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Cited by 17HIV Research and TreatmentCellular transport and secretionVirus-based gene therapy research

Identification of Host Trafficking Genes Required for HIV-1 Virological Synapse Formation in Dendritic Cells

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Bayliss, Rebecca, Wheeldon, James, Caucheteux, Stephan M., Niessen, Carien M., Piguet, Vincent·2020·Journal of Virology
DOI 10.1128/jvi.01597-19PMC PMC7163131
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Abstract

The lentivirus human immunodeficiency virus (HIV) targets and destroys CD4 + T cells, leaving the host vulnerable to life-threatening opportunistic infections associated with AIDS. Dendritic cells (DCs) form a virological synapse (VS) with CD4 + T cells, enabling the efficient transfer of virus between the two cells. We have identified cellular factors that are critical in the induction of the VS. We show that ADP-ribosylation factor 1 (ARF1), bridging integrator 1 (BIN1), and Rab GTPases RAB7L1 and RAB8A are important regulators of HIV-1 trafficking to the VS and therefore the infection of CD4 + T cells. We found these cellular factors were essential for endosomal protein trafficking and formation of the VS and that depletion of target proteins prevented virus trafficking to the plasma membrane by retaining virus in intracellular vesicles. Identification of key regulators in HIV-1 trans -infection between DC and CD4 + T cells has the potential for the development of targeted therapy to reduce trans -infection of HIV-1 in vivo .

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  • Depletion of cellular proteins involved in endosomal trafficking prevents translocation of HIV-1 viral particles from intracellular compartments to the plasma membrane and significantly reduces trans-infection.

    “In a recent work by Bayliss et al., the depletion of some cellular proteins involved in endosomal trafficking prevented the translocation of HIV-1 viral particles from intracellular compartments to the plasma membrane, and significantly reduced trans-infection [95].”

    From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [95]

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Authors
Bayliss, R., Wheeldon, J., Caucheteux, S. M., Niessen, C. M., & Piguet, V.
Affiliations
  • Cardiff University (GB)
  • University of Toronto (CA)
  • University of Cologne (DE)
Corresponding author
Piguet, Vincent
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2020-04-16
Volume
94
Issue
9
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.01597-19
PMC
PMC7163131
OpenAlex
W3008999977
Cited by
17
References
8
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Virology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
Funders
  • Wellcome Trust (AC11900001)
  • Cardiff University (AL11900010)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
HIV-1, virological synapse, dendritic cells, CD4+ T cells, trans-infection, Arf1, BIN1, Rab8a, Rab GTPases, ADP-ribosylation factor, intracellular vesicles, plasma membrane
MeSH terms
Dendritic Cells, Humans, Monocytes, Nuclear Proteins, Virion, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, rab GTP-Binding Proteins, ADP-Ribosylation Factor 1, Protein Transport, Tumor Suppressor Proteins, Adaptor Proteins, Signal Transducing, gag Gene Products, Human Immunodeficiency Virus, Immunological Synapses, High-Throughput Screening Assays, Primary Cell Culture

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