ allowed the reallocation of two FTE positions.”
Quote in the paperNot a substantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Findingown data
Bacterial culture assessment (urine cultures) by AI decreases the time required to release results to clinicians.
“We demonstrated that bacterial culture assessment (urine cultures) by AI decreases the time required to release results to clinicians and reduces the hands-on time required by technologists to analyze and finalize laboratory analysis.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Findingown data
At QEII, the overall mean TTRR decreased by approximately 1 h and 19 min between June 2023 and May 2025.
“Overall, the mean TTRR decreased by approximately 1 h and 19 min between June 2023 and May 2025.”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
At Dynacare, following PM implementation, the proportion of final culture reports released by 17 h increased from 10.8% PrePM to 27.4% PostPM.
“The proportion of final culture reports released by 17 h increased from 10.8% (PrePM) to 27.4% (PostPM).”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
In both a low-volume tertiary care hospital and a high-volume community laboratory, PhenoMATRIX (PM) enabled earlier availability of interpretable results.
“In both a low-volume tertiary care hospital and a high-volume community laboratory, PM enabled earlier availability of interpretable results; however, reductions in time to result reporting (TTRR) were contingent on workflows for result release.”
Quote in the paperSubstantial claim - Findingown data
At Dynacare, the proportion of final culture reports pending beyond 24 h decreased by 18.1% (from 41.3% PrePM to 23.2% PostPM).
“The proportion of final culture reports pending beyond 24 h decreased by 18.1% (41.3% PrePM to 23.2% PostPM).”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
Integration of PM+ at the tertiary care site resulted in a TTRR reduction of approximately 1.3 h.
“Integration of PM+ enabled automated release of negative results as they became available, resulting in a TTRR reduction of approximately 1.3 h.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Findingown data
Bacterial culture assessment (urine cultures) by AI reduces the hands-on time required by technologists to analyze and finalize laboratory analysis.
“We demonstrated that bacterial culture assessment (urine cultures) by AI decreases the time required to release results to clinicians and reduces the hands-on time required by technologists to analyze and finalize laboratory analysis.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Findingown data
At QEII, the proportion of urine cultures pending final reports beyond 24 h decreased from 29.7% PrePM and 29.8% PostPM to 24.1% PM+.
“Consequently, the proportion of cultures pending final reports beyond 24 h decreased from 29.7% (PrePM) and 29.8% (PostPM) to 24.1% (PM+).”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
At Dynacare, by 24 h, 76.8% of final urine culture reports were released PostPM vs 58.7% PrePM.
“by 24 h, 76.8% of final urine culture reports were released vs 58.7% PrePM”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
At Dynacare, a small proportion of urine cultures (0.4%) in the PostPM data set were finalized before 16 h of incubation.
“A small proportion of urine cultures (0.4%) in the PostPM data set were finalized before 16 h of incubation.”
Quote in the paperNot a substantial claim - Findingown data
At Dynacare, by 18 h, 50.8% of reports were finalized PostPM compared with 21.6% PrePM.
“By 18 h, 50.8% of reports were finalized compared to 21.6% before implementation”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
- Findingown data
At the tertiary care site, implementation of PM alone was associated with increased TTRR.
“At the tertiary care site, implementation of PM alone was associated with increased TTRR, reflecting delays between result availability and reporting.”
Quote in the paperSubstantial claim - Findingown data
Across both laboratory settings, AI integration into automated microbiology workflows improved the timeliness of result availability.
“Across both laboratory settings, AI integration into automated microbiology workflows improved the timeliness of result availability, while reductions in TTRR were achieved when supported by workflow changes that enabled earlier reporting.”
Quote in the paperSubstantial claim - Findingreasoning
At Halifax, a second FTE was reallocated from urine screening to another area of the laboratory.
“a second FTE was reallocated from the urine screening to another area of the laboratory”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Findingown data
Reductions in TTRR were achieved when supported by workflow changes that enabled earlier reporting.
“Across both laboratory settings, AI integration into automated microbiology workflows improved the timeliness of result availability, while reductions in TTRR were achieved when supported by workflow changes that enabled earlier reporting.”
Quote in the paperSubstantial claim - Findingown data
At QEII, PostPM+ urine cultures were reported as negative, positive, and mixed growth in 58%, 25%, and 17% of cases, respectively.
“58%, 25%, and 17% for the PostPM+ phase”
Quote in the paperNot a substantial claim - Findingreasoning
At Dynacare, following PM implementation, PM-generated results were available earlier than previously manually interpreted cultures PrePM.
“Workflow changes occurred at Dynacare following PM implementation to facilitate review and release of PM-generated results, which were available earlier than the previously manually interpreted cultures PrePM.”
Quote in the paperSubstantial claim - Interpretationown data
At the community laboratory, the TTRR improvement was achieved by advancing manual screening workflows from 16:00 to 08:00.
“At the community laboratory, where PM+ was not implemented, a TTRR improvement of approximately 5.3 h was achieved by advancing manual screening workflows (08:00 vs 16:00), facilitating earlier review and release of PM-generated results.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Interpretationown data
AI-driven interpretation improves efficiency primarily when coupled with mechanisms that translate earlier result availability into earlier reporting.
“This finding highlights that AI-driven interpretation improves efficiency primarily when coupled with mechanisms that translate earlier result availability into earlier reporting.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Interpretationown data
Reductions in time to result reporting (TTRR) were contingent on workflows for result release.
“In both a low-volume tertiary care hospital and a high-volume community laboratory, PM enabled earlier availability of interpretable results; however, reductions in time to result reporting (TTRR) were contingent on workflows for result release.”
Quote in the paperSubstantial claim - Interpretationown data
This technology is widely applicable for most laboratories.
“The same ultimate benefits were seen in both institutions demonstrating that this technology is widely applicable for most laboratories.”
Quote in the paperSubstantial claim- Rests on an assumption: The two study laboratories are representative of most clinical microbiology laboratories.
- Interpretationown data
Advancing manual screening workflows facilitated earlier review and release of PM-generated results at the community laboratory.
“At the community laboratory, where PM+ was not implemented, a TTRR improvement of approximately 5.3 h was achieved by advancing manual screening workflows (08:00 vs 16:00), facilitating earlier review and release of PM-generated results.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Interpretationreasoning
When normalized to test volume, the reallocation of one FTE at Dynacare represents a reduction in technologist time per specimen, reflecting increased efficiency in culture screening and result interpretation.
“When normalized to test volume, this represents a reduction in technologist time per specimen, reflecting increased efficiency in culture screening and result interpretation.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
- Interpretationreasoning
The increased TTRR at the tertiary care site reflected delays between result availability and reporting.
“At the tertiary care site, implementation of PM alone was associated with increased TTRR, reflecting delays between result availability and reporting.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Interpretationown data
AI-driven culture assessment reduces TTRR when coupled with processes that enable timely result release, either through automated reporting or optimized laboratory review workflows.
“These findings indicate that AI-driven culture assessment reduces TTRR when coupled with processes that enable timely result release, either through automated reporting or optimized laboratory review workflows.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
- Interpretationown data
At Dynacare, the early finalizations reflect minor timing variation related to automated imaging schedules rather than systematic deviation from incubation protocols.
“These instances reflect minor timing variation related to automated imaging schedules rather than systematic deviation from incubation protocols.”
Quote in the paperNot a substantial claim - Interpretationreasoning
Successful implementation of AI in clinical microbiology depends not only on algorithm performance but also on thoughtful integration into laboratory operations to realize its full clinical and operational benefits.
“These findings highlight that successful implementation of AI in clinical microbiology depends not only on algorithm performance but also on thoughtful integration into laboratory operations to realize its full clinical and operational benefits.”
Quote in the paperSubstantial claim - Interpretationown data
The impact of AI on TTRR is not inherent to the technology itself but is contingent on the integration of AI outputs into laboratory workflows.
“The present study extends these findings by demonstrating that the impact of AI on TTRR is not inherent to the technology itself but is contingent on the integration of AI outputs into laboratory workflows.”
Quote in the paperSubstantial claim - Interpretationown data
The benefits of AI are maximized when paired with workflow strategies that enable timely release of results, either through automated reporting (PM+) or optimized manual review processes.
“However, as demonstrated in this study, the benefits of AI are maximized when paired with workflow strategies that enable timely release of results, either through automated reporting (PM+) or optimized manual review processes.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 5
- May combine two claims. 15
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationAutomated technologies improve efficiency compared to manual methods across laboratories of varying size and patient acuity.
“Automated technologies improve efficiency compared to manual methods across laboratories of varying size and patient acuity (1).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [1] Culbreath K, Piwonka H, Korver J, Noorbakhsh M. 2021. Benefits derived from full laboratory automation in microbiology: a tale of four laboratories. J Clin Microbiol 59: 01969– 20. doi: 10.1128/JCM.01969-20 PMC8106725 33239383 source
May combine two claims.
PremisecitationFull laboratory automation improves culture processing and mitigates staffing challenges.
“Full laboratory automation has already been shown to improve culture processing and mitigate staffing challenges (7–9).”
Quote in the paperNot a substantial claim1 of 3 sources checked- cites [7] Graham M, Tilson L, Streitberg R, Hamblin J, Korman TM. 2016. Improved standardization and potential for shortened time to results with BD kiestra total laboratory automation of early urine cultures: a prospective comparison with manual processing. Diagn Microbiol Infect Dis 86: 1– 4. doi: 10.1016/j.diagmicrobio.2016.06.020 27422083 source
- cites [8] Keyak C. 2019. Utilizing digital imaging to determine optimal incubation times for routine urine cultures. Med Lab Observ 51: 40– 44.
Not checked in the free run.
- cites [9] Mutters NT, Hodiamont CJ, de Jong MD, Overmeijer HPJ, van den Boogaard M, Visser CE. 2014. Performance of kiestra total laboratory automation combined with MS in clinical microbiology practice. Ann Lab Med 34: 111– 117. doi: 10.3343/alm.2014.34.2.111 24624346 PMC3948823 source
May combine two claims.
PremisecitationAlgorithm-assisted culture interpretation accelerates reporting and reduces the proportion of cultures requiring extended review.
“These observations are consistent with prior studies demonstrating that algorithm-assisted culture interpretation (by Culbreath et al.) accelerates reporting and reduces the proportion of cultures requiring extended review (1).”
Quote in the paperSubstantial claim1 of 2 sources checked- cites Culbreath et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [1] Culbreath K, Piwonka H, Korver J, Noorbakhsh M. 2021. Benefits derived from full laboratory automation in microbiology: a tale of four laboratories. J Clin Microbiol 59: 01969– 20. doi: 10.1128/JCM.01969-20 PMC8106725 33239383 source
The Results (TriCore Reference Laboratories) report faster reporting after algorithm-assisted automation: median turnaround time fell to 21 hours, and fewer cultures took over 48 hours to reach a final report. But the same section says the proportion requiring additional laboratory workup remained about 40% across stages (39% with algorithm-assisted automation). The paper supports faster reporting, not a reduced proportion requiring additional workup. (LLM, conf=0.88)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationSmart incubation shortens incubation times while maintaining accuracy and enabling faster identification and antimicrobial susceptibility testing results.
“Smart incubation has been shown to shorten incubation times while maintaining accuracy and enabling faster identification and antimicrobial susceptibility testing results (10).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [10] Cintrón M, Clark B, Miranda E, Babady NE. 2025. Utility of digital images captured after 4 h of incubation on a microbiology laboratory automation system in guiding the work-up of subcultures from positive blood cultures. J Clin Microbiol 63: e0132024. doi: 10.1128/jcm.01320-24 39704521 PMC11837544 source
May combine two claims.
Findingown dataImplementation of PM at Dynacare was associated with measurable productivity gains, including the reallocation of one full-time equivalent (FTE) technologist from the urine bench.
“In addition to improvements in TTRR, implementation of PM at Dynacare was associated with measurable productivity gains, including the reallocation of one full-time equivalent (FTE) technologist from the urine bench.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAt QEII, approximately 77% of urine cultures are negative or reported as normal urogenital flora.
“Approximately 77% of the QEII’s urine cultures are negative or reported as normal urogenital flora.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAt QEII, by 18 h, 49.6% of urine cultures had a final report available with PM+, compared with 33.0% PrePM and 22.2% PostPM.
“By 18 h, 49.6% of urine cultures had a final report available, compared with 33.0% (PrePM) and 22.2% (PostPM).”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
May combine two claims.
Findingown dataAt QEII, at 24 h, 75.9% of final urine culture results were released with PM+, compared with 70.3% PrePM and 70.2% PostPM.
“At 24 h, 75.9% of final urine culture results were released with PM+, compared with 70.3% (PrePM) and 70.2% (PostPM).”
Quote in the paperSubstantial claim- Rests on an assumption: The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
May combine two claims.
Findingown dataAt Dynacare, case review showed that early finalizations reflected either administrative outcomes or cultures imaged slightly earlier (~15.5 h) by WASPLab and finalized promptly when no ID or AST was required.
“Case review showed these reflected either administrative outcomes (e.g., duplicate specimen cancelations or specimens not processed due to laboratory incidents) or cultures imaged slightly earlier (~15.5 h) by WASPLab and finalized promptly when no ID or AST was required (e.g., no growth).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAt QEII, PrePM urine cultures were reported as negative, positive, and mixed growth in 56%, 23%, and 21% of cases, respectively.
“The PrePM urine cultures were reported as negative, positive, and mixed growth in 56%, 23%, and 21% of cases, respectively”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAt Dynacare in May 2023 PostPM, urine cultures were reported as negative, positive, and mixed growth in 51%, 29%, and 20% of cases, respectively.
“51%, 29%, and 20% in May 2023 (PostPM)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAt QEII, PostPM urine cultures were reported as negative, positive, and mixed growth in 54%, 24%, and 22% of cases, respectively.
“54%, 24%, and 22% for the PostPM phase”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAt Dynacare in May 2022 PrePM, urine cultures were reported as negative, positive, and mixed growth in 53%, 29%, and 18% of cases, respectively.
“In May 2022 (PrePM), urine cultures were reported as negative, positive, and mixed growth in 53%, 29%, and 18% of cases, respectively”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningAt QEII, implementation of PM alone did not reduce TTRR, reflecting delays between result availability and manual release.
“At the tertiary care site (QEII), implementation of PM alone did not reduce TTRR, reflecting delays between result availability and manual release.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
Interpretationown dataWhile PM facilitated earlier availability of interpretable culture results at both sites, reductions in TTRR were only realized when paired with processes that supported earlier review or automated reporting.
“While PM facilitated earlier availability of interpretable culture results at both sites, reductions in TTRR were only realized when paired with processes that supported earlier review or automated reporting.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
Interpretationown dataThese findings support the role of AI not only in accelerating reporting but also in optimizing labor utilization in high-throughput environments.
“These findings support the role of AI not only in accelerating reporting but also in optimizing labor utilization in high-throughput environments.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
Interpretationown dataThis dual-site study demonstrates that AI-assisted culture interpretation improves TTRR in automated microbiology laboratories, but the magnitude of improvement depends on workflows that enable timely result release.
“This dual-site study demonstrates that artificial intelligence-assisted culture interpretation improves TTRR in automated microbiology laboratories; however, the magnitude of improvement depends on workflows that enable timely result release.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
Interpretationown dataAt QEII, integration of PM+ enabled automated release of negative and non-significant cultures and resulted in a measurable reduction in TTRR (~1.3 h) and a shift toward earlier reporting timepoints.
“In contrast, integration of PM+, which enabled automated release of negative and non-significant cultures, resulted in a measurable reduction in TTRR (~1.3 h) and a shift toward earlier reporting timepoints.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
InterpretationreasoningThe TTRR improvement at Dynacare was not solely attributable to AI interpretation, but rather to concurrent workflow modifications that enabled earlier result review, including expansion of urine culture screening from evening-only to combined day and evening shifts.
“This improvement was not solely attributable to AI interpretation, but rather to concurrent workflow modifications that enabled earlier result review, including expansion of urine culture screening from evening-only to combined day and evening shifts.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
May combine two claims.
InterpretationreasoningThe workflow changes at Dynacare facilitated earlier action on PM-generated results and underscore the importance of aligning laboratory workflows with AI-enabled data availability.
“These changes facilitated earlier action on PM-generated results and underscore the importance of aligning laboratory workflows with AI-enabled data availability.”
Quote in the paperSubstantial claim- Rests on an assumption: The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
The paper relies on this without support.
This is the first dual-site evaluation of PM AI-driven algorithms and their impact on TTRR in North America.
“This represents the first dual-site evaluation of PM AI-driven algorithms and their impact on TTRR in North America.”
The paper relies on this without support.
Automation in clinical microbiology is essential to address persistent staffing shortages and increasing specimen volumes.
“Automation in clinical microbiology has become essential to address persistent staffing shortages and increasing specimen volumes.”
The paper relies on this without support.
The two study laboratories are representative of most clinical microbiology laboratories.
“This study was performed in two different laboratories that differed not only in geography but also in scope and scale. The same ultimate benefits were seen in both institutions demonstrating that this technology is widely applicable for most laboratories.”
The paper relies on this without support.
The observed changes in TTRR were attributable to PM/PM+ and workflow changes rather than other temporal or laboratory factors.
“These findings indicate that AI-driven culture assessment reduces TTRR when coupled with processes that enable timely result release, either through automated reporting or optimized laboratory review workflows.”
The paper relies on this without support.
The observed TTRR improvements can be attributed to the described AI and workflow interventions rather than to other temporal or site-specific factors.
“This dual-site study demonstrates that artificial intelligence-assisted culture interpretation improves TTRR in automated microbiology laboratories; however, the magnitude of improvement depends on workflows that enable timely result release.”
The paper relies on this without support.
The TTRR data were collected and measured consistently across PrePM, PostPM, and PM+ phases at each site.
“The TTRR for PrePM, PostPM, and PostPM+ phases are shown in Fig. 1.”
The paper relies on this without support.
The PM/PM+ culture interpretations are sufficiently accurate that final reports reflect valid culture results.
“Urine cultures with a final result of no growth or normal urogenital flora of less than 10 colonies were automatically released and reported via PM+.”
The paper relies on this without support.
There is an ongoing shortage of qualified medical laboratory technologists.
“The ongoing shortage of qualified medical laboratory technologists and increasing specimen volumes underscore the importance of technologies that optimize efficiency without compromising quality.”
The paper relies on this without support.
Specimen volumes are increasing.
“The ongoing shortage of qualified medical laboratory technologists and increasing specimen volumes underscore the importance of technologies that optimize efficiency without compromising quality.”
The paper relies on this without support.
The addition of AI software such as PhenoMATRIX enables continuous assessment of culture plates and prioritization of review.
“The addition of AI software such as PhenoMATRIX enables continuous assessment of culture plates and prioritization of review.”
The paper relies on this without support.
This study is the first dual-site evaluation in North America assessing the impact of PM AI-driven algorithms on urine culture TTRR.
“This study represents, to our knowledge, the first dual-site evaluation in North America assessing the impact of PM AI-driven algorithms on urine culture TTRR.”
Cites
Mutters, N. T., Hodiamont, C. J., Jong, M. D. D., Overmeijer, H. P. J., Boogaard, M. V. D., & E.Visser, C. (2014) · Annals of Laboratory Medicine · doi:10.3343/alm.2014.34.2.111 · Cited by 82 · see citing works
Faron, M. L., Buchan, B. W., Vismara, C., Lacchini, C., Bielli, A., Gesu, G., Liebregts, T., van Bree, A., Jansz, A., Soucy, G., et al. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.02778-15 · Cited by 69 · see citing works
Faron, M. L., Buchan, B. W., Coon, C., Liebregts, T., van Bree, A., Jansz, A. R., Soucy, G., Korver, J., & Ledeboer, N. A. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.01040-16 · Cited by 63 · see citing works
Van, T. T., Mata, K., & Dien Bard, J. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00811-19 · Cited by 60 · see citing works
Benefits Derived from Full Laboratory Automation in Microbiology: a Tale of Four Laboratories
Culbreath, K., Piwonka, H., Korver, J., & Noorbakhsh, M. (2021) · Journal of Clinical Microbiology · doi:10.1128/jcm.01969-20 · Cited by 44 · see citing works
Faron, M. L., Buchan, B. W., Relich, R. F., Clark, J., & Ledeboer, N. A. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01683-19 · Cited by 41 · see citing works
Graham, M., Tilson, L., Streitberg, R., Hamblin, J., & Korman, T. M. (2016) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2016.06.020 · Cited by 40 · see citing works
Baker, J., Timm, K., Faron, M., Ledeboer, N., & Culbreath, K. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01902-19 · Cited by 29 · see citing works
Cintrón, M., Clark, B., Miranda, E., & Babady, N. E. (2025) · Journal of Clinical Microbiology · doi:10.1128/jcm.01320-24 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Keyak C. 2019. Utilizing digital imaging to determine optimal incubation times for routine urine cultures. Med Lab Observ 51:40–44.
Cited by
Still being checked.
- Authors
- Davidson, R., Heinstein, C., Patriquin, G., Goneau, L. W., Brown, L. A., & Hill, B. J.
- Affiliations
- Dalhousie University (CA)
- Queen Elizabeth II Health Sciences Centre (CA)
- University of Toronto (CA)
- Dynacare Laboratory
- Copan Diagnostics, Inc.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2026-08-12
- Volume
- 64
- Issue
- 8
- Pages
- e0035426-e0035426
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC13463692
- OpenAlex
- W7167927033
- Semantic Scholar
- 30a01217cd4731045fd3d1f0c576191af80aa5e3
- Cited by
- 2
- References
- 9
- Citations by year
- 2026: 2
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Clinical Microbiology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Keywords
- artificial intelligence, urine culture, turnaround time, interpretation of results, laboratory automation, clinical microbiology laboratory, laboratory workflow optimization
- MeSH terms
- Artificial Intelligence, Canada, Humans, Microbiological Techniques, Time Factors, Workflow, Automation, Laboratory, Tertiary Care Centers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-23.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-23.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
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