Cited by 561MicroRNA in disease regulationCancer-related Molecular PathwaysCancer-related molecular mechanisms research

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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

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Ivanovska, Irena, Ball, Alexey S., Diaz, Robert L., Magnus, Jill F., Kibukawa, Miho, Schelter, Janell M., Kobayashi, Sumire V., Lim, Lee, Burchard, Julja, Jackson, Aimee L., Linsley, Peter S., Cleary, Michele A.·2008·Molecular and Cellular Biology

DOI 10.1128/mcb.01977-07PMC PMC2268421

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Abstract

microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.

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Authors: Ivanovska, I., Ball, A. S., Diaz, R. L., Magnus, J. F., Kibukawa, M., Schelter, J. M., Kobayashi, S. V., Lim, L., Burchard, J., Jackson, A. L., Linsley, P. S., & Cleary, M. A.
Affiliations: Rosetta Inpharmatics LLC, Seattle, Washington 98109
Corresponding author: Ivanovska, Irena
ORCID: Ivanovska, Irena
Diaz, Robert L.
Lim, Lee
Burchard, Julja
Jackson, Aimee L.
Linsley, Peter S.
Cleary, Michele A.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2008-04-01
Volume: 28
Issue: 7
Pages: 2167-2174
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.01977-07
PMC: PMC2268421
OpenAlex: W2100975741
Cited by: 561
References: 52
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 26 · 2018: 25 · 2017: 21 · 2016: 32 · 2015: 37 · 2014: 52 · 2013: 58 · 2012: 53
FWCI: 20.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, CDKN1A/p21, cell cycle progression, cyclin-dependent kinase inhibitors, microRNA target regulation, tumor cell proliferation
MeSH terms: Breast, Cell Cycle, Cell Line, Transformed, DNA Damage, Doxorubicin, Female, Humans, Neoplasm Proteins, RNA, Messenger, RNA, Neoplasm, Genes, cdc, RNA Interference, RNA, Small Interfering, MicroRNAs, Cyclin-Dependent Kinase Inhibitor p21

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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

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