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Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
Open accessAbstract
Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the delta isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient mice. The mice are viable but have decreased numbers of mature B cells, a block in pro-B-cell differentiation, and a B1 B-cell deficiency. Both immunoglobulin M receptor-induced Ca(2+) flux and proliferation in response to B-cell mitogens are attenuated. Immunoglobulin levels are decreased substantially. The ability to respond to T-cell-independent antigens is markedly reduced, and the ability to respond to T-cell-dependent antigens is completely eliminated. Germinal center formation in the spleen in response to antigen stimulation is disrupted. These results define a nonredundant signaling pathway(s) utilizing the delta isoform of p110 PI3K for the development and function of B cells.
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Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors
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Metadata
- Authors
- Jou, S.-T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J.-R., Carpino, N., Wang, D., & Ihle, J. N.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-12-01
- Volume
- 22
- Issue
- 24
- Pages
- 8580-8591
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2166470267
- Cited by
- 357
- References
- 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
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