Cited by 666Bacteriophages and microbial interactionsEvolution and Genetic DynamicsMicrobial Community Ecology and Physiology

Explaining Microbial Population Genomics through Phage Predation

Open access
Rodriguez-Valera, Francisco, Martin-Cuadrado, Ana-Belen, Rodriguez-Brito, Beltran, Pašić, Lejla, Thingstad, T. Frede, Rohwer, Forest, Mira, Alex·2009·Nature Reviews Microbiology

Abstract

The remarkable differences that have been detected by metagenomics in the genomes of strains of the same bacterial species are difficult to reconcile with the widely accepted paradigm that periodic selection within bacterial populations will regularly purge genomic diversity by clonal replacement. We have found that many of the genes that differ between strains affect regions that are potential phage recognition targets. We therefore propose the constant-diversity dynamics model, in which the diversity of prokaryotic populations is preserved by phage predation. We provide supporting evidence for this model from metagenomics, mathematical analysis and computer simulations. Periodic selection and phage predation dynamics are not mutually exclusive; we compare their predictions to shed light on the ecological circumstances under which each type of dynamics could predominate.

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Crossref · 10.1038/nrmicro2235

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69 of 69 references verified0 citation errors · 0 not checkable

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  • Bacteriophages have a regulatory role in population dynamics through density-dependent predation.

    “Analogously, bacteriophages have a regulatory role in population dynamics through density-dependent predation [29].”

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Authors
Rodriguez-Valera, F., Martin-Cuadrado, A.-B., Rodriguez-Brito, B., Pašić, L., Thingstad, T. F., Rohwer, F., & Mira, A.
Affiliations
  • University of Ljubljana (SI)
  • University of Bergen (NO)
  • San Diego State University (US)
Venue
Nature Reviews Microbiology
Published
2009-11
Volume
7
Issue
11
Pages
828-836
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W1991604124
Cited by
663
References
69
Citations by year
2026: 17 · 2025: 38 · 2024: 36 · 2023: 34 · 2022: 43 · 2021: 45 · 2020: 39 · 2019: 46 · 2018: 45 · 2017: 47 · 2016: 36 · 2015: 52 · 2014: 47 · 2013: 41 · 2012: 44
FWCI
3.71
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of the University of Ljubljana (University of Ljubljana) (publishedVersion, other-oa)
Topics
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
phage predation, bacterial diversity, metagenomics, clonal replacement
MeSH terms
Bacteria, Bacteriophages, Models, Biological, Population Dynamics, Selection, Genetic, Species Specificity, Genome, Bacterial, Computational Biology, Genomics

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