The central role of hypothalamic inflammation in the acute illness response and cachexia

Burfeind, Kevin G.; Michaelis, Katherine A.; Marks, Daniel L.

doi:10.1016/j.semcdb.2015.10.038

Cited by 156Regulation of Appetite and ObesityNutrition and Health in AgingMuscle Physiology and Disorders

The central role of hypothalamic inflammation in the acute illness response and cachexia

Open access

Burfeind, Kevin G., Michaelis, Katherine A., Marks, Daniel L.·2016·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2015.10.038PMC PMC4872506

Open this paper in CoChat — free account

Abstract

When challenged with a variety of inflammatory threats, multiple systems across the body undergo physiological responses to promote defense and survival. The constellation of fever, anorexia, and fatigue is known as the acute illness response, and represents an adaptive behavioral and physiological reaction to stimuli such as infection. On the other end of the spectrum, cachexia is a deadly and clinically challenging syndrome involving anorexia, fatigue, and muscle wasting. Both of these processes are governed by inflammatory mediators including cytokines, chemokines, and immune cells. Though the effects of cachexia can be partially explained by direct effects of disease processes on wasting tissues, a growing body of evidence shows the central nervous system (CNS) also plays an essential mechanistic role in cachexia. In the context of inflammatory stress, the hypothalamus integrates signals from peripheral systems, which it translates into neuroendocrine perturbations, altered neuronal signaling, and global metabolic derangements. Therefore, we will discuss how hypothalamic inflammation is an essential driver of both the acute illness response and cachexia, and why this organ is uniquely equipped to generate and maintain chronic inflammation. First, we will focus on the role of the hypothalamus in acute responses to dietary and infectious stimuli. Next, we will discuss the role of cytokines in driving homeostatic disequilibrium, resulting in muscle wasting, anorexia, and weight loss. Finally, we will address mechanisms and mediators of chronic hypothalamic inflammation, including endothelial cells, chemokines, and peripheral leukocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.semcdb.2015.10.038

Cites

162 of 162 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The HPA axis can be stimulated by peripheral inflammatory responses to infection or trauma resulting in sympathetic activation of a positive feedback loop whereby hypothalamic inflammatory signaling drives and is sustained by local production of IL-1β, IL-6, and TNFα.
“The primary stress response axis, the hypothalamic-pituitary-adrenal (HPA) axis, can be stimulated by peripheral inflammatory responses to infection or trauma resulting in the sympathetic activation of a positive feedback loop whereby hypothalamic inflammatory signaling drives and is sustained by local production of IL-1β, IL-6, and TNFα10.”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [10]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
The complexity of NF-κB signaling in inflammation and cancer
Hoesel, B., & Schmid, J. A. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-86 · Cited by 3,194 · see citing works
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822 · cited 1× · see citing works
“Direct stimulation by ACTH causes production and release of cortisol from the zona fasiculata of the adrenal cortex [36].”
Background
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1× · see citing works
“Furthermore, elevated circulating levels of TNFα and IL-6 in cardiac cachexia are the strongest predictor for pathological weight loss [75,76].”
Background
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works
Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works
Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers
Collins, T., Read, M. A., Neish, A. S., Whitley, M. Z., Thanos, D., & Maniatis, T. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.10.7542214 · Cited by 1,718 · see citing works
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Cancer cachexia: understanding the molecular basis
Argilés, J. M. A., Busquets, S., Stemmler, B., & López-Soriano, F. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3829 · Cited by 1,518 · see citing works
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282 · see citing works
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
Mitch, W. E., & Goldberg, A. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352507 · Cited by 1,163 · see citing works
The Molecular Basis of Skeletal Muscle Atrophy
Jackman, R. W., & Kandarian, S. C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00579.2003 · Cited by 1,008 · see citing works
Origin and differentiation of microglia
Ginhoux, F., Lim, S., Hoeffel, G., Low, D., & Huber, T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00045 · Cited by 905 · cited 1× · see citing works
“Most intriguing of all is the recent discovery that microglia have a distinct ontogeny from the peripheral immune system, which may explain why it differs in its responses to inflammatory events [72].”
Background
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
TNF‐α and adipocyte biology
Cawthorn, W. P., & Sethi, J. K. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.051 · Cited by 792 · see citing works
Neuronal ‘On’ and ‘Off’ signals control microglia
Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777 · see citing works
Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
Muñoz‐Cánoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013) · The FEBS Journal · doi:10.1111/febs.12338 · Cited by 774 · see citing works
Blood-brain barrier disruption in multiple sclerosis
Minagar, A., & Alexander, J. S. (2003) · Multiple Sclerosis · doi:10.1191/1352458503ms965oa · Cited by 685 · see citing works
Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation
D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kvetnansky, R., et al. (2007) · Nature Medicine · doi:10.1038/nm1611 · Cited by 656 · see citing works
The role of mast cells in allergic inflammation
Amin, K. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.09.007 · Cited by 644 · see citing works
β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat
Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638 · see citing works
Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.
Valdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629 · see citing works
Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?
Wardlaw, J. M., Sandercock, P. A. G., Dennis, M. S., & Starr, J. (2003) · Stroke · doi:10.1161/01.str.0000058480.77236.b3 · Cited by 628 · see citing works
Inflammation as a causative factor in the aetiology of Parkinson's disease
Whitton, P. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707167 · Cited by 625 · see citing works
Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus
Cowley, M. A., Pronchuk, N., Fan, W., Dinulescu, D. M., Colmers, W. F., & Cone, R. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80829-6 · Cited by 616 · see citing works
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Dl, M., & Low, M. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801913 · Cited by 591 · see citing works
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577 · see citing works
Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
Shimizu, N., Yoshikawa, N., Ito, N., Maruyama, T., Suzuki, Y., Takeda, S.-I., Nakae, J., Tagata, Y., Nishitani, S., Takehana, K., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.001 · Cited by 498 · see citing works
Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
Ransohoff, R. M., Hamilton, T. A., Tani, M., Stoler, M. H., Shick, H. E., Major, J. A., Estes, M. L., Thomas, D. M., & Tuohy, V. K. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.6.8472896 · Cited by 496 · see citing works
Penetration of interleukin-6 across the murine blood-brain barrier
Banks, W. A., Kastin, A. J., & Gutierrez, E. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90933-4 · Cited by 485 · see citing works
Leukemia inhibitory factor (LIF)
Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.001 · Cited by 478 · see citing works
Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.
Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474 · cited 1× · see citing works
“In addition, some cytokines, including IL-6 [80], TNFα [81], and IL-1β [82], can cross through various transporter systems.”
Background
Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation
Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903610410 · Cited by 471 · see citing works
Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
Cayrol, R., Wosik, K., Berard, J. L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., Haqqani, A. S., Kreymborg, K., Krug, S., Moumdjian, R., et al. (2008) · Nature Immunology · doi:10.1038/ni1551 · Cited by 444 · see citing works
NF-κB mediates the protein loss induced by TNF-α in differentiated skeletal muscle myotubes
Li, Y., & Reid, M. B. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1165 · Cited by 443 · see citing works
Immune–neural connections: how the immune system’s response to infectious agents influences behavior
McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works
Neuronal CXCL10 Directs CD8 <sup>+</sup> T-Cell Recruitment and Control of West Nile Virus Encephalitis
Klein, R. S., Lin, E., Zhang, B., Luster, A. D., Tollett, J., Samuel, M. A., Engle, M., & Diamond, M. S. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11457-11466.2005 · Cited by 424 · see citing works
Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure
Anker, S. D. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1446 · Cited by 374 · see citing works
Signaling pathways perturbing muscle mass.
Glass, D. J. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833862df · Cited by 359 · see citing works
The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism
Fortier, M., Kent, S., Ashdown, H. F., Poole, S., Boksa, P., & Luheshi, G. N. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00293.2004 · Cited by 354 · see citing works
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Millington, G. W. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-18 · Cited by 345 · see citing works
Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide
Quan, N., Whiteside, M., & Herkenham, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00350-3 · Cited by 335 · see citing works
Distribution of fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
Elmquist, J. K., Scammell, T. E., Jacobson, C. D., & Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960715)371:1 · Cited by 335 · see citing works
The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)
Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.007 · Cited by 318 · see citing works
The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid
Rodríguez, E. M., Blázquez, J. L., & Guerra, M. (2010) · Peptides · doi:10.1016/j.peptides.2010.01.003 · Cited by 308 · see citing works
Cytokine signals propagate through the brain
Vitković, L., Konsman, J. P., Bockaert, J., Dantzer, R., Homburger, V., & Jacque, C. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000813 · Cited by 306 · see citing works
Role of the central melanocortin system in cachexia.
Marks, D. L., LING, N. C., & Cone, R. D. (2001) · PubMed · Cited by 289 · see citing works
Self-citation
Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.
Metcalf, D., & Gearing, D. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5948 · Cited by 282 · see citing works
Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood–brain barrier
Nadeau, S., & Rivest, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00225-0 · Cited by 279 · see citing works
Cell adhesion molecules and ischemic stroke
Yılmaz, G., & Granger, D. N. (2008) · Neurological Research · doi:10.1179/174313208x341085 · Cited by 276 · see citing works
The regulation of muscle mass by endogenous glucocorticoids
Braun, T. P., & Marks, D. L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00012 · Cited by 273 · see citing works
Self-citation
Increased Sensitivity of Injured and Adjacent Uninjured Rat Primary Sensory Neurons to Exogenous Tumor Necrosis Factor-α after Spinal Nerve Ligation
Schäfers, M., Lee, D. H., Brors, D., Yaksh, T. L., & Sorkin, L. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-03028.2003 · Cited by 269 · see citing works
Blood-brain barrier alterations in ageing and dementia
Popescu, B. O., Toescu, E. C., Popescu, L. M., Bajenaru, O. A., Muresanu, D. F., Schultzberg, M., & Bogdanović, N. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.321 · Cited by 235 · see citing works
Interactions between Tumor Necrosis Factor-α, Hypothalamic Corticotropin-Releasing Hormone, and Adrenocorticotropin Secretion in the Rat*
BERNARDINI, R., KAMILARIS, T. C., CALOGERO, A. E., JOHNSON, E. O., GOMEZ, M. T., GOLD, P. W., & CHROUSOS, G. P. (1990) · Endocrinology · doi:10.1210/endo-126-6-2876 · Cited by 232 · see citing works
Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver
Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 228 · see citing works
Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
Ollmann, M. M., Lamoreux, M. L., Wilson, B. D., & Barsh, G. S. (1998) · Genes & Development · doi:10.1101/gad.12.3.316 · Cited by 226 · see citing works
Reversal of Cancer Anorexia by Blockade of Central Melanocortin Receptors in Rats
Wisse, B. E., Frayo, R. S., Schwartz, M. W., & Cummings, D. E. (2001) · Endocrinology · doi:10.1210/endo.142.8.8324 · Cited by 226 · see citing works
Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors
Fiebich, B. L., Biber, K. P. H., Lieb, K., van Calker, D., Berger, T., Bauer, J., & Gebicke‐Haerter, P. J. (1996) · Glia · doi:10.1002/(sici)1098-1136(199610)18:2 · Cited by 225 · see citing works
Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis
Braun, T. P., Zhu, X., Szumowski, M., Scott, G. D., Grossberg, A. J., Levasseur, P. R., Graham, K., Khan, S., Damaraju, S., Colmers, W. F., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111020 · Cited by 213 · see citing works
Self-citation
Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior
Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3723-13.2014 · Cited by 209 · see citing works
Product ion of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes
Fábry, Z., Fitzsimmons, K. M., Herlein, J. A., Moninger, T. O., Dobbs, M. B., & HART, M. N. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90281-3 · Cited by 207 · see citing works
Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice
Hu, Z., Wang, H., Lee, I. H., Du, J., & Mitch, W. E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38770 · Cited by 205 · see citing works
Cancer anorexia-cachexia syndrome: cytokines and neuropeptides
Ramos, E. J., Suzuki, S., Marks, D. L., Inui, A., Asakawa, A., & Meguid, M. M. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134363.53782.cb · Cited by 196 · see citing works
Self-citation
Muscle wasting in cancer.
Johns, N., Stephens, N., & Fearon, K. (2013) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2013.05.032 · Cited by 194 · see citing works
Cytokines and oxidative signalling in skeletal muscle
Reid, M. B., & Li, Y. ‐. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00824.x · Cited by 187 · see citing works
Anorexia induced by cytokine interactions at pathophysiological concentrations
Sonti, G., Ilyin, S. E., & Plata‐Saláman, C. R. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.6.r1394 · Cited by 181 · see citing works
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte–endothelial interactions
Rossi, B., Angiari, S., Zenaro, E., Budui, S. L., & Constantin, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710432 · Cited by 169 · see citing works
Hypothalamic mechanisms in cachexia
Grossberg, A. J., Scarlett, J. M., & Marks, D. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.011 · Cited by 160 · see citing works
Self-citation
Endothelial-Specific Knockdown of Interleukin-1 (IL-1) Type 1 Receptor Differentially Alters CNS Responses to IL-1 Depending on Its Route of Administration
Ching, S., Zhang, H., Belevych, N., He, L., Lai, W., Pu, X.-A., Jaeger, L. B., Chen, Q., & Quan, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3357-07.2007 · Cited by 156 · see citing works
Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus
Sergeyev, V., Broberger, C., & Hökfelt, T. G. M. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00088-2 · Cited by 153 · see citing works
Role of central melanocortins in endotoxin-induced anorexia
Huang, Q.-H., Hruby, V. J., & Tatro, J. B. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.3.r864 · Cited by 150 · see citing works
Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain
Ronaldson, P. T., DeMarco, K. M., Sanchez‐Covarrubias, L., Solinsky, C. M., & Davis, T. P. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.32 · Cited by 144 · see citing works
Endothelial activation and circulating markers of endothelial activation in kidney disease
Rabelink, T. J., de Boer, H. C., & van Zonneveld, A. J. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.65 · Cited by 143 · see citing works
Regulation of Central Melanocortin Signaling by Interleukin-1β
Scarlett, J. M., Jobst, E. E., Enriori, P. J., Bowe, D. D., Batra, A. K., Grant, W. F., Cowley, M. A., & Marks, D. L. (2007) · Endocrinology · doi:10.1210/en.2007-0017 · Cited by 143 · see citing works
Self-citation
Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment
Arijs, I., Hertogh, G. D., Machiels, K., Steen, K. V., Lemaire, K., Schraenen, A., Lommel, L. V., Quintens, R., Assche, G. V., Vermeire, S., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.27 · Cited by 141 · see citing works
CXCL10 Is the Key Ligand for CXCR3 on CD8+ Effector T Cells Involved in Immune Surveillance of the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System
Christensen, J. E., Rieper, C. D. L., Moos, T., Christensen, J. P., & Thomsen, A. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4235 · Cited by 140 · see citing works
Cancer cachexia syndrome developed in nude mice bearing melanoma cells producing leukemia-inhibitory factor.
Mori, M., Yamaguchi, K., Honda, S., Nagasaki, K., Ueda, M., Abe, O., & Abe, K. (1991) · PubMed · Cited by 138 · see citing works
TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient—Effects on leptin and insulin signaling pathways
Romanatto, T., Cesquini, M., do Amaral, M. E. C., Roman, É. A., Moraes, J. C., Torsoni, M. A., Cruz-Neto, A. P., & Velloso, L. A. (2007) · Peptides · doi:10.1016/j.peptides.2007.03.006 · Cited by 131 · see citing works
The blood-brain barrier and cerebral microcirculation in Alzheimer disease.
Kalaria, R. N. (1992) · PubMed · Cited by 130 · see citing works
Liver–brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders
D’Mello, C., & Swain, M. G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.009 · Cited by 129 · see citing works
Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance
Benzler, J., Ganjam, G. K., Pretz, D., Oelkrug, R., Koch, C. E., Legler, K., Stöhr, S., Culmsee, C., Williams, L. M., & Tups, A. (2015) · Diabetes · doi:10.2337/db14-0093 · Cited by 129 · see citing works
CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation
Wu, F., Zhao, Y., Jiao, T., Shi, D., Zhu, X., Zhang, M., Shi, M., & Zhou, H. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0316-6 · Cited by 124 · see citing works
Interleukin-1β induced vascular permeability is dependent on induction of endothelial Tissue Factor (TF) activity
Puhlmann, M., Weinreich, D. M., Farma, J. M., Carroll, N. M., Turner, E. M., & Alexander, H. R. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-37 · Cited by 122 · see citing works
Apoptosis in the Skeletal Muscle of Rats with Heart Failure is Associated with Increased Serum Levels of TNF-α and Sphingosine
Libera, L. D., Sabbadini, R. A., Renken, C. W., Ravara, B., Sandri, M., Betto, R., Angelini, A., & Vescovo, G. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1453 · Cited by 115 · see citing works
Atrophy of Skeletal Muscle in Patients With Cushing's Syndrome
Pleasure, D. E., Walsh, G. O., & Engel, W. K. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480200024002 · Cited by 114 · see citing works
Tanycytes: A Gateway to the Metabolic Hypothalamus
Langlet, F. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12191 · Cited by 113 · see citing works
IL‐1β, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF‐κB pathways
Kim, Y., Hwang, S., Oh, E., Oh, S., & Han, I. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21011 · Cited by 105 · see citing works
TNF‐α–secreting monocytes are recruited into the brain of cholestatic mice†‡
Kerfoot, S. M., D’Mello, C., Nguyen, H. H., Ajuebor, M. N., Kubes, P., Le, T. P., & Swain, M. G. (2005) · Hepatology · doi:10.1002/hep.21003 · Cited by 105 · see citing works
Cancer‐ and endotoxin‐induced cachexia require intact glucocorticoid signaling in skeletal muscle
Braun, T. P., Grossberg, A. J., Krasnow, S. M., Levasseur, P. R., Szumowski, M., Zhu, X., Maxson, J. E., Knoll, J. G., Barnes, A. P., & Marks, D. L. (2013) · The FASEB Journal · doi:10.1096/fj.13-230375 · Cited by 103 · see citing works
Self-citation
Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat.
Bodnar, R. J., Pasternak, G. W., Mann, P. E., Paúl, D., Warren, R. S., & Donner, D. B. (1989) · PubMed · Cited by 102 · see citing works
Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model
Ko, E. M., Ma, J. H., Guo, F., Miers, L. A., Lee, E., Bannerman, P. G. C., Burns, T., Ko, D., Sohn, J., Soulika, A. M., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-105 · Cited by 99 · see citing works
Chemokines and chemokine receptors: New actors in neuroendocrine regulations
Rostène, W. H., Guyon, A., Kular, L., Godefroy, D., Barbieri, F., Bajetto, A., Banisadr, G., Callewaere, C., Conductier, G., & Rovère, C. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.001 · Cited by 98 · see citing works
NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia
Jang, P., NamKoong, C., Kang, G. M., Hur, M., Kim, S., Kim, G. H., Kang, Y., Jeon, M.-J., Kim, E. H., Lee, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070706 · Cited by 96 · see citing works
Muscle Atrophy in Response to Cytotoxic Chemotherapy Is Dependent on Intact Glucocorticoid Signaling in Skeletal Muscle
Braun, T. P., Szumowski, M., Levasseur, P. R., Grossberg, A. J., Zhu, X., Agarwal, A., & Marks, D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106489 · Cited by 93 · see citing works
Self-citation
Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones
Frost, R. A., & Lang, C. H. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000165003.16578.2d · Cited by 93 · see citing works
Chemokines and brain functions
Banisadr, G., Rostene, W., Kitabgi, P., & Parsadaniantz, S. (2005) · Current Drug Target -Inflammation & Allergy · doi:10.2174/1568010054022097 · Cited by 93 · see citing works
Hypothalamic Actions of Tumor Necrosis Factor α Provide the Thermogenic Core for the Wastage Syndrome in Cachexia
Arruda, A. P., Milanski, M., Romanatto, T., Solon, C., Coope, A., Alberici, L. C., Festuccia, W. T., Hirabara, S. M., Ropelle, E. R., Curi, R., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0865 · Cited by 92 · see citing works
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C
Murray, C., Griffin, É. W., O'Loughlin, E. K., Lyons, A., Sherwin, E., Ahmed, S., Stevenson, N. J., Harkin, A., & Cunningham, C. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.009 · Cited by 87 · see citing works
Anorexic But Not Pyrogenic Actions of Interleukin‐1 are Modulated by Central Melanocortin‐3/4 Receptors in the Rat
Lawrence, C. B., & Rothwell, N. J. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00660.x · Cited by 87 · see citing works
Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals
Wisse, B. E., Ogimoto, K., Tang, J., Harris, M. K., Raines, E. W., & Schwartz, M. W. (2007) · Endocrinology · doi:10.1210/en.2007-0394 · Cited by 85 · see citing works
Regulation of Agouti-Related Protein Messenger Ribonucleic Acid Transcription and Peptide Secretion by Acute and Chronic Inflammation
Scarlett, J. M., Zhu, X., Enriori, P. J., Bowe, D. D., Batra, A. K., Levasseur, P. R., Grant, W. F., Meguid, M. M., Cowley, M. A., & Marks, D. L. (2008) · Endocrinology · doi:10.1210/en.2007-1680 · Cited by 85 · see citing works
Self-citation
Cell adhesion molecules contribute to Alzheimer’s disease: multiple pathway analyses of two genome‐wide association studies
Liu, G., Jiang, Y., Wang, P., Feng, R., Jiang, N., Chen, X., Song, H., & Chen, Z. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07547.x · Cited by 83 · see citing works
Expression and Role of CXCL10 during the Encephalitic Stage of Experimental and Clinical African Trypanosomiasis
Amin, D. N., Rottenberg, M. E., Thomsen, A. R., Ngoyi, D. M., Fenger, C., Kristensson, K., Büscher, P., Finsen, B. R., & Masocha, W. (2009) · The Journal of Infectious Diseases · doi:10.1086/644597 · Cited by 83 · see citing works
Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice
Cheng, L., Yu, Y., Szabo, A., Wu, Y., Wang, H., Camer, D., & Huang, X. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.12.011 · Cited by 80 · see citing works
Chemokines/intercrines and central regulation of feeding
Plata‐Saláman, C. R., & Borkoski, J. P. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.5.r1711 · Cited by 78 · see citing works
Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: characterization of brain cytokine and neuropeptide systems mRNAs
Gayle, D. A., Ilyin, S. E., Flynn, M. C., & Plata‐Saláman, C. R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00280-7 · Cited by 76 · see citing works
Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice
Utsuyama, M., & Hirokawa, K. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00208-x · Cited by 75 · see citing works
Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction
Peng, J., He, F. P., Zhang, C., Deng, X., & Yin, F. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-28 · Cited by 73 · see citing works
Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus
Quan, N., He, L., & Lai, W. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00951-6 · Cited by 70 · see citing works
Interleukin-6 Regulates the Expression of Hypothalamic Neuropeptides Involved in Body Weight in a Gender-Dependent Way
Señarís, R. M., Trujillo‐Güiza, M. L., Navia, B., Comes, G., Ferrer, B., Giralt, M., & Hidalgo, J. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02158.x · Cited by 70 · see citing works
Selectin Antagonists
Romano, S. J. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504020-00002 · Cited by 70 · see citing works
Arcuate Nucleus Proopiomelanocortin Neurons Mediate the Acute Anorectic Actions of Leukemia Inhibitory Factor via gp130
Grossberg, A. J., Scarlett, J. M., Zhu, X., Bowe, D. D., Batra, A. K., Braun, T. P., & Marks, D. L. (2009) · Endocrinology · doi:10.1210/en.2009-1135 · Cited by 66 · see citing works
Self-citation
Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?)
Seelaender, M. C. L., Júnior, M. L. B., Lira, F. S., Silvério, R., & Fanelli, F. R. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.01.011 · Cited by 65 · see citing works
TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus
Denis, R., Arruda, A. P., Romanatto, T., Milanski, M., Coope, A., Solon, C., Razolli, D. S., & Velloso, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.013 · Cited by 65 · see citing works
MyD88 Is a Key Mediator of Anorexia, But Not Weight Loss, Induced by Lipopolysaccharide and Interleukin-1β
Ogimoto, K., Harris, M. K., & Wisse, B. E. (2006) · Endocrinology · doi:10.1210/en.2006-0465 · Cited by 65 · see citing works
Dissecting the role of cocaine- and amphetamine-regulated transcript (CART) in the control of appetite
Murphy, K. G. (2005) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/4.2.95 · Cited by 65 · see citing works
Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods
Beretta, E., Dhillon, H., Kalra, P. S., & Kalra, S. P. (2002) · Peptides · doi:10.1016/s0196-9781(02)00021-9 · Cited by 58 · see citing works
Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins
Doherty, P. C., Hou, S., & Southern, P. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90228-q · Cited by 58 · see citing works
Soluble, platelet-bound, and total P-selectin as indices of platelet activation in congestive heart failure
Chung, I. K.-K., Choudhury, A., Patel, J. V., & Lip, G. Y. H. (2008) · Annals of Medicine · doi:10.1080/07853890802227089 · Cited by 54 · see citing works
Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain
Hisashi, Y., Masabumi, M., & Masamichi, S. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00097-5 · Cited by 50 · see citing works
AKT1 and SELP Polymorphisms Predict the Risk of Developing Cachexia in Pancreatic Cancer Patients
Avan, A., Avan, A., Large, T. Y. S. L., Mambrini, A., Funel, N., Maftouh, M., Ghayour‐Mobarhan, M., Cantore, M., Boggi, U., Peters, G. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108057 · Cited by 48 · see citing works
Regulatory T cells actively infiltrate metastatic brain tumors
Lesniak (2009) · International Journal of Oncology · doi:10.3892/ijo_00000282 · Cited by 48 · see citing works
MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus
Yamawaki, Y., Kimura, H., Hosoi, T., & Ozawa, K. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00395.2009 · Cited by 47 · see citing works
P‐selectin genotype is associated with the development of cancer cachexia
Tan, B. H. L., Fladvad, T., Braun, T. P., Vigano, A. A. L., Strasser, F., Deans, D. A. C., Skipworth, R. J. E., Solheim, T. S., Damaraju, S., Ross, J. A., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200231 · Cited by 47 · see citing works
Self-citation
Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia
von Meyenburg, C., Hrupka, B. H., Arsenijevic, D., Schwartz, G. J., Landmann, R., & Langhans, W. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00659.2003 · Cited by 47 · see citing works
The Role of Proinflammatory Cytokines in Wasting Disease During Lymphocytic Choriomeningitis Virus Infection1
Kamperschroer, C., & Quinn, D. (2002) · Journal of Immunology · doi:10.4049/jimmunol.169.1.340 · Cited by 46 · see citing works
Interleukin-1β induced activation of the hypothalamus–pituitary–adrenal axis is dependent on interleukin-1 receptors on non-hematopoietic cells
Matsuwaki, T., Eskilsson, A., Kugelberg, U. Ö., Jönsson, J., & Blomqvist, A. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.015 · Cited by 45 · see citing works
Fulminant Lymphocytic Choriomeningitis Virus-Induced Inflammation of the CNS Involves a Cytokine-Chemokine-Cytokine-Chemokine Cascade
Christensen, J. E., Simonsen, S., Fenger, C., Sørensen, M. R., Moos, T., Christensen, J. P., Finsen, B. R., & Thomsen, A. R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1079 · Cited by 44 · see citing works
High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes
Guyenet, S. J., Hồng, N. T., Hwang, B. H., Schwartz, M. W., Baskin, D. G., & Thaler, J. P. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.033 · Cited by 44 · see citing works
Central role of the melanocortin-4 receptors in appetite regulation after endotoxin1
Sartin, J. L., Marks, D. L., McMahon, C. D., Daniel, J. A., Levasseur, P. R., Wagner, C. G., Whitlock, B. K., & Steele, B. (2008) · Journal of Animal Science · doi:10.2527/jas.2008-0916 · Cited by 42 · see citing works
Self-citation
Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge
Borges, B. C., Rorato, R. C., Avraham, Y., da Silva, L. E. C. M., de Castro, M., Vorobiav, L., Berry, E. M., Antunes-Rodrigues, J., & Elias, L. L. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00558.2010 · Cited by 41 · see citing works
Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands
Pritchard, L. E., Armstrong, D., Davies, N., Oliver, R. L., Schmitz, C., Brennand, J. C., Wilkinson, G. H., & White, A. E. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1800183 · Cited by 40 · see citing works
Expression of P‐selectin and intercellular adhesion molecule‐1 in human brain after focal infarction or cardiac arrest
Love, S., & Barber, R. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2001.00356.x · Cited by 40 · see citing works
Circulating TGF-β1 Does Not Cross the Intact Blood-Brain Barrier
Kastin, A. J., Akerstrom, V. L., & Pan, W. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:21:1:43 · Cited by 39 · see citing works
Hypothalamic Inflammation Without Astrogliosis in Response to High Sucrose Intake Is Modulated by Neonatal Nutrition in Male Rats
Fuente-Martín, E., García‐Cáceres, C., Díaz, F., Argente-Arizón, P., Granado, M., Barrios, V., Argente, J., & Chowen, J. A. (2013) · Endocrinology · doi:10.1210/en.2012-2196 · Cited by 39 · see citing works
High-Fat Fish Oil Diet Prevents Hypothalamic Inflammatory Profile in Rats
Pimentel, G. D., Lira, F. S., Neto, J. C. R., do Nascimento, C. M. O., Oyama, L. M., Watanabe, R. L. H., & Ribeiro, E. B. (2013) · ISRN Inflammation · doi:10.1155/2013/419823 · Cited by 37 · see citing works
Gamma Interferon Signaling in Macrophage Lineage Cells Regulates Central Nervous System Inflammation and Chemokine Production
Lin, A. A., Tripathi, P., Sholl, A., Jordan, M. B., & Hildeman, D. A. (2009) · Journal of Virology · doi:10.1128/jvi.02477-08 · Cited by 36 · see citing works
TGFα and the Blood–Brain Barrier: Accumulation in Cerebral Vasculature
Pan, W., Vallance, K., & Kastin, A. J. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7215 · Cited by 36 · see citing works
Neutrophil-activating peptide-1 /interleukin-8 mRNA is localized in rat hypothalamus and hippocampus
Licinio, J., Wong, M., & Gold, P. W. (1992) · Neuroreport · doi:10.1097/00001756-199209000-00008 · Cited by 30 · see citing works
An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells
Stamm, A. W., Valentine, L. E., Potts, R. A., & Premenko‐Lanier, M. (2012) · Virology · doi:10.1016/j.virol.2012.01.005 · Cited by 30 · see citing works
Chronic central nervous system exposure to interleukin-1 beta causes catabolism in the rat
Hill, A. G., Jacobson, L., Gonzalez, J., Rounds, J., Majzoub, J. A., & Wilmore, D. W. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.5.r1142 · Cited by 29 · see citing works
Involvement of nitric oxide in lipopolysaccharide induced anorexia
Riediger, T., Cordani, C., Potes, C. S., & Lutz, T. A. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.04.015 · Cited by 29 · see citing works
Differential effects of tumor necrosis factor-alpha and -beta on rat ventromedial hypothalamic neurons in vitro
Katafuchi, T., Motomura, K., Baba, S., Ota, K., & Hori, T. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1966 · Cited by 28 · see citing works
Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
Thaler, J. P., Choi, S. J., Sajan, M. P., Ogimoto, K., Hồng, N. T., Matsen, M. E., Benoit, S. C., Wisse, B. E., Farese, R. V., & Schwartz, M. W. (2009) · Endocrinology · doi:10.1210/en.2009-0509 · Cited by 26 · see citing works
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice.
Takahashi, N., Brouckaert, P., & Fiers, W. (1991) · PubMed · Cited by 26 · see citing works
T cells activate the tumor necrosis factor-α system during hemodialysis, resulting in tachyphylaxis
van Riemsdijk, I. C., Baan, C. C., Loonen, E. H. M., Knoop, C. J., Betônico, G. N., Niesters, H. G. M., Zietse, R., & Weimar, W. W. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.059003883.x · Cited by 25 · see citing works
Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen
del Rey, A., Randolf, A., Wildmann, J., Besedovsky, H. O., & Jessop, D. S. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.009 · Cited by 24 · see citing works
Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice
Traynor, T. R., Majde, J. A., Bohnet, S. G., & Krueger, J. M. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.08.008 · Cited by 21 · see citing works
Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signaling
Borner, T., Pinkernell, S., Lutz, T. A., & Riediger, T. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.005 · Cited by 20 · see citing works
TNFα mimics the endocrine but not the thermoregulatory responses of bacterial lipopolysaccharide (LPS): Correlation with FOS-expression in the brain
Tolchard, S., Hare, A., Nutt, D., & Clarke, G. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00002-0 · Cited by 18 · see citing works
Effects of pyrogenic immunomodulators on the release of corticotrophin‐releasing factor‐41 and prostaglandin E2 from the intact rat hypothalamus in vitro
Milton, N. G. N., Self, C. H., & Hillhouse, E. W. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13535.x · Cited by 16 · see citing works
Effects of IFN-β, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls
Vanderlocht, J., Hendriks, J. J. A., Venken, K., Stinissen, P., & Hellings, N. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.04.012 · Cited by 14 · see citing works
Human Naturally Occurring and Adaptive Regulatory T cells Secrete High Levels of Leukaemia Inhibitory Factor upon Activation
Mahic, M., Kalland, M. E., Aandahl, E. M., Torgersen, K. M., & Taskén, K. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02148.x · Cited by 13 · see citing works
Endotoxemia-induced muscle wasting is associated with the change of hypothalamic neuropeptides in rats
Duan, K., Yu, W., Lin, Z., Tan, S., Bai, X., Gao, T., Xi, F., & Li, N. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.10.002 · Cited by 13 · see citing works
Inflammatory Mediators and the Blood-Brain Barrier
Dorovini‐Zis, K., & Easton, A. (2015) · CRC Press eBooks · doi:10.1201/b18606-10 · Cited by 1 · see citing works

Flagged first, then by citations

3 of the 165 references couldn’t be matched to a known paper.

Sorted by citations

Cancer-associated cachexia
Baracos, V. E., Martin, L., Korc, M., Guttridge, D. C., & Fearon, K. C. H. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.105 · Cited by 1,738 · see citing works
Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
da Silva, S. P., Santos, J., Silva, M. P. C. E., da Costa, R. M. G., & Medeiros, R. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12528 · Cited by 375 · see citing works
Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals
Geßner, D. K., Ringseis, R., & Eder, K. (2016) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12579 · Cited by 343 · see citing works
Inter-tissue communication in cancer cachexia
Argilés, J. M. A., Stemmler, B., López-Soriano, F. J., & Busquets, S. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0123-0 · Cited by 305 · see citing works
Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
Suriben, R., Chen, M. J., Higbee, J., Oeffinger, J., Ventura, R., Li, B., Mondal, K., Gao, Z., Ayupova, D. A., Taskar, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0945-x · Cited by 308 · see citing works
A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis
Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., & Chen, N. (2019) · Cells · doi:10.3390/cells8070738 · Cited by 237 · see citing works
The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
Michaelis, K. A., Norgard, M. A., Zhu, X., Levasseur, P. R., Sivagnanam, S., Liudahl, S. M., Burfeind, K. G., Olson, B. G., Pelz, K. R., Ramos, D. M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12657-w · Cited by 231 · see citing works
Self-citation
STAT3 in the Systemic Inflammation of Cancer Cachexia
Zimmers, T., Fishel, M., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 216 · see citing works
Cancer Cachexia: More Than Skeletal Muscle Wasting
Schmidt, S. F., Rohm, M., Herzig, S., & Díaz, M. B. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.10.001 · Cited by 219 · see citing works
Understanding cachexia in the context of metastatic progression
Biswas, A., & Acharyya, S. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0251-4 · Cited by 199 · see citing works
The interplay of immunology and cachexia in infection and cancer
Baazim, H., Antonio-Herrera, L., & Bergthaler, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00624-w · Cited by 188 · see citing works
COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: A post-hoc analysis of a prospective cohort study
di Filippo, L., LORENZO, R. D., D’Amico, M., Sofia, V. M., Roveri, L., Mele, R., Saibene, A., Rovere, P. Q., & Conte, C. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.043 · Cited by 190 · see citing works
Establishment and characterization of a novel murine model of pancreatic cancer cachexia
Michaelis, K. A., Zhu, X., Burfeind, K. G., Krasnow, S. M., Levasseur, P. R., Morgan, T. K., & Marks, D. L. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12225 · Cited by 148 · see citing works
Self-citation
The Gut–Liver Axis in the Control of Energy Metabolism and Food Intake in Animals
Ringseis, R., Geßner, D. K., & Eder, K. (2019) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-021419-083852 · Cited by 127 · see citing works
Let thy food be thy medicine….when possible
Witkamp, R. F., & van Norren, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.026 · Cited by 130 · see citing works
From Infection to Death: An Overview of the Pathogenesis of Visceral Leishmaniasis
Costa, C. H. N., Chang, K. P., Costa, D. L., & Cunha, F. V. M. (2023) · Pathogens · doi:10.3390/pathogens12070969 · Cited by 109 · see citing works
Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals
Scott, M. B., Styring, A., & McCullagh, J. (2022) · Pathogens · doi:10.3390/pathogens11070770 · Cited by 94 · see citing works
Mitochondrial dynamics in cancer-induced cachexia
van der Ende, M., Grefte, S., Plas, R., Meijerink, J., Witkamp, R. F., Keijer, J., & van Norren, K. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.008 · Cited by 87 · see citing works
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Jin, S., Kim, J. G., Park, J. W., Koch, M., Horváth, T. L., & Lee, B. J. (2016) · Scientific Reports · doi:10.1038/srep29424 · Cited by 86 · see citing works
Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer
Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Buenafe, A. C., Olson, B. G., Michaelis, K. A., Torres, E. R. S., Jeng, S., et al. (2020) · eLife · doi:10.7554/elife.54095 · Cited by 77 · see citing works
Self-citation
Neuroinflammation and depressive disorder: The role of the hypothalamus
Černáčková, A., Ďuračková, Z., Trebatická, J., & Mravec, B. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.03.005 · Cited by 68 · see citing works
Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease–associated cachexia
Zhu, X., Callahan, M. F., Gruber, K. A., Szumowski, M., & Marks, D. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138392 · Cited by 58 · see citing works
Self-citation
Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells
Krasnow, S. M., Knoll, J. G., Verghese, S. C., Levasseur, P. R., & Marks, D. L. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0908-4 · Cited by 60 · see citing works
Self-citation
The systemic hallmarks of cancer
Paul, D. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.63 · Cited by 59 · see citing works
Neural Mechanisms of Cancer Cachexia
Olson, B. G., Diba, P., Korzun, T., & Marks, D. L. (2021) · Cancers · doi:10.3390/cancers13163990 · Cited by 59 · see citing works
Self-citation
The role of hypothalamic inflammation, the hypothalamic–pituitary–adrenal axis and serotonin in the cancer anorexia–cachexia syndrome
van Norren, K., Dwarkasing, J. T., & Witkamp, R. F. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000401 · Cited by 59 · see citing works
Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance
Michaelis, K. A., Norgard, M. A., Levasseur, P. R., Olson, B. G., Burfeind, K. G., Buenafe, A. C., Zhu, X., Jeng, S., McWeeney, S. K., & Marks, D. L. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.004 · Cited by 58 · see citing works
Self-citation
Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia
Olson, B. G., Marks, D. L., & Grossberg, A. J. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12630 · Cited by 58 · see citing works
Self-citation
Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy
Sharma, S., Tiarks, G., Haight, J. A., & Bassuk, A. G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.612073 · Cited by 57 · see citing works
Imaging modalities for diagnosis and monitoring of cancer cachexia
Han, J., Harrison, L., Patzelt, L., Wu, M., Junker, D., Herzig, S., Díaz, M. B., & Karampinos, D. C. (2021) · EJNMMI Research · doi:10.1186/s13550-021-00834-2 · Cited by 55 · see citing works
Hypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight Dysregulation
Burfeind, K. G., Yadav, V., & Marks, D. L. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0700-3 · Cited by 51 · see citing works
Self-citation
Cachexia as Evidence of the Mechanisms of Resistance and Tolerance during the Evolution of Cancer Disease
Macciò, A., Sanna, E., Neri, M., Oppi, S., & Madeddu, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062890 · Cited by 49 · see citing works
Cachexia and advanced dementia
Minaglia, C., Giannotti, C., Boccardi, V., Mecocci, P., Serafini, G., Odetti, P. R., & Monacelli, F. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12380 · Cited by 49 · see citing works
TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia
Burfeind, K. G., Zhu, X., Levasseur, P. R., Michaelis, K. A., Norgard, M. A., & Marks, D. L. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.021 · Cited by 46 · see citing works
Self-citation
Cancer-Associated Cachexia: A Systemic Consequence of Cancer Progression
Biswas, A., & Acharyya, S. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033642 · Cited by 42 · see citing works
Inflammation as a mediator between adverse childhood experiences and adult depression: A meta-analytic structural equation model
Zagaria, A., Fiori, V., Vacca, M., Lombardo, C., Pariante, C. M., & Ballesio, A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.072 · Cited by 45 · see citing works
The clinical relevance and mechanism of skeletal muscle wasting
Duan, K., Gao, X., & Zhu, D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.07.029 · Cited by 42 · see citing works
Targeting cancer cachexia: Molecular mechanisms and clinical study
Wang, Y., An, Z.-Y., Lin, D., & Jin, W. (2022) · MedComm · doi:10.1002/mco2.164 · Cited by 42 · see citing works
Leucine Supplementation in Cancer Cachexia: Mechanisms and a Review of the Pre-Clinical Literature
Beaudry, A. G., & Law, M. L. (2022) · Nutrients · doi:10.3390/nu14142824 · Cited by 40 · see citing works
Virtual reality-empowered deep-learning analysis of brain cells
Kaltenecker, D., Al-Maskari, R., Negwer, M., Hoeher, L., Kofler, F., Zhao, S., Todorov, M., Rong, Z., Paetzold, J. C., Wiestler, B., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02245-2 · Cited by 38 · see citing works
Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus
Fu, Y., Kaneko, K., Lin, H.-Y., Mo, Q., Xu, Y., Suganami, T., Ravn, P., & Fukuda, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa102 · Cited by 38 · see citing works
Immunoregulation in cancer-associated cachexia
Wu, Q., Liu, Z., Li, B., Liu, Y., & Wang, P. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.04.018 · Cited by 39 · see citing works
From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics
Korzun, T., Moses, A. S., Diba, P., Sattler, A. L., Taratula, O. R., Sahay, G., Taratula, O., & Marks, D. L. (2023) · Pharmaceuticals · doi:10.3390/ph16081088 · Cited by 37 · see citing works
Self-citation
Animal models of cardiac cachexia
Molinari, F., Malara, N., Mollace, V., Rosano, G. M. C., & Ferraro, E. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.05.071 · Cited by 34 · see citing works
Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer
Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Michaelis, K. A., Olson, B. G., & Marks, D. L. (2020) · Glia · doi:10.1002/glia.23796 · Cited by 33 · see citing works
Self-citation
Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS
Barlampa, D., Bompoula, M. S., Bargiota, Α., Kalantaridou, S., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020520 · Cited by 37 · see citing works
Emerging Treatment Options For Cancer-Associated Cachexia: A Literature Review
Naito, T. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s196802 · Cited by 34 · see citing works
Hypothalamus-skeletal muscle crosstalk during exercise and its role in metabolism modulation
Ibeas, K., Herrero, L., Mera, P., & Serra, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114640 · Cited by 35 · see citing works
Respiratory Syncytial Virus (RSV) Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology
Sharma, A., Wu, W., Sung, B., Huang, J., Tsao, T., Li, X., Gomi, R., Tsuji, M., & Worgall, S. (2016) · Journal of Virology · doi:10.1128/jvi.00259-16 · Cited by 30 · see citing works
Molecular and Neural Mechanism of Dysphagia Due to Cancer
Okuni, I., Otsubo, Y., & Ebihara, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137033 · Cited by 30 · see citing works
Molecular Mechanisms of Cachexia: A Review
Neshan, M., Tsilimigras, D. I., Han, X., Hua Zhu, C., & Pawlik, T. M. (2024) · Cells · doi:10.3390/cells13030252 · Cited by 30 · see citing works
Cancer cachexia: molecular mechanism and pharmacological management
Li, Y., Jin, H., Chen, Y., Huang, T., Mi, Y., & Zou, Z. (2021) · Biochemical Journal · doi:10.1042/bcj20201009 · Cited by 28 · see citing works
Molecular and immunological origins of catatonia
Beach, S. R., Luccarelli, J., Praschan, N. C., Fusunyan, M. A., & Fricchione, G. L. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.03.013 · Cited by 28 · see citing works
How much does reduced food intake contribute to cancer-associated weight loss?
Martin, L., & Kubrak, C. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000379 · Cited by 28 · see citing works
Sickness and the Social Brain: How the Immune System Regulates Behavior across Species
Devlin, B. A., Smith, C. J. W., & Bilbo, S. D. (2021) · Brain Behavior and Evolution · doi:10.1159/000521476 · Cited by 26 · see citing works
Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2
Li, X., Holtrop, T., Jansen, F. A. C., Olson, B. G., Levasseur, P. R., Zhu, X., Poland, M., Schalwijk, W., Witkamp, R. F., Marks, D. L., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13093 · Cited by 25 · see citing works
Self-citation
Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model
Bernardo, B. L., Joaquim, S., Garren, J. M., Boucher, M., Houle, C. D., LaCarubba, B., Qiao, S., Wu, Z., Esquejo, R. M., Peloquin, M., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12618 · Cited by 25 · see citing works
Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies
Koh, K., Scott, R., Feliciano, E. M. C., Janowitz, T., Goncalves, M. D., White, E., Laird, B. J. A., Haase, K., & Jamal‐Hanjani, M. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0293 · Cited by 27 · see citing works
Clinical Approach to Commonly Encountered Problems
Hines, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44329-6.00007-3 · Cited by 24 · see citing works
Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia
Hegde, M., Daimary, U. D., Girisa, S., Kumar, A., & Kunnumakkara, A. B. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221087962 · Cited by 23 · see citing works
How progressive cancer endangers the heart: an intriguing and underestimated problem
Ausoni, S., Calamelli, S., Saccà, S., & Azzarello, G. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09869-8 · Cited by 25 · see citing works
Plasma MicroRNA Expression Profiles in Psoriasis
Xiao, S., Liu, X., Wang, X., Lv, H., Zhao, J., Guo, X., Xian, F., Ji, Y., & Zhang, G. (2020) · Journal of Immunology Research · doi:10.1155/2020/1561278 · Cited by 21 · see citing works
Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives
Kottorou, A. E., Dimitrakopoulos, F.-I. D., & Tsezou, A. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101101 · Cited by 21 · see citing works
Inter-organ cross-talk in human cancer cachexia revealed by spatial metabolomics
Sun, N., Krauss, T., Seeliger, C., Kunzke, T., Stöckl, B., Feuchtinger, A., Zhang, C., Voss, A., Heisz, S., Prokopchuk, O., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156034 · Cited by 20 · see citing works
Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia
Olson, B. G., Norgard, M. A., Levasseur, P. R., Zhu, X., & Marks, D. L. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12745 · Cited by 18 · see citing works
Self-citation
Assessing pathophysiology of cancer anorexia
Laviano, A., Koverech, A., & Seelaender, M. C. L. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000394 · Cited by 19 · see citing works
Effects of Grape By-Products on Oxidative Stress and Inflammation in Farm Animals: An Overview of Studies Performed in Pigs, Chickens, and Cattle
Eder, K., Ringseis, R., & Geßner, D. K. (2025) · Animals · doi:10.3390/ani15111536 · Cited by 17 · see citing works
Multidimensional Predictors of Cancer-Related Fatigue Based on the Predisposing, Precipitating, and Perpetuating (3P) Model: A Systematic Review
Wang, Y., Tian, L., Liu, X., Zhang, H., Tang, Y., Zhang, H., Nie, W., & Wang, L. (2023) · Cancers · doi:10.3390/cancers15245879 · Cited by 17 · see citing works
Hypothalamic Inflammation at a Crossroad of Somatic Diseases
Mravec, B., Horváthová, Ľ., & Černáčková, A. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0631-4 · Cited by 17 · see citing works
Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients
Simoes, E., Uchida, R. R., Nucci, M. P., Duran, F., Lima, J. D. C. C., Gama, L. R., da Costa, N. A., Otaduy, M. C. G., Bin, F. C., Otoch, J. P., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13742 · Cited by 16 · see citing works
Postoperative consequences of cancer cachexia after head and neck free flap reconstruction
Jones, A. J., Davis, K. P., Novinger, L. J., Bonetto, A., Mantravadi, A. V., Sim, M. W., Yesensky, J. A., & Moore, M. G. (2022) · Head & Neck · doi:10.1002/hed.27072 · Cited by 16 · see citing works
Associations of inflammation with symptom burden in patients with acute myeloid leukemia
Lacourt, T. E., Kavelaars, A., Galloway-Peña, J., Sahasrabhojane, P. V., Shah, N. D., Futreal, P. A., Kontoyiannis, D. P., Shelburne, S. A., & Heijnen, C. J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.018 · Cited by 16 · see citing works
Nicotinamide Riboside Neutralizes Hypothalamic Inflammation and Increases Weight Loss Without Altering Muscle Mass in Obese Rats Under Calorie Restriction: A Preliminary Investigation
de Castro, J. M., Stein, D. J., Medeiros, H. R., de Oliveira, C., & Torres, I. L. D. S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.648893 · Cited by 15 · see citing works
Cachectic muscle wasting in acute myeloid leukaemia: a sleeping giant with dire clinical consequences
Campelj, D. G., Timpani, C. A., & Rybalka, E. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12880 · Cited by 13 · see citing works
Meaningful measures in cancer cachexia: implications for practice and research
McDonald, J. J., Fallon, M., & Laird, B. J. A. (2019) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000472 · Cited by 15 · see citing works
Pathological features of tissues and cell populations during cancer cachexia
Girolamo, D. D., & Tajbakhsh, S. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00108-9 · Cited by 15 · see citing works
Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome
Morris, M. C., Cooney, K. E., Sedghamiz, H., Abreu, M., Collado, F., Balbin, E. G., Craddock, T. J. A., Klimas, N. G., Broderick, G., & Fletcher, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.002 · Cited by 14 · see citing works
Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities
Lv, X., & Ding, S. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1608612 · Cited by 16 · see citing works
Tumor-derived cyclooxygenase-2 fuels hypothalamic inflammation
Li, X., Zhu, X., Diba, P., Shi, X., Vrieling, F., Jansen, F. A. C., Balvers, M. G. J., de Bus, I., Levasseur, P. R., Sattler, A. L., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.11.002 · Cited by 13 · see citing works
Self-citation
Microbiome-Modifiers for Cancer-Related Fatigue Management: A Systematic Review
Belloni, S., Caruso, R., Giacon, C., Baroni, I., Conte, G., Magon, A., & Arrigoni, C. (2024) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2024.151619 · Cited by 13 · see citing works
Brainstem prolactin-releasing peptide contributes to cancer anorexia-cachexia syndrome in rats
Batista, K. N. I., Schraner, M., & Riediger, T. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108289 · Cited by 12 · see citing works
A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain
Uzu, M., Nonaka, M., Miyano, K., Sato, H., Kurebayashi, N., Yanagihara, K., Sakurai, T., Hisaka, A., & Uezono, Y. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.04.005 · Cited by 13 · see citing works
Effects of various mRNA-LNP vaccine doses on neuroinflammation in BALB/c mice
Kirshina, A., Kazakova, A., Kolosova, E., Имашева, Е. А., Vasileva, O., Zaborova, O. V., Terenin, I. M., Muslimov, A., & Reshetnikov, V. V. (2022) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2022.068 · Cited by 15 · see citing works
Neuroprotective and Anti-Inflammatory Activity of Undaria pinnatifida Fucoidan In Vivo—A Proteomic Investigation
Yang, C. N., Dwan, C. A., Wimmer, B. C., Ronci, M., Wilson, R., Johnson, L. R., & Caruso, V. (2025) · Marine Drugs · doi:10.3390/md23050189 · Cited by 12 · see citing works
Nutritional and Morphofunctional Assessment of Post-ICU Patients with COVID-19 at Hospital Discharge: NutriEcoMuscle Study
Joaquín, C., Lesmes, I. B., Bretón, M. J. O., Burgos, R., Bellido, D., Matía‐Martín, P., Olmos, M. Á. M., Zugasti, A., Fernández, M. R., Romero, F. B., et al. (2024) · Nutrients · doi:10.3390/nu16060886 · Cited by 11 · see citing works
The Interplay Among Pancreatic Cancer, Cachexia, Body Composition, and Diabetes
Dunne, R. F., & Roeland, E. J. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.07.001 · Cited by 11 · see citing works
Altered Neuroendocrine Immune Responses, a Two-Sword Weapon against Traumatic Inflammation
Yang, C., Gao, J., Du, J., Yang, X., & Jiang, J. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.21916 · Cited by 11 · see citing works
Ventilatory pattern variability as a biometric for severity of acute lung injury in rats
Young, B., Loparo, K. A., Dick, T. E., & Jacono, F. J. (2019) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2019.03.009 · Cited by 11 · see citing works
The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment
Paul, D., & Nedelcu, A. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1040034 · Cited by 10 · see citing works
Bariatric Surgery and COVID-19: What We Have Learned from the Pandemic in Iran: a Retrospective Observational Cohort Study
Moradpour, G., Amini, M., Moeinvaziri, N., Hosseini, S. V., Rajabi, S., Clark, C. C. T., Hosseini, B., Vafa, L., & Haghighat, N. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05761-8 · Cited by 10 · see citing works
Understanding the appetite modulation pathways: The role of the FFA1 and FFA4 receptors
Freitas, R. D. S., & Campos, M. M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114503 · Cited by 10 · see citing works
Brain inflammation and its predictive value for post-operative pain in total knee arthroplasty patients
Alshelh, Z., Brusaferri, L., Morrissey, E. J., Torrado-Carvajal, Á., Kim, M., Akeju, O., Grmek, G., Chane, C. A., Murphy, J. P., Schrepf, A., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.05.008 · Cited by 9 · see citing works
One-Week Exposure to a Free-Choice High-Fat High-Sugar Diet Does Not Interfere With the Lipopolysaccharide-Induced Acute Phase Response in the Hypothalamus of Male Rats
Belegri, E., Eggels, L., la Fleur, S. E., & Boelen, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00186 · Cited by 8 · see citing works
Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Bobermin, L. D., Sesterheim, P., da Costa, D. S., Rezena, E., Schmitz, I., da Silva, A., de Moraes, A. D. M., Souza, D. O., Wyse, Â. T. D. S., Leipnitz, G., et al. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04073-w · Cited by 8 · see citing works
Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis
do Nascimento, P. L., Brandt, C. T., & Petroianu, A. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.01.044 · Cited by 8 · see citing works
Multi-scale network targeting: A holistic systems-biology approach to cancer treatment
Paul, D., & Komarova, N. L. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.08.004 · Cited by 8 · see citing works
Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins
Hartke, A.-S., Schreiber, C. S., Lau, K., Wiesweg, I., Waltl, I., Kalinke, U., Richter, F., & Käufer, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106773 · Cited by 7 · see citing works
Estrogen Maintains Skeletal Muscle in Septic Rats Associated with Altering Hypothalamic Inflammation and Neuropeptides
Zhao, C., Li, J., Cheng, M., Shi, J., Shen, J., Gao, T., Xi, F., & Yu, W. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-100221 · Cited by 7 · see citing works
Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain
Černáčková, A., Mikova, L., Horváthová, Ľ., Tillinger, A., & Mravec, B. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577068 · Cited by 7 · see citing works
Enhanced lipid utilization is coupled to the sickness responses triggered by lipopolysaccharide
Park, B. S., Kim, Y. J., Jeong, D. Y., Kim, Y., Kim, J. K., Lee, B. J., & Kim, J. G. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.04.043 · Cited by 7 · see citing works

Hypothalamic inflammation and energy homeostasis: Resolving the paradox
Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144 · see citing works
Pathophysiology and treatment of inflammatory anorexia in chronic disease
Braun, T. P., & Marks, D. L. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0015-1 · Cited by 99 · see citing works
Self-citation
DOI 10.1007/s13539-010-0015-1 REVIEW Pathophysiology and treatment of inflammatory anorexia
Braun, T. P., & Marks, D. L. (2010)
Self-citation
Whatever Way Weight Goes, Inflammation Shows
Clarke, I. J. (2010) · Endocrinology · doi:10.1210/en.2009-1470 · Cited by 8 · see citing works
The role of the hypothalamus in the development of cancer cachexia
Stagikas, D., Simos, Y. V., Lakkas, L. S., Filis, P., Peschos, D., & Tsamis, K. I. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114909 · Cited by 9 · see citing works

Authors: Burfeind, K. G., Michaelis, K. A., & Marks, D. L.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Marks, Daniel L.
ORCID: Burfeind, Kevin G.
Michaelis, Katherine A.
Marks, Daniel L.
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2016-06
Volume: 54
Pages: 42-52
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2015.10.038
PMC: PMC4872506
OpenAlex: W2189988755
Cited by: 156
References: 165
Citations by year: 2026: 7 · 2025: 20 · 2024: 13 · 2023: 15 · 2022: 18 · 2021: 24 · 2020: 17 · 2019: 15 · 2018: 11 · 2017: 10 · 2016: 6
FWCI: 0.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA184324)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: hypothalamic inflammation, cachexia, fever, anorexia, fatigue, cytokines, chemokines, muscle atrophy, weight loss, chronic inflammation, neuroendocrine regulation, endothelial cells, peripheral blood leukocytes, infection, nutritional stress
MeSH terms: Animals, Cachexia, Humans, Hypothalamus, Inflammation, Models, Biological, Obesity, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The central role of hypothalamic inflammation in the acute illness response and cachexia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks