BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y., & Araki, H. (2007) · Nature · doi:10.1038/nature05465 · Cited by 530 · see citing works

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 454 · see citing works

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

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Molecular pathogenesis of Fanconi anemia: recent progress

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The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 368 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

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BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

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A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

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The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

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Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

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DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae

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Mechanisms to control rereplication and implications for cancer

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Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

Kumaraswamy, E., & Shiekhattar, R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00961-07 · Cited by 110 · see citing works

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

Yan, S., & Michael, W. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810185 · Cited by 107 · see citing works

How ATR turns on: TopBP1 goes on ATRIP with ATR: Figure 1.Preprint

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Human TopBP1 Ensures Genome Integrity during Normal S Phase

Kim, J., McAvoy, S., Smith, D. I., & Chen, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10907-10915.2005 · Cited by 72 · see citing works

The Drosophila mus101 Gene, Which Links DNA Repair, Replication and Condensation of Heterochromatin in Mitosis, Encodes a Protein With Seven BRCA1 C-Terminus Domains

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TOPping up ATR Activity

Bártek, J., & Mailand, N. (2006) · Cell · doi:10.1016/j.cell.2006.02.029 · Cited by 12 · see citing works

The essential kinase ATR: ensuring faithful duplication of a challenging genome

Saldivar, J. C., Cortez, D., & Cimprich, K. A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.67 · Cited by 829 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

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DNA helicases involved in DNA repair and their roles in cancer

Brosh, R. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3560 · Cited by 345 · see citing works

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works

Expanded roles of the Fanconi anemia pathway in preserving genomic stabilityPreprint

Kee, Y., & D’Andrea, A. D. (2010) · Genes & Development · doi:10.1101/gad.1955310 · Cited by 309 · see citing works

ATR: a master conductor of cellular responses to DNA replication stress

Flynn, R. L., & Zou, L. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.09.005 · Cited by 290 · see citing works

ATR autophosphorylation as a molecular switch for checkpoint activation

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

Sarkies, P., Murat, P., Phillips, L. G., Patel, K. J., Balasubramanian, S., & Sale, J. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr868 · Cited by 211 · see citing works

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

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DNA damage tolerance: a double-edged sword guarding the genome.

Ghosal, G., & Chen, J. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.04.01 · Cited by 204 · see citing works

BRCT domains

Leung, C. C. Y., & Glover, J. N. M. (2011) · Cell Cycle · doi:10.4161/cc.10.15.16312 · Cited by 165 · see citing works

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

Leimbacher, P.-A., Jones, S. E., Shorrocks, A.-M. K., Zompit, M. D. M., Day, M. W., Blaauwendraad, J., Bundschuh, D., Bonham, S., Fischer, R., Fink, D. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.014 · Cited by 136 · see citing works

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

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DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster

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The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

Huang, M., ‍Kim, J. M., Shiotani, B., Yang, K., Zou, L., & D’Andrea, A. D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.005 · Cited by 134 · see citing works

BRCA1 gene: function and deficiency

Takaoka, M., & Miki, Y. (2017) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1182-2 · Cited by 126 · see citing works

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways

Wardlaw, C. P., Carr, A. M., & Oliver, A. W. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.06.004 · Cited by 122 · see citing works

TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73

Liu, K., Ling, S., & Lin, W.-C. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05574-11 · Cited by 122 · see citing works

DNA replication stress and cancer chemotherapy

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BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

Pathania, S., Nguyen, J., Hill, S. J., Scully, R., Adelmant, G., Marto, J. A., Feunteun, J., & Livingston, D. M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.002 · Cited by 120 · see citing works

MDC1 collaborates with TopBP1 in DNA replication checkpoint control

Wang, J., Gong, Z., & Chen, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201010026 · Cited by 118 · see citing works

The BLM dissolvasome in DNA replication and repair

Manthei, K. A., & Keck, J. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1325-1 · Cited by 111 · see citing works

Human single-stranded DNA binding proteins are essential for maintaining genomic stability

Ashton, N. W., Bolderson, E., Cubeddu, L., O'Byrne, K. J., & Richard, D. J. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-9 · Cited by 113 · see citing works

PTIP associates with Artemis to dictate DNA repair pathway choicePreprint

Wang, J., Asaithamby, A., Löbrich, M., Li, Y., Chen, D. J., Chen, J., & Gong, Z. (2014) · Genes & Development · doi:10.1101/gad.252478.114 · Cited by 109 · see citing works

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

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Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

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The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

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Fanconi anemia: a disorder defective in the DNA damage response

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TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

Broderick, R., Nieminuszczy, J., Blackford, A. N., Winczura, A., & Niedźwiedź, W. (2015) · Nature Communications · doi:10.1038/ncomms7572 · Cited by 80 · see citing works

History of DNA Helicases

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TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

Blackford, A. N., Nieminuszczy, J., Schwab, R. A., Galanty, Y., Jackson, S. P., & Niedźwiedź, W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.012 · Cited by 70 · see citing works

BRCA1 tumor suppressor network: focusing on its tail

Wang, B. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-6 · Cited by 78 · see citing works

Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia

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Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

Rappas, M., Oliver, A. W., & Pearl, L. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq743 · Cited by 77 · see citing works

DNA polymerase κ‐dependent DNA synthesis at stalled replication forks is important for CHK1 activation

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

Peng, M., Cong, K., Panzarino, N. J., Nayak, S. U., Calvo, J. A., Deng, B., Zhu, L. J., Mórocz, M., Hegedűs, L., Haracska, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.065 · Cited by 67 · see citing works

BRCA1 in the DNA damage response and at telomeres

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Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control

Leung, C. C. Y., Gong, Z., Chen, J., & Glover, J. N. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189555 · Cited by 67 · see citing works

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

Wang, J., Chen, J., & Gong, Z. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.012 · Cited by 62 · see citing works

The DNA damage response: balancing the scale between cancer and ageing.

Seviour, E. G., & Lin, S.-Y. (2010) · Aging · doi:10.18632/aging.100248 · Cited by 61 · see citing works

Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

Lee, Y., Katyal, S., Downing, S. M., Zhao, J., Russell, H. R., & McKinnon, P. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3097 · Cited by 59 · see citing works

Fanconi anemia and Bloom's syndrome crosstalk through FANCJ–BLM helicase interaction

Suhasini, A. N., & Brosh, R. M. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.09.003 · Cited by 57 · see citing works

Homologs of Breast Cancer Genes in Plants

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Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays

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SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing

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A Boolean network model of the FA/BRCA pathway

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Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage

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Functions of TopBP1 in preserving genome integrity during mitosis

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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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Chk1 suppressed cell death

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FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response

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Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells

Gagou, M. E., Ganesh, A. N., Thompson, R. H., Phear, G. A., Sanders, C. M., & Meuth, M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4404 · Cited by 43 · see citing works

Fanconi anemia: at the Crossroads of DNA repair

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BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

Day, M. W., Rappas, M., Ptasińska, K., Boos, D., Oliver, A. W., & Pearl, L. H. (2018) · eLife · doi:10.7554/elife.39979 · Cited by 41 · see citing works

DNA helicases and their roles in cancer

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FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice

Sun, X., Brieño‐Enríquez, M. A., Cornelius, A. J., Modzelewski, A. J., Maley, T. T., Campbell-Peterson, K. M., Holloway, J. K., & Cohen, P. E. (2015) · Chromosoma · doi:10.1007/s00412-015-0549-2 · Cited by 38 · see citing works

Interaction between Rad9–Hus1–Rad1 and TopBP1 activates ATR–ATRIP and promotes TopBP1 recruitment to sites of UV-damage

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BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1

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ADAR1 links R-loop homeostasis to ATR activation in replication stress response

Zhang, B., Li, Y., Zhang, J., Wang, Y., Liang, C., Lü, T., Zhang, C., Liu, L., Qin, Y. F., He, J., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad839 · Cited by 37 · see citing works

And‐1 coordinates with Claspin for efficient Chk1 activation in response to replication stress

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The Regulation of Homologous Recombination by Helicases

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Rescue of replication failure by Fanconi anaemia proteins

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The accumulation of DNA repair defects is the molecular origin of carcinogenesis

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Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication

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Structural Insight into BLM Recognition by TopBP1

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FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation

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Genome-wide Identification of IRF1 Binding Sites Reveals Extensive Occupancy at Cell Death Associated Genes

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PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability

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Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1

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The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization

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TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

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Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles

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hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ

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WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

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The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice

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MDC1 collaborates with TopBP1 in DNA replication checkpoint control

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BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

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TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

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