The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14 + Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy
Open accessAbstract
In vitro studies show that human immunodeficiency virus type 1 (HIV-1) does not replicate in freshly isolated monocytes unless monocytes differentiate to monocyte-derived macrophages. Similarly, HIV-1 may replicate in macrophages in vivo, whereas it is unclear whether blood monocytes are permissive to productive infection with HIV-1. We investigated HIV-1 replication in CD14 + monocytes and resting and activated CD4 + T cells by measuring the levels of cell-associated viral DNA and mRNA and the genetic evolution of HIV-1 in seven acutely infected patients whose plasma viremia had been <100 copies/ml for 803 to 1,544 days during highly active antiretroviral therapy (HAART). HIV-1 DNA was detected in CD14 + monocytes as well as in activated and resting CD4 + T cells throughout the course of study. While significant variation in the decay slopes of HIV-1 DNA was seen among individual patients, viral decay in CD14 + monocytes was on average slower than that in activated and resting CD4 + T cells. Measurements of HIV-1 sequence evolution and the concentrations of unspliced and multiply spliced mRNA provided evidence of ongoing HIV-1 replication, more pronounced in CD14 + monocytes than in resting CD4 + T cells. Phylogenetic analyses of HIV-1 sequences indicated that after prolonged HAART, viral populations related or identical to those found only in CD14 + monocytes were seen in plasma from three of the seven patients. In the other four patients, HIV-1 sequences in plasma and the three cell populations were identical. CD14 + monocytes appear to be one of the potential in vivo sources of HIV-1 in patients receiving HAART.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Self-citationCytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes
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Cited by
Ancuta, P., Kamat, A., Kunstman, K. J., Kim, E.-Y., Autissier, P., Wurcel, A., Zaman, T., Stone, D., Mefford, M., Morgello, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002516 · Cited by 499
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
Eisele, E., & Siliciano, R. F. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.010 · Cited by 474
Josefsson, L., von Stockenstrom, S., Faria, N. R., Sinclair, E., Bacchetti, P., Killian, M., Epling, L., Tan, A., Ho, T., Lemey, P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308313110 · Cited by 277
Donaghy, H., Gazzard, B., Gotch, F., & Patterson, S. (2003) · Blood · doi:10.1182/blood-2002-10-3189 · Cited by 274
Williams, D. W., Eugenin, E. A., Calderon, T. M., & Berman, J. W. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811394 · Cited by 212
Metadata
- Authors
- Zhu, T., Muthui, D., Holte, S., Nickle, D., Feng, F., Brodie, S., Hwangbo, Y., Mullins, J. I., & Corey, L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-01-15
- Volume
- 76
- Issue
- 2
- Pages
- 707-716
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2042982138
- Cited by
- 300
- References
- 7
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14 + Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy. https://app.cochat.ai/papers/10.1128/jvi.76.2.707-716.2002
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- Zhu, T., Muthui, D., Holte, S., Nickle, D., Feng, F., Brodie, S., Hwangbo, Y., Mullins, J. I., & Corey, L. (2002). Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14 + Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy. Journal of Virology. https://doi.org/10.1128/jvi.76.2.707-716.2002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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