Cited by 1,013Probiotics and Fermented FoodsReproductive tract infections researchGut microbiota and health

The DOI matches its Crossref record; 293 of the 293 references it cites were found in a registry or an index.

Genes and Molecules of Lactobacilli Supporting Probiotic Action

Open access

Lebeer, Sarah, Vanderleyden, Jos, De Keersmaecker, Sigrid C. J.·2008·Microbiology and Molecular Biology Reviews

Open this paper in CoChat — free account

Abstract

SUMMARY: Lactobacilli have been crucial for the production of fermented products for centuries. They are also members of the mutualistic microbiota present in the human gastrointestinal and urogenital tract. Recently, increasing attention has been given to their probiotic, health-promoting capacities. Many human intervention studies demonstrating health effects have been published. However, as not all studies resulted in positive outcomes, scientific interest arose regarding the precise mechanisms of action of probiotics. Many reported mechanistic studies have addressed mainly the host responses, with less attention being focused on the specificities of the bacterial partners, notwithstanding the completion of Lactobacillus genome sequencing projects, and increasing possibilities of genomics-based and dedicated mutant analyses. In this emerging and highly interdisciplinary field, microbiologists are facing the challenge of molecular characterization of probiotic traits. This review addresses the advances in the understanding of the probiotic-host interaction with a focus on the molecular microbiology of lactobacilli. Insight into the molecules and genes involved should contribute to a more judicious application of probiotic lactobacilli and to improved screening of novel potential probiotics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mmbr.00017-08

Cites

293 of 293 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Two-Component Signal Transduction
Stock, A., Robinson, V. L., & Goudreau, P. N. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.183 · Cited by 3,653
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776

Show all 290 references

Research works printed but not linked: 1

Yan, F., C. Vanderpool, H. Cao, and D. B. Polk. 2007. Soluble proteins produced by Lactobacillus rhamnosus GG (LGG) activate EGF receptor to regulate the anti-apoptotic response in intestinal epithelial cells. Gastroenterology132:A102-A103.

Sorted by citations

Items 101–200 of 1,001

Genome Analysis of Lactobacillus plantarum Isolated From Some Indian Fermented Foods for Bacteriocin Production and Probiotic Marker Genes
Goel, A., Halami, P. M., & Tamang, J. P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00040 · Cited by 125
Limosilactobacillus reuteri in Health and Disease
Abuqwider, J., Altamimi, M., & Mauriello, G. (2022) · Microorganisms · doi:10.3390/microorganisms10030522 · Cited by 131
Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35
Evrard, B., Coudeyras, S., Dosgilbert, A., Charbonnel, N., Alamé, J., Tridon, A., & Forestier, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018735 · Cited by 123
Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet
Machado, M. V., & Cortez‐Pinto, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040481 · Cited by 129
Probiotic features of Lactobacillus strains isolated from Ragusano and Pecorino Siciliano cheeses
Caggia, C., Angelis, M. D., Pitino, I., Pino, A., & Randazzo, C. L. (2015) · Food Microbiology · doi:10.1016/j.fm.2015.03.010 · Cited by 120
Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms
Turpin, W., Humblot, C., Thomas, M., & Guyot, J. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.07.032 · Cited by 125
Lactobacilli Have a Niche in the Human Nose
Boeck, I. D., van den Broek, M. F. L., Allonsius, C. N., Spacova, I., Wittouck, S., Martens, K., Wuyts, S., Cauwenberghs, E., Jokicevic, K., Vandenheuvel, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107674 · Cited by 121
Self-citation
Lactobacillaceae and Cell Adhesion: Genomic and Functional Screening
Turpin, W., Humblot, C., Noordine, M.-L., Thomas, M., & Guyot, J.-P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038034 · Cited by 118
The Potential Use of Probiotics to Improve Animal Health, Efficiency, and Meat Quality: A Review
Al‐Shawi, S. G., Dang, D., YOUSIF, A. Y., Al-Younis, Z. K., Najm, T. A., & Matarneh, S. K. (2020) · Agriculture · doi:10.3390/agriculture10100452 · Cited by 136
Novel probiotic candidates for humans isolated from raw fruits and vegetables
Vitali, B., Minervini, G., Rizzello, C. G., Spisni, E., Maccaferri, S., Brigidi, P., Gobbetti, M., & Cagno, R. D. (2012) · Food Microbiology · doi:10.1016/j.fm.2011.12.027 · Cited by 112
Cross-talk between probiotic lactobacilli and host immune system
Kemgang, T. S., Kapila, S., Shanmugam, V. P., & Kapila, R. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12521 · Cited by 121
Effects of probiotic administration on zebrafish development and reproduction.
Carnevali, O., Avella, M., & Gioacchini, G. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.022 · Cited by 111
Postbiotic L. plantarum RG14 improves ruminal epithelium growth, immune status and upregulates the intestinal barrier function in post-weaning lambs
Izuddin, W. I., Loh, T. C., Foo, H. L., Samsudin, A. A., & Humam, A. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46076-0 · Cited by 117
Impact of lipoteichoic acid modification on the performance of the probiotic Lactobacillus rhamnosus GG in experimental colitis
Claes, I. J. J., Lebeer, S., Shen, C., Verhoeven, T. L. A., Dilissen, E., Hertogh, G., Bullens, D. M. A., Ceuppens, J. L., Assche, G. V., Vermeire, S., et al. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04228.x · Cited by 114
Self-citation
The quest for probiotic effector molecules—Unraveling strain specificity at the molecular level
Lee, I.-C., Tomita, S., Kleerebezem, M., & Bron, P. A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.010 · Cited by 112
GABA-Producing Natural Dairy Isolate From Artisanal Zlatar Cheese Attenuates Gut Inflammation and Strengthens Gut Epithelial Barrier in vitro
Bajić, S. S., Đokić, J., Dinić, M., Veljović, K., Golić, N., Mihajlović, S., & Tolinački, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00527 · Cited by 109
Protection from Intestinal Inflammation by Bacterial Exopolysaccharides
Jones-Burrage, S. E., Paynich, M. L., Kearns, D. B., & Knight, K. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303369 · Cited by 109
Real-time analysis of gut flora in Entamoeba histolytica infected patients of Northern India
Verma, A. K., Verma, R. P., Ahuja, V., & Paul, J. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-183 · Cited by 105
Surface proteins of Propionibacterium freudenreichii are involved in its anti-inflammatory properties
Maréchal, C. L., Péton, V., Plé, C., Vroland, C., Jardin, J., Briard‐Bion, V., Durant, G., Chuat, V., Loux, V., Foligné, B., et al. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.07.018 · Cited by 113
The role of Lactobacillus species in the control of Candida via biotrophic interactions
Zangl, I., Pap, I.-J., Aspöck, C., & Schüller, C. (2020) · Microbial Cell · doi:10.15698/mic2020.01.702 · Cited by 113
Synbiotic as Feed Additives Relating to Animal Health and Performance
Hamasalim, H. J. (2016) · Advances in Microbiology · doi:10.4236/aim.2016.64028 · Cited by 105
Functional Analysis of the p40 and p75 Proteins from Lactobacillus casei BL23
Bäuerl, C., Pérez‐Martínez, G., Yan, F., Polk, D. B., & Monedero, V. (2010) · Microbial Physiology · doi:10.1159/000322233 · Cited by 117
Induction of bacteriocin production by coculture is widespread among plantaricin-producing Lactobacillus plantarum strains with different regulatory operons
Maldonado‐Barragán, A., Caballero‐Guerrero, B., Lucena-Padrós, H., & Ruiz-Barba, J. L. (2012) · Food Microbiology · doi:10.1016/j.fm.2012.08.009 · Cited by 103
Functional annotation of the genome unravels probiotic potential of Bacillus coagulans HS243
Kapse, N. G., Engineer, A. S., Vasudevan, G., Wagh, S., & Dhakephalkar, P. K. (2018) · Genomics · doi:10.1016/j.ygeno.2018.05.022 · Cited by 107
Expression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice
Verma, A., Xu, K., Du, T., Zhu, P., Liang, Z., Liao, S., Zhang, J., Raizada, M. K., Grant, M. B., & Li, Q. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.06.007 · Cited by 102
A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption
Jang, H. R., Park, H., Kang, D., Chung, H., Nam, M. H., Lee, Y., Park, J., & Lee, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0293-4 · Cited by 105
Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity
Zeise, K. D., Woods, R. J., & Huffnagle, G. B. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00323-20 · Cited by 107
Carrot Juice Fermentations as Man-Made Microbial Ecosystems Dominated by Lactic Acid Bacteria
Wuyts, S., Beeck, W. V., Oerlemans, E. F. M., Wittouck, S., Claes, I. J. J., Boeck, I. D., Weckx, S., Lievens, B., Vuyst, L. D., & Lebeer, S. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.00134-18 · Cited by 107
Self-citation
Probiotic attributes of Lactobacillus fermentum isolated from human feces and dairy products
Archer, A. C., & Halami, P. M. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6679-x · Cited by 108
Lactobacillus-produced exopolysaccharides and their potential health benefits: A review
Patten, D. A., & Laws, A. P. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0117 · Cited by 100
Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss
Rong, J., Zheng, H., Liu, M., Hu, X., Wang, T., Zhang, X., Jin, F., & Wang, L. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0525-2 · Cited by 99
Diversity of non-starter lactic acid bacteria in autochthonous dairy products from Western Balkan Countries - Technological and probiotic properties
Terzić-Vidojević, A., Veljović, K., Tolinački, M., Živković, M., Lukić, J., Lozo, J., Fira, Đ., Jovčić, B., Strahinić, I., Begović, J., et al. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109494 · Cited by 108
Intestinal Delivery of Probiotics: Materials, Strategies, and Applications
Li, C., Wang, Z., Xiao, H., & Wu, F. (2024) · Advanced Materials · doi:10.1002/adma.202310174 · Cited by 103
Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health
Ceapa, C., Wopereis, H., Rezaïki, L., Kleerebezem, M., Knol, J., & Oozeer, R. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.04.004 · Cited by 98
Preliminary probiotic and technological characterization of Pediococcus pentosaceus strain KID7 and in vivo assessment of its cholesterol-lowering activity
Damodharan, K., Lee, Y. S., Palaniyandi, S. A., Yang, S. H., & Suh, J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00768 · Cited by 97
Role of Lactobacillus reuteri cell and mucus-binding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro
Jensen, H., Roos, S., Jonsson, H., Rud, I., Grimmer, S., van Pijkeren, J., Britton, R. A., & Axelsson, L. T. (2014) · Microbiology · doi:10.1099/mic.0.073551-0 · Cited by 97
Enhanced acid tolerance in Lactobacillus casei by adaptive evolution and compared stress response during acid stress
Zhang, J., Wu, C., Du, G., & Chen, J. (2012) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0346-6 · Cited by 97
The biofilm mode of life boosts the anti-inflammatory properties ofLactobacillus
Rieu, A., Aoudia, N., Jégo, G., Chluba, J., Yousfi, N., Briandet, R., Deschamps, J., Gasquet, B., Monedero, V., Garrido, C., et al. (2014) · Cellular Microbiology · doi:10.1111/cmi.12331 · Cited by 101
Proteins of novel lactic acid bacteria from Apis mellifera mellifera: an insight into the production of known extra-cellular proteins during microbial stress
Butler, E. I., Alsterfjord, M., Olofsson, T. C., Karlsson, C. A. Q., Malmström, J. A., & Vásquez, A. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-235 · Cited by 99
Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules
Singh, A., Vishwakarma, V., & Singhal, B. (2018) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2018.94012 · Cited by 97
Adhesion Properties of Food-Associated Lactobacillus plantarum Strains on Human Intestinal Epithelial Cells and Modulation of IL-8 Release
García-González, N., Prete, R., Battista, N., & Corsetti, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02392 · Cited by 95
Adhesion mechanisms of lactic acid bacteria: conventional and novel approaches for testing
Alp, D., & Kuleaşan, H. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2730-x · Cited by 98
Probiotics for the airways: Potential to improve epithelial and immune homeostasis
Martens, K., Pugin, B., Boeck, I. D., Spacova, I., Steelant, B., Seys, S., Lebeer, S., & Hellings, P. W. (2018) · Allergy · doi:10.1111/all.13495 · Cited by 97
Self-citation
Characterization of MabA, a modulator ofLactobacillus rhamnosusGG adhesion and biofilm formation
Vélez, M. P., Petrova, M., Lebeer, S., Verhoeven, T. L. A., Claes, I. J. J., Lambrichts, I., Tynkkynen, S., Vanderleyden, J., & Keersmaecker, S. C. J. D. (2010) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2010.00680.x · Cited by 97
Self-citation
Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels
Fang, F., Li, Y., Bumann, M., Raftis, E. J., Casey, P. G., Cooney, J. C., Walsh, M. A., & O’Toole, P. W. (2009) · Journal of Bacteriology · doi:10.1128/jb.00506-09 · Cited by 95
EPS-SJ Exopolisaccharide Produced by the Strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 Is Involved in Adhesion to Epithelial Intestinal Cells and Decrease on E. coli Association to Caco-2 Cells
Živković, M., Miljković, M., Ruas‐Madiedo, P., Markelic, M. B., Veljović, K., Tolinački, M., Bajić, S. S., Korać, A., & Golić, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00286 · Cited by 99
In vitro studies on probiotic and antioxidant properties of Lactobacillus brevis strain LAP2 isolated from Hentak, a fermented fish product of North-East India
Aarti, C., Khusro, A., Varghese, R., Arasu, M. V., Agastian, P., Al-Dhabi, N. A., Soundharrajan, I., & Choi, K. C. (2017) · LWT · doi:10.1016/j.lwt.2017.07.055 · Cited by 95
Metagenomic analysis revealed beneficial effects of probiotics in improving the composition and function of the gut microbiota in dogs with diarrhoea
Xu, H., Zhao, F., Hou, Q., Huang, W., Liu, Y., Zhang, H., & Sun, Z. (2019) · Food & Function · doi:10.1039/c9fo00087a · Cited by 92
Zebrafish gut colonization by mCherry-labelled lactic acid bacteria
Russo, P., Iturria, I., Mohedano, M. L., Caggianiello, G., Rainieri, S., Fiocco, D., Pardo, M. Á., López, P., & Spano, G. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-6351-x · Cited by 95
A Diverse Repertoire of Exopolysaccharide Biosynthesis Gene Clusters in Lactobacillus Revealed by Comparative Analysis in 106 Sequenced Genomes
Deo, D., Davray, D., & Kulkarni, R. (2019) · Microorganisms · doi:10.3390/microorganisms7100444 · Cited by 90
Proteomics of the bacterial cross-talk by quorum sensing
Cagno, R. D., Angelis, M. D., Calasso, M. P., & Gobbetti, M. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.09.003 · Cited by 90
LAB-Secretome: a genome-scale comparative analysis of the predicted extracellular and surface-associated proteins of Lactic Acid Bacteria
Zhou, M., Theunissen, D. H. J., Wels, M., & Siezen, R. J. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-651 · Cited by 90
Lactobacillus reuteri Inhibition of Enteropathogenic Escherichia coli Adherence to Human Intestinal Epithelium
Walsham, A. D. S., MacKenzie, D. A., Cook, V., Wemyss-Holden, S. A., Hews, C. L., Juge, N., & Schüller, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00244 · Cited by 89
Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity
MacKenzie, D. A., Tailford, L. E., Hemmings, A. M., & Juge, N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040907 · Cited by 88
Lacticaseibacillus rhamnosus: A Suitable Candidate for the Construction of Novel Bioengineered Probiotic Strains for Targeted Pathogen Control
Mathipa-Mdakane, M. G., & Thantsha, M. S. (2022) · Foods · doi:10.3390/foods11060785 · Cited by 89
Piliation of Lactobacillus rhamnosus GG Promotes Adhesion, Phagocytosis, and Cytokine Modulation in Macrophages
Garcia, C. V., Petrova, M., Claes, I. J. J., Boeck, I. D., Verhoeven, T. L. A., Dilissen, E., von Ossowski, I., Palva, A., Bullens, D. M. A., Vanderleyden, J., et al. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03949-14 · Cited by 95
Self-citation
Oral Microalgae-Nano Integrated System against Radiation-Induced Injury
Zhang, D., He, J., Cui, J., Wang, R., Tang, Z., Yu, H., & Zhou, M. (2023) · ACS Nano · doi:10.1021/acsnano.3c01502 · Cited by 88
Effect of Flavan-3-ols on the Adhesion of Potential Probiotic Lactobacilli to Intestinal Cells
Bustos, I., García‐Cayuela, T., Hernández‐Ledesma, B., Peláez, C., Requena, T., & Martínez‐Cuesta, M. C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301133g · Cited by 88
A Critical Appraisal of Probiotics for Mastitis Control
Rainard, P., & Foucras, G. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00251 · Cited by 92
Genomic Diversity of Lactobacillus salivarius
Raftis, E. J., Salvetti, E., Torriani, S., Felis, G. E., & O’Toole, P. W. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01687-10 · Cited by 85
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens
Dec, M., Urban‐Chmiel, R., Stępień–Pyśniak, D., & Wernicki, A. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0203-z · Cited by 88
Advances in Probiotic Regulation of Bone and Mineral Metabolism
McCabe, L. R., & Parameswaran, N. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0403-7 · Cited by 85
In vitro screening of lactic acid bacteria for multi-strain probiotics
Pringsulaka, O., Rueangyotchanthana, K., Suwannasai, N., Watanapokasin, R. Y., Amnueysit, P., Sunthornthummas, S., Sukkhum, S., Sarawaneeyaruk, S., & Rangsiruji, A. (2015) · Livestock Science · doi:10.1016/j.livsci.2015.01.016 · Cited by 86
Biotechnology of health-promoting bacteria
Douillard, F. P., & de Vos, W. M. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.03.008 · Cited by 98
The Development of High-Quality Multispecies Probiotic Formulations: From Bench to Market
Grumet, L., Tromp, Y., & Stiegelbauer, V. (2020) · Nutrients · doi:10.3390/nu12082453 · Cited by 90
Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics
Sanders, M. E., Klaenhammer, T. R., Ouwehand, A. C., Pot, B., Johansen, E., Heimbach, J. T., Marco, M. L., Tennilä, J., Ross, R. P., Franz, C. M. A. P., et al. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12363 · Cited by 85
Genome Instability in Lactobacillus rhamnosus GG
Sybesma, W., Douwe Molenaar, B., van IJcken, W. F. J., Venema, K., & Kort, R. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03566-12 · Cited by 84
Antibiotic Resistance Crisis: An Update on Antagonistic Interactions between Probiotics and Methicillin-Resistant Staphylococcus aureus (MRSA)
Nataraj, B. H., & Mallappa, R. H. (2021) · Current Microbiology · doi:10.1007/s00284-021-02442-8 · Cited by 83
Functionality of the S-layer protein from the probiotic strain Lactobacillus helveticus M92
Beganović, J., Frece, J., Kos, B., Pavunc, A. L., Habjanič, K., & Šušković, J. (2011) · Antonie van Leeuwenhoek · doi:10.1007/s10482-011-9563-4 · Cited by 83
Journey of the Probiotic Bacteria: Survival of the Fittest
Mendonça, A. A., Pinto-Neto, W. D. P., da Paixão, G. A., Santos, D. D. S., De Morais, M. A., & De Souza, R. B. (2022) · Microorganisms · doi:10.3390/microorganisms11010095 · Cited by 82
Development of a shelf-stable, gel-based delivery system for probiotics by encapsulation, 3D printing, and freeze-drying
Kuo, C.-C., Clark, S., Qin, H., & Shi, X. (2022) · LWT · doi:10.1016/j.lwt.2022.113075 · Cited by 82
Biosorption of copper by wine-relevant lactobacilli
Schut, S., Zauner, S., Hampel, G., König, H., & Claus, H. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.11.039 · Cited by 82
Review: Adaptation of Beneficial Propionibacteria, Lactobacilli, and Bifidobacteria Improves Tolerance Toward Technological and Digestive Stresses
Gaucher, F., Bonnassié, S., Rabah, H., Marchand, P., Blanc, P., Jeantet, R., & Jan, G. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00841 · Cited by 88
Human Intestinal Dendritic Cells Decrease Cytokine Release against Salmonella Infection in the Presence of Lactobacillus paracasei upon TLR Activation
Bermúdez-Brito, M., Muñoz‐Quezada, S., Gómez‐Llorente, C., Matencio, E., Bernal, M. J., Romero, F., & Gil, Á. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043197 · Cited by 85
Analysis of the fecal microbiota of fast- and slow-growing rainbow trout (Oncorhynchus mykiss)
Chapagain, P., Arivett, B. A., Cleveland, B. M., Walker, D. M., & Salem, M. (2019) · BMC Genomics · doi:10.1186/s12864-019-6175-2 · Cited by 81
The Probiotic Properties of Lactic Acid Bacteria and Their Applications in Animal Husbandry
Deng, Z., Hou, K., Zhao, J., & Wang, H. (2021) · Current Microbiology · doi:10.1007/s00284-021-02722-3 · Cited by 80
Cell surface-associated compounds of probiotic lactobacilli sustain the strain-specificity dogma
Bron, P. A., Tomita, S., Mercenier, A., & Kleerebezem, M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.001 · Cited by 86
Ecological Therapeutic Opportunities for Oral Diseases
Hoare, A., Marsh, P. D., & Diaz, P. I. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0006-2016 · Cited by 85
Probiotic (symbiotic) bacterial languages
Ba, S. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.05.009 · Cited by 80
Functional Properties and Antimicrobial Activity from Lactic Acid Bacteria as Resources to Improve the Health and Welfare of Honey Bees
Iorizzo, M., Letizia, F., Ganassi, S., Testa, B., Petrarca, S., Albanese, G., Criscio, D. D., & Cristofaro, A. D. (2022) · Insects · doi:10.3390/insects13030308 · Cited by 82
In Vitro Evaluation of Lactobacillus gasseri Strains of Infant Origin on Adhesion and Aggregation of Specific Pathogens
Ferreira, C. L. D. L. F., Grześkowiak, Ł., Collado, M. C., & Salminen, S. (2011) · Journal of Food Protection · doi:10.4315/0362-028x.jfp-11-074 · Cited by 78
Genomic Comparison of Lactobacillus helveticus Strains Highlights Probiotic Potential
Fontana, A., Falasconi, I., Molinari, P., Treu, L., Basile, A., Vezzi, A., Campanaro, S., & Morelli, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01380 · Cited by 81
Growth phase‐associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial‐type whey medium
Laakso, K., Koskenniemi, K., Koponen, J., Kankainen, M., Surakka, A., Salusjärvi, T., Auvinen, P., Savijoki, K., Nyman, T. A., Kalkkinen, N., et al. (2011) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00275.x · Cited by 86
Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation
Nishiyama, K., Yamamoto, Y., Sugiyama, M., Takaki, T., Urashima, T., Fukiya, S., Yokota, A., Okada, N., & Mukai, T. (2017) · mBio · doi:10.1128/mbio.00928-17 · Cited by 77
Metabolomics analysis of Lactobacillus plantarum ATCC 14917 adhesion activity under initial acid and alkali stress
Wang, W., He, J., Pan, D., Wu, Z. F., Guo, Y., Zeng, X., & Lian, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196231 · Cited by 76
Anterior Nares Diversity and Pathobionts Represent Sinus Microbiome in Chronic Rhinosinusitis
Boeck, I. D., Wittouck, S., Martens, K., Claes, J., Jorissen, M., Steelant, B., van den Broek, M. F. L., Seys, S., Hellings, P. W., Vanderveken, O. M., et al. (2019) · mSphere · doi:10.1128/msphere.00532-19 · Cited by 79
Self-citation
Expression and delivery of an endolysin to combat Clostridium perfringens
Gervasi, T., Horn, N., Wegmann, U., Dugo, G., Narbad, A., & Mayer, M. J. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5128-y · Cited by 76
Characterization of Pro-Inflammatory Flagellin Proteins Produced by Lactobacillus ruminis and Related Motile Lactobacilli
Neville, B. A., Forde, B. M., Claesson, M. J., Darby, T. M., Coghlan, A., Nally, K., Ross, R. P., & O’Toole, P. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040592 · Cited by 80
Surface Proteome Analysis of a Natural Isolate of Lactococcus lactis Reveals the Presence of Pili Able to Bind Human Intestinal Epithelial Cells
Meyrand, M., Guillot, A., Goin, M., Furlan, S., Armalytė, J., Kulakauskas, S., Cortes‐Perez, N. G., Thomas, G., Chat, S., Péchoux, C., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.029066 · Cited by 75
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation
Wu, Q., Liu, M., Yang, J., Wang, J., & Zhu, Y. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03044-15 · Cited by 75
Isolation, characterization and comparative genomics of potentially probiotic Lactiplantibacillus plantarum strains from Indian foods
Surve, S., Shinde, D. B., & Kulkarni, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-05850-3 · Cited by 74
Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria
Kosmerl, E., Rocha-Mendoza, D., Ortega‐Anaya, J., Jiménez‐Flores, R., & García‐Cano, I. (2021) · Microorganisms · doi:10.3390/microorganisms9020341 · Cited by 74
Probiotic Species in the Management of Periodontal Diseases: An Overview
Zhang, Y., Ding, Y., & Guo, Q. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.806463 · Cited by 80
Impact of genomics on the field of probiotic research: historical perspectives to modern paradigms
Johnson, B. R., & Klaenhammer, T. R. (2014) · Antonie van Leeuwenhoek · doi:10.1007/s10482-014-0171-y · Cited by 79
In vitro interactions between probiotic bacteria and milk proteins probed by atomic force microscopy
Burgain, J., Gaïani, C., Francius, G., Revol‐Junelles, A., Cailliez‐Grimal, C., Lebeer, S., Tytgat, H. L. P., Vanderleyden, J., & Scher, J. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.11.032 · Cited by 74
Self-citation
Surface proteins from Lactobacillus kefir antagonize in vitro cytotoxic effect of Clostridium difficile toxins
Carasi, P., Trejo, F. M., Pérez, P. F., Antoni, G. L. D., & Serradell, M. D. L. Á. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.11.002 · Cited by 75
Lactobacillus Reuteri DSM 17938 (Limosilactobacillus reuteri) in Diarrhea and Constipation: Two Sides of the Same Coin?
Saviano, A., Brigida, M., Migneco, A., Gunawardena, G., Zanza, C., Candelli, M., Franceschi, F., & Ojetti, V. (2021) · Medicina · doi:10.3390/medicina57070643 · Cited by 73
Progress in engineering acid stress resistance of lactic acid bacteria
Wu, C., Huang, J., & Zhou, R. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5435-3 · Cited by 74
Comprehensive pan‐genome analysis of Lactiplantibacillus plantarum complete genomes
Carpi, F. M., Coman, M. M., Silvi, S., Picciolini, M., Verdenelli, M. C., & Napolioni, V. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15199 · Cited by 72
The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG
Lebeer, S., Claes, I. J. J., Balog, C. I. A., Schoofs, G., Verhoeven, T. L. A., Nys, K., von Ossowski, I., de Vos, W. M., Tytgat, H. L. P., Agostinis, P., et al. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-15 · Cited by 75
Self-citation

Authors: Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J.
Affiliations: KU Leuven (BE)
Centre of Microbial and Plant Genetics, K. U. Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
ORCID: Lebeer, Sarah
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2008-12
Volume: 72
Issue: 4
Pages: 728-764
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00017-08
PMC: PMC2593565
OpenAlex: W2100189539
Cited by: 1,013
References: 290
Citations by year: 2026: 62 · 2025: 55 · 2024: 51 · 2023: 53 · 2022: 73 · 2021: 66 · 2020: 82 · 2019: 65 · 2018: 61 · 2017: 62 · 2016: 40 · 2015: 62 · 2014: 63 · 2013: 53 · 2012: 55
FWCI: 4.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
Funders: Fonds Wetenschappelijk Onderzoek
Vlaamse regering
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: lactobacilli, probiotics, probiotic mechanisms of action, mutant analysis, probiotic screening, fermented foods, gut microbiota, urogenital microbiota
MeSH terms: Animals, Food Microbiology, Genes, Bacterial, Humans, Intestines, Lactobacillus, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genes and Molecules of Lactobacilli Supporting Probiotic Action

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks