The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade
Open accessAbstract
A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade. The stable beta-globin mRNA was rendered unstable by insertion of the 2, 500-nucleotide Cox-2 3' untranslated region (3' UTR). The chimeric transcript was stabilized by a constitutively active form of MAPK kinase 6, an activator of p38. This stabilization was blocked by SB203580, an inhibitor of p38, and by two different dominant negative forms of MAPK-activated protein kinase 2 (MAPKAPK-2), a kinase lying downstream of p38. Constitutively active MAPKAPK-2 was also able to stabilize chimeric beta-globin-Cox-2 transcripts. The MAPKAPK-2 substrate hsp27 may be involved in stabilization, as beta-globin-Cox-2 transcripts were partially stabilized by phosphomimetic mutant forms of hsp27. A short (123-nucleotide) fragment of the Cox-2 3' UTR was necessary and sufficient for the regulation of mRNA stability by the p38 cascade and interacted with a HeLa protein immunologically related to AU-rich element/poly(U) binding factor 1.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 2×
“The tetracycline-responsive reporter system (20, 59) permits regulatory sequences and pathways to be mapped by performing RNA stability experiments in the absence of toxic transcriptional inhibitors.”
BackgroundAU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948
Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay
Myer, V. E., Fan, X. C., & Steitz, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2130 · Cited by 302
Cited by
AU-rich elements and associated factors: are there unifying principles?
Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 907
Regulation of mRNA stability in mammalian cells
Guhaniyogi, J., & Brewer, G. (2001) · Gene · doi:10.1016/s0378-1119(01)00350-x · Cited by 729
Self-citationTargeting NOX, iNOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals
Murakami, A., & Ohigashi, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.23161 · Cited by 478
MAPKAP kinases — MKs — two's company, three's a crowd
Gaestel, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1834 · Cited by 413
UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression
Bachelor, M. A., & Bowden, G. T. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2003.09.017 · Cited by 268
Giovannini, M. G., Scali, C., Prosperi, C., Bellucci, A., Vannucchi, M. G., Rosi, S., Pepeu, G., & Casamenti, F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0538 · Cited by 190
Roger, T., Chanson, A., Knaup‐Reymond, M., & Calandra, T. (2005) · European Journal of Immunology · doi:10.1002/eji.200535413 · Cited by 184
Modulation of mRNA stability as a novel therapeutic approach
Eberhardt, W., Doller, A., Akool, E.-S., & Pfeilschifter, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.002 · Cited by 173
RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate
García-Mauriño, S. M., Rivero-Rodríguez, F., Velázquez-Cruz, A., Hernández-Vellisca, M., Díaz-Quintana, A., De la Rosa, M. A., & Díaz-Moreno, I. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00071 · Cited by 174
Role of P38 MAPK in UVB-Induced Inflammatory Responses in the Skin of SKH-1 Hairless Mice
Kim, A. L., Labasi, J. M., Zhu, Y., Tang, X., McClure, K., Gabel, C. A., Athar, M., & Bickers, D. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23747.x · Cited by 153
Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.184 · Cited by 135
Marchese, F. P., Aubareda, A., Tudor, C., Saklatvala, J., Clark, A. R., & Dean, J. L. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.136473 · Cited by 136
Self-citationNeuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway
Pascale, A., Amadio, M., Scapagnini, G., Lanni, C., Racchi, M., Provenzani, A., Govoni, S., Alkon, D. L., & Quattrone, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504702102 · Cited by 129
Control of cytokine mRNA expression by RNA-binding proteins and microRNAs
Palanisamy, V., Jakymiw, A., Van Tubergen, E. A., D’Silva, N. J., & Kirkwood, K. L. (2012) · Journal of Dental Research · doi:10.1177/0022034512437372 · Cited by 117
Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer
Haar, E. T., Prabakhar, P., Liu, X., & Lepre, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611165200 · Cited by 100
Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C. P., Olajide, O. A., Martínez-Sánchez, G., & Fiebich, B. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.017 · Cited by 95
Faour, W. H., Mancini, A., He, Q. W., & Di Battista, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212790200 · Cited by 86
Metadata
- Authors
- Lasa, M., Mahtani, K. R., Finch, A., Brewer, G., Saklatvala, J., & Clark, A. R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-06
- Volume
- 20
- Issue
- 12
- Pages
- 4265-4274
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2129377911
- Cited by
- 413
- References
- 3
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- green
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