The DOI matches its Crossref record; 293 of the 293 references it cites were found in a registry or an index.
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Open accessAbstract
SUMMARY: Lactobacilli have been crucial for the production of fermented products for centuries. They are also members of the mutualistic microbiota present in the human gastrointestinal and urogenital tract. Recently, increasing attention has been given to their probiotic, health-promoting capacities. Many human intervention studies demonstrating health effects have been published. However, as not all studies resulted in positive outcomes, scientific interest arose regarding the precise mechanisms of action of probiotics. Many reported mechanistic studies have addressed mainly the host responses, with less attention being focused on the specificities of the bacterial partners, notwithstanding the completion of Lactobacillus genome sequencing projects, and increasing possibilities of genomics-based and dedicated mutant analyses. In this emerging and highly interdisciplinary field, microbiologists are facing the challenge of molecular characterization of probiotic traits. This review addresses the advances in the understanding of the probiotic-host interaction with a focus on the molecular microbiology of lactobacilli. Insight into the molecules and genes involved should contribute to a more judicious application of probiotic lactobacilli and to improved screening of novel potential probiotics.
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“In particular, genomics is required to identify and elucidate antimicrobial genetic determinants, including bacteriocin and AMP biosynthesis gene clusters, which play critical roles in probiotic-mediated inhibition of pathogenic bacteria [13].”
From Comparative Genomics-Based Evaluation of Lacticaseibacillus rhamnosus KFOM 0134 as a Probiotic against Staphylococcus aureus (2026) · cites this paper as [13]
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“Studies have suggested a set of genes associated with resistance to stress, active metabolism in the host, adhesion, and immunomodulation as genes with probiotic properties [37,38,39].”
From Genomic Characterization of Lactiplantibacillus plantarum Strains: Potential Probiotics from Ethiopian Traditional Fermented Cottage Cheese (2024) · cites this paper as [39]
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Nodem, S. F. S., Yemele, D. M., Iwewe, Y. S., Zoua, A. P., Ndjida, R. G., Arnaud, G. E., Corina, M. M. J., Ndeguena, F. K., Fodouop, S. P. C., Selestin, S. D., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11156-x
Metadata
- Authors
- Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J.
- Affiliations
- KU Leuven (BE)
- Centre of Microbial and Plant Genetics, K. U. Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
- ORCID
- Lebeer, Sarah
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2008-12
- Volume
- 72
- Issue
- 4
- Pages
- 728-764
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC2593565
- OpenAlex
- W2100189539
- Cited by
- 1,013
- References
- 290
- Citations by year
- 2026: 62 · 2025: 55 · 2024: 51 · 2023: 53 · 2022: 73 · 2021: 66 · 2020: 82 · 2019: 65 · 2018: 61 · 2017: 62 · 2016: 40 · 2015: 62 · 2014: 63 · 2013: 53 · 2012: 55
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- lactobacilli, probiotics, probiotic mechanisms of action, mutant analysis, probiotic screening, fermented foods, gut microbiota, urogenital microbiota
- MeSH terms
- Animals, Food Microbiology, Genes, Bacterial, Humans, Intestines, Lactobacillus, Probiotics
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