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The Biology of Streptococcus mutans

Lemos, J.A., Palmer, S.R., Zeng, L., Wen, Z.T., Kajfasz, J.K., Freires, I.A., Abranches, J., Brady, L.J.·2019·Microbiology Spectrum
DOI 10.1128/microbiolspec.gpp3-0051-2018PMC PMC6615571
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Abstract

As a major etiological agent of human dental caries, Streptococcus mutans resides primarily in biofilms that form on the tooth surfaces, also known as dental plaque. In addition to caries, S. mutans is responsible for cases of infective endocarditis with a subset of strains being indirectly implicated with the onset of additional extraoral pathologies. During the past 4 decades, functional studies of S. mutans have focused on understanding the molecular mechanisms the organism employs to form robust biofilms on tooth surfaces, to rapidly metabolize a wide variety of carbohydrates obtained from the host diet, and to survive numerous (and frequent) environmental challenges encountered in oral biofilms. In these areas of research, S. mutans has served as a model organism for ground-breaking new discoveries that have, at times, challenged long-standing dogmas based on bacterial paradigms such as Escherichia coli and Bacillus subtilis . In addition to sections dedicated to carbohydrate metabolism, biofilm formation, and stress responses, this article discusses newer developments in S. mutans biology research, namely, how S. mutans interspecies and cross-kingdom interactions dictate the development and pathogenic potential of oral biofilms and how next-generation sequencing technologies have led to a much better understanding of the physiology and diversity of S. mutans as a species.

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Metadata

Authors
Lemos, J. A., Palmer, S. R., Zeng, L., Wen, Z. T., Kajfasz, J. K., Freires, I. A., Abranches, J., & Brady, L. J.
Venue
Microbiology Spectrum
Publisher
American Society for Microbiology
Published
2019-02-08
Volume
7
Issue
1
ISSN
2165-0497
DOI
10.1128/microbiolspec.gpp3-0051-2018
PMC
PMC6615571
Cited by
794
References
8
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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