Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals
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Abstract
While waiting for an efficient vaccine to protect against SARS-CoV-2 infection, alternative approaches to treat or prevent acute COVID-19 are urgently needed. Transfusion of convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks after the onset of the symptoms. If neutralizing activity is required for the efficacy of convalescent plasma transfer, our results suggest that convalescent plasma should be recovered rapidly after the donor recovers from active infection.
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Neutralizing antibody responses decay rapidly in early convalescence.
“However, neutralizing antibody responses decay rapidly in early convalescence9,14–17.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [17]
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Self-citationCOVID ‐19 and plasma cells: Is there long‐lived protection?*
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Longitudinal Systemic and Mucosal Immune Responses to SARS-CoV-2 Infection
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Short-term antibody response after 1 dose of BNT162b2 vaccine in patients receiving hemodialysis
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The challenge of avidity determination in SARS‐CoV‐2 serology
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Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects
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Schasfoort, R. B. M., van Weperen, J., van Amsterdam, M., Parisot, J., Hendriks, J., Koerselman, M., Karperien, M., Mentink, A., Bennink, M. L., Krabbe, H. G., et al. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113165 · Cited by 31 · see citing works
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Self-citationThe intestinal microbiota and improving the efficacy of COVID-19 vaccinations
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Single-Molecule FRET Imaging of Virus Spike–Host Interactions
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Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins
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Self-citationAntigenic variation of SARS‐CoV‐2 in response to immune pressure
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Identification of SARS-CoV-2–specific immune alterations in acutely ill patients
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Self-citationAntibody Binding to SARS-CoV-2 S Glycoprotein Correlates with but Does Not Predict Neutralization
Ding, S., Laumaea, A., Benlarbi, M., Beaudoin-Bussières, G., Gasser, R., Medjahed, H., Pancera, M., Stamatatos, L., McGuire, A. T., Bazin, R., et al. (2020) · Viruses · doi:10.3390/v12111214 · Cited by 30 · see citing works
Self-citationBiparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern
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A Review on Immunological Responses to SARS-CoV-2 and Various COVID-19 Vaccine Regimens
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Comprehensive Flow Cytometry Profiling of the Immune System in COVID-19 Convalescent Individuals
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Tauzin, A., Gong, S. Y., Chatterjee, D., Ding, S., Painter, M. M., Goel, R. R., Beaudoin-Bussières, G., Marchitto, L., Boutin, M., Laumaea, A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111554 · Cited by 27 · see citing works
Self-citationElevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19
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Self-citationSustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study
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Anand, S. P., Prévost, J., Richard, J., Perreault, J., Tremblay, T., Drouin, M., Fournier, M., Lewin, A., Bazin, R., & Finzi, A. (2021) · Transfusion · doi:10.1111/trf.16318 · Cited by 23 · see citing works
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Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 Infection
Tauzin, A., Gendron‐Lepage, G., Nayrac, M., Anand, S. P., Bourassa, C., Medjahed, H., Goyette, G., Dubé, M., Bazin, R., Kaufmann, D., et al. (2022) · Viruses · doi:10.3390/v14030532 · Cited by 22 · see citing works
Self-citationImmune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing
Zhao, P.-S., Zou, J., Zhou, F., Zhu, Y., Song, Q., Yu, D.-D., & Li, X.-P. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108767 · Cited by 16 · see citing works
Epidemiological assessment of SARS-CoV-2 reinfection
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ABO blood group is involved in the quality of the specific immune response anti-SARS-CoV-2
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Potential SARS-CoV-2 vaccines: Concept, progress, and challenges
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Immune response induced by novel coronavirus infection
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Self-citationDiscriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
van Rijswijck, D. M. H., Bondt, A., Hoek, M., van der Straten, K., Caniels, T. G., Poniman, M., Eggink, D., Reusken, C. B. E. M., de Bree, G. J., Sanders, R. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33899-1 · Cited by 20 · see citing works
Persistence of SARS-CoV-2-Specific Antibodies for 13 Months after Infection
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SARS-CoV-2 Spike Expression at the Surface of Infected Primary Human Airway Epithelial Cells
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Self-citationMustapha, J. O., Abdullahi, I. N., Ajagbe, O., Emeribe, A. U., Fasogbon, S. A., Onoja, S. O., Ugwu, C. E., Umeozuru, C. M., Ajayi, F. O., Tanko, W. N., et al. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e05951 · Cited by 17 · see citing works
RetractedVE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
Ding, S., Ullah, I., Gong, S. Y., Grover, J. R., Mohammadi, M., Chen, Y., Vézina, D., Beaudoin-Bussières, G., Verma, V. T., Goyette, G., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104528 · Cited by 17 · see citing works
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Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients
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Deciphering Fc-effector functions against SARS-CoV-2
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- Authors
- Beaudoin-Bussières, G., Laumaea, A., Anand, S. P., Prévost, J., Gasser, R., Goyette, G., Medjahed, H., Perreault, J., Tremblay, T., Lewin, A., Gokool, L., Morrisseau, C., Bégin, P., Tremblay, C., Martel-Laferrière, V., Kaufmann, D. E., Richard, J., Bazin, R., & Finzi, A.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Héma-Québec (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Centre de Recherche du CHUM, Quebec, Canada
- Corresponding author
- Finzi, Andrés
- ORCID
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2020-10-27
- Volume
- 11
- Issue
- 5
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC7569150
- OpenAlex
- W3092801527
- Cited by
- 189
- References
- 29
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 12 · 2023: 16 · 2022: 49 · 2021: 84 · 2020: 22
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship@McGill (McGill) (submittedVersion)
- Federal Open Science Repository of Canada / Le Dépôt fédéral de science ouverte du Canada (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministere de l'Economie et de l'Innovation du Quebec
- Gouvernement du Canada | Canadian Institutes of Health Research
- Mitacs
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, COVID-19 pandemic, convalescent plasma, plasma transfusion, neutralizing antibodies, humoral immune response, spike protein, antibody waning, convalescent plasma donors, passive immunotherapy
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Convalescence, Cross Reactions, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Coronavirus Infections, Young Adult, Immunity, Humoral, Antibodies, Neutralizing, Pandemics, Spike Glycoprotein, Coronavirus
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