Cited by 189SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing

Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals

Open access
Beaudoin-Bussières, Guillaume, Laumaea, Annemarie, Anand, Sai Priya, Prévost, Jérémie, Gasser, Romain, Goyette, Guillaume, Medjahed, Halima, Perreault, Josée +11 more·2020·mBio

Published version of a preprint

Abstract

While waiting for an efficient vaccine to protect against SARS-CoV-2 infection, alternative approaches to treat or prevent acute COVID-19 are urgently needed. Transfusion of convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks after the onset of the symptoms. If neutralizing activity is required for the efficacy of convalescent plasma transfer, our results suggest that convalescent plasma should be recovered rapidly after the donor recovers from active infection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/mbio.02590-20

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Beaudoin-Bussières, G., Laumaea, A., Anand, S. P., Prévost, J., Gasser, R., Goyette, G., Medjahed, H., Perreault, J., Tremblay, T., Lewin, A., Gokool, L., Morrisseau, C., Bégin, P., Tremblay, C., Martel-Laferrière, V., Kaufmann, D. E., Richard, J., Bazin, R., & Finzi, A.
Affiliations
  • Centre Hospitalier de l’Université de Montréal (CA)
  • Héma-Québec (CA)
  • Centre Hospitalier Universitaire Sainte-Justine (CA)
  • Centre de Recherche du CHUM, Quebec, Canada
Corresponding author
Finzi, Andrés
Venue
mBio
Published
2020-10-27
Volume
11
Issue
5
ISSN
  • 2150-7511 (ISSN-L)
  • 2161-2129
OpenAlex
W3092801527
Cited by
189
References
29
Citations by year
2026: 1 · 2025: 5 · 2024: 12 · 2023: 16 · 2022: 49 · 2021: 84 · 2020: 22
FWCI
5.61
Type
journal article
Language
en
Open access
Locations
  • mBio (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship@McGill (McGill) (submittedVersion)
  • Federal Open Science Repository of Canada / Le Dépôt fédéral de science ouverte du Canada (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministere de l'Economie et de l'Innovation du Quebec
  • Gouvernement du Canada | Canadian Institutes of Health Research
  • Mitacs
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords
SARS-CoV-2, COVID-19 pandemic, convalescent plasma, plasma transfusion, neutralizing antibodies, humoral immune response, spike protein, antibody waning, convalescent plasma donors, passive immunotherapy
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Convalescence, Cross Reactions, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Coronavirus Infections, Young Adult, Immunity, Humoral, Antibodies, Neutralizing, Pandemics, Spike Glycoprotein, Coronavirus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review