The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA
Open accessAbstract
Transforming growth factor beta (TGF-beta) signaling facilitates metastasis in advanced malignancy. While a number of protein-encoding genes are known to be involved in this process, information on the role of microRNAs (miRNAs) in TGF-beta-induced cell migration and invasion is still limited. By hybridizing a 515-miRNA oligonucleotide-based microarray library, a total of 28 miRNAs were found to be significantly deregulated in TGF-beta-treated normal murine mammary gland (NMuMG) epithelial cells but not Smad4 knockdown NMuMG cells. Among upregulated miRNAs, miR-155 was the most significantly elevated miRNA. TGF-beta induces miR-155 expression and promoter activity through Smad4. The knockdown of miR-155 suppressed TGF-beta-induced epithelial-mesenchymal transition (EMT) and tight junction dissolution, as well as cell migration and invasion. Further, the ectopic expression of miR-155 reduced RhoA protein and disrupted tight junction formation. Reintroducing RhoA cDNA without the 3' untranslated region largely reversed the phenotype induced by miR-155 and TGF-beta. In addition, elevated levels of miR-155 were frequently detected in invasive breast cancer tissues. These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention.
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Cited by
Molecular mechanisms of epithelial–mesenchymal transition
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Metadata
- Authors
- Kong, W., Yang, H., He, L., Zhao, J.-J., Coppola, D., Dalton, W. S., & Cheng, J. Q.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-11-01
- Volume
- 28
- Issue
- 22
- Pages
- 6773-6784
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2110935705
- Cited by
- 689
- References
- 11
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Kong, W., Yang, H., He, L., Zhao, J.-J., Coppola, D., Dalton, W. S., & Cheng, J. Q. (2008). MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00941-08
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