Cited by 1,013Probiotics and Fermented FoodsReproductive tract infections researchGut microbiota and health

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Genes and Molecules of Lactobacilli Supporting Probiotic Action

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Lebeer, Sarah, Vanderleyden, Jos, De Keersmaecker, Sigrid C. J.·2008·Microbiology and Molecular Biology Reviews

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Abstract

SUMMARY: Lactobacilli have been crucial for the production of fermented products for centuries. They are also members of the mutualistic microbiota present in the human gastrointestinal and urogenital tract. Recently, increasing attention has been given to their probiotic, health-promoting capacities. Many human intervention studies demonstrating health effects have been published. However, as not all studies resulted in positive outcomes, scientific interest arose regarding the precise mechanisms of action of probiotics. Many reported mechanistic studies have addressed mainly the host responses, with less attention being focused on the specificities of the bacterial partners, notwithstanding the completion of Lactobacillus genome sequencing projects, and increasing possibilities of genomics-based and dedicated mutant analyses. In this emerging and highly interdisciplinary field, microbiologists are facing the challenge of molecular characterization of probiotic traits. This review addresses the advances in the understanding of the probiotic-host interaction with a focus on the molecular microbiology of lactobacilli. Insight into the molecules and genes involved should contribute to a more judicious application of probiotic lactobacilli and to improved screening of novel potential probiotics.

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Authors: Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J.
Affiliations: KU Leuven (BE)
Centre of Microbial and Plant Genetics, K. U. Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
ORCID: Lebeer, Sarah
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2008-12
Volume: 72
Issue: 4
Pages: 728-764
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00017-08
PMC: PMC2593565
OpenAlex: W2100189539
Cited by: 1,013
References: 290
Citations by year: 2026: 62 · 2025: 55 · 2024: 51 · 2023: 53 · 2022: 73 · 2021: 66 · 2020: 82 · 2019: 65 · 2018: 61 · 2017: 62 · 2016: 40 · 2015: 62 · 2014: 63 · 2013: 53 · 2012: 55
FWCI: 4.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
Funders: Fonds Wetenschappelijk Onderzoek
Vlaamse regering
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: lactobacilli, probiotics, probiotic mechanisms of action, mutant analysis, probiotic screening, fermented foods, gut microbiota, urogenital microbiota
MeSH terms: Animals, Food Microbiology, Genes, Bacterial, Humans, Intestines, Lactobacillus, Probiotics

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Genes and Molecules of Lactobacilli Supporting Probiotic Action

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