Nucleotide sequence and organization of the adeno-associated virus 2 genome
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The complete nucleotide sequence of the adeno-associated virus 2 genome was determined. The single-stranded genome is 4,675 nucleotides in length and contains inverted terminal repeats of 145 nucleotides, the first 125 nucleotides of which form a palindromic sequence. Within the inverted terminal repetitions, there are two distinct sequences representing an inversion of 43 nucleotides that can exist on either terminus. The 5' and 3' termini of three major mRNA transcripts, which are present in both spliced and unspliced forms, were also mapped on the viral genome. Potential initiation and termination codons for efficient protein synthesis were identified, and genome segments were assigned that code for three major viral capsid proteins and, possibly, some as-yet-unidentified, nonstructural viral proteins.
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The maximum packaging capacity of members of the Parvoviridae family is approximately 4.5-5.5 kb.
“This suggests that the maximum packaging capacity of members of the Parvoviridae family is approximately 4.5-5.5 kb.”
From Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids (2016) · cites this paper as [19]
The available passage reports that the adeno-associated virus 2 genome is 4,675 nucleotides long, within the claimed 4.5–5.5 kb range. It does not establish a maximum packaging capacity for AAV2 or for the Parvoviridae family; searches for packaging capacity and encapsidation found no such passage. (LLM, conf=0.84)
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Self-citation
- Authors
- Srivastava, A., Lusby, E. W., & Berns, K. I.
- ORCID
- Srivastava, A
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1983-02
- Volume
- 45
- Issue
- 2
- Pages
- 555-564
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC256449
- OpenAlex
- W1648736195
- Cited by
- 721
- References
- 0
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- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- adeno-associated virus type 2, viral genome structure, nucleotide sequence, inverted terminal repeats, palindromic sequences, mRNA transcripts, capsid protein, non-structural proteins, single-stranded DNA viruses
- MeSH terms
- Dependovirus, Amino Acid Sequence, Base Sequence, Capsid, Codon, DNA, Viral, Genes, Viral, Repetitive Sequences, Nucleic Acid, Transcription, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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