Cited by 128Virus-based gene therapy researchParvovirus B19 Infection StudiesVirology and Viral Diseases

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Human Adeno-Associated Virus Type 5 Is Only Distantly Related to Other Known Primate Helper-Dependent Parvoviruses

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Bantel-Schaal, Ursula, Delius, Hajo, Schmidt, Rainer, zur Hausen, Harald·1999·Journal of Virology

DOI 10.1128/jvi.73.2.939-947.1999PMC PMC103913

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Abstract

We have characterized 95% (4,404 nucleotides) of the genome of adeno-associated virus type 5 (AAV5), including part of the terminal repeats and the terminal resolution site. Our results show that AAV5 is different from all other described AAV serotypes at the nucleotide level and at the amino acid level. The sequence homology to AAV2, AAV3B, AAV4, and AAV6 at the nucleotide level is only between 54 and 56%. The positive strand contains two large open reading frames (ORFs). The left ORF encodes the nonstructural (Rep) proteins, and the right ORF encodes the structural (Cap) proteins. At the amino acid level the identities with the capsid proteins of other AAVs range between 51 and 59%, with a high degree of heterogeneity in regions which are considered to be on the exterior surface of the viral capsid. The overall identity for the nonstructural Rep proteins at the amino acid level is 54.4%. It is lowest at the C-terminal 128 amino acids (10%). There are only two instead of the common three putative Zn fingers in the Rep proteins. The Cap protein data suggest differences in capsid surfaces and raise the possibility of a host range distinct from those of other parvoviruses. This may have important implications for AAV vectors used in gene therapy.

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Authors: Bantel-Schaal, U., Delius, H., Schmidt, R., & zur Hausen, H.
Affiliations: Deutsches Krebsforschungszentrum Heidelberg, Forschungsschwerpunkt Angewandte Tumorvirologie F0400, D-69120 Heidelberg, Germany
German Cancer Research Center (DE)
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1999-02
Volume: 73
Issue: 2
Pages: 939-947
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.73.2.939-947.1999
PMC: PMC103913
OpenAlex: W2119056879
Cited by: 128
References: 61
Citations by year: 2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 6 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 5.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: AAV serotypes, sequence homology, capsid protein, Rep protein, zinc finger, terminal repeats, host range, gene therapy vectors, parvovirus
MeSH terms: Dependovirus, Amino Acid Sequence, Animals, Base Sequence, Capsid, DNA-Binding Proteins, DNA, Viral, HeLa Cells, Helper Viruses, Humans, Molecular Sequence Data, Primates, Viral Proteins, Genome, Viral, Sequence Homology, Amino Acid, Parvovirus

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Human Adeno-Associated Virus Type 5 Is Only Distantly Related to Other Known Primate Helper-Dependent Parvoviruses

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