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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression
Open accessAbstract
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.
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“Previous studies have shown that miR-106b targets several genes implicated in cell cycles, such as cyclin-dependent kinase inhibitor 1A (p21), E2F transcription factor, TAF5-like RNA polymerase II, and phosphatase and tensin homolog (Ivanovska et al., 2008; Pichiorri et al., 2008; Poliseno et al., 2010; Trompeter et al., 2011).”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Ivanovska et al., 2008
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Metadata
- Authors
- Ivanovska, I., Ball, A. S., Diaz, R. L., Magnus, J. F., Kibukawa, M., Schelter, J. M., Kobayashi, S. V., Lim, L., Burchard, J., Jackson, A. L., Linsley, P. S., & Cleary, M. A.
- Affiliations
- Rosetta Inpharmatics LLC, Seattle, Washington 98109
- Corresponding author
- Ivanovska, Irena
- ORCID
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-04-01
- Volume
- 28
- Issue
- 7
- Pages
- 2167-2174
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2268421
- OpenAlex
- W2100975741
- Cited by
- 561
- References
- 52
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 26 · 2018: 25 · 2017: 21 · 2016: 32 · 2015: 37 · 2014: 52 · 2013: 58 · 2012: 53
- FWCI
- 20.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, CDKN1A/p21, cell cycle progression, cyclin-dependent kinase inhibitors, microRNA target regulation, tumor cell proliferation
- MeSH terms
- Breast, Cell Cycle, Cell Line, Transformed, DNA Damage, Doxorubicin, Female, Humans, Neoplasm Proteins, RNA, Messenger, RNA, Neoplasm, Genes, cdc, RNA Interference, RNA, Small Interfering, MicroRNAs, Cyclin-Dependent Kinase Inhibitor p21
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