Evidence that Ergosterol Biosynthesis Modulates Activity of the Pdr1 Transcription Factor in Candida glabrata

Vu, Bao Gia; Thomas, Grace Heredge; Moye-Rowley, W. Scott

doi:10.1128/mbio.00934-19

Cited by 59Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Evidence that Ergosterol Biosynthesis Modulates Activity of the Pdr1 Transcription Factor in Candida glabrata

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Vu, Bao Gia, Thomas, Grace Heredge, Moye-Rowley, W. Scott·2019·mBio

DOI 10.1128/mbio.00934-19PMC PMC6561024

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Abstract

A likely contributor to the increased incidence of non- albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 . Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly. Here we provide evidence that Pdr1 is activated without azole drugs by the use of genetic means to inhibit expression of azole drug target-encoding gene ERG11 . These acute reductions in Erg11 levels lead to elevated Pdr1 activity even though no drug is present. A key transcriptional regulator of the ERG pathway, Upc2A, is shown to directly bind to the PDR1 and CDR1 promoters. We interpret these data as support for the view that Pdr1 function is responsive to ergosterol biosynthesis and suggest that this connection reveals the normal physiological circuitry in which Pdr1 participates.

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In Kluyveromyces lactis, KIUpc2, whose homolog activates Pdr1 in response to fluconazole in Candida glabrata, has been reported to be involved in the oxidative stress response.
“In Kluyveromyces lactis, KIUpc2, whose homolog activates Pdr1 in response to fluconazole in C. glabrata [46], has been reported to be involved in the oxidative stress response [47].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [46]
Upc2A in Candida glabrata directly binds to the promoter region of CDR1.
“Vu et al. demonstrated that the transcription factor Upc2A in Candida glabrata can directly bind to the promoter region of the CDR1 gene [18].”
From Disruption of the UPC2 Gene Enhances Fluconazole Antifungal Activity by Inhibiting HAC1 mRNA Splicing in Candida albicans (2026) · cites this paper as [18]
Upc2A also regulates CDR1 expression and extensive overlap exists between the regulatory networks mediated by Upc2A and Pdr1 in C. glabrata.
“Recently, it was demonstrated that the zinc cluster transcription factor Upc2A also regulates CDR1 expression and that extensive overlap exists between the regulatory networks mediated by Upc2A and Pdr1 in C. glabrata27,59.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [59]

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Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518 · see citing works
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
Longtine, M. S., Mckenzie, A., DeMarini, D. J., Shah, N. G., Wach, A., Brachat, A., Philippsen, P., & Pringle, J. R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199807)14:10 · Cited by 5,367 · see citing works
Copper toxicity, oxidative stress, and antioxidant nutrients
Gaetke, L. M. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00159-8 · Cited by 2,166 · see citing works
Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species
Whaley, S. G., Berkow, E. L., Rybak, J. M., Nishimoto, A. T., Barker, K. S., & Rogers, P. D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02173 · Cited by 900 · see citing works
Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707 · see citing works
Fluconazole resistance in Candida species: a current perspective
Berkow, E., & Lockhart, S. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s118892 · Cited by 542 · see citing works
How to bolster the antifungal pipeline
Denning, D., & Bromley, M. (2015) · Science · doi:10.1126/science.aaa6097 · Cited by 462 · see citing works
TAC1 , Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2
Coste, A. T., Karababa, M., Ischer, F., Bille, J., & Sanglard, D. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1639-1652.2004 · Cited by 407 · see citing works
Epidemiology and Outcomes of Invasive Candidiasis Due to Non-albicans Species of Candida in 2,496 Patients: Data from the Prospective Antifungal Therapy (PATH) Registry 2004–2008
Pfaller, M. A., Andes, D. R., Diekema, D. J., Horn, D. L., Reboli, A. C., Rotstein, C., Franks, B., & Azie, N. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101510 · Cited by 396 · see citing works
The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans
Morschhäuser, J., Barker, K. S., Liu, T. T., Blaß-Warmuth, J., Homayouni, R., & Rogers, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030164 · Cited by 355 · see citing works
A nuclear receptor-like pathway regulating multidrug resistance in fungi
Thakur, J. K., Arthanari, H., Yang, F., Pan, S.-J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., et al. (2008) · Nature · doi:10.1038/nature06836 · Cited by 343 · see citing works
The ATP Binding Cassette Transporter Gene CgCDR1 from Candida glabrata Is Involved in the Resistance of Clinical Isolates to Azole Antifungal Agents
Sanglard, D., Ischer, F., Calabrese, D., Majcherczyk, P. A., & Bille, J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.11.2753 · Cited by 337 · see citing works
Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances
Baron, U., & Bujard, H. (2000) · Methods in Enzymology · doi:10.1016/s0076-6879(00)27292-3 · Cited by 335 · see citing works
Azole Resistance in Candida glabrata : Coordinate Upregulation of Multidrug Transporters and Evidence for a Pdr1-Like Transcription Factor
Vermitsky, J.-P., & Edlind, T. D. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3773-3781.2004 · Cited by 285 · see citing works
Candida glabrata PDR1 , a Transcriptional Regulator of a Pleiotropic Drug Resistance Network, Mediates Azole Resistance in Clinical Isolates and Petite Mutants
Tsai, H.-F., Krol, A. A., Sarti, K. E., & Bennett, J. E. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1384-1392.2006 · Cited by 237 · see citing works
Pdr1 regulates multidrug resistance in Candida glabrata : gene disruption and genome‐wide expression studies
Vermitsky, J., Earhart, K. D., Smith, W. L., Homayouni, R., Edlind, T. D., & Rogers, P. D. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05235.x · Cited by 233 · see citing works
Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2
Yang, H., Tong, J., Lee, C. W., Ha, S., Eom, S. H., & Im, Y. J. (2015) · Nature Communications · doi:10.1038/ncomms7129 · Cited by 223 · see citing works
Upregulation of ERG Genes in Candida Species by Azoles and Other Sterol Biosynthesis Inhibitors
Henry, K. W., Nickels, J. T., & Edlind, T. D. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.10.2693-2700.2000 · Cited by 216 · see citing works
Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility
Geber, A., Hitchcock, C. A., Swartz, J. E., Pullen, F. S., Marsden, K. E., Kwon-Chung, K. J., & Bennett, J. E. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.12.2708 · Cited by 203 · see citing works
ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence
Chung, D., Barker, B. M., Carey, C. C., Merriman, B., Werner, E. R., Lechner, B. E., Dhingra, S., Cheng, C., Xu, W., Blosser, S. J., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004487 · Cited by 193 · see citing works
Yeast Analysis, Spectrophotometric Semimicrodetermination of Ergosterol in Yeast
Breivik, O. N., & Owades, J. L. (1957) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60075a005 · Cited by 193 · see citing works
A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
Hagiwara, D., Miura, D., Shimizu, K., Paul, S., Ohba, A., Gonoi, T., Watanabe, A., Kamei, K., Shintani, T., Moye-Rowley, W. S., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006096 · Cited by 156 · see citing works
Self-citation
Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance
Katiyar, S. K., Alastruey-Izquierdo, A., Healey, K. R., Johnson, M. E., Perlin, D. S., & Edlind, T. D. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00813-12 · Cited by 148 · see citing works
Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
Becker, J. M., Kauffman, S., Hauser, M., Huang, L.-Y., Lin, M. T.-Y., Sillaots, S., Jiang, B., Xu, D., & Roemer, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009845107 · Cited by 135 · see citing works
Responding to the Emergence of Antifungal Drug Resistance: Perspectives from the Bench and the Bedside
Beardsley, J., Halliday, C. L., Chen, S. C. ‐., & Sorrell, T. C. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0059 · Cited by 126 · see citing works
Genomewide Location Analysis of Candida albicans Upc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance
Znaidi, S., Weber, S., Zin Al-Abdin, O., Bomme, P., Saidane, S., Drouin, S., Lemieux, S., De Deken, X., Robert, F., & Raymond, M. (2008) · Eukaryotic Cell · doi:10.1128/ec.00070-08 · Cited by 119 · see citing works
Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles
Hu, C., Zhou, M., Wang, W., Sun, X., Yarden, O., & Li, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00009 · Cited by 114 · see citing works
Potent Synergistic Effect of Doxycycline with Fluconazole against Candida albicans Is Mediated by Interference with Iron Homeostasis
Fiori, A., & Van Dijck, P. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06017-11 · Cited by 112 · see citing works
AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus
Paul, S., Stamnes, M., Thomas, G. H., Liu, H., Hagiwara, D., Gomi, K., Filler, S. G., & Moye-Rowley, W. S. (2019) · mBio · doi:10.1128/mbio.02563-18 · Cited by 91 · see citing works
Self-citation
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Whaley, S. G., & Rogers, P. D. (2016) · Current Infectious Disease Reports · doi:10.1007/s11908-016-0554-5 · Cited by 85 · see citing works
Expression Plasmids for Use inCandida glabrata
Zordan, R. E., Yuxia, R., Pan, S., Rotondo, G., Peñas, A. D. L., Iluore, J., & Cormack, B. P. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.006908 · Cited by 82 · see citing works
Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata
Paul, S., Schmidt, J. A., & Moye-Rowley, W. S. (2011) · Eukaryotic Cell · doi:10.1128/ec.00277-10 · Cited by 78 · see citing works
Self-citation
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Nagi, M., Nakayama, H., Tanabe, K., Bard, M., Aoyama, T., Okano, M., Higashi, S., Ueno, K., Chibana, H., Niimi, M., et al. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01470.x · Cited by 68 · see citing works
UPC2A Is Required for High-Level Azole Antifungal Resistance in Candida glabrata
Whaley, S. G., Caudle, K. E., Vermitsky, J.-P., Chadwick, S. G., Toner, G., Barker, K. S., Gygax, S. E., & Rogers, P. D. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02217-13 · Cited by 52 · see citing works
Identification of Genomic Binding Sites for Candida glabrata Pdr1 Transcription Factor in Wild-Type and ρ 0 Cells
Paul, S., Bair, T. B., & Moye-Rowley, W. S. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03921-14 · Cited by 45 · see citing works
In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata
Nakayama, H., Nakayama, N., Arisawa, M., & Aoki, Y. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3037-3045.2001 · Cited by 39 · see citing works
Evidence for autoregulation of camR, which encodes a repressor for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid
Aramaki, H., Sagara, Y., Hosoi, M., et al. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.24.7828-7833.1993 · Cited by 29 · see citing works
Synergistic effect of fluconazole and doxycycline against Candida albicans biofilms resulting from calcium fluctuation and downregulation of fluconazole-inducible efflux pump gene overexpression
Gao, Y., Li, H. Z., Liu, S., Zhang, X., & Sun, S. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.072421-0 · Cited by 28 · see citing works
Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor
Khakhina, S., Šimoničová, L., & Moye-Rowley, S. (2018) · Molecular Microbiology · doi:10.1111/mmi.13913 · Cited by 27 · see citing works
Development of a Tightly Controlled Off Switch for Saccharomyces cerevisiae Regulated by Camphor, a Low-Cost Natural Product
Ikushima, S., Zhao, Y., & Boeke, J. D. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.012765 · Cited by 24 · see citing works
Construction and Use of a Recyclable Marker To Examine the Role of Major Facilitator Superfamily Protein Members in Candida glabrata Drug Resistance Phenotypes
Vu, B. G., & Moye-Rowley, S. (2018) · mSphere · doi:10.1128/msphere.00099-18 · Cited by 17 · see citing works
Self-citation
The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae
Dewhurst-Maridor, G., Abegg, D., David, F., Rougemont, J., Scott, C. C., Adibekian, A., & Riezman, H. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-03-0169 · Cited by 11 · see citing works
Negative regulation of Candida glabrata Pdr1 by the deubiquitinase subunit Bre5 occurs in a ubiquitin independent manner
Paul, S. K., McDonald, W. H., & Moye-Rowley, S. (2018) · Molecular Microbiology · doi:10.1111/mmi.14109 · Cited by 11 · see citing works

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“glabrata [46], has been reported to be involved in the oxidative stress response [47].”
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Lv, Q., Qin, Y., Yan, L., Wang, L., Zhang, C., & Jiang, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00218 · Cited by 13 · see citing works
Cold atmospheric plasma inhibits the growth of Candida albicans by affecting ergosterol biosynthesis and suppresses the fungal virulence factors in vitro
Rahimi-Verki, N., Shapoorzadeh, A., Razzaghi‐Abyaneh, M., Atyabi, S.-M., Shams‐Ghahfarokhi, M., Jahanshiri, Z., & Gholami‐Shabani, M. (2015) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2015.12.007 · Cited by 52 · see citing works
Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles inCandida glabrata
Faria‐Ramos, I., Tavares, P. R., Farinha, S., Neves-Maia, J., Miranda, I. M., Silva, R. M., Estevinho, L. M., Pina‐Vaz, C., & Rodrigues, A. G. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12193 · Cited by 30 · see citing works
Influence of growth conditions on cell surface hydrophobicity of Candida albicans and Candida glabrata
Hazen, K. C., Plotkin, B. J., & Klimas, D. M. (1986) · Infection and Immunity · doi:10.1128/iai.54.1.269-271.1986 · Cited by 104 · see citing works

Authors: Vu, B. G., Thomas, G. H., & Moye-Rowley, W. S.
Affiliations: University of Iowa (US)
Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
ORCID: Vu, Bao Gia
Moye-Rowley, W. Scott
Venue: mBio
Publisher: American Society for Microbiology
Published: 2019-06-25
Volume: 10
Issue: 3
ISSN: 2150-7511 (ISSN-L)
2161-2129
DOI: 10.1128/mbio.00934-19
PMC: PMC6561024
OpenAlex: W2952191518
Cited by: 59
References: 43
Citations by year: 2026: 6 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 5 · 2020: 10 · 2019: 1 · 2018: 1
FWCI: 2.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.asm.org/non-commercial-tdm-license (tdm)
Locations: mBio (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: HHS | National Institutes of Health (GM49825)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: ergosterol biosynthesis, ERG11, Candida glabrata, azole resistance, CDR1, ABC transporters, transcriptional regulation, drug target genes
MeSH terms: Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Ergosterol, Fungal Proteins, Transcription Factors, Trans-Activators, Gene Expression Regulation, Fungal, Drug Resistance, Multiple, Fungal, Candida glabrata, Biosynthetic Pathways

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Evidence that Ergosterol Biosynthesis Modulates Activity of the Pdr1 Transcription Factor in Candida glabrata

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