The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription
Open accessAbstract
We previously isolated a cDNA clone encoding interferon consensus sequence-binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, that binds to the interferon (IFN)-stimulated response element (ISRE) of many IFN-regulated genes. In this investigation, we studied the functional role of ICSBP by transient cotransfection of ICSBP cDNA with IFN-responsive reporter genes into the human embryonal carcinoma cell line N-Tera2. These cells were shown not to express ICSBP or IRF-2, thus allowing functional analysis of transfected cDNAs. Cotransfection of ICSBP into cells treated with retinoic acid or any of the IFNs (alpha, beta, or gamma) repressed expression of a chloramphenicol acetyltransferase reporter driven by the major histocompatibility complex class I gene promoter. Similarly, ICSBP repressed expression of chloramphenicol acetyltransferase reporters driven by the ISREs of the 2'-5' oligoadenylate synthetase, guanylate-binding protein, and ISG-15 genes in IFN-treated cells. The repression was dependent on the presence of the ISRE in the reporter. Deletion analysis showed that the putative N-terminal DNA binding domain of ICSBP by itself is capable of mediating the repression. Using the same cotransfection conditions as for ICSBP, a similar repression of these reporters was observed with IRF-2. Finally, ICSBP repressed the IRF-1-mediated induction of major histocompatibility complex class I and IFN-beta reporters in the absence of IFN or retinoic acid. Taken together, these results suggest that ICSBP is a negative regulatory factor capable of repressing transcription of target genes induced by IFN, retinoic acid, or IRF-1.
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In the citing paper
“ICSBP/IRF8 is expressed exclusively in myeloid and B-cells (10)”
In the citing paper
“Likewise, previous reporter analysis indicated that ICSBP is a repressor of ISRE-dependent transcription (36, 57).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [36]
In the citing paper
“transfection of ICSBP alone reduced ISRE reporter activity by ∼ 40% irrespective of IFN𝛄 treatment, consistent with the previous finding that ICSBP represses ISRE-dependent transcription (36, 57).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [36]
In the citing paper
“Subsequent studies have shown that ICSBP is a transcriptional repressor acting through the IFN-stimulated response element (ISRE). (6,20,21)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [20]
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Pestka, S., Langer, J. A., Zoon, K. C., & Samuel, C. E. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003455 · Cited by 1,826
Lymphokine Control of In Vivo Immunoglobulin Isotype Selection
Finkelman, F. D., Holmes, J. M., Katona, I. M., Urban, J. F., Beckmann, M. P., Park, L. S., Schooley, K., Coffman, R. L., Mosmann, T. R., & Paul, W. E. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001511 · Cited by 1,301
Gorman, C. M., Merlino, G. T., Willingham, M. C., Pastan, I. H., & Howard, B. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.22.6777 · Cited by 1,257
Stewart, W. E. (1979) · Springer eBooks · doi:10.1007/978-3-7091-3432-0 · Cited by 1,165
Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., & Taniguchi, T. (1988) · Cell · doi:10.1016/s0092-8674(88)91307-4 · Cited by 971
Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., & Taniguchi, T. (1989) · Cell · doi:10.1016/0092-8674(89)90107-4 · Cited by 957
Luster, A. D., Unkeless, J. C., & Ravetch, J. V. (1985) · Nature · doi:10.1038/315672a0 · Cited by 944
Rosen, C. A., Sodroski, J., & Haseltine, W. A. (1985) · Cell · doi:10.1016/s0092-8674(85)80062-3 · Cited by 824
Andrews, P. W. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90316-6 · Cited by 806
Gunning, P. W., Leavitt, J. C., Muscat, G. E. O., Ng, S. Y., & Kedes, L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.4831 · Cited by 739
The interferon system. A bird's eye view of its biochemistry.
Sen, G. C., & Lengyel, P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42719-6 · Cited by 633
Levy, D. E., Kessler, D. S., Pine, R. I., Reich, N. C., & Darnell, J. E., Jr. (1988) · Genes & Development · doi:10.1101/gad.2.4.383 · Cited by 559
Friedman, R. L., & Stark, G. R. (1985) · Nature · doi:10.1038/314637a0 · Cited by 491
Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., & Darnell, J. E., Jr. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8555 · Cited by 490
Levy, D. E., Kessler, D. S., Pine, R. I., & Darnell, J. E., Jr. (1989) · Genes & Development · doi:10.1101/gad.3.9.1362 · Cited by 468
Arcari, P., Martinelli, R., & Salvatore, F. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.23.9179 · Cited by 409
Veals, S. A., Schindler, C., Leonard, D. G. B., Fu, X.-Y., Aebersold, R. H., Darnell, J. E., Jr., & Levy, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3315 · Cited by 384
Pellegrini, S., John, J., Shearer, M., Kerr, I. M., & Stark, G. R. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.4605 · Cited by 374
Cytoplasmic activation of GAF, an IFN‐gamma‐regulated DNA‐binding factor.
Decker, T., Lew, D. J., Mirkovitch, J., & Darnell, J. E., Jr. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08026.x · Cited by 369
Harada, H., Willison, K. R., Sakakibara, J., Miyamoto, M., Fujita, T., & Taniguchi, T. (1990) · Cell · doi:10.1016/0092-8674(90)90163-9 · Cited by 368
Liu, Y., & Janeway, C. A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1735 · Cited by 361
Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1
Fujita, T., Kimura, Y., Miyamoto, M., Barsoumian, E. L., & Taniguchi, T. (1989) · Nature · doi:10.1038/337270a0 · Cited by 358
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356
Self-citationIdentification and characterization of a novel repressor of beta-interferon gene expression.Preprint
Keller, A., & Maniatis, T. (1991) · Genes & Development · doi:10.1101/gad.5.5.868 · Cited by 345
Pine, R. I., Decker, T., Kessler, D. S., Levy, D. E., & Darnell, J. E., Jr. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2448 · Cited by 331
Human β-interferon gene expression is regulated by an inducible enhancer element
Goodbourn, S., Zinn, K., & Maniatis, T. (1985) · Cell · doi:10.1016/s0092-8674(85)80024-6 · Cited by 286
Lew, D. J., Decker, T., Strehlow, I., & Darnell, J. E., Jr. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.182 · Cited by 277
Revel, M., & Chebath, J. (1986) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(86)90134-9 · Cited by 267
A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
Reid, L. E., Brasnett, A. H., Gilbert, C. S., Porter, A. C. G., Gewert, D. R., Stark, G. R., & Kerr, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.840 · Cited by 257
Reis, L. F. L., Harada, H., Wolchok, J. D., Taniguchi, T., & Vilček, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05041.x · Cited by 243
IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells.
Maraskovsky, E., Chen, W. F., & Shortman, K. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.4.1210 · Cited by 240
The regulation and expression of MHC class I genes
David‐Watine, B., Israël, A., & Kourilsky, P. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90114-o · Cited by 233
Overlapping positive and negative regulatory domains of the human beta-interferon gene.
Goodbourn, S., & Maniatis, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1447 · Cited by 232
γ-Interferon is one of several direct B cell-maturing lymphokines
Sidman, C. L., Marshall, J. D., Shultz, L. D., Gray, P. W., & Johnson, H. M. (1984) · Nature · doi:10.1038/309801a0 · Cited by 232
Israël, A., Kimura, A., Fournier, A., Fellous, M., & Kourilsky, P. (1986) · Nature · doi:10.1038/322743a0 · Cited by 229
Fujita, T., Shibuyà, H., Hotta, H., Yamanishi, K., & Taniguchi, T. (1987) · Cell · doi:10.1016/0092-8674(87)90288-1 · Cited by 216
Levy, D. E., Lew, D. J., Decker, T., Kessler, D. S., & Darnell, J. E., Jr. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08216.x · Cited by 212
Larner, A. C., Chaudhuri, A., & Darnell, J. E., Jr. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42492-6 · Cited by 205
Fujita, T., Ohno, S., Yasumitsu, H., & Taniguchi, T. (1985) · Cell · doi:10.1016/s0092-8674(85)80022-2 · Cited by 202
Transcriptional regulation of interferon-stimulated genes.
Williams, B. R. G. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb21041.x · Cited by 179
Interferon‐induced binding of nuclear factors to promoter elements of the 2‐5A synthetase gene.
Rutherford, M., Hannigan, G. E., & Williams, B. R. G. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02872.x · Cited by 178
A 46-nucleotide promoter segment from an IFN-α gene renders an unrelated promoter inducible by virus
Ryals, J. A., Dierks, P. M., Ragg, H., & Weissmann, C. (1985) · Cell · doi:10.1016/s0092-8674(85)80023-4 · Cited by 178
Shirayoshi, Y., Burke, P., Appella, E., & Ozato, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.5884 · Cited by 163
Self-citationDifferent pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes
MacDonald, N. J., Kuhl, D., Maguire, D. J., Näf, D., Gallant, P., Goswamy, A., Hug, H., Büeler, H., Chaturvedi, M. M., de la Fuente, J., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90091-r · Cited by 151
Benech, P. D., Vigneron, M., Peretz, D., Revel, M., & Chebath, J. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.12.4498 · Cited by 138
Decker, T., Lew, D. J., & Darnell, J. E., Jr. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5147 · Cited by 134
ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURE
Artzt, K., & Jacob, F. (1974) · Transplantation · doi:10.1097/00007890-197406000-00015 · Cited by 126
Dale, T. C., Rosen, J. M., Guille, M., Lewin, A. R., Porter, A., Kerr, I. M., & Stark, G. R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03444.x · Cited by 121
Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein.
Amaldi, I., Reith, W., Berte, C. C., & Mach, B. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.3.999 · Cited by 111
Fujita, T., Miyamoto, M., Kimura, Y., Hammer, J., & Taniguchi, T. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.9.3335 · Cited by 105
Sugita, K., Miyazaki, J., Appella, E., & Ozato, K. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.7.2625 · Cited by 105
Self-citationKeller, A., & Maniatis, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3309 · Cited by 104
Blanar, M. A., Baldwin, A. S., Flavell, R. A., & Sharp, P. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03484.x · Cited by 103
Complete nucleotide sequence of the murine H-2kkgene. Comparison of three H-2K locus alleles
Arnold, B., Burgert, H.-G., Archibald, A. L., & Kvist, S. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.24.9473 · Cited by 103
The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes
Nguyen, C., Sodoyer, R., Trucy, J., Strachan, T., & Jordan, B. (1985) · Immunogenetics · doi:10.1007/bf00430931 · Cited by 94
Levy, D. E., & Darnell, J. E., Jr. (1990) · PubMed · Cited by 90
5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma.
Wright, T. M., & Farber, J. M. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.2.417 · Cited by 80
Sequence of a cDNA coding for human IRF-1
Maruyama, M., Fujita, T., & Taniguchi, T. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.8.3292 · Cited by 77
Dey, A., Thornton, A. M., Lonergan, M., Weissman, S. M., Chamberlain, J. W., & Ozato, K. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3590 · Cited by 76
Self-citationThe control of interferon‐inducible gene expression
Kerr, I. M., & Stark, G. R. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80802-a · Cited by 70
Politis, A. D., Sivo, J., Driggers, P. H., Ozato, K., & Vogel, S. N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.801 · Cited by 68 · cited 4×
“What is then the significance of the redundance of factors which seemingly exert the same function? It should be noted that ICSBP shows a very restricted cell and tissue specificity, and it is expressed predominantly in cells of the lymphocyte and macrophage lineages (21, 64, 80).”
BackgroundResultInfluentialSelf-citationBandyopadhyay, S. K., Kalvakolanu, D. V., & Sen, G. C. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5055 · Cited by 67
Interferon synthesis in the early post-implantation mouse embryo
Barlow, D. P., Randle, B. J., & Burke, D. C. (1984) · Differentiation · doi:10.1111/j.1432-0436.1984.tb01433.x · Cited by 66
Interferon induction of gene transcription analyzed by in vivo footprinting.
Mirkovitch, J., Decker, T., & Darnell, J. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.1 · Cited by 63
Nagata, T., Segars, J. H., Levi, B. Z., & Ozato, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.3.937 · Cited by 60
Self-citationInterferon‐γ is not an antiviral, but a growth‐promoting factor for t lymphocytes
Landolfo, S., Gariglio, M., Gribaudo, G., Jemma, C., Giovarelli, M., & Cavallo, G. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180403 · Cited by 59
Loh, J. E., Chang, C., Fodor, W. L., & Flavell, R. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05180.x · Cited by 55
Tsujimoto, M., Feinman, R., & Vilček, J. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.7.2272 · Cited by 53
Yan, C., & Tamm, I. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.144 · Cited by 49
Flanagan, J. R., Murata, M., Burke, P., Shirayoshi, Y., Appella, E., Sharp, P. A., & Ozato, K. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3145 · Cited by 42
Self-citationInduction of major histocompatibility class I antigens by interferons in undifferentiated F9 cells
Wan, Y. Y., Orrison, B. M., Lieberman, R., Lazarovici, P., & Ozato, K. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041300214 · Cited by 40
Self-citationSequence of a cDNA coding for human IRF-2
Itoh, S., Harada, H., Fujita, T., MIMURA, T., & Taniguchi, T. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.20.8372 · Cited by 37
Enhancer functions andin vitroprotein binding of native and mutated interferon-responsive sequences
Cohen, B., Vaiman, D., & Chebath, J. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.4.1679 · Cited by 30
Andrews, P. W., Trinchieri, G., PERUSSIA, B., & Baglioni, C. (1987) · PubMed · Cited by 29
Driggers, P. H., Elenbaas, B., An, J., Lee, I. J., & Ozato, K. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.10.2533 · Cited by 26
Self-citationRegulation of major histocompatibility complex class I genes.
Burke, P., & Ozato, K. (1989) · PubMed · Cited by 21
Self-citationControl of β-Interferon Expression in Murine Embryonal Carcinoma F9 Cells
Francis, M. K., & Lehman, J. M. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.8.3553-3556.1989 · Cited by 19
Research works printed but not linked: 12
- 10.1128/mcb.10.10.5055-5063.1990 · DOI
- 10.1128/mcb.7.12.4498-4504.1987 · DOI
- 10.1016/0003-2697(87)90021-2 · DOI
- 10.1128/mcb.11.10.5147-5153.1991 · DOI
- 10.1128/mcb.12.8.3590-3599.1992 · DOI
- 10.1128/mcb.11.1.182-191.1991 · DOI
- 10.1128/mcb.12.1.1-9.1992 · DOI
- 10.1128/mcb.9.11.4605-4612.1989 · DOI
- 10.1128/mcb.10.6.2448-2457.1990 · DOI
- 10.1128/mcb.7.7.2625-2630.1987 · DOI
- 10.1128/mcb.12.8.3315-3324.1992 · DOI
- Weisz A. P. Marx R. Sharf E. Appella P. H. Driggers K. Ozato and B. Levi. The cloning and characterization of the human homologue of ICSBP that binds enhancer element common to interferon inducible genes. J. Biol. Chem. in press.
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Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
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“, 1989) and the IFN-consensus sequence-binding protein (ICSBP, also called IRF-8 ; Nelson et al., 1993), are known to bind ISREs and negatively regulate expression, and may help to prevent expression in the absence of IFN or down-regulate the induced response.”
BackgroundMethodHoltschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644
Self-citation
Metadata
- Authors
- Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K.
- Affiliations
- National Institutes of Health (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 13
- Issue
- 1
- Pages
- 588-599
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC358938
- OpenAlex
- W1857506864
- Cited by
- 192
- References
- 83
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IRF2, IRF1, interferon-stimulated response element, transcriptional repression, interferon-beta, retinoic acid, MHC class I, 2',5'-oligoadenylate synthetase, guanylate-binding proteins, DNA-binding domain, embryonal carcinoma cells
- MeSH terms
- Interferon Regulatory Factor-8, Base Sequence, Binding Sites, Carrier Proteins, Cells, Cultured, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, MHC Class I, Humans, Interferons, Oligodeoxyribonucleotides, Phosphoproteins, Repressor Proteins, RNA, Messenger, Transcription Factors, Transcription, Genetic, Gene Expression, Polymerase Chain Reaction, Interferon-beta, Interferon Regulatory Factors, Interferon Regulatory Factor-2, Interferon Regulatory Factor-1, In Vitro Techniques
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