The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus
Open accessAbstract
A series of recombinant molecules were constructed which direct the expression of the easily assayed gene chloramphenicol acetyltransferase. We have used these recombinants to show that the 73/72-base-pair tandem repeat unit from the Moloney murine sarcoma virus long terminal repeat shares a number of properties with the prototypic enhancer element, the simian virus 40 72-base-pair repeat. Specifically, the Moloney murine sarcoma virus sequence significantly enhances the level of gene expression at both 5' and 3' locations and in either orientation relative to the test gene. It is able to enhance gene activity both from its own promoter and from a heterologous (simian virus 40) promoter. The 73/72-base-pair subunits of the Moloney murine sarcoma virus enhancer differ in sequence by four nucleotides and also in the strength of their enhancer function. The promoter distal A repeat is at least three times as active as the promoter proximal B repeat in enhancing chloramphenicol acetyltransferase expression. Results of these studies also show that the enhancer sequence alone is unable to induce gene activity but requires other promoter elements, including a proximal GC-rich sequence and the Goldberg-Hogness box.
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Cited by
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
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Self-citationThe pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
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Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
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The human glucocerebrosidase gene and pseudogene: Structure and evolution
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Metadata
- Authors
- Laimins, L. A., Gruss, P., Pozzatti, R., & Khoury, G.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1984-01
- Volume
- 49
- Issue
- 1
- Pages
- 183-189
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1947635334
- Cited by
- 324
- References
- 37
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Laimins, L. A., Gruss, P., Pozzatti, R., & Khoury, G. (1984). Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. Journal of Virology. https://doi.org/10.1128/jvi.49.1.183-189.1984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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